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| 1 | Pollen Typhae Total Flavone Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis in Human Aortic-Vascular Smooth Muscle Cells through Down-Regulating PERK-eIF2α-ATF4-CHOP Pathway显示文摘Objective: To test the hypothesis that the inhibition of endoplasmic reticulum(ER) stress-induced apoptosis in oxidized low-density lipoproteins(ox-LDL)-induced human aortic-vascular smooth muscle cells(HA-VSMCs) was associated with suppression of the protein kinase RNA-like ER kinase(PERK)-eukaryotic translation initiation factor 2α(e IF2α)-activating transcription factor 4(ATF4)-CCAAT/enhancer binding protein homologous protein(CHOP) signaling pathway by Pollen Typhae total flavone(PTF). Methods: Primary HA-VSMCs were cultured and identified. The cultured HA-VSMCs were randomized into 5 groups, including a normal control group, an ox-LDL group(70 μg/m L high ox-LDL), an HPTF group(70 μg/m L high ox-LDL+500 μg/m L PTF), an MPTF group(70 μg/m L high ox-LDL+250 μg/m L PTF), and a LPTF group(70 μg/m L high ox-LDL+100 μg/m L PTF) in the first part;and a normal control group, an ox-LDL group(70 μg/mL high ox-LDL), an MPTF group(70 μg/m L high ox-LDL+250 μg/m L PTF), a sh RNA group(transducted with PERK shRNA lentiviral particles), a scramble shRNA group(transducted with control shRNA lentiviral particles), an MPTF+ox-LDL+shRNA group(250 μg/mL PTF+70 μg/mL high ox-LDL+PERK shRNA lentiviral particles) and an ox-LDL+shRNA group(70 μg/mL high ox-LDL+PERK shRNA lentiviral particles) in the second part. The protein expression levels of ER-associated apoptosis proteins were detected by Western blot, and their m RNA expression levels were detected by quantitative real-time reverse transcription-polymerase chain reaction. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay was applied to test cel viability, and the level of apoptosis was monitored by flow cytometry. Results: The MTT assay and flow cytometry showed that the ox-LDL group had a significant increase in apoptosis, which was attenuated in PTF treatment groups and sh RNA groups. Moreover, the ox-LDL group had increased protein and m RNA levels of binding immunoglobulin protein and ER-associated apoptosis proteins, such as PERK, e IF2α, ATF4 and CHOP, which were attenuated in PTF treatment groups and sh RNA groups. Conclusions: The apoptosis induced by ox-LDL had a strong relation to ER stress. The protective effect of PTF on ER stressinduced apoptosis was associated with inhibition of the PERK-eIF2α-ATF4-CHOP pathway, which might be a potential therapeutic strategy for enhancing the stability of atherosclerotic plaques. | CHEN Ming-tai HUANG Ruo-lan OU Li-jun CHEN Ying-nan MEN Ling CHANG Xiao WANG Ling YANG Yu-zhu ZHANG Zhong | 2019 | Chinese Journal of Integrative Medicine2019，25，8： | 9 |
| 2 | Facile synthesis of bimodal macroporous g-C_3N_4/SnO_2 nanohybrids with enhanced photocatalytic activity显示文摘It is of vital importance to construct highly interconnected,macroporous photocatalyst to improve its efficiency and applicability in solar energy conversion and environment remediation.Graphitic-like C_3N_4(g-C_3N_4),as an analogy to two-dimensional(2D)graphene,is highly identified as a visible-lightresponsive polymeric semiconductor.Moreover,the feasibility of g-C_3N_4 in making porous structures has been well established.However,the preparation of macroporous g-C_3N_4 with abundant porous networks and exposure surface,still constitutes a difficulty.To solve it,we report a first facile preparation of bimodal macroporous g-C_3N_4 hybrids with abundant in-plane holes,which is simply enabled by in-situ modification through thermally treating the mixture of thiourea and SnCl_4(pore modifier)after rotary evaporation.For one hand,the formed in-plane macropores endow the g-C_3N_4 system with plentiful active sites and short,cross-plane diffusion channels that can greatly speed up mass transport and transfer.For another,the heterojunctions founded between g-C_3N_4 and SnO_2 consolidate the electron transfer reaction to greatly reduce the recombination probability.As a consequence,the resulted macroporous gC_3N_4/SnO_2 nanohybrid had a high specific surface area(SSA)of 44.3 m^2/g that was quite comparable to most nano/mesoporous g-C_3N_4 reported.The interconnected porous network also rendered a highly intensified light absorption by strengthening the light penetration.Together with the improved mass transport and electron transfer,the macroporous g-C_3N_4/SnO_2 hybrid exhibited about 2.4-fold increment in the photoactivity compared with pure g-C_3N_4.Additionally,the recyclability of such hybrid could be guaranteed after eight successive uses. | Yingzhi Chen Wenhao Li Dongjian Jiang Kuo Men Zhen Li Ling Li Shizheng Sun Jingyuan Li Zheng-Hong Huang Lu-Ning Wang | 2019 | Science Bulletin2019，64，1： | 7 |
| 3 | A causal analysis on the forma- tion of by-products in tannin extract desulfurization-kinetics and mechanism research on HS- with oxygen 显示文摘 | Niu Y X Ling K C Men X Q | 2010 | Energ Sources:PartA2010，33，1： | 1 |
| 4 | Design and manufacturing of the antechamber for BEPCII storage rings显示文摘Antechamber which composes the arc vacuum chamber of storage rings is one of the key devices of BEPCII. It has the characteristic of various specifications, large size, complex structure, and high dimension accuracy. This paper gives a review on the structure features and the procedure of production, including the mechanical machining process, cleaning and welding process of high vacuum aluminum alloy, ultrahigh vacuum test and so on. In view of the occurrence of the concave deformation, the reasons are analyzed and the correction method developed is introduced too. | Ling Kang (1) ChunHua Li (1) KaiXi Huang (1) HuaMin Qu (1) YiQing Zou (1) Yan Zhang (1) LuXiang Han (1) LingLing Men (1) | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 1 |
