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| 1 | Association of elevated hs-CRP and multiple infarctions with outcomes of minor stroke or TIA: subgroup analysis of CHANCE randomised clinical trial显示文摘Background and purpose The relationship of high-sensitive C-reactive protein(hs-CRP)levels and infarction numbers with the prognosis of stroke is uncertain.This study evaluated the association of different hs-CRP levels and infarction numbers with the prognosis of acute minor ischaemic stroke or transient ischaemic attack(TIA).Methods A subset of 807 patients with both hs-CRP measurement and baseline MRI was included from the Clopidogrel in High-risk Patients with Acute Non-disabling Cerebrovascular Events trial.The primary efficacy outcome was the occurrence of an ischaemic stroke at the 1-year follow-up.Infarction numbers were classified as multiple acute infarctions(MAIs),single acute infarction and no acute infarction(NAI).The association between different hs-CRP levels with different infarction numbers and the risk of any outcome was analysed using multivariable Cox regression models.Results Among the 807 patients,84(10.4%)patients had a recurrent ischaemic stroke within 1 year.After adjustment for conventional confounding factors,patients with both elevated hs-CRP levels and MAIs were associated with approximately 4.7-fold of risk of ischaemic stroke within 1 year(16.7% vs 3.5%,HR 4.68,95% CI 1.54 to 14.23,p=0.007),compared with those with non-elevated hs-CRP levels and NAI.Similar results were observed for the composite events.Conclusions Combined elevated hs-CRP levels and MAIs may increase 1-year stroke risk stratification efficiency in patients with minor ischaemic stroke or TIA compared with using those markers alone,which indicated that the combination of inflammatory and imaging markers might improve the effectiveness of risk stratification concerning minor ischaemic stroke or TIA. | Guangyao Wang Jing Jing Jiejie Li Yuesong Pan Hongyi Yan Xia Meng Xingquan Zhao Liping Liu Hao Li David Z Wang Yongjun Wang Yilong Wang | 2021 | Stroke & Vascular Neurology2021，6，1： | 11 |
| 2 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 3 | Dual antiplatelet therapy may increase the risk of non-intracranial haemorrhage in patients with minor strokes: a subgroup analysis of the CHANCE trial显示文摘Aim:The aim of this study was to explore the difference between haemorrhagic events among those patients on either aspirin or aspirin plus clopidogrel who were enrolled in the Clopidogrel in High-Risk Patients with Acute Non-disabling Ischemic Cerebrovascular Events(CHANCE)trial.Methods:This was an ad hoc analysis of the CHANCE trial;data on all patients with any haemorrhagic event were reviewed and analysed.Cox proportional hazards regression was used to determine factors association with any bleeding.Results:In the CHANCE trial,there were a total of 101(2%)haemorrhagic events reported from 50 different hospitals.The clopidogrel–aspirin group had 60(2.3%)cases and the aspirin group had 41(1.6%,p=0.09).Moderate or severe haemorrhagic events occurred in 7 patients(0.3%)in the clopidogrel–aspirin group and in 8(0.3%)in the aspirin group(p=0.73).Of 36(0.7%)cases of intracranial haemorrhages,20(0.4%)were in the clopidogrel–aspirin group and 16(0.3%)in the aspirin group.Each group had 8(0.3%)cases of symptomatic haemorrhagic strokes.Other common haemorrhagic events included 24(0.5%)cases of skin bruises,13(0.3%)gastrointestinal haemorrhages,9(0.2%)gum haemorrhages and 8(0.2%)intraocular haemorrhages.Conclusions:There was no overall significant difference in haemorrhagic events(p=0.29),especially in the rate of intracranial haemorrhages between the 2 treatment groups.However,patients enrolled with minor strokes had an increased risk of haemorrhagic events regardless of treatment group,not seen in patients with high-risk transient ischaemic attacks.Being elderly,of male gender and with a history of aspirin or proton pump inhibitor usage were associated with increased risk of haemorrhage.Patients with higher body mass index had lower risk of haemorrhagic events. | David Wang Li Gui Yi Dong Hao Li Shujuan Li Huaguang Zheng Anxin Wang Xia Meng Li-Ping Liu Yi-Long Wang Guangyao Wang Jing Jing Zixiao Li Xing-Quan Zhao Yong-Jun Wang on behalf of the investigators for the CHANCE trial | 2016 | Stroke & Vascular Neurology2016，1，2： | 8 |
