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| 1 | Serum cytokine profile in patients with hepatitis B e antigen-negative chronic active hepatitis B and inactive hepatitis B virus carriers显示文摘An insufficient cellular immune response seems to be critical for the immunopathogenesis of chronic hepatitis B virus infection.We have previously demonstrated no differences of T-lymphocyte subsets in blood between inactive hepatitis B s antigen(HBsAg) carriers and patients with HBeAg-negative chronic active hepatitis B.This study investigated the peripheral blood cytokine profile in patients with HBeAg-negative chronic active hepatitis B infection(Group A,n = 21) and inactive HBsAg carriers(Group B,n = 13).Serum cytokines [interferon(IFN)-γ,tumor necrosis factor-α,interleukin(IL)-1b,IL-4,IL-12,IL-10,IL-2,IL-5,IL-8] were analyzed by using flow cytometry.Patients with chronic active disease presented with significantly decreased levels of IFN-γ and IL-10 compared to inac-tive carriers(P = 0.048 and P = 0.008,respectively).In HBeAg-negative chronic active hepatitis B patients,a significant negative correlation of IFN-γ levels with serum hepatitis B viral load was noted(P = 0.021).In conclusion,patients with HBeAg-negative chronic active hepatitis B and HBsAg inactive carriers display a different cytokine profile.Decreased Th1 response observed in patients with chronic active hepatitis B could be implicated in the persistence of virus replication and ongoing progression of liver disease. | Dimitra Dimitropoulou Marina Karakantza Georgios L Theodorou Lydia Leonidou Stelios F Assimakopoulos Athanasia Mouzaki Charalambos A Gogos | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，1： | 13 |
| 2 | Toward a new era of hepatitis B virus therapeutics:The pursuit of a functional cure显示文摘Hepatitis B virus(HBV)infection,although preventable by vaccination,remains a global health problem and a major cause of chronic liver disease.Although current treatment strategies suppress viral replication very efficiently,the optimal endpoint of hepatitis B surface antigen(HBsAg)clearance is rarely achieved.Moreover,the thorny problems of persistent chromatin-like covalently closed circular DNA and the presence of integrated HBV DNA in the host genome are ignored.Therefore,the scientific community has focused on developing innovative therapeutic approaches to achieve a functional cure of HBV,defined as undetectable HBV DNA and HBsAg loss over a limited treatment period.A deeper understanding of the HBV life cycle has led to the introduction of novel direct-acting antivirals that exert their function through multiple mechanisms,including inhibition of viral entry,transcriptional silencing,epigenetic manipulation,interference with capsid assembly,and disruption of HBsAg release.In parallel,another category of new drugs aims to restore dysregulated immune function in chronic hepatitis B accompanied by lethargic cellular and humoral responses.Stimulation of innate immunity by pattern-recognition receptor agonists leads to upregulation of antiviral cytokine expression and appears to contribute to HBV containment.Immune checkpoint inhibitors and adoptive transfer of genetically engineered T cells are breakthrough technologies currently being explored that may elicit potent HBV-specific T-cell responses.In addition,several clinical trials are attempting to clarify the role of therapeutic vaccination in this setting.Ultimately,it is increasingly recognized that elimination of HBV requires a treatment regimen based on a combination of multiple drugs.This review describes the rationale for progressive therapeutic interventions and discusses the latest findings in the field of HBV therapeutics. | Efthymios P Tsounis Evanthia Tourkochristou Athanasia Mouzaki Christos Triantos | 2021 | World Journal of Gastroenterology2021，27，21： | 5 |
| 3 | Tregs and kidney: From diabetic nephropathy to renal transplantation显示文摘Kidney transplantation is recognised as the most effective treatment for patients with end-stage renal disease(ESRD). Kidney transplantation continues to face several challenges including long-term graft and patient survival, and the side effects of immunosuppressive therapy. The tendency in kidney transplantation is to avoid the side effects of immunosuppresants and induce immune tolerance. Regulatory T-cells(Tregs) contribute to self-tolerance, tolerance to alloantigen and transplant tolerance, mainly by suppressing the activation and function of reactive effector T-cells. Additionally, Tregs are implicated in the pathogenesis of diabetes, which is the leading cause of ESRD, suggesting that these cells play a role both in the pathogenesis of chronic kidney disease and the induction of transplant tolerance. Several strategies to achieve immunological tolerance to grafts have been tested experimentally, and include combinations of co-stimulatory blockade pathways, T-cell depletion, in vivo Treg-induction and/or infusion of exvivo expanded Tregs. However, a successful regimen that induces transplant tolerance is not yet available for clinical application. This review brings together certain key studies on the role of Tregs in ESRD, diabetes and kidney transplantation, only to emphasize that many more studies are needed to elucidate the clinical significance and the therapeutic applications of Tregs. | Periklis Dousdampanis Kostantina Trigka Athanasia Mouzaki | 2016 | World Journal of Transplantation2016，6，3： | 4 |
