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| 1 | Holocene lake deposits of Bosten Lake,southern Xinjiang,China显示文摘A 9.25-m-long sediment core from Bosten Lake, Xinjiang, provides detailed information about changes in the water budget and biological acticity over the last 8400 calendar years. The chronology is constructed from six AMS radiocarbon dates on the terrestrial plant remains. Based on analyses of TOC, CO3, detrital compounds and biogenic SiO2, lake level fluctuations and periods of remarkably-negative water budget appeared at 8.4—8.2 cal ka, 7.38—7.25 cal ka, 5.7—5.5 cal ka, 3.7—3.4 cal ka and 3.3—2.9 cal ka, respectively. As they are in-phase with low lake levels at Sumxi Co and Bangong Co in western Tibet Plateau and with paleolakes in Inner Mongolia, a climate-induced change to somewhat drier and warmer conditions is inferred. A further drop in lake level after 1320 AD of about 200 yr duration may be attributed to a negative water balance prior to the main phase of the Little Ice Age. Deep and stable lake phases of 1500 yr and 1800 yr duration at 7.2—5.7 cal ka and 5.5—3.7 cal ka coincide with maximum moisture during the Holocene Megathermal in China. The long term trend towards aridity since about 4.3 cal ka can clearly be recognised. The reduced water budget of Bosten Lake from 640—1200 AD may be attributed to local effects. | B.Wuennemann CHENFahu F.Riedel ZHANGChengiun S.Mischke CHENGuangjie D.Demske MINGJin | 2003 | Chinese Science Bulletin2003，48，14： | 15 |
| 2 | Changes in Extreme Maximum Temperature Events and Population Exposure in China under Global Warming Scenarios of 1.5 and 2.0°C: Analysis Using the Regional Climate Model COSMO-CLM显示文摘We used daily maximum temperature data(1986–2100) from the COSMO-CLM(COnsortium for Small-scale MOdeling in CLimate Mode) regional climate model and the population statistics for China in 2010 to determine the frequency, intensity, coverage, and population exposure of extreme maximum temperature events(EMTEs) with the intensity–area–duration method. Between 1986 and 2005(reference period), the frequency, intensity, and coverage of EMTEs are 1330–1680 times yr^(–1), 31.4–33.3°C, and 1.76–3.88 million km^2, respectively. The center of the most severe EMTEs is located in central China and 179.5–392.8 million people are exposed to EMTEs annually. Relative to 1986–2005, the frequency, intensity, and coverage of EMTEs increase by 1.13–6.84, 0.32–1.50, and15.98%–30.68%, respectively, under 1.5°C warming; under 2.0°C warming, the increases are 1.73–12.48, 0.64–2.76,and 31.96%–50.00%, respectively. It is possible that both the intensity and coverage of future EMTEs could exceed the most severe EMTEs currently observed. Two new centers of EMTEs are projected to develop under 1.5°C warming, one in North China and the other in Southwest China. Under 2.0°C warming, a fourth EMTE center is projected to develop in Northwest China. Under 1.5 and 2.0°C warming, population exposure is projected to increase by23.2%–39.2% and 26.6%–48%, respectively. From a regional perspective, population exposure is expected to increase most rapidly in Southwest China. A greater proportion of the population in North, Northeast, and Northwest China will be exposed to EMTEs under 2.0°C warming. The results show that a warming world will lead to increases in the intensity, frequency, and coverage of EMTEs. Warming of 2.0°C will lead to both more severe EMTEs and the exposure of more people to EMTEs. Given the probability of the increased occurrence of more severe EMTEs than in the past, it is vitally important to China that the global temperature increase is limited within 1.5°C. | Mingjin ZHAN Xiucang LI Hemin SUN Jianqing ZHAI Tong JIANG Yanjun WANG | 2018 | Journal of Meteorological Research2018，32，1： | 11 |
