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| 1 | Stretching and imaging studies of single DNA molecules显示文摘DNA molecules were stretched on silanized mica surface with the molecular combing technique, and detected with fluorescence microscopy and atomic force microscopy. Meantime, DNA molecules were stretched with a modified dynamic molecular combing technique and studied with atomic force microscopy. The results indicate that, compared with the dynamic molecular combing technique, the modified dynamic molecular combing technique has advantages of less-sample demand and less contamination to sample; as compared with the molecular combing technique, it has better aligning effect and reproducibility. Combination of this kind of DNA molecular manipulating technique with the single DNA molecule detecting technique by atomic force microscopy and fluorescence microscopy will play an important role in the basic research of molecular dynamics and the application of gene research. | ZHANG Yi CHEN Shengfu OUYANG Zhenqian HU Jun XIONG Qihua LI Bin HUANG Yibo LI Minqian JIN Chengzhi | 2000 | Chinese Science Bulletin2000，45，15： | 13 |
| 2 | Weak minimum aberration and maximum number of clear two-factor interactions in 2_(IV)^(m-p)designs显示文摘 | YANG Guijun,LIU Minqian & ZHANG Runchu Department of Statistics, Tianjin University of Finance and Economics, Tianjin 300222, China Department of Statistics, School of Mathematical Sciences and LPMC, Nankai University, Tianjin 300071, China | 2005 | Science China Mathematics2005，48，11： | 12 |
| 3 | Some results on 4~m2~n designs with clear two-factor interaction components显示文摘Clear effects criterion is one of the important rules for selecting optimal fractional factorial designs,and it has become an active research issue in recent years.Tang et al.derived upper and lower bounds on the maximum number of clear two-factor interactions(2fi's) in 2n-(n-k) fractional factorial designs of resolutions III and IV by constructing a 2n-(n-k) design for given k,which are only restricted for the symmetrical case.This paper proposes and studies the clear effects problem for the asymmetrical case.It improves the construction method of Tang et al.for 2n-(n-k) designs with resolution III and derives the upper and lower bounds on the maximum number of clear two-factor interaction components(2fic's) in 4m2n designs with resolutions III and IV.The lower bounds are achieved by constructing specific designs.Comparisons show that the number of clear 2fic's in the resulting design attains its maximum number in many cases,which reveals that the construction methods are satisfactory when they are used to construct 4m2n designs under the clear effects criterion. | ZHAO ShengLi ZHANG RunChu LIU MinQian | 2008 | Science China Mathematics2008，51，7： | 7 |
| 4 | Bounds on the maximum numbers of clear two-factor interactions for 2^((n1+n2)-(k1+k2)) fractional factorial split-plot designs显示文摘Fractional factorial split-plot (FFSP) designs have an important value of investigation for their special structures.There are two types of factors in an FFSP design: the whole-plot (WP) factors and sub-plot (SP) factors,which can form three types of two-factor interactions:WP2fi,WS2fi and SP2fi.This paper considers FFSP designs with resolution Ⅲ or Ⅳ under the clear effects criterion.It derives the upper and lower bounds on the maximum numbers of clear WP2fis and WS2fis for FFSP designs,and gives some methods for constructing the desired FFSP designs.It further examines the performance of the construction methods. | ZI Xuemin ZHANG Runchu LIU Minqian | 2006 | Science China Mathematics2006，49，12： | 7 |
| 5 | Delay of ZGA initiation occurred in 2-cell blocked mouse embryos显示文摘One-cell mouse embryos from KM strain and B6C3F1 strain were cultured in M16 medium, in which2-cell block generally occurs. Embryos of KM strain exhibited 2-cell block, whereas B6C3F1 embryos,which are regarded as a nonblocking strain, proceeded to the 4-cell stage in our culture condition. It is oftenassumed that the block of early development is due to the failure of zygotic gene activation (ZGA) in culturedembryos. In this study we examined protein synthesis patterns by two-dimensional gel electrophoresis of[35S] methionine radiolabeled 2-cell embryos. Embryos from the blocking strain and the nonblocking strainwere compared in their development both in vitro and in vivo. The detection of TRC expression, a markerof ZGA, at 42 h post hCG in KM embryos developed in vitro suggested that ZGA was also initiated even inthe 2-cell arrested embryos. Nevertheless, a significant delay of ZGA was observed in KM strain as comparedwith normally developed B6C3F1 embryos. At the very beginning of major ZGA as early as 36 h post hCG,TRC has already been expressed in B6C3F1 embryos developed in vitro and KM embryos developed in vivo.But for 2-cell blocked KM embryos, TRC was still not detectable even at 38 h post hCG. These evidencessuggest that 2-cell-blocked embryos do initiate ZGA, and that 2-cell block phenomenon is due not to thedisability in initiating ZGA, but to a delay of ZGA. | JIAJINGQIU WUWENZHANG ZHILIWU YIHONGWANG MINQIAN YIPINGLI | 2003 | Cell Research2003，13，3： | 7 |