| 4 | Properties and microstructure of NiO/SDC materials for SOFC anode applications显示文摘NiO/SDC composites and Ni/SDC cermets for solid oxide fuel cell (SOFC) anode applications were prepared from nickel oxide(NiO)and samaria doped ceria (SDC) powders by the powder metallurgy process. The physical and mechanical properties, as well as the microstructure of the NiO/SDC composites and the Ni/SDC cermets were investigated. It is shown that the sintering temperature of the NiO/SDC composites and NiO content plays an important role in determining the microstructure and properties of the NiO/SDC composites, which, in turn, influences the microstructure,electrical conductivity, and mechanical properties of the Ni/SDC cermets. The present study demonstrated that composition and tprocess parameters must be appropriately selected to optimize the microstructure and the properties of NiO/SDC materials for solid oxide fuel cell applications. | CHENG Jigui DENG Liping ZHANG Benrui SHI Ping MENG Guangyao | 2007 | Rare Metals2007，26，2： | 3 |
| 5 | Preparation and gas sensitivity properties of ZnFe 2 O 4 semiconductors显示文摘 | Chu Xiangfeng Liu Xingqin Meng Guangyao | 1999 | Sensors & Actuators: B Chemical1999，，1： | 1 |
| 6 | Cobalt-free oxide Ba 0.5 Sr 0.5 Fe 0.8 Cu 0.2 O 3? δ for proton-conducting solid oxide fuel cell cathode显示文摘 | Ling Zhao Beibei He Yihan ling Zhiqing Xun Ranran Peng Guangyao Meng Xingqin Liu | 2010 | International Journal of Hydrogen Energy2010，，8： | 1 |
| 7 | Low-temperature solid oxide fuel cells with novel La 0.6 Sr 0.4 Co 0.8 Cu 0.2 O 3? δ perovskite cathode and functional graded anode显示文摘 | Bin Lin Jinfan Chen Yihan Ling Xiaozhen Zhang Yinzhu Jiang Ling Zhao Xingqin Liu Guangyao Meng | 2009 | Journal of Power Sources2009，，6： | 1 |
| 8 | 显示文摘 | Liu Xingqin Meng Guangyao | 1999 | Materials Research Bulletin1999，34，5： | 1 |
| 9 | Synthesis and characterization of volatile metal β - diketonate chelates of M(DPM)n, (M= Ce, Gd,Y, Zr, n = 3, 4) used as precursors for MOCVD显示文摘 | Haizheng Song Yinzhu Jiang Changrong Xia Guangyao Meng Dingkun Peng | 2003 | Journal Crystal Growth2003，，250： | 1 |
| 10 | Effect of Gd (Sm) doping on properties of ceria electrolyte for solid oxide fuel cells显示文摘 | Shaowu Zha Changrong Xia Guangyao Meng | 2002 | Journal of Power Sources2002，，1： | 1 |
| 11 | Preparation and gas sentivity properties of ZnFe2O4 semiconductors显示文摘 | CHU XIANGFENG LIU XINQIN MENG GUANGYAO | 1999 | Sensors and Actuators1999，55，： | 1 |
| 12 | 显示文摘 | Zha Shaowu Xia Changrong Meng Guangyao | 2003 | Journal of Power Sources2003，115，： | 1 |
| 13 | Solid State Ionics显示文摘 | Wenjun Zheng Wenqin Pang Guangyao Meng | 1998 | 108 : 37 - 411998，108，： | 1 |
| 14 | Separation of stable oil–water emulsion by the hydrophilic nano-sized ZrO 2 modified Al 2 O 3 microfiltration membrane显示文摘 | Jian-er Zhou Qibing Chang Yongqing Wang Jinming Wang Guangyao Meng | 2010 | Separation and Purification Technology2010，，3： | 1 |
| 15 | Preparation and gas sensitivity properties of ZnFe2O4 semiconductor显示文摘 | Chu Xiangfeng Liu Xingqin Meng Guangyao | 1999 | Sensors Actuators B1999，，55： | 1 |
| 16 | 显示文摘 | Chen Fanglin Sorensen O T Meng Guangyao | 1997 | Solid State Ionics1997，100，： | 1 |
| 17 | Preparation of cordierite-based porous ceramic micro filtration membranes using waste fly ash as the main raw materials显示文摘 | Dong Yingchao Liu Xingqin Meng Guangyao | 2006 | J Membr Sci2006，285，： | 1 |
| 18 | Ceramic membrane fuel cells based on solid proton electrolytes显示文摘 | Meng Guangyao Ma Guilin Ma Oianli | 2007 | Solid State Ionics2007，178，710： | 1 |
| 19 | Ceramic membrane fuel cells based in solid proton electrolytes显示文摘 | Meng Guangyao Ma Guilin Ma Qianli | 2007 | Solid State Ionics2007，178，710： | 1 |
| 20 | Effect of NiO/YSZ compositions on the co-sintering process of anode-supported fuel cell显示文摘 | BAO Weitao CHANG Qibing MENG Guangyao | 2005 | J Membr Sci2005，259，12： | 1 |
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