| 3 | Meta-analysis of Traditional Chinese Medicine in treating functional dyspepsia of liver-stomach disharmony syndrome显示文摘OBJECTIVE:To systematically assess the clinical effectiveness of traditional Chinese medicine(TCM) in the treatment of functional dyspepsia(FD) of liver-stomachdisharmonysyndromebymeta-analysis.METHODS:Random controlled trials(RCTs) were retrieved from databases,including Pubmed,China national knowledge infrastructure,Wanfang Data,VIP Information,and the Cochrane Library.Trials were selected according to inclusion criteria.The effects of traditional Chinese medicine(TCM) versus prokinetic agents in the treatment of functional dyspepsia(FD) of liver-stomach disharmony syndrome were compared by meta-analysis.RevMan 5.0.24 was used for data analysis.The effective rate was assessed by odds ratios(ORs),and 95% confidence intervals(CIs) were calculated.The cure rate was analyzed by the Peto OR.Simple statistical analysis was chosen to assess the frequency of prescribed Chinese herbs in treating this syndrome.RESULTS:Thirteen trials were included,involving 1153 patients,and these were of poor methodological quality.Twelve studies mentioned the effective rate and cure rate.TCM therapy showed a better clinical effect rate compared with that with prokinetic agents [OR:3.2,95% CI(2.27,4.51)].The TCM group also had a better cure rate than that in the group of prokinetic agents [Peto OR:2.26,95% CI(1.61,3.18)].With regard to the frequency of Chinese herbs used in these 13 trials,Baishao(Radix Paeoniae),Chaihu(Radix Bupleuri),and Gancao(Radix Glycyrrhizae) were mostly prescribed,followed by Xiangfu(Rhizoma Cyperi),Zhishi(Fructus Aurantii Immaturus),Zhiqiao(Fructus Aurantii),Foshou(Citrus medica var.sarcodactylis),and Chenpi(Pericarpium Citri Reticulatae).No serious adverse effects were reported.CONCLUSION:TCM therapy shows a superior effective rate and cure rate compared with those in prokinetic agents in the treatment of FD of liver-stomach disharmony syndrome.However,further strictly designed RCTs are required because of the poor quality of included trials. | Chuijie Wang Mingjin Zhu Wei Xia Wei Jiang Yan Li | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 9 |
| 4 | The synchronicity and difference in the change of suspended sediment concentration in the Yangtze River Estuary显示文摘从长江盆的沉积分泌物在最近的年里有一个逐步的减少趋势。扣押三座峡水库加重了这个减少的趋势并且通过传播效果在长江河口影响了推迟的沉积集中(SSC ) 的变化。长江河口的 SSC 数据在 19592012 期间显示出那:(1 ) 在南方的 SSC 在河口并且在长江分叉近海海区域显示了减少的趋势并且向海少些减少了。同时,在在 SSC 和沉积分泌物之间的减少的大小的差别向海变得更大。(2 ) 为北方布朗奇,优先的流动没很变化,但是 SSC 趋于减少,它被 SSC 的减少主要在南方布朗奇和中国东方海引起。( 3 )由于减少的流量和相对加强的潮,在在 20032012 的浅节移动了的酒吧中的 SSC 的山峰区域为在 19842002 与那相比联合起来的大约 1/6 经度里面,并且里面动人的距离在洪水季节的顺序>年度一般水准>旱季。(4 ) 在南方经过的入口,因为增加由暂停引起了,岸沟交换是, SSC 主要减少了不到减少在盆和海区域由锋利的 SSC 减少引起了。颠倒在中间的节是真的,在 SSC 显示出一个增加的趋势的地方。(5 ) 在北方经过的入口在减少的流动裂口和沉积裂口比率的联合影响下面,在盆和海区域和暂停的减少的数量的减少的 SSC, SSC 显示了一个减少的趋势。在中间的节,因为增加的数量由沉积引起了,温习塘是多于减少的数量由外部环境引起了,显著地, SSC 趋于增加。整体地,在沉积分泌物的锋利的减少在长江河口引起了同步 SSC 减少。但是在 SSC 从盆在沉积分泌物在对锋利的减少的 SSC 的反应显示了增加的趋势,显示的 synchronicity 和差别的地方,仍然有区域。 | YANG Yunping DENG Jinyun ZHANG Mingjin LI Yitian LIU Wanli | 2015 | Journal of Geographical Sciences2015，25，4： | 8 |
| 5 | Heterogeneous reactions of gaseous methanesulfonic acid with NaCl and sea salt particles显示文摘Methanesulfonic acid(MSA) has been identified as one of the most important intermediate products of DMS reactions in the atmosphere.Although considerable amounts of MSA have been found in the ma-rine boundary layer,little is known about the interaction of gaseous MSA with sea salt particles.To understand the fate of MSA in the atmosphere and its potential importance in atmospheric chemistry,the heterogeneous reactions of gaseous MSA with micron-scale NaCl and sea salt particles were studied using diffuse reflectance infrared Fourier transform spectrometry,X-ray photoelectron spectroscopy,and scanning electron microscopy.The CH3SO3Na and CH3SO3-were the major products of the condensed phase of the reaction of gaseous MSA with NaCl and with sea salt particles.The steady-state uptake coefficient was determined to be(5.94±2.32)×10-7(1 σ) for the reaction of gaseous MSA with NaCl particles and(2.23±1.25)×10-7(1 σ) for the reaction of gaseous MSA with sea salt parti-cles.The heterogeneous reaction of MSA with NaCl particles was found to be first-order for MSA.The reaction mechanisms were discussed. | TANG MingJin ZHU Tong | 2009 | Science China Chemistry2009，52，1： | 7 |