| 6 | Construction of optimal supersaturated designs by the packing method显示文摘A supersaturated design is essentially a factorial design with the equal occurrence of levels property and no fully aliased factors in which the number of main efits potential in factor screening experiments. A packing design is an important object in combinatorial design theory. In this paper, a strong link between the two apparently unrelated kinds of designs is shown. Several criteria for comparing supersaturated designs are proposed, their properties and connections with other existing criteria are discussed.A combinatorial approach, called the packing method, for constructing optimal supersaturated designs is presented, and properties of the resulting designs are also investigated.Comparisons between the new designs and other existing designs are given, which show that our construction method and the newly constructed designs have good properties. | FANG Kaitai GE Gennian LIU Minqian | 2004 | Science China Mathematics2004，47，1： | 4 |
| 7 | Some results on resolvable incomplete block designs显示文摘This paper is concerned with the uniformity of a certain kind of resolvable incomplete block (RIB for simplicity) design which is called the PRIB design here. A sufficient and necessary condition is obtained, under which a PRIB design is the most uniform in the sense of a discrete discrepancy measure, and the uniform PRIB design is shown to be connected. A construction method for such designs via a kind of U-type designs is proposed, and an existence result of these designs is given. This method sets up an important bridge between PRIB designs and U-type designs. | LIU Minqian & FANG Kaitai Department of Statistics, Nankai University, Tianjin 300071, China Department of Mathematics, Hong Kong Baptist University, Hong Kong, China | 2005 | Science China Mathematics2005，48，4： | 3 |
| 8 | Imaging bacteriorhodopsin-like molecules of claret-membranes from Tibet halobacteria xz515 by atomic force microscope显示文摘Halobacteria H.sp.xz 515 was isolated from a salt lake in Tibet. Although proton release-and-uptake across claret membrane is in reverse order compared to bacteri-orhodopsin in purple membrane from Halobacterium Sali-narum, and its efficiency of proton pump is much lower, AFM image shows that the molecules are still arranged in a two-dimensional hexagonal lattice of trimers. Primary structure of C- to G-helix of the archaerhodopsin shows that it has only 56% homology with bacteriorhodopsin. But the interactive amino acid residues at the interface between B-and D-helixes are conserved. These amino acid residues are believed to play a significant role in the stability of protein oligomers. | TANG Lin SUN Qing’an LI Qingguo HUANG Yibo WEI Qingqing ZHANG Yi HU Jun ZHANG Zhihong LI Minqian YANG Fujia | 2001 | Chinese Science Bulletin2001，46，22： | 2 |
| 9 | Construction of column-orthogonal designs for computer experiments显示文摘Latin hypercube design and uniform design are two kinds of most popular space-filling designs for computer experiments. The fact that the run size equals the number of factor levels in a Latin hypercube design makes it difficult to be orthogonal. While for a uniform design, it usually has good space-filling properties, but does not necessarily have small or zero correlations between factors. In this paper, we construct a class of column-orthogonal and nearly column-orthogonal designs for computer experiments by rotating groups of factors of orthogonal arrays, which supplement the designs for computer experiments in terms of various run sizes and numbers of factor levels and are flexible in accommodating various combinations of factors with different numbers of levels. The resulting column-orthogonal designs not only have uniformly spaced levels for each factor but also have uncorrelated estimates of the linear effects in first order models. Further, they are 3-orthogonal if the corresponding orthogonal arrays have strength equal to or greater than three. Along with a large factor-to-run ratio, these newly constructed designs are economical and suitable for screening factors for physical experiments. | SUN FaSheng PANG Fang LIU MinQian | 2011 | Science China Mathematics2011，54，12： | 2 |
