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| 1 | Apoptosis and non-alcoholic fatty liver diseases显示文摘The number of patients with nonalcoholic fatty liver diseases(NAFLD) including nonalcoholic steatohepatitis(NASH), has been increasing. NASH causes cirrhosis and hepatocellular carcinoma(HCC) and is one of the most serious health problems in the world. The mechanism through which NASH progresses is still largely unknown. Activation of caspases, Bcl-2 family proteins, and c-Jun N-terminal kinase-induced hepatocyte apoptosis plays a role in the activation of NAFLD/NASH. Apoptotic hepatocytes stimulate immune cells and hepatic stellate cells toward the progression of fibrosis in the liver through the production of inflammasomes and cytokines. Abnormalities in glucose and lipid metabolism as well as microbiota accelerate these processes. The production of reactive oxygen species, oxidative stress, and endoplasmic reticulum stress is also involved. Cell death, including apoptosis, seems very important in the progression of NAFLD and NASH. Recently, inhibitors of apoptosis have been developed as drugs for the treatment of NASH and may prevent cirrhosis and HCC. Increased hepatocyte apoptosis may distinguish NASH from NAFLD, and the improvement of apoptosis could play a role in controlling the development of NASH. In this review, the association between apoptosis and NAFLD/NASH are discussed. This review could provide their knowledge, which plays a role in seeing the patients with NAFLD/NASH in daily clinical practice. | Tatsuo Kanda Shunichi Matsuoka Motomi Yamazaki Toshikatsu Shibata Kazushige Nirei Hiroshi Takahashi Tomohiro Kaneko Mariko Fujisawa Teruhisa Higuchi Hitomi Nakamura Naoki Matsumoto Hiroaki Yamagami Masahiro Ogawa Hiroo Imazu Kazumichi Kuroda Mitsuhiko Moriyama | 2018 | World Journal of Gastroenterology2018，24，25： | 32 |
| 2 | Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model显示文摘Osteoarthritis(OA) is a degenerative joint disease and a major cause of pain and disability in older adults. We have previously identified epidermal growth factor receptor(EGFR) signaling as an important regulator of cartilage matrix degradation during epiphyseal cartilage development. To study its function in OA progression, we performed surgical destabilization of the medial meniscus(DMM) to induce OA in two mouse models with reduced EGFR activity, one with genetic modification(EgfrWa5/1mice) and the other one with pharmacological inhibition(gefitinib treatment). Histological analyses and scoring at 3 months post-surgery revealed increased cartilage destruction and accelerated OA progression in both mouse models. TUNEL staining demonstrated that EGFR signaling protects chondrocytes from OA-induced apoptosis, which was further confirmed in primary chondrocyte culture. Immunohistochemistry showed increased aggrecan degradation in these mouse models, which coincides with elevated amounts of ADAMTS5 and matrix metalloproteinase 13(MMP13), the principle proteinases responsible for aggrecan degradation, in the articular cartilage after DMM surgery. Furthermore, hypoxia-inducible factor 2a(HIF2a), a critical catabolic transcription factor stimulating MMP13 expression during OA, was also upregulated in mice with reduced EGFR signaling. Taken together, our findings demonstrate a primarily protective role of EGFR during OA progression by regulating chondrocyte survival and cartilage degradation. | Xianrong Zhang Ji Zhu Fei Liu Yumei Li Abhishek Chandra L Scott Levin Frank Beier Motomi Enomoto-Iwamoto Ling Qin | 2014 | Bone Research2014，2，3： | 9 |
| 3 | Intervertebral disc development and disease-related genetic polymorphisms显示文摘The intervertebral disc(IVD)comprises a gelatinous inner core(nucleus pulposus;NP)and concentric rings(annulus fibrosus;AF).The NP,an important structure for shock absorption in the vertebrate spinal motion segment,can be traced back to the notochord in ontogenetic lineage.In vertebrates,the notochord undergoes mucinoid changes,and had been considered vestigial until recently.However,observed correlations between IVD degeneration and back pain in humans have renewed interest in the IVD in biomedical fields.Beyond its mechanical contribution to development,the notochord is also an essential signaling center,which coordinates formation of the neural tube and somites.The pertinent signaling molecules,particularly TGF-b and bone morphogenetic proteins(BMPs),continue to play roles in the adult tissues and have been utilized for tissue regeneration.Genetic factors are major determinants of who will develop IVD degeneration and related back pain,and seem to correlate better with disc degeneration and back pain than do external forces on the spine.In summary,the spinal column is a landmark development in evolution.Genes directing the development of the IVD may also contribute to its maintenance,degeneration,and regeneration.Likewise,structural genes as well as genes responsible for maintenance of the structure are related to IVD degeneration.Finally,genes responsible for inflammation may play a dual role in exacerbating degeneration or facilitating repair responses depending on the context. | Jason W.Ashley Motomi Enomoto-Iwamoto Lachlan J.Smith Robert L.Mauck Danny Chan Joseph Lee Martin F.Heyworth Howard An Yejia Zhang | 2016 | Genes & Diseases2016，3，3： | 3 |
