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| 1 | Expression of intestinal trefoil factor, proliferating cell nuclear antigen and histological changes in intestine of rats after intrauterine asphyxia显示文摘AIM: To study the expressions of intestinal trefoil factor (ITF) and proliferating cell nuclear antigen (PCNA) and histologic changes in intestine, to investigate the relationship between ITF and intestinal damage and repair after intrauterine hypoxia so as to understand the mechanism of intestinal injury and to find a new way to prevent and treat gastrointestinal diseases.METHODS: Wistar rats, pregnant for 21 d, were used to establish animal models of intrauterine asphyxia by clamping one side of vessels supplying blood to uterus for 20 min, another side was regarded as sham operation group. Intestinal tissues were taken away at 0, 24, 48and 72 h after birth and stored in different styles. ITF mRNA was detected by RT-PCR. PCNA expression was measured by immunohistochemistry. Intestinal tissues were studied histologically by HE staining in order to observe the areas and degree of injury and to value the intestinal mucosa injury index (IMDI).RESULTS: ITF mRNA appeared in full-term rats and increased with age. After ischemia, ITF mRNA was decreased to the minimum (0.59±0.032) 24 h after birth, then began to increase higher after 72 h than it was in the control group (P<0.01). PCNA positive staining located in goblet cell nuclei. The PCNA level had a remarkable decline (53.29±1.97) 48 h after ischemia. Structure changes were obvious in 48-h group, IMDI (3.40±0.16) was significantly increased. Correlation analyses showed that IMDI had a negative correlation with ITF mRNA and PCNA (r = -0.543,P<0.05; r = -0.794, P<0.01, respectively).CONCLUSION: Intrauterine ischemia can result in an early decrease of ITF mRNA expression. ITF and PCNA may play an important role in the damage and repair of intestinal mucosa. | Ling-FenXu JunLi MeiSun Hong-WeiSun | 2005 | World Journal of Gastroenterology2005，11，15： | 5 |
| 2 | Abnormal polymorph conversion of calcium carbonate anti nano -self-assembly of vaterite by a supported liquid membrane system显示文摘 | QINGSHENG WU DONG MEISUN HUA JIE LIU | 2004 | Crystal Growth & Design2004，4，： | 1 |
| 3 | Mechanism of Action of Camptothecin显示文摘 | LEROY F.LIU SHYAMAL D.DESAI TSAI‐KUNLI YONGMAO MEISUN SAI‐PENGSIM | 2006 | Annals of the New York Academy of Sciences2006，，1： | 1 |
| 4 | Da-Bu-Yin-Wan andQian-Zheng-San, two traditional Chinese herbal formulas, up-regulatethe expression of mitochondrial subunit NADH dehydrogenase 1synergistically in the mice model of Parkinson's disease 显示文摘 | Yi Zhang Hong MeiSun Xin He | 2013 | Journal ofEthnopharmacology2013，146，1： | 1 |
| 5 | Integrin β3 and its ligand regulate the expression of uPA through p38 MAPK in breast cancer显示文摘 | RUIWANG ZHAO‐QINGLI XUHAN BAI‐LINLI XIAO‐YIMI LI‐MEISUN MINSONG YAN‐CHUNHAN YANZHAO EN‐HUAWANG | 2010 | APMIS2010，，12： | 1 |
| 6 | 出门别忘带教养显示文摘不少人遇到过这样的情况:在某些安静的公共场合,一些孩子在大吵大闹,或大音量开着手机,他们的父母在身边却为孩子的这种“活泼”而自豪,有人责备只会说一句“孩子就是这样的”。 | Meisun | 2018 | 环境与生活2018，0，4： | 0 |
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