| 6 | Lithium-based ionic liquids as novel lubricant additives for multiply alkylated cyclopentanes(MACs)显示文摘Two lithium-based ionic liquids(ILs,L-C3N3,and L-P3N3)were synthesized and evaluated as novel lubricant additives for multiply alkylated cyclopentanes(MACs).They were found to be approximately 1.0%soluble in MACs at room temperature(RT),whereas traditional ILs,such as 1-ethyl-3-methylimidazolium tetrafluoroborate(L-B102),1-hexyl-3-methylimidazolium hexafluorophosphate(L-P106),and 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide(L-F102),could not be dissolved in this base oil.Friction tests indicated that these ILs exhibit excellent friction-reducing and anti-wear properties both at RT and at 100°C.They can improve the tribological properties of MACs at RT to a greater extent than the commonly used lubricant zinc dialkyldithiophosphate(T204),even at a concentration of 0.1%.The load ramp test showed that MACs with L-C3N3 and L-P3N3 also exhibit high load-carrying capabilities.Scanning electron microscope(SEM)and X-ray photoelectron spectrometer(XPS)results indicated that physical adsorption and complex tribochemical reactions occurred between the ILs and metal surfaces during the sliding process,thereby forming a surface protective film that significantly contributed to the excellent tribological properties of the new ILs. | Zenghong SONG Yongmin LIANG Mingjin FAN Feng ZHOU Weimin LIU | 2013 | Friction2013，1，3： | 7 |
| 7 | Triptolide suppresses pancreatic cancer cell proliferation by inhibiting hedgehog signaling pathway activity显示文摘Dear Editor,Pancreatic cancer (PCa) is a high-grade gastrointestinal malignancy more commonly occurring in elderly populations with lower than 5% overall 5-year survival rate (Hidalgo, 2010). PCa responds poorly to most chemotherapeutic agents, and therefore it is imperative to develop novel therapeutic agents that have anti-cancer activities against PCa. | Juanjuan Feng Mingjin Rao Man Wang Lin Liang Zhi Chen Xiufeng Pang Weiqiang Lu Zhenliang Sun | 2019 | Science China(Life Sciences)2019，62，10： | 6 |
| 8 | Optimization of working parameters for puddling and flatting machine in paddy field显示文摘In order to improve the soil preparation quality,a wide puddling and flatting machine for paddy field was designed with the functionality of tillage,soil crushing,puddling,burying stubble and flatting in one-time operation,which can be equipped on tractors with high power.This study focused on the design and analysis of key components of the machine including puddling equipment,flat shovel and balance structure.Optimal results with field trials and response surface analysis showed that the machine can operate optimally when the working speed,puddling depth and angle of flat shovel were 1.05 km/h,16 cm and 31.30°,respectively.The surface flatness standard deviation was 3.7 cm,and slurry degree was 1.03 g/cm3.Field validation test results were consistent with the optimal parameters,which was able to meet agronomic requirements of mechanical planting in China. | Xu Chunlin Zhang Chengliang Li Lianhao Li Mingjin | 2016 | International Journal of Agricultural and Biological Engineering2016，9，3： | 5 |
| 9 | A comparative study on different regeneration processes of Pt-Sn/γ-Al2O3 catalysts for propane dehydrogenation显示文摘Three different regeneration processes including hydrogen or nitrogen purging and coke-burning treatment were used to restore the Pt-Sn/γ-Al_2O_3 catalysts, through which propane dehydrogenation reaction was performed in a consecutive reaction-regeneration mode. It was found that the catalyst using hydrogen regeneration showed the best stability compared with those regenerated by nitrogen purging and coke-burning treatment, suggesting that hydrogen regeneration is an effective approach for maintaining the performance of Pt-Sn/γ-Al_2O_3 catalysts in propane dehydrogenation reaction. The effect of different regeneration atmospheres on the metal active center and the coke deposition was investigated by XRD,TEM, N_2-physisorption, TPO, TG and Raman technologies, and the results revealed that hydrogen or nitrogen regeneration resulted in little impact on the size and structure of metal active center, retaining the effective Pt Sn phase over the catalyst. Moreover, hydrogen regeneration not only removed the low dense components of the coke, but also altered the property of the residual coke through hydrogenation, leading to a higher mobility of coke, and thus a higher accessibility of the metal active centers. Whereas nitrogen regeneration only removed the low dense components of the coke. Although coke-burning regeneration caused a thorough coke removal, the catalyst subjected to repeated redox exhibited poor stability due to metal agglomeration, phase segregation and the resulting large Pt_3Sn particle and core-shell structure with a Sn-rich surface. | Changyong Sun Junyin Luo Mingjin Cao Ping Zheng Guocheng Li Jiahao Bu Zhou Cao Shihong Chen Xiaowei Xie | 2018 | Journal of Energy Chemistry2018，27，1： | 5 |
