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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Effect of age on mortality, hospitalizations and response to digoxin in patients with heart failure: the DIG study显示文摘 | Rich MW McSherry F Williford WO | 2001 | J Am Coll Cardiol2001，38，3： | 1 |
| 3 | Land suitability analysis for the upper Gila River watershed显示文摘 | Steiner F McSherry L Jill Cohen | 2000 | Landscape and Urban Planning2000，50，： | 1 |
| 4 | The incidence and causes of death following surgery for nonmalignant biliary tract disease显示文摘 | McSherry C K Glenn F | 1980 | Ann Surg1980，131，： | 1 |
| 5 | Privacy integrated queries: an extensible platform for privacy-preserving data analysis显示文摘 | MCSHERRY F | 2010 | Communication of the ACM2010，53，9： | 1 |
| 6 | Calibrating Noise to Sensitivity in Private Data Analysis显示文摘 | Dwork C McSherry F Nissim K | 2006 | Theory of Cryptog- raphy2006，25，20： | 1 |
| 7 | Land Suitability analysis for the upper Gila River watershed显示文摘 | Steiner F McSherry L Cohen J | 2000 | Landscape and Urban Planning2000，50，4： | 1 |
| 8 | lamd suitability analysis for the upper Gila River watershed 显示文摘 | Stelner F McSherry L Cohen J | 2000 | Landscape and urban planning2000，50，4： | 1 |
| 9 | Land suitability analysis for the upper Gila River watershed 显示文摘 | Steiner F McSherry L Cohen J | 2000 | Landscape and urban planning2000，50，： | 1 |
| 10 | A watershed at a watershed: the potential for environ- mentally sensitive area protection in the upper显示文摘 | STEINER F BLAIR J MCSHERRY L | 2000 | San Pedro Drainage Basin2000，49，： | 1 |
| 11 | Privacy integrated queries:an extensible platform for privacy-preserving data analysis显示文摘 | Mcsherry F | 2010 | Communications of the ACM2010，53，9： | 1 |
| 12 | Land suitability analysis for the upper Gila River watershed显示文摘 | Steiner F McSherry L Cohen J | 2000 | Landscape and UrbanPlanning2000，50，4： | 1 |
| 13 | Privacy integrated queries:an extensible platform for privacy-preserving data analysis显示文摘 | McSHERRY F | 2010 | Communications of the ACM2010，53，9： | 1 |
| 14 | Carcinoma of the colon and rectum显示文摘 | McSherry CK Cornell GN Glenn F | 1969 | Ann Surg1969，169，4： | 1 |
| 15 | Effect of age on mortality, hospitalizations and response to digoxin in patients with heart failure: the DIG study显示文摘 | Rich MW McSherry F Williford WO etal | 2001 | JAm Coil Cardiol2001，38，3： | 1 |
| 16 | Land Suitability Analysis for the Upper Gila River Watershed显示文摘 | STEINER F MCSHERRY L COHEN J | 2000 | Landscape and Urban Planning2000，50，1： | 1 |
| 17 | Preparations and properties of castor-oil-urethane foams显示文摘 | YEADON D A MCSHERRY W F GOLDBLATT L A | 1959 | Journal of America Oil Chemists'' Scoiety1959，36，： | 1 |
| 18 | Land suitability analysis for the upper Gila River watershed 显示文摘 | Steiner F McSherry L Jill Cohen | 2000 | Landscape and Urban Planning2000，50，： | 1 |
| 19 | The incidence and causes ofdeath following surgery for non malignant bil-iary tract diseases 显示文摘 | MCSHERRY CK GLENN F | 1980 | Ann Surg1980，191，3： | 1 |
| 20 | The incidence and causes of death following surgery for nonmalignant biliary tract disease显示文摘 | Glenn F | 1980 | Ann Surg1980，131，： | 1 |
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