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| 1 | Comparative pharmacokinetics of tetramethylpyrazine phosphate in rat plasma and extracellular fluid of brain after intranasal,intragastric and intravenous administration显示文摘The purpose of this study was to compare the pharmacokinetic profiles of tetramethylpyrazine phosphate(TMPP)in plasma and extracellular fluid of the cerebral cortex of rats via three delivery routes:intranasal(i.n.),intragastric(i.g.)and intravenous(i.v.)administration.After i.n.,i.g.and i.v.administration of a single-dose at 10 mg/kg,cerebral cortex dialysates and plasma samples drawn from the carotid artery were collected at timed intervals.The concentration of TMPP in the samples was analyzed by HPLC.The area under the concentration-time curve(AUC)and the ratio of the AUCbrain to the AUCplasma(drug targeting efficiency,DTE)was calculated to evaluate the brain targeting efficiency of the drug via these different routes of administration.After i.n.administration,TMPP was rapidly absorbed to reach its peak plasma concentration within 5 min and showed a delayed uptake into cerebral cortex(t_(max)=15 min).The ratio of the AUCbrain dialysates value between i.n.route and i.v.injection was 0.68,which was greater than that obtained after i.g.administration(0.43).The systemic bioavailability obtained with i.n.administration was greater than that obtained by the i.g.route(86.33%vs.50.39%),whereas the DTE of the nasal route was 78.89%,close to that of oral administration(85.69%).These results indicate that TMPP is rapidly absorbed from the nasal mucosa into the systemic circulation,and then crosses the blood-brain barrier(BBB)to reach the cerebral cortex.Intranasal administration of TMPP could be a promising alternative to intravenous and oral approaches. | Dongmei Meng Haoyang Lu Shanshan Huang Minyan Wei Pingtian Ding Xianglin Xiao Yuehong Xu Chuanbin Wu | 2014 | Acta Pharmaceutica Sinica B2014，4，1： | 5 |
| 2 | Honeycomb-patterned films of polystyrene/poly(ethylene glycol): Preparation, surface aggregation and protein adsorption显示文摘Highly ordered honeycomb-patterned polystyrene (PS)/poly(ethylene glycol) (PEG) films were prepared by a water-assisted method using an improved setup, which facilitated the formation of films with higher regularity, better reproducibility, and larger area of honeycomb structures. Surface aggregation of hydrophilic PEG and adsorption of bovine serum albumin (BSA) on the honeycomb-patterned films were investigated. Field emission scanning electron microscopy (FESEM) and atomic force microscopy (AFM) were used to observe the surface morphologies of the films before and after being rinsed with water. As confirmed by the FESEM images and the AFM phase images, PEG was enriched in the pores and could be gradually removed by water. The adsorption of fluorescence-labeled BSA on the films was studied in visual form using laser scanning confocal microscopy. Results clearly demonstrated that the protein-resistant PEG was selectively enriched in the pores. This water-assisted method may be a latent tool to prepare honeycomb-patterned biofunctional surfaces. | WAN LingShu KE BeiBei LI XiaoKai MENG XiangLin ZHANG LuYao XU ZhiKang | 2009 | Science China Chemistry2009，52，7： | 3 |
| 3 | Allotransplantation of adult spinal cord tissues after complete transected spinal cord injury: long-term survival and functional recovery in canines显示文摘Spinal cord injury(SCI), especially complete transected SCI, leads to loss of cells and extracellular matrix and functional impairments. In a previous study, we transplanted adult spinal cord tissues(aSCTs) to replace lost tissues and facilitate recovery in a rat SCI model. However, rodents display considerable differences from human patients in the scale, anatomy and functions of spinal cord systems, and responses after injury. Thus, use of a large animal SCI model is required to examine the repair efficiency of potential therapeutic approaches. In this study, we transplanted allogenic aSCTs from adult dogs to the lesion area of canines after complete transection of the thoracic spinal cord, and investigated the long-term cell survival and functional recovery. To enhance repair efficiency, a growth factor cocktail was added during aSCT transplantation, providing a favorable microenvironment. The results showed that transplantation of a SCTs, in particular with the addition of growth factors, significantly improves locomotor function restoration and increases the number of neurofilament-, microtubule-associated protein2-, 5-hydroxytryptamine-, choline