| 10 | Study on the element geochemical charactersitics of the Shazi large-sized anatase ore deposit in Qinglong, Guizhou Province显示文摘The Shazi anatase ore deposit in Qinglong, Guizhou Province, is a large-sized anatase deposit that has been recently explored. The characteristics of major oxides in the ore are similar to those of modern laterite weathering crust and laterite in the laterite-type gold deposits in the western part of Guizhou Province. Studies on the REE characteristics of basalts and anatase ores in the study region showed that both of them do have extremely strong affinities. There are two groups of trace elements in the ores, i.e., Au-Ag-As-Sb-Hg-Tl association and Sc-TiO2-Cu-Fe-Mn association, reflecting that the formation of anatase ore is related to the formation of siliceous claystone at the early stage of eruption of the Emeishan basaltic magma. The siliceous claystones are the major country rocks for the formation of laterite-type gold ores and anatase ores. In the region anatase ores are rich in Sc and the basalts enriched in Fe, Mn, Ti and Sc are the material source of metallogenesis. | ZHANG Min NIE Aiguo XIE Fei ZHU Mingjin ZHANG Zhuru | 2014 | Chinese Journal Of Geochemistry2014，33，3： | 4 |
| 11 | A Modified Hadamard Based SLM without Side Information for PAPR Reduction in OFDM Systems显示文摘High peak-to-average power ratio(PAPR) is a concern in orthogonal frequency division multiplexing(OFDM) systems. Hadamard based selected mapping(HSLM) which uses Hadamard code as the phase sequence in selected mapping(SLM) is an attractive technique to reduce PAPR. But it requires sending side information(SI) to the receiver for each data block, and this results in a reduction in bandwidth efficiency. In this paper, we proposed a modified PAPR reduction method called semi-Hadamard based selected mapping(semi-HSLM) to decouple the phase information matrix into a phase rotation matrix for PAPR reduction and a SI matrix for side information hiding. We proposed a semi-hadamard matrix generation method to generate the phase rotation matrix, and designed a cyclic shift matrix as the SI matrix. Compared with the traditional HSLM, the semi-HSLM saves half of the phase storage and achieves good PAPR reduction performance. | Ning Li Mingjin Li Zhongliang Deng | 2019 | China Communications2019，16，12： | 3 |
| 12 | Recent advances in preparation,properties and device applications of twodimensional h-BN and its vertical heterostructures显示文摘Two-dimensional(2D) layered materials,such as graphene,hexagonal boron nitride(h-BN),molybdenum disulfide(Mo S_2/,have attracted tremendous interest due to their atom-thickness structures and excellent physical properties.h-BN has predominant advantages as the dielectric substrate in FET devices due to its outstanding properties such as chemically inert surface,being free of dangling bonds and surface charge traps,especially the large-band-gap insulativity.h-BN involved vertical heterostructures have been widely exploited during the past few years.Such heterostructures adopting h-BN as dielectric layers exhibit enhanced electronic performance,and provide further possibilities for device engineering.Besides,a series of intriguing physical phenomena are observed in certain vertical heterostructures,such as superlattice potential induced replication of Dirac points,band gap tuning,Hofstadter butterfly states,gate-dependent pseudospin mixing.Herein we focus on the rapid developments of h-BN synthesis and fabrication of vertical heterostructures devices based on h-BN,and review the novel properties as well as the potential applications of the heterostructures composed of h-BN. | Huihui Yang Feng Gao Mingjin Dai Dechang Jia Yu Zhou Pingan Hu | 2017 | Journal of Semiconductors2017，38，3： | 3 |