| 10 | Microplastic pollution and enrichment of distinct microbiota in sediment of mangrove in Zhujiang River estuary,China显示文摘The microbial communities colonized on microplastics(MPs)have attracted widespread attention.However,few studies focused on the MPs impacts on mangrove ecosystems,particularly on bacterial communities.We investigated the MPs pollution in mangrove of Zhujiang(Pearl)River estuary(ZRE).To study the potential risk posed by MPs to the mangrove ecosystems,the differences in bacterial communities,functions,and complexity between MPs and sediment samples were reported for the first time.Microplastics(2991±1586 items/kg dry weight(dw))in sediment were mainly fibers and polyethylene,mostly transparent,and in size less than 0.5 mm.Bacterial communities and functions significantly differed from MPs in mangrove sediment.Compared with sediment,MPs significantly enriched members of Proteobacteria,Bacteroidetes,and Actinobacteria,as well as the bacteria associated with plastic-degrading and human diseases on their surface,suggesting that microbial communities on MPs may promote MPs degradation and the spread of diseases,posing potential risk to mangrove ecosystems and human health.Although bacteria on MPs exhibited a lower diversity,the co-occurrence network analysis indicated that network of bacteria colonized on MPs was bigger and more complex than those of mangrove sediment,illustrating that MPs can act as a distinct habitat in this special ecosystem.This study provides a new perspective for increasing our understanding of microplastic pollution in mangrove ecosystems. | Muting YAN Xiaofeng CHEN Wei CHU Weixin LI Minqian LI Zeming CAI Han GONG | 2023 | Journal of Oceanology and Limnology2023，41，1： | 1 |
| 11 | Uniform supersaturated design and its construction显示文摘 | Kaitai Fang Gennian Ge Minqian Liu | 2002 | Science in China Series A: Mathematics2002，，8： | 1 |
| 12 | Advances in the development of amorphous solid dispersions:The role of polymeric carriers显示文摘Amorphous solid dispersion(ASD)is one of the most effective approaches for delivering poorly soluble drugs.In ASDs,polymeric materials serve as the carriers in which the drugs are dispersed at the molecular level.To prepare the solid dispersions,there are many polymers with various physicochemical and thermochemical characteristics available for use in ASD formulations.Polymer selection is of great importance because it influences the stability,solubility and dissolution rates,manufacturing process,and bioavailability of the ASD.This review article provides a comprehensive overview of ASDs from the perspectives of physicochemical characteristics of polymers,formulation designs and preparation methods.Furthermore,considerations of safety and regulatory requirements along with the studies recommended for characterizing and evaluating polymeric carriers are briefly discussed. | Jie Zhang Minshan Guo Minqian Luo Ting Cai | 2023 | Asian Journal of Pharmaceutical Sciences2023，18，4： | 1 |
| 13 | Selection and study on minoligand of Acanthamoeba which could induce tumor cells to apoptosis by phage display technique显示文摘Acanthamoeba are free-living protozoa organisms that live abroad in nature. Pathogenic Acanthamoeba can cause a fatal granulomatous amoebic encephalitis and keratitis. Some species of Acanthamoeba can induce some tumor cells apoptosis in vitro. Prom 1996 we have proved that Acanthamoeba L strain (A. lugdunensis-A. quina), firstly got by us from keratitis patients in China, could induce tumor cells' apoptosis, including PC12, B16 cells et al. In this research we proved that both the body and the lysis of Acanthamoeba could induce mouse melanoma B16 cells apoptosis. But the apoptosis mechanism was poorly understood. | XUELIANGGAO MINQIAN 等 | 2002 | Cell Research2002，12，3： | 1 |
| 14 | A multiparameter data system for the Shanghai nuclear microprobe显示文摘 | Zhu Jieqing Li Minqian Gu Yingmei | 1991 | Nucl Instr and Meth B1991，54，123： | 1 |
| 15 | WASHINGTON AND NATO EXPANSION显示文摘With a strong push from the second Clinton Administration,NATO’s en-largement eastward is now in full steam.The momentum for this rush pickedup on the eve of the US general election in 1996.In his presidential campaigning,Bill Clinton announced a timetable for NATO extension with 1997 as the year forthe admission of the first batch of new members.The tempo has further sped upsince the March 20-21 1997 US-Russia Helsinki Summit. | Zhang Minqian* *Associate Research Professor, China Institute of Contemporary International Relations | 1997 | Contemporary International Relations1997，7，5： | 0 |
