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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Microbial biomass estimated by phospholipids phosphate in soil with diverse microbial communities显示文摘 | Hiu T C J McPherson E F Harris J A | 1993 | Soil Biochem1993，25，： | 1 |
| 3 | Winter rainfall interception by two mature open-grown trees in dsvis,California显示文摘 | Xiao Q F Mcpherson E G Ustin S L | | 0，，04： | 1 |
| 4 | Microbial biomass estimated by phospholipid phosphate in soils with diverse microbial communities显示文摘 | HILL T C J MCPHERSON E F HARRIS J A | 1993 | Soil Biol Biochem1993，25，12： | 1 |
| 5 | Benefits and costs ofstreet trees in Lisbon,Portugal显示文摘 | SOARES A L REGO F C MCPHERSON E G | 2011 | Urban Forestry&Urban Greening2011，10，： | 1 |
| 6 | Pathology quiz: Small cell osteosarcoma 显示文摘 | McPherson F Chamyan G Gilbert-Barness E | 2001 | Pediatr Pathol Mol Med2001，20，4： | 1 |
| 7 | Assessing the benefits and costs of the urban forest 显示文摘 | Dwyer J F McPherson E G Schroeder H W | 1992 | Journal of Arboricuhure1992，18，5： | 1 |
| 8 | A method for locatingpotential tree-planting sites in urban areas:A case study of Los Angeles, USA 显示文摘 | Wu C X Xiao Q F Mcpherson E G | 2008 | Urban Forestry & Urban Greening2008，7，2： | 1 |
| 9 | Assessing the benefits and costs of the urban forest显示文摘 | DWYER JOHN F GREGORY MCPHERSON E SCHROEDER HERBERT W | 1992 | Journal of Arboriculture1992，18，5： | 1 |
| 10 | Million trees Los Angeles canopy cover and benefit assessment 显示文摘 | Mcpherson E G Simpson J R Xiao Q F | 2011 | Landscape and Urban Planning2011，99，1： | 1 |
| 11 | Assessing the Benefits and Costs of the Urban Forest显示文摘 | Dwyer J F McPherson E Q Schroeder H W et ai | 1992 | Journal of Arborculture1992，18，5： | 1 |
| 12 | Rainfall interception of three trees in Oakland, California 显示文摘 | Xiao Q F McPherson E G | 2011 | Urban Ecosystems2011，14，4： | 1 |
| 13 | Winter rainfall interception by two mature open grown trees in Davis, California显示文摘 | Xiao Q F Mcpherson E G Ustin S L | 2000 | Hydrological Processes2000，14，4： | 1 |
| 14 | Winter rainfall interception by two mature open-grown trees in Davis, California显示文摘 | Xiao Q F Mcpherson E G Ustin S L | 2000 | Hydrological Processes2000，14，4： | 1 |
| 15 | Winter rainfall interception by two mature opengrown trees in Davis,California显示文摘 | Xiao Q F Mcpherson E G Ustin S L | 2000 | Hydrological Processes2000，14，4： | 1 |
| 16 | Assessing the benefits and costs of the urban forest显示文摘 | DWYER J F MCPHERSON E G SCHROEDER S M | 1992 | Journal of Arboriculture1992，18，5： | 1 |
| 17 | Erytropoie- tin concentrations in cerebrospinal fluid of nonhuman primates and fetal sheep following high - dose recombinant erythropoietin 显示文摘 | JUUL S E MCPHERSON R J FARRELL F X | 2004 | Biol Neonate2004，85，2： | 1 |
| 18 | Effect of porosity on performance of windbreaks显示文摘 | Moysey E B Mcpherson F B | 1966 | Transactions of the ASAE1966，9，1： | 1 |
| 19 | Winter rainfall interception by two mature open-grown trees in Davis, California 显示文摘 | XIAO Q F MCPHERSON E G USTIN S L | 2000 | Hydrological Processes2000，14，4： | 1 |
| 20 | Assessing the Benefits and Costs of the Urban Forest显示文摘 | Dwyer J F McPherson E G Schroeder H W | 1992 | Journal of Arborculture1992，18，5： | 1 |
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