| 13 | Extracellular calcium elicits feedforward regulation of the roll-like receptor-triggered innate immune response显示文摘 | Songqing Tang Taoyong Chen Mingjin Yang Lei Wang Zhou Yu Bin Xie Cheng Qian Sheng Xu Nan Li Xuetao Cao Jianli Wang | 2017 | Cellular & Molecular Immunology2017，14，2： | 3 |
| 14 | Development and Application of CDOS Series Catalysts for Bottoms Cracking显示文摘Development of CDOS catalyst for bottoms cracking is based on DOSY zeolite,which is characterized by high metal tolerance.The results of DOSY tests have shown that the catalyst has better activity retention at high metal content in the feed.The performance of catalyst tested in the bench scale was superior over that of the reference catalyst.The results of catalyst application have shown that the CDOS series catalysts have better bottoms cracking activity,high metal tolerance,excellent dry gas selectivity,and enhanced liquid yield. | Wang Mingjin Xu Mingde Zhu Yuxia | 2013 | China Petroleum Processing & Petrochemical Technology2013，15，4： | 2 |
| 15 | Recent Progress in Atmospheric Chemistry Research in China: Establishing a Theoretical Framework for the “Air Pollution Complex”显示文摘Atmospheric chemistry research has been growing rapidly in China in the last 25 years since the concept of the“air pollution complex”was first proposed by Professor Xiaoyan TANG in 1997.For papers published in 2021 on air pollution(only papers included in the Web of Science Core Collection database were considered),more than 24000 papers were authored or co-authored by scientists working in China.In this paper,we review a limited number of representative and significant studies on atmospheric chemistry in China in the last few years,including studies on(1)sources and emission inventories,(2)atmospheric chemical processes,(3)interactions of air pollution with meteorology,weather and climate,(4)interactions between the biosphere and atmosphere,and(5)data assimilation.The intention was not to provide a complete review of all progress made in the last few years,but rather to serve as a starting point for learning more about atmospheric chemistry research in China.The advances reviewed in this paper have enabled a theoretical framework for the air pollution complex to be established,provided robust scientific support to highly successful air pollution control policies in China,and created great opportunities in education,training,and career development for many graduate students and young scientists.This paper further highlights that developing and low-income countries that are heavily affected by air pollution can benefit from these research advances,whilst at the same time acknowledging that many challenges and opportunities still remain in atmospheric chemistry research in China,to hopefully be addressed over the next few decades. | Tong ZHU Mingjin TANG Meng GAO Xinhui BI Junji CAO Huizheng CHE Jianmin CHEN Aijun DING Pingqing FU Jian GAO Yang GAO Maofa GE Xinlei GE Zhiwei HAN Hong HE Ru-Jin HUANG Xin HUANG Hong LIAO Cheng LIU Huan LIU Jianguo LIU Shaw Chen LIU Keding LU Qingxin MA Wei NIE Min SHAO Yu SONG Yele SUN Xiao TANG Tao WANG Tijian WANG Weigang WANG Xuemei WANG Zifa WANG Yan YIN Qiang ZHANG Weijun ZHANG Yanlin ZHANG Yunhong ZHANG Yu ZHAO Mei ZHENG Bin ZHU Jiang ZHU | 2023 | Advances in Atmospheric Sciences2023，40，8： | 2 |
| 16 | Jurassic granitoid dike in Luodian, Guizhou Province: discovery and geological significance显示文摘In this paper, the Jurassic granitoid dike that intrudes into Permian diabase was reported in Luokun,Luodian County, south Guizhou. Zircon LA-ICP-MS U–Pb dating of the granitoid dike yielded an age of 164.3 ± 2.4 Ma with the e Hf(t) range from + 7.8 to + 12.1. The high contents of SiO_2(65.2%–66.8%) and total alkali(Na_2O + K_2O: 9.01%–9.95%), and low contents of Mg, Fe, Ca, P and Ti show the characteristics of alkali-rich granite. The total contents of rare earth elements range from 289.90 to 394.23 ppm. The Rb, Ba, K, Th, U and other LILE, Ta, Sr, P, Ti are enriched, and heavy rare earth elements are depleted. Petrogeochemical characteristics show that the dike was derived from a partial melting of newly-grown basaltic crust, and contaminated by crustal materials before experiencing strong fractional crystallization. The dike was formed in the intraplate post-orogenic extension stage and indicates that parental magma rose to the shallow crust through a fault. This provides new evidence of tectonic and mantle-crust magmatic activities and may contribute to regional Au mineralization in southern Guizhou and neighboring areas. | Mingjin Zhu Aiguo Nie Yazhou Tian Xinsong Wang Jun Sun | 2019 | Acta Geochimica2019，38，1： | 2 |
