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| 1 | Hepatic fibrosis in biliary-obstructed rats is prevented by Ginkgo biloba treatment显示文摘AIM: To assess the antioxidant and antifibrotic effects of long-term Ginkgo biloba administration on liver fibrosis induced by biliary obstruction in rats.METHODS: Liver fibrosis was induced in male Wistar albino rats by bile duct ligation and scission (BDL). Ginkgo administered for 28 d. At the end of the treatment period,all rats were killed. Serum aspartate aminotransferase (AST),alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determined to assess liver functions and tissue damage, respectively. Tumor necrosis factor-α (TNF-α) was also assayed in serum samples. Liver tissues were taken for determination of the hepatic malondialdehyde (MDA) and glutathione (GSH) levels,myeloperoxidase (MPO) activity and collagen content.Production of reactive oxidants was monitored by chemiluminescence (CL) assay. Serum AST, ALT, LDH, and TNF-α levels were elevated in the BDL group as compared to control group and were significantly decreased by EGb treatment.RESULTS: Hepatic GSH level, depressed by BDL, was elevated back to control level in EGb-treated BDL group.Increase in tissue MDA level, MPO activity and collagen content due to BDL were also attenuated by EGb treatment.Furthermore, luminol and lucigenin CL values in BDL group increased dramatically compared to control and reduced by EGb treatment.CONCLUSION: Our results suggest that Ginkgo biloba protects the liver from oxidative damage following BDL in rats. This effect possibly involves the inhibition of neutrophil infiltration and lipid peroxidation; thus, restoration of oxidant and antioxidant status in the tissue. | Gksel pener Levent Kabasakal Meral Yüksel Nursal Gedik Ynci Alican | 2005 | World Journal of Gastroenterology2005，11，35： | 7 |
| 2 | Erythrocyte Membrane Anionic Content and Urinary Glycosaminoglycan Excretion in Type 1 Diabetes: Association with Retinopathy显示文摘 | ? zlem Yenice Haluk Kazoko&gbreve lu Eda ? zcan Meral Yü ksel G? ksenin Adigü zel Goncagü l Haklar Dilek Gogas Yavuz | 2006 | Current Eye Research2006，，11： | 1 |
| 3 | Relationship be- tween the serum concentrations of serotonin and lipids and ag- gression in dogs显示文摘 | Cakirolu D Meral Y Sancak AA | 2007 | Vet Rec2007，161，2： | 1 |
| 4 | Long-term outcome and late effects in patients transplanted with mobilised blood or bone marrow: a randomised trial显示文摘 | Birte Friedrichs André Tichelli Andrea Bacigalupo Nigel H Russell Tapani Ruutu Michael Y Shapira Meral Beksac Dirk Hasenclever Gérard Socié Norbert Schmitz | 2010 | Lancet Oncology2010，，4： | 1 |
| 5 | Asymptomatic proteinuriain a child with recurrent urinary tract infections-questions显示文摘 | Meral TB Demet A Y eim Oetal | 2012 | Pediatric nephrology2012，27，5： | 1 |
| 6 | Partial splenic embolization in betathalassemia major显示文摘 | Meral A Serinir B Sadikoglu Y | 2000 | A case report Jurk J Pediatr2000，42，1： | 1 |
| 7 | Antioxidant responses of shoots and roots of lentil to NaCl-salinity stress显示文摘 | Ebru Bandeo?lu Füsun Eyido?an Meral Yücel Hüseyin Avni ?ktem | 2004 | Plant Growth Regulation2004，，1： | 1 |
| 8 | Characterization of a simple bac- terial consortium for effective treatment of wastewaters with reactive dyes and Cr(VI) 显示文摘 | NUR K K JEPPE L N MERAL Y | 2007 | Chemosphere2007，67，4： | 1 |
| 9 | Nutritional Assessment Via Anthropometric and Biochemical Measurements with Stable COPD显示文摘 | Meral M Araz O Ucar E Y | 2012 | Turk J Med Sci2012，42，2： | 1 |
| 10 | Photobiological hydrogen production by using olive mill wastewater as a sole substrate source显示文摘 | ELA E UFUK G MERAL Y | 2004 | International Journal of Hydrogen Energy2004，29，2： | 1 |
| 11 | Different interstock lengths effects on 'Star Ruby' grapefruit and 'Kütdiken' lemon for some plant nutrient elements显示文摘 | BILGE Y TURGUT Y MERAL I | 2014 | Turkish Journal of Agricultural and Natural Sciences2014，，2： | 1 |
| 12 | Matrix representation of dual qua- ternions显示文摘 | Jafari M Meral M Yayli Y | 2014 | Gazi University Journat of Science2014，26，4： | 1 |
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