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| 1 | Role of PRMTs in cancer: Could minor isoforms be leaving a mark?显示文摘Protein arginine methyltransferases(PRMTs) catalyze the methylation of a variety of protein substrates, many of which have been linked to the development, progression and aggressiveness of different types of cancer. Moreover, aberrant expression of PRMTs has been observed in several cancer types. While the link between PRMTs and cancer is a relatively new area of interest, the functional implications documented thus far warrant further investigations into its therapeutic potential. However, the expression of these enzymes and the regulation of their activity in cancer are still significantly understudied. Currently there are nine main members of the PRMT family. Further, the existence of alternatively spliced isoforms for several of these family members provides an additional layer of complexity. Specifically, PRMT1, PRMT2, CARM1 and PRMT7 have been shown to have alternative isoforms and others may be currently unrealized. Our knowledge with respect to the relative expression and the specific functions of these isoforms is largely lacking and needs attention. Here we present a review of the current knowledge of theknown alternative PRMT isoforms and provide a rationale for how they may impact on cancer and represent potentially useful targets for the development of novel therapeutic strategies. | R Mitchell Baldwin Alan Morettin Jocelyn C té | 2014 | World Journal of Biological Chemistry2014，5，2： | 14 |
| 2 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 3 | Herbal extracts as hepatoprotectants against acetaminophen hepatotoxicity显示文摘Many plant-derived natural products have the potential to be hepatoprotective and therefore can be used to treat acute and chronic liver diseases. The challenge is to identify the most promising compounds and evaluate their protective mechanism. In a recently published article, Wang et al evaluated extracts of the plant Gentiana manshurica Kitagawa (GM) in a model of acetaminophen hepatotoxicity. The authors concluded that GM is hepatoprotective against acetaminopheninduced liver injury due to its antioxidant properties and anti-apoptotic capacity. We would like to discuss the limitations of this experimental approach and question the conclusion based on the data presented in this manuscript and the published literature. | Hartmut Jaeschke C David Williams Mitchell R McGill Anwar Farhood | 2010 | World Journal of Gastroenterology2010，16，19： | 3 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | Programmed assembly of DNA functionalized quantum dots 显示文摘 | MITCHELL G P MIRKIN C A LETSINGER R L | 1999 | J Am Chem Soc1999，121，35： | 1 |
| 6 | Reasons fornon randomization in the UK3 trial of surgical app roach in localizedWilms' tumour requiting a difficult day one randomization:a UKCCSGWilms' Tumour Group study显示文摘 | Pritchard-Jones K Mitchell C Shannon R | 2003 | Med Pediatr Oncol2003，41，： | 1 |
| 7 | Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen 显示文摘 | Mitchell PJ Wang C Tijian R | 1987 | Cell1987，50，6： | 1 |
| 8 | Assessing variation in the radial profile of sap flux density in Pinus species and its effect on daily water use显示文摘 | Ford C Mcguire M A Mitchell R J | 2004 | Tree Physiology2004，24，3： | 1 |
| 9 | Direct observation of behaviour of Au nanoclusters on TiO2(110) at elevated temperatures显示文摘 | MITCHELL C E J HOWARD A CARGEN M EGDLL R G | 2001 | Surface Science2001，490，： | 1 |
| 10 | The treatment ofWilms'tumo-ur:the United Kingdom Children 's Cancer Study GroupthirdWilms' tumour study显示文摘 | Mitchell C Shannon R Vujanic | 2003 | Med Pediatr Oncol2003，41，： | 1 |
| 11 | New development in solid state fermentation: l-bioprocess and products 显示文摘 | PANDEY A C R SOCCOL C R MITCHELL D | 2000 | Process Biochemistry2000，35，10： | 1 |
| 12 | Independent determinants of operative mortality for patients with aortic dissections显示文摘 | MILLER D C MITCHELL R S OYER P E | 1984 | Circulation1984，70，32： | 1 |
| 13 | Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen显示文摘 | MITCHELL P J WANG C TJIAN R | 1987 | Cell1987，51，： | 1 |
| 14 | A genetic polymorohism of the N-oxidation of trimethylamine in humans 显示文摘 | A1-Waiz M Ayesh R Mitchell S C | 1987 | Clin Pbarmacol Ther1987，42，5： | 1 |
| 15 | Ovipostional responses of three Heliothis species ( Lepidoptrea: Noctuidae) to allelo chemicals from cultivated and wild host plants 显示文摘 | MITCHELL E R TINGLE F C HEATH R R | 1990 | Chem Ecol1990，16，6： | 1 |
| 16 | Strategic Applications of Named Reactions in Organic Synthesis显示文摘 | CAMBIE R C MITCHELL L H RUTLE-qgGE P S | 1998 | Aust J Chem1998，51，15： | 1 |
| 17 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 18 | Estim- ation of basic density of Eucalyptus globules using near- infrared spectroscopy显示文摘 | Schimleck L R Mitchell A L Raymond C A | 1999 | Canadian Journal of Forest Research1999，29，2： | 1 |
| 19 | Elastic modulus of single-walled carbon nanotube/poly(methyl methacrylate)nanocomposites显示文摘 | Mitchell C A Krishnamoorti R | 2004 | Journal of Polymer Science Part B:Polymer Physics2004，42，12： | 1 |
| 20 | Cellular infiltration of the human arterial adventitia associated with atheromatous plaques显示文摘 | SCHWARTZ C J MITCHELL J R A | 1962 | Circulation1962，26，： | 1 |
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