| 17 | Effect of Tianshu capsule in treatment of migraine:a meta-analysi of randomized control trials显示文摘OBJECTIVE: To review the efficacy of Tianshu cap sule in the treatment of migraine. METHODS: Retrieving papers from Pubmed, co chrane central register of controlled trials (CEN TRAL), Weipu database (VIP) , China biology medi cine (CBM), China national knowledge infrastruc ture (CNKI), and Wanfang Data. Two reviewers retrieved and extracted the information indepen dently. Retrieval time scale is up to August 2012,Software Review Manager 5.1 was used for analysis. RESULTS: A total of 10 studies including 937 migraine patients. The merged data shows Tianshu capsule had a higher effective rate in treating migraine, and there is no significant heterogeneity between Tianshu capsule group and control group (χ2=6.33, df=9, P=0.71, I2=0% ), OR=4.18 [95% CI (2.93,5.95)]. Tianshu capsule alone compared to conventional therapy also showed advantages, and there was low heterogeneity (χ2=4.53, df=3, P=0.21, I2 = 34%), OR=3.95 [95% CI (2.32, 6.72)]. Meta-analysis results show that clinical efficacy of Tianshu capsule was better than that of the control group in the treatment of migraine and there was a significant difference (P<0.000 01). CONCLUSION: Tianshu capsule had better efficacy in the treatment of migraine with fewer adverse effects. | Wei Xia Mingjin Zhu Zhe Zhang Deizhao Kong Wei Xiao Lianqun Jia Guanlin Yang | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 2 |
| 18 | Interfacial film properties of asphaltenes and resins 显示文摘 | Li Mingyuan Xu Mingjin Ma Yu | 2002 | Fuel2002，81，： | 1 |
| 19 | Simultaneous analysis of alkaloids from Zanthoxylum nitidum by high performance liquid chromatography–diode array detector–electrospray tandem mass spectrometry显示文摘 | Mingjin Liang Weidong Zhang Jiang Hu Runhui Liu Chuan Zhang | 2006 | Journal of Pharmaceutical and Biomedical Analysis2006，，2： | 1 |
| 20 | Profiling the pattern of the human T-cell receptorγδcomplementary determinant region 3 repertoire in patients with lung carcinoma via high-throughput sequencing analysis显示文摘γδT cells function as sentinels in early host responses to infections and malignancies.Specifically,γδT cells recognize tumor-associated stress antigens via T-cell receptor(TCR)γδand play important roles in the antitumor immune response.In this study,we characterized the pattern of the human TCRγδcomplementary determinant region 3(CDR3)repertoire in patients with lung carcinoma(LC)via high-throughput sequencing.The results showed that the diversity of CDR3δwas significantly reduced,and that of CDR3γwas unchanged in LC patients compared with healthy individuals;in addition,LC patients shared significantly more CDR3δsequences with each other than healthy individuals.The CDR3 length distribution and N-addition length distribution did not significantly differ between LC patients and healthy individuals.In addition,the CDR3 repertoire tended to use more Vδ2 and fewer Vδ1 germline gene fragments among LC patients.Moreover,we found a combination of four TCRγδrepertoire features that focus on CDR3δand can be used as a biomarker for LC diagnosis.Our research suggests that the TCRγδCDR3 repertoire changed in LC patients due to the antitumor immune response byγδT cells in vivo,and these changes primarily focus on the amplification of certain tumor-specific CDR3δclones among patients.This study demonstrates the role ofγδT cells from the TCRγδCDR3 repertoire in tumor immunity and lays the foundation for elucidating the mechanism underlying the function ofγδT cells in antitumor immunity. | Hui Chen Mingjin Zou Da Teng Yu Hu Jianmin Zhang Wei He | 2019 | Cellular & Molecular Immunology2019，16，3： | 1 |
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