acetyltransferase-and tyrosine hydroxylase-positive neurons in the lesion area at 6 months post-surgery. In addition, we demonstrated that donor neurons in a SCTs can survive for a long period after transplantation. This study showed for the first time that transplanting aSCTs combined with growth factor supplementation facilitates reconstruction of injured spinal cords, and consequently promotes long lasting motor function recovery in a large animal complete transected SCI model, and therefore could be considered as a possible therapeutic strategy in humans. | He Shen Shuyu Wu Xi Chen Bai Xu Dezun Ma Yannan Zhao Yan Zhuang Bing Chen Xianglin Hou Jiayin Li Yudong Cao Xianyong Fu Jun Tan Wen Yin Juan Li Li Meng Ya Shi Zhifeng Xiao Xingjun Jiang Jianwu Dai | 2020 | Science China(Life Sciences)2020，63，12： | 3 |
| 4 | Thermo-responsive stick-slip behavior of advancing water contact angle on the surfaces of poly(N-isopropylacrylamide)-grafted polypropylene membranes显示文摘Wettability of a solid surface is highly important to its practical application,especially for the surface that shows thermoresponsive properties.In this paper,we describe a thermo-responsive stick-slip behavior of water droplets on the surfaces of poly(N-isopropylacrylamide)(PNIPAM)-grafted polypropylene membranes.Field emission scanning electron microscope(FESEM) images elucidate that the morphology of PNIPAM-grafted membrane surface is thermo-responsive,i.e.,the surface becomes rougher above the lower critical solution temperature(LCST) of PNIPAM.On the surface of nascent polypropylene membranes,the water droplet shows a smooth motion resulting in advancing and receding water contact angles of 111° and ~65°,respectively.On the PNIPAM-grafted membrane surfaces,the water droplet shows a stick-slip pattern above the LCST,whereas it advances smoothly below the LCST.This phenomenon is reproducible and can be ascribed to the energy barriers enhanced by the shrink of PNIPAM chains above the LCST.We also find that the slip contact angle decreases from 102° to 92° after several stick-slip cycles.This decrease is attributed to the water adsorption on the grafted PNIPAM layer,which is confirmed by the continuous decrease of the receding water contact angle. | WAN LingShu,MENG XiangLin,YANG YunFeng,TIAN Jing & XU ZhiKang Key Laboratory of Macromolecular Synthesis and Functionalization,Ministry of Education Department of Polymer Science and Engineering,Zhejiang University,Hangzhou 310027,China | 2010 | Science China Chemistry2010，53，1： | 2 |
| 5 | Arsenic promotes angiogenesis in vitro via a heme oxygenase-1-dependent mechanism显示文摘 | Dan Meng Xin Wang Qingshan Chang Andrew Hitron Zhuo Zhang Mei Xu Gang Chen Jia Luo Binghua Jiang Jing Fang Xianglin Shi | 2010 | Toxicology and Applied Pharmacology2010，，3： | 1 |
| 6 | The effect of collagen-binding vascular endothelial growth factor on the remodeling of scarred rat uterus following full-thickness injury显示文摘 | Nacheng Lin Xin’an Li Tianran Song Jingmei Wang Kui Meng Jun Yang Xianglin Hou Jianwu Dai Yali Hu | 2011 | Biomaterials2011，，： | 1 |
| 7 | Building global imagefeatures for scene recognition 显示文摘 | MENG Xianglin WANG Zhengzhi WU Lizhen | 2012 | Patter Recognition2012，，45： | 1 |
| 8 | In situ bone regeneration with sequential delivery of aptamer and BMP2 from an ECM-based scaffold fabricated by cryogenic free-form extrusion显示文摘In situ tissue engineering is a powerful strategy for the treatment of bone defects.It could overcome the limitations of traditional bone tissue engineering,which typically involves extensive cell expansion steps,low cell survival rates upon transplantation,and a risk of immuno-rejection.Here,a porous scaffold polycaprolactone(PCL)/decellularized small intestine submucosa(SIS)was fabricated via cryogenic free-form extrusion,followed by surface modification with aptamer and PlGF-2_(123-144)*-fused BMP2(pBMP2).The two bioactive molecules were delivered sequentially.The aptamer Apt19s,which exhibited binding affinity to bone marrow-derived mesenchymal stem cells(BMSCs),was quickly released,facilitating the mobilization and recruitment of host BMSCs.BMP2 fused with a PlGF-2_(123-144)peptide,which showed“super-affinity”to the ECM matrix,was released in a slow and sustained manner,inducing BMSC osteogenic differentiation.In vitro results showed that the sequential release of PCL/SIS-pBMP2-Apt19s promoted cell migration,proliferation,alkaline phosphatase activity,and mRNA expression of osteogenesis-related genes.The in vivo results demonstrated that the sequential release system of PCL/SIS-pBMP2-Apt19s evidently increased bone formation in rat calvarial critical-sized defects compared to the sequential release system of PCL/SIS-BMP2-Apt19s.Thus,the novel delivery system shows potential as an ideal alternative for achieving cell-free scaffold-based bone regeneration in situ. | Tingfang Sun Chunqing Meng Qiuyue Ding Keda Yu Xianglin Zhang Wancheng Zhang Wenqing Tian Qi Zhang Xiaodong Guo Bin Wu Zekang Xiong | 2021 | Bioactive Materials2021，6，11： | 1 |