| 4 | Cause and Management of Recurrent Primary Spontaneous Pneumothorax After Thoracoscopic Stapler Blebectomy显示文摘 | Takashi Muramatsu Mie Shimamura Motohiko Furuichi Tatsuhiko Nishii Shinji Takeshita Shinichiro Ishimoto Hiroaki Morooka Yoko Tanaka Chiyoshi Yagasaki Kazumitsu Ohmori Motomi Shiono | 2011 | Asian Journal of Surgery2011，，2： | 2 |
| 5 | Warning for unprincipled colorectal endoscopic submucosal dissection: Accurate diagnosis and reasonable treatment strategy显示文摘 | Shinji Tanaka Motomi Terasaki Nana Hayashi Shiro Oka Kazuaki Chayama | 2012 | Digestive Endoscopy2012，，2： | 2 |
| 6 | Expression of Exogenous Genes Under the Control of Endogenous HSP70 and CAB Promoters in the Closterium Peraeerosum-strigosum-littorale Complex显示文摘 | Jun Abel Yuji Hiwatashi Motomi Ito | 2008 | Plant Cell Physiol2008，49，4： | 1 |
| 7 | Evolving Preoperative Evaluation of Patients with Pancreatic Cancer: Does Laparoscopy Have a Role in the Current Era?显示文摘 | Skye C. Mayo Donald F. Austin Brett C. Sheppard Motomi Mori Donald K. Shipley Kevin G. Billingsley | 2008 | Journal of the American College of Surgeons2008，，1： | 1 |
| 8 | Analysis of gymnosperm two-AP2-domain-containing genes显示文摘 | Mikao Shigyo Motomi Ito | 2004 | Development Genes and Evolution2004，，3： | 1 |
| 9 | Chloroplast DNA phylogeny of asian bamboos(bambusoideae,poaceae) and systematic implication显示文摘 | Motomi I Siro K | 1994 | Journal of Plant Research1994，，107： | 1 |
| 10 | Valved conduit operation for aortic regurgitation associated with Beh?et’s disease显示文摘 | Motomi Ando Yosikado Sasako Yutaka Okita Osamu Tagusari Soichiro Kitamura | 2000 | The Japanese Journal of Thoracic and Cardiovascular Surgery2000，，7： | 1 |
| 11 | China's first urban monorail system in Chongqing显示文摘 | Sekitani Taketoshi Hiraishi Motomi Yamasaki Soichiro | 2005 | Hitachi Review2005，54，4： | 1 |
| 12 | Hospital-acquired candidemia: the attributable mortality and excess length of stay 显示文摘 | Wey S B Motomi N Pfaller M A tt al | 1988 | Arch Intern Med1988，148，12： | 1 |
| 13 | Clinical outcomes of endoscopic submucosal dissection for rectal tumor close to the dentate line显示文摘 | Koichi Nakadoi Shinji Tanaka Nana Hayashi Shun-ichiro Ozawa Motomi Terasaki Sayaka Takata Hiroyuki Kanao Shiro Oka Kazuaki Chayama | 2012 | Gastrointestinal Endoscopy2012，，2： | 1 |
| 14 | Type A acute aortic dissection: Immediate and mid-term results of emergency aortic replacement with the aid of gelatin resorcin formalin glue显示文摘 | Mitsumasa Hata Motomi Shiono Akira Sezai Mitsuru Iida Nanao Negishi Yukiyasu Sezai | 2004 | The Annals of Thoracic Surgery2004，，3： | 1 |
| 15 | Intraspecific sequence variation of chloroplast DNA reflecting variety and geographical distribution of Polygonurn cuspidatum (Polygonaceae) in Japan显示文摘 | ATSUSHI INAMURA YAYOI OHASHI ETSUKO SATO YOSHIKA YODA TAKEHIRO MASUZAWA MOTOMI ITO KOICHI YOSHINAGA | 2000 | Journal of Plant Research2000，113，： | 1 |
| 16 | Runx3 is required for full activa- tion of regulatory T ceils to prevent colitis - associated tomor forma- tion显示文摘 | Manabu S Koji A Motomi O | 2011 | J Immunol2011，186，11： | 1 |
| 17 | Increase of Bone Marrow–Derived Secretory Lineage Epithelial Cells During Regeneration in the Human Intestine显示文摘 | Tomoko Matsumoto Ryuichi Okamoto Tomoharu Yajima Takehiko Mori Shinichiro Okamoto Yasuo Ikeda Makio Mukai Motomi Yamazaki Shigeru Oshima Kiichiro Tsuchiya Tetsuya Nakamura Takanori Kanai Hideyuki Okano Johji Inazawa Toshifumi Hibi Mamoru Watanabe | 2005 | Gastroenterology2005，，7： | 1 |
| 18 | Antioxidantactivity of various teas against free radicals and LDL oxidation显示文摘 | Reiko Ohmori Tamami Iwamoto Motomi Tagb | 2005 | Lipids2005，40，8： | 1 |
| 19 | HLA GENE AND HAPLOTYPE FREQUENCIES IN THE NORTH AMERICAN POPULATION: The National Marrow Donor Program Donor Registry显示文摘 | Motomi Mori Patrick G. Beatty Michael Graves Kenneth M. Boucher Edgar L. Milford | 1997 | Transplantation1997，，7： | 1 |
| 20 | Postoperative Renal Function After Elective Abdominal Aortic Aneurysm Repair Requiring Suprarenal Aortic Cross-Clamping显示文摘 | Fabio A. Kudo Toshiya Nishibe Keiko Miyazaki Toshifumi Murashita Keishu Yasuda Motomi Ando Masayasu Nishibe | 2004 | Surgery Today2004，，12： | 1 |
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