| 5 | A Causal Analysis on the Formation of By-products in Tannin Extract Desulfurization-ki- netics and Mechanism Research on HSwith Oxygen显示文摘 | Niu Y X Ling K C Men X Q | 2011 | Energy Sources Part A2011，33，1： | 1 |
| 6 | A Causal Analysis on the Formation of By-products in Tannin Extract Desulfurization-kinetics and Mechanism Research on HS-with Oxygen显示文摘 | Niu Y X Ling K C Men X Q | | 0，，01： | 1 |
| 7 | Oxidation mechanism of three Fe-Al alloys with and without addition of 0.1 at% yttrium at 800℃显示文摘The isothermal oxidation behavior of Fe-10 Al,Fe-15 Al,Fe-20 Al alloys with and without the addition of0.1 at% Y was studied at 800℃ under 1×105 Pa of flowing pure O2 for 24 h.The oxidation of three Fe-Al alloys can be divided into transient state and steady state oxidation stages.The oxidation of each stage is approximately in accordance with the parabolic law.The addition of 0.1 at% Y changes the oxidation behavior obviously and leads to a significant increase of the weight gain of Fe-10 Al and Fe-15 Al.The scale grown on Fe-10 Al is much thicker and more complicated than that grown on Fe-20 Al,which is composed of an exclusive thin layer of Al2 O3 protective film.Due to the formation of a large number of nodules,the scales grown on Fe-15 AI cannot provide full protection for the alloy.Scale micro structure of the three Fe-Al-0.1 Y alloys is similar to their corresponding Fe-Al alloys.However,nodules with very small size still appear on the surface of Fe-20 Al-0.1 Y alloy.The critical Al concentration to form an exclusive Al2 O3 protective layer for Fe-Al binary alloy is on the borderline between 15 at%-20 at%.For Fe-Al-0.1 Y alloy,the presence of 20 at% Al is not enough to inhibit the growth of nodules. | Xunhu Xu Hua Wei Junhuai Xiang Ling Wang Mingfeng Liu Honghua Zhang Dandan Men Jiangshan An | 2020 | Journal of Rare Earths2020，38，10： | 0 |
| 8 | Research on error accumulation control of three-dimensional adjustment with offset constraint显示文摘Background Currently,laser tracker is the primary instrument used to carry out three-dimensional position measurement in accelerator alignment.Theoretically,three-dimensional measuring data processed by three-dimensional adjustment are more rigorous,however,error accumulation is found in practice.Purpose In order to control error accumulation and further improve the measurement accuracy of accelerator alignment,this research introduces the laser alignment system into the activity of measurement and data processing.Methods A measurement scheme combining laser tracker and laser alignment system is proposed.To construct the constraint condition,the offset values from the measuring points to the laser straight-line datum were used.To carry out the three-dimensional adjustment with offset constraint,the laser tracker observations were used.Results A three-dimensional adjustment function model of laser tracker observations is given.The construction method of the constraint equation is researched,and the calculation formulas of the three-dimensional adjustment with offset constraint are derived.A 200 m linac tunnel control network is designed,using simulation measurement method,the measuring data of laser tracker and the offset values from the measuring points to the laser straight-line datum were generated.The simulated data are calculated by the method given in this paper and the result is analyzed.Conclusion Simulation result shows introducing the laser alignment system into laser tracker measurement and applying the three-dimensional adjustment with offset constraint can effectively suppress the error accumulation caused by long distance move station measurement. | Wang Xiaolong Kang Ling Dong Lan Li Bo Men Lingling Luo Tao Wang Tong Liang Jing He Zhenqiang Ke Zhiyong Ma Na Lu Shang Han Yuanying Yan Luping Zhang Luyan Liu Xiaoyang Yan Haoyue Li Chunhua Wu Lei | 2022 | Radiation Detection Technology and Methods2022，6，4： | 0 |
| 9 | Investigation of AlN Thin Films as Buried Insulator in SOI Structure显示文摘Self heating effects in silicon on insulator (SOI) devices limit the applicability of SOI materials in electronics in cases where high power dissipation is expected. AlN film as a potential candidate for buried insulator material in SOI structures is investigated. Ion beam enhanced deposition (IBED) is used to manufacture large area AlN films. SIMS measurements indicate the formation of AlN films. The characterization of the films reveals that the quality of the films strongly depends on the evaporation rate of Al. For the film with high quality deposited at 0.05 nm/s, it has higher component of N, excellent dielectric property and a smoother surface with roughness RMS value of 0.13 nm, and can be bonded directly at room temperature by the smart cut process. SOI structure with the AlN film as buried insulator has formed successfully for the first time, which is confirmed by XTEM micrograph. | MEN Chuan ling 1,2 , XU Zheng 2, AN Zheng hua 1, XIE Xin yun 1, LIN Cheng lu 1 (1.Institute of Microelectronic Materials, School of Material Science & Engineering, Tongji University, Shanghai 200092,CHN 2.State Key Laboratory of Functiona | 2002 | Semiconductor Photonics and Technology2002，8，4： | 0 |
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