| 16 | Individual Word Length Patterns for Fractional Factorial(Split-Plot)Designs显示文摘Fractional factorial(FF)designs are commonly used for factorial experiments in many fields.When some prior knowledge has shown that some factors are more likely to be significant than others,Li,et al.(2015)proposed a new pattern,called the individual word length pattern(IWLP),which,defined on a column of the design matrix,measures the aliasing of the effect assigned to this column and effects involving other factors.In this paper,the authors first investigate the relationships between the IWLP and other popular criteria for regular FF designs.As we know,fractional factorial split-plot(FFSP)designs are important both in theory and practice.So another contribution of this paper is extending the IWLP criterion from FF designs to FFSP designs.The authors propose the IWLP of a factor from the whole-plot(WP),or sub-plot(SP),denoted by the I_w WLP and Is WLP respectively,in the FFSP design.The authors further propose combined word length patterns C_(w) WLP and Cs WLP,in order to select good designs for different cases.The new criteria C_(w) WLP and Cs WLP apply to the situations that the potential important factors are in WP or SP,respectively.Some examples are presented to illustrate the selected designs based on the criteria established here. | HAN Xiaoxue CHEN Jianbin YANG Jianfeng LIU Minqian | 2023 | Journal of Systems Science & Complexity2023，36，5： | 0 |
| 17 | Process-microstructure-properties of CuAlNi shape memory alloys fabricated by laser powder bed fusion显示文摘Cu-based shape memory alloys(SMAs)show great potential in the application of high temperature,but their performance improvement combining with additive manufacturing is still challenging.In this paper,nearly defect-free(99.7%relative density)CuAlNi SMAs with two types of thermal-induced martensites,18R and 2H,were successfully fabricated by laser powder bed fusion(LPBF).The remelting printing strat-egy with systematic optimization framework including densification and printability analysis was used to get optimal process window.The twin-related self-accommodation structure with long period stacking order substructure was formed during additive manufacturing process.The as-build samples show excel-lent mechanical properties(ultimate compressive strength of 1593±10 MPa and large fracture strain of 23.0%±0.1%)with double-yielding,and outstanding shape memory effect,with maximum recoverable strain of 3.39% and nearly 100%recovery rate under compressive strain not exceeding 6%.Furthermore,the microstructural evolution in LPBF involving remelting,martensitic transformation,and 2H marten-site was discussed.This result not only builds the microstructure framework involving high reflectivity alloys and martensitic transformation but also provides insight into the applicability of LPBF process in producing Cu-based SMAs. | Yankun Zhang Lianyong Xu Lei Zhao Danyang Lin Minqian Liu Xueyan Qi Yongdian Han | 2023 | Journal of Materials Science & Technology2023，，21： | 0 |
| 18 | Real time observation of the photocleavage of single DNA molecules显示文摘A method for real time observation of photo-cleavage of stretched λDNA at single molecular level by a fluorescent microscope coupled with CCD is developed. DNA molecules stained with YOYO-1 are stretched by the mo-lecular combing technique and fixed on a modified slide. Then the process of photocleavage and relaxation of DNA under radiation of blue light is observed. We speculate that the conformation change of stretched DNA and the effect of water are likely to facilitate the effect of YOYO photocleav-age DNA molecules. The photocleavage effect of YOYO for stretched DNA may be useful to study DNA elasticity, cancer research as well as the interaction between DNA and dyes. | LI Bin , HU Jun , WANG Ying, WU Shiying, HUANG Yibo & LI Minqian Shanghai Institute of Nuclear Research,Chinese Academy of Sciences, Shanghai 201800,China | 2003 | Chinese Science Bulletin2003，48，7： | 0 |
| 19 | On Construction of Optimal Two-Level Designs with Multi Block Variables显示文摘当运用一个实验时,试验性的单位的不同类可以导致处理效果的差的评价。因此,在运用实验前选择一个好堵住的图案是合乎需要的。主要,一个单个块变量在文学被使用为简洁对待不同类。在实践,然而,不同类经常来自多堵住变量。最近,称为 B 2-GMC 的一个新标准为二水平的常规图案被建议与多堵住变量。这份报纸在第一次构造一些 B 2-GMC 图案上建议一个系统的理论。实验者们能容易根据构造方法获得 B 2-GMC 图案。B 2-GMC 图案的职业人员在节 4 被加亮,并且有小跑尺寸的图案为实际使用在附录 B 被公布。 | ZHAO Yuna ZHAO Shengli LIU Minqian | 2018 | Journal of Systems Science & Complexity2018，31，3： | 0 |
| 20 | Invaluable Trust A Visit to Bernice Hemphill, an Old Friend of ACWF显示文摘IN March of last year, on my way to New York to attend the NGO Consultation, I stopped in San Francisco. Before I left I called Bernice. She told me she was not well. Before I went to America again in June of this year to visit some of my relatives, I asked my ex-colleagues at the International Liaison Department of the All-China Women’s Federation | HONG LIU Guan Minqian is the former chief of the International Liaison Department of the All-China Women’s Federation | 1996 | Women of China1996，，12： | 0 |
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