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| 1 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 2 | Label-retaining liver cancer cells are relatively resistant to sorafenib显示文摘 | Hong-Wu Xin Chenwi M Ambe Danielle M Hari Gordon W Wiegand Tyler C Miller Jin-Qiu Chen Andrew J Anderson Satyajit Ray John E Mullinax Tomotake Koizumi Russell C Langan Douglas Burka Michelle A Herrmann Paul K Goldsmith Alexander Stojadinovic Udo Rudloff S | 2013 | Gut2013，，12： | 2 |
| 3 | Efficient studies of long-distance Bmp5 gene regulation using bacterial artificial chromosomes显示文摘 | Ralph J D Gregory A M Michelle D J | 2000 | Proc Natl Acad Sci USA2000，97，4： | 1 |
| 4 | The fate of the oil spilled from the Exxon Valdez显示文摘 | WOLFE D A HAMEEDI M J MICHEL J | 1994 | Environ Sci Technol1994，28，13： | 1 |
| 5 | Decomposition of laser altimeter waveforms 显示文摘 | Michelle A H Jean B M Bryan J | 2000 | IEEE Transaction on Geoseienee and Remote Sensing2000，38，4： | 1 |
| 6 | Evaluation of extraction and purification methods for obtaining PCR-amplifiable DNA from compost for microbial community analysis显示文摘 | LaMontagne M G Michel F C J Holden P A | 2002 | Journal of Microbiological Methods2002，49，3： | 1 |
| 7 | 查看详情显示文摘 | Landen O L Boehly T R Bradley D K Braun D G Callahan D A Celliers P M Collins G W Dewald E L Divol L Glenzer S H Hamza A Hicks D G Hoffman N Izumi N Jones O S Kirkwood R K Kyrala G A Michel P Milovich J Munro D H Nikroo A Olson R E Robey H F Spears B K Th | | 0，，： | 1 |
| 8 | Activation of the interferon system by short interfering RNAs显示文摘 | Carol A S Michelle H de Veer M J | 2003 | Nat Cell Biol2003，5，： | 1 |
| 9 | Smoke Suppression by Metal Oxides in PVC显示文摘 | Edeleson D V J Kuck A Michel R M Lum | 1980 | Combust Flame1980，38，： | 1 |
| 10 | TG1050,an immunotherapeutic to treat chronic hepatitis B,induces robust T cells and exerts an antiviral effect in HBVpersistent mice显示文摘 | Martin P Dubois C Jacquier E Dion S ManciniBourgine M Godon O Kratzer R Lelu-Santolaria K Evlachev A Meritet J F Schlesinger Y Villeval D Strub J M Van Dorsselaer A Marchand J B Geist M Brandely R Findeli A Boukhebza H Menguy T Silvestre N Michel M L InchauspéG | 2015 | Gut2015，64，12： | 1 |
| 11 | Short-Term Load Forecasting: Sire-ilar Day-Based Wavelet Neural Networks 显示文摘 | Y Chen P B Luh C Guan Y Zhao L D Michel M A Coolbeth Friedland P B and S J Rourke | 2010 | IEEE Transactions on Power Systems2010，25，1： | 1 |
| 12 | Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats显示文摘 | Simonides Warner S Mulcahey Michelle A Redout Everaldo M Muller Alice Zuidwijk Marian J Visser Theo J Wassen Frank W J S Crescenzi Alessandra da-Silva Wagner S Harney John Engel Felix B Obregon Maria-Jesús Larsen P Reed Bianco Antonio C Huan | 2008 | Journal of Clinical Investigation2008，，3： | 1 |
| 13 | Thermodynamic consistency in dissipative particle dynamics simulations of strongly nonideal liquids and liquid mixtures 显示文摘 | Trofimov S Y Nies E L F Michels M A J | 2002 | J Chem Phys2002，117，： | 1 |
| 14 | Thermodynamic Modeling of Asphaltene Stacking显示文摘 | BRANDT H C A HENDRIKS E M MICHELS M A J | 1995 | Journal of Physical Chemistry1995，99，10： | 1 |
| 15 | Evaluation of extraction and purification methods for obtaining PCR amplifiable DNA from compost for microbial community analysis显示文摘 | LanMontagn M G Michel J F C Holden P A | 2002 | Journal of Microbiological Methods2002，49，3： | 1 |
| 16 | Has it been affect all along? A test of work - to - family and family - to - work models of conflict, enrichment, and satisfaction 显示文摘 | Michel J S Clark M A | 2009 | Personality and Individual Differ- ences2009，47，： | 1 |
| 17 | A Qualitative Study of Potential Suicide Risk Factors in Returning Combat Veterans显示文摘 | Brenner Lisa A Gutierrez Peter M Cornette Michelle M Betthauser Lisa M Bahraini Nazanin Staves Pamela J | 2008 | Journal of Mental Health Counseling2008，，： | 1 |
| 18 | Severe bleeding from submucosal lipo- maof the duodenum 显示文摘 | Michel L A Ballet T Collard J M | 1998 | J Clin Gas- troenterol1998，10，5： | 1 |
| 19 | The effects of vacuum annealing on the structure and surface chemistry of iron: Nickel alloy nanoparticles显示文摘 | MICHELLE D THOMAS B S RICHARD A C OLGA R ROBERT J B GARETH M H | 2010 | Journal of Nanoparticle Research2010，12，6： | 1 |
| 20 | The technical and commercial potential of an incremental ring rolling process显示文摘 | ALLWOOD J M KOPP R MICHELS D MUSIC O OZTOP M STANISTREET T F TEKKAYA A E TIEDEMMAN 1 | 2005 | CIRP Annals: Manufacturing Technology2005，54，： | 1 |
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