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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Global data assimilation experiments with scatterometer winds from SEASAT-A显示文摘 | Yu T W Mcpherson R D | 1984 | Monthly Weather Review1984，112，1： | 1 |
| 3 | Maturity of operational numer- ical weather prediction :medium range 显示文摘 | KALNAY E JORD S J MCPHERSON R D | 1998 | Bulletin of the American Mete- orological Society1998，79，： | 1 |
| 4 | Psychometrically equivalent polish bisyllabicwords spoken by male and female talkers显示文摘 | HARRIS R W NIELSEN W S MCPHERSON D L | 2004 | Audiofo-nologia2004，25，： | 1 |
| 5 | Cloning of Serratiamarcescens gene encoding chitinase显示文摘 | Fuchis R L Mcpherson S A Drahos D J | 1986 | Appl Environ Microbiol1986，51，1： | 1 |
| 6 | A numerical study effect of a coastal irregularity on the sea breeze 显示文摘 | Mcpherson R D | 1970 | J Appl Meteor1970，9，： | 1 |
| 7 | Electron Spin Resonance Spectra of V^2+ , Mn^2+ , and Ni^2+ in Single Crystals of CsMgBr3 and CsMgI3 显示文摘 | Mcpherson G L Koch R C Stacky G D | 1974 | Journal of Chemical Physics1974，60，4： | 1 |
| 8 | Effects of light restriction on broiler performance and specific body structure measurements显示文摘 | Ingram D R Hatten L F McPherson B N | 2000 | Journal of Applied Poultry Research2000，9，4： | 1 |
| 9 | Maturity of operational nu- merical weather prediction: medium range显示文摘 | Kalnay E LordS J McPherson R D | 1998 | Bulletin of the American Meteorological Society1998，79，： | 1 |
| 10 | Global data assimilation experiments with scatterometer winds from SEASAT-A显示文摘 | YU T W MCPHERSON R D | 1984 | Mon Wea Ree1984，112，： | 1 |
| 11 | Maryland' s Nontraditional Pathway to the Doctor of Pharmacy Degree : Development and Improvement 显示文摘 | McPherson M L Kerr R A Fedder D O | 1999 | Am J Pharm Educ1999，63，： | 1 |
| 12 | Measuring and Analyzing Urban Tree Cover显示文摘 | Nowak D J Rowntree R A McPherson E G | | 0，，： | 1 |
| 13 | Cardiac memory: a mechanical and electrical phenomenon显示文摘 | Alessandrini R Mcpherson D Kadish AH | 1997 | Am J Physiol1997，272，： | 1 |
| 14 | Investigation of the role of SREBP-1 c in the pathogenesis of HCV-related steatosis显示文摘 | McPherson S Jonsson J R Barrie H D | 2008 | J Hepatol2008，49，6： | 1 |
| 15 | Occurrence of five thrips species on flue-cured tobacco and impact on spotted wilt disease incidence in Georgia显示文摘 | McPherson R M Pappu H R Jones D C | 1999 | 83(8): 765-7671999，83，8： | 1 |
| 16 | Cloning of a Serratia marcescens gene encoding chitinase 显示文摘 | FUCHS R L MCPHERSON S A DRAHOS D J | 1986 | Appl Environ Microbiol1986，51，3： | 1 |
| 17 | Effects of light restriction on broiler performance and specific body structure measurements显示文摘 | INGRAM D R HATTEN III L F MCPHERSON B N | 2000 | J Appl Poult Res2000，9，4： | 1 |
| 18 | Cardiac memory= a mechanical and electrical phenome- non显示文摘 | ALESSANDRINI R S MCPHERSON D D KAD1SH A H | 1997 | Am J Physiot1997，272，42： | 1 |
| 19 | Field evaluation of soybean engineered with a synthetic cry1Ac transgene for resistance to corn earworm, soybean looper, velvetbean caterpillar (Lepidoptera: Noctuidae), and lesser corn-stalk borer (Lepidoptera: Pyralidae) 显示文摘 | Walker D R All J McPherson R M | 2000 | Journal of Economic Entomology2000，93，3： | 1 |
| 20 | Maturity of operational numerical weather prediction:medium range显示文摘 | Lord S J McPherson R D | 1998 | Bulletin of the American Meteorological Society1998，79，： | 1 |
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