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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Collecting Electrospun Nanofibers with Patterned Electrodes 显示文摘 | Li D Ouyang G McCann J T | 2005 | Nano Letters2005，5，5： | 1 |
| 3 | Rheologic reflection in hypertriglyceridemia-induced pancreatitis 显示文摘 | Martin D McCann E G|ynn P | 2009 | South Med J2009，102，10： | 1 |
| 4 | Competitive Behavior and Nonfinancial Objectives:Entry, Exit, and Pricing Decisions in Closely Held Firms 显示文摘 | McCann B T Vroom G | 2013 | Organization Science2013，25，4： | 1 |
| 5 | Prospective evaluation of a Dacron cuffed hemodialysis catheter for prolonged use 显示文摘 | Schwab S Buller G Mccann R | 1988 | Am J Kidney Dis1988，11，2： | 1 |
| 6 | Ni- trogen-linked diphosphine ligands with ethers attached to nitrogen for chromium-catalyzed ethylene tri- and tet- ramerizations 显示文摘 | ELOWE P R MCCANN C PRINGLE P G | 2006 | Organometallics2006，25，22： | 1 |
| 7 | Distributed stochastic cross-layer optimization for multi-hop wireless networks with cooperative communications显示文摘 | YANG S S SHENG Z G MCCANN J A | 2013 | IEEE Transactions on Mobile Computing2013，13，10： | 1 |
| 8 | Community Satisfaction:Theory and Measurement显示文摘 | Ladewig H McCann G C | 1980 | Rural Sociology1980，，1： | 1 |
| 9 | Contemporary man agement of and outcomes from cardiac device related infections 显示文摘 | Margey R McCann H Blake G | 2010 | Europace2010，12，1： | 1 |
| 10 | Changes in plasma lipids and dietary intake accompanying shifts in perceived work-load and stress显示文摘 | McCann B S Warnick G R Knopp R H | 1990 | Psychosomatic Medicine1990，2，： | 1 |
| 11 | Survival of patients with documented autologous recovery after SCT for severe aplastic anemia: a study by the WPSAA of the EBMT 显示文摘 | Piccin A McCann S Socie G | 2010 | Bone Marrow Transplant2010，45，6： | 1 |
| 12 | Diagnosis, assessment, and treatment of bone turnover abnormalities in renal osteodystrophy显示文摘 | Kevin J Martin Klaus Olgaard Jack W Coburn Giorgio M Coen Masafumi Fukagawa Craig Langman Hartmut H Malluche James T McCarthy Shaul G Massry Otto Mehls Isidro B Salusky Justin M Silver Miroslaw T Smogorzewski Eduardo M Slatopolsky Linda McCann | 2004 | American Journal of Kidney Diseases2004，，3： | 1 |
| 13 | Effect of osteoporosis on bone mineral density and fracture repair in a rat femoral fracture model显示文摘 | McCann RM Col eary G Geddis C | | 0，，03： | 1 |
| 14 | Diversity loss with persistent human disturbance increases vulnerability to ecosystem collapse显示文摘 | MacDougall AS McCann KS Gellner G 2013 | 2013 | Nature2013，494，： | 1 |
| 15 | Experimental investigation of supersonic gaseous injection into a supersonic freestream显示文摘 | MCCANN G J BOWERSOX R D W | 1996 | AIAA Journal1996，34，： | 1 |
| 16 | Experimental verifications of numerical predictions for the hydrodynamic performance of horizontal axis marine current turbines显示文摘 | BAHAJ A S BATTEN W M J MCCANN G | 2007 | Renewable Energy2007，32，15： | 1 |
| 17 | Collecting Electrospun Nanofibers with Patterned Electrodes显示文摘 | Li D Ouyang G McCann JT | 2005 | Nano Letters2005，5，5： | 1 |
| 18 | Modifying the solar spectrum to enhance silicon solar cell efficiency-An overview of available materials 显示文摘 | Strumpel C McCann M Beaucarne G | 2007 | Solar Energy Materials and Solar Cells2007，91，4： | 1 |
| 19 | Modifying the solar spectrum to enhance silicon solar cell efficiency-An overview of available materials 显示文摘 | Strumpel C Mccann M Beaucarne G | 2007 | Solar Energy Mater Solar Cells2007，91，4： | 1 |
| 20 | Pricing response to entry and agglomeration effects 显示文摘 | McCann B T Vroom G | 2010 | Strategic Management Journal2010，31，10： | 1 |
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