| 9 | Collagen scaffolds modified with CNTF and bFGF promote facial nerve regeneration in minipigs显示文摘 | Yi Cui Chao Lu Danqing Meng Zhifeng Xiao Xianglin Hou Wenyong Ding Depeng Kou Yao Yao Bing Chen Zhen Zhang Jiayin Li Juli Pan Jianwu Dai | 2014 | Biomaterials2014，，： | 1 |
| 10 | Experimental and simulation study on luminous characteristics of Trichel discharge in air at picosecond time resolution显示文摘The optical morphology of discharge is the main characteristic parameter describing the physical process of the discharge,and the luminescence behavior is inextricably linked to the motion behavior of charged particles.Since the Trichel discharge in air is a weak ionization event occurring on the sub-nanosecond time scale,micron space scale and accompanied by weak luminescence,the current experimental observation means have a low spatial and temporal resolution,which is insufficient to study the details of its luminescence properties clearly.To address this problem,the intensity of light generated by Trichel discharge in air is first measured and resolved in time and space using a constructed ultrafast optical counting and imaging system.At a very high temporal resolution of 55 ps,it is found that both its light emission and current pulse showed a trend of first rapid growth and then slow decline on the time scale of tens of nanoseconds.Later,in order to further investigate the connection between the microscopic behavior of charged particles and photons,a two-dimensional hydrodynamic simulation model with three components(electrons,positive ions,and negative ions)is developed and the current simulation results are in good agreement with the experimental results.The results show that the size of the ionization region and the interaction between particles in the discharge process are the main factors affecting the Trichel pulse and its photoemission.Electrons play a dominant role in photon generation during the rise time process,while it is the recombination process of positive and negative charges,which contributes the main photons during the fall time process.Finally,it is proposed that the expression of photon flux should be amended to include an additional term responsible for the photons generated due to recombination.The study helps to advance the understanding of the luminescence characteristics and the discharge mechanism of Trichel discharge. | Xianglin Meng Hui Song Gehao Sheng Xiuchen Jiang | 2023 | High Voltage2023，8，3： | 0 |
| 11 | Experimental research on the influence of temperature on the discharge signal of void defects in GIS显示文摘Temperature is an important environmental factor during the operation of gas‐insulated switchgear(GIS),affecting the evaluation results of the GIS equipment to increase the risk of the power system.However,the influence of temperature on the partial discharge detection signal of GIS is still unclear.Aimed at the common void defects in GIS,the law of change on the number of ultrahigh‐frequency(UHF)pulses,the UHF amplitude,the characteristic value of the UHF map,and the maximum apparent charge of a single pulse with temperature are obtained using the UHF method and IEC60270,and corresponding theoretical analysis is carried out.The results show that an increase in temperature leads to a decrease in the void discharge delay time,causing an increase in UHF pulses and a decrease in the apparent charge of a single discharge pulse in the experiment.The in-crease of temperature makes the void discharge current rise quickly so that the induced UHF amplitude increases.In the range of 40-70℃,the maximum pulse amplitude in-creases by approximately 30%for every 10℃ increase,and the average pulse amplitude increases by approximately 12%.The result of UHF signals affected by temperature obtained in this study has research significance for the realisation of a comprehensive evaluation of the insulation state of GIS equipment considering temperature. | Zhaoqi Zhang Hui Song Xianglin Meng Gehao Sheng Xiuchen Jiang | 2022 | High Voltage2022，7，2： | 0 |
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