| 4 | Nucleic acid vaccines: A taboo broken and prospect for a hepatitis B virus cure显示文摘Although a prophylactic vaccine is available,hepatitis B virus(HBV)remains a major cause of liver-related morbidity and mortality.Current treatment options are improving clinical outcomes in chronic hepatitis B;however,true functional cure is currently the exception rather than the rule.Nucleic acid vaccines are among the emerging immunotherapies that aim to restore weakened immune function in chronically infected hosts.DNA vaccines in particular have shown promising results in vivo by reducing viral replication,breaking immune tolerance in a sustained manner,or even decimating the intranuclear covalently closed circular DNA reservoir,the hallmark of HBV treatment.Although DNA vaccines encoding surface antigens administered by conventional injection elicit HBVspecific T cell responses in humans,initial clinical trials failed to demonstrate additional therapeutic benefit when administered with nucleos(t)ide analogs.In an attempt to improve vaccine immunogenicity,several techniques have been used,including codon/promoter optimization,coadministration of cytokine adjuvants,plasmids engineered to express multiple HBV epitopes,or combinations with other immunomodulators.DNA vaccine delivery by electroporation is among the most efficient strategies to enhance the production of plasmid-derived antigens to stimulate a potent cellular and humoral anti-HBV response.Preliminary results suggest that DNA vaccination via electroporation efficiently invigorates both arms of adaptive immunity and suppresses serum HBV DNA.In contrast,the study of mRNA-based vaccines is limited to a few in vitro experiments in this area.Further studies are needed to clarify the prospects of nucleic acid vaccines for HBV cure. | Efthymios P Tsounis Athanasia Mouzaki Christos Triantos | 2021 | World Journal of Gastroenterology2021，27，41： | 3 |
| 5 | Association between magnesium concentration and HbA1c in children and adolescents with type 1 diabetes mellitus (儿童与青少年1型糖尿病患者的镁浓度与HbA1c之间的关系)显示文摘 | Assimina Galli‐Tsinopoulou Ioanna Maggana Ioannis Kyrgios Konstantina Mouzaki Maria G. Grammatikopoulou Charilaos Stylianou Kyriaki Karavanaki | 2014 | Journal of Diabetes2014，，： | 2 |
| 6 | Intestinal microbiota in patients with nonalcoholic fatty liver disease显示文摘 | Marialena Mouzaki Elena M. Comelli Bianca M. Arendt Julia Bonengel Scott K. Fung Sandra E. Fischer Ian D. McGilvray Johane P. Allard | 2013 | Hepatology2013，，1： | 2 |
| 7 | Rifaximin for the prevention of spontaneous bacterial peritonitis显示文摘According to a review article by Biecker et al published in a previous issue of World Journal of Gastroenterology in March 2011,intestinal decontamination with norfloxacin remains the mainstay of primary prophylaxis of spontaneous bacterial peritonitis(SBP) at the expense of development of quinolone-resistant bacteria after long-term use.In our research,the administration of a 4-wk regimen with rifaximin 1200 mg/d reduced significantly the ascitic neutrophil count in cirrhotic patients with sterile ascites in line with a significant decrease in plasma endotoxin levels.Our observations concur with recent findings,showing a significantly reduced 5-year probability of SBP in cirrhotic patients taking rifaximin. | Georgios N Kalambokis Athanasia Mouzaki Maria Rodi Epameinondas V Tsianos | 2012 | World Journal of Gastroenterology2012，18，14： | 2 |
| 8 | Vickers hardness studies of calcium oxalate monohydrate and brushite urinary stones 显示文摘 | Bouropoulos N Mouzakis DE Bithelis G | 2006 | J Endourol2006，20，： | 1 |
| 9 | Cytoldne produc- tion and hospital mortality in patients with sepsis-induced stress hyperglycemia显示文摘 | Leonidou L Mouzaki A Michalaki M | 2007 | Infection2007，55，4： | 1 |
| 10 | Serum transforming growth factor-β1 is related to the degree of immunoparesis in patients with multiple myeloma显示文摘 | Maria-Christina Kyrtsonis Constantina Repa George (XXXV) Z Dedoussis Athanasia Mouzaki Argyris Simeonidis Marina Stamatelou Alice Maniatis | 1998 | Medical Oncology1998，，2： | 1 |
| 11 | Thl and Th2 cytokines in a patient with Evans' syndrome and profound lymphopenia 显示文摘 | Karakantza M Mouzaki A Theodoropoulou M | 2000 | B r J Haematol2000，110，4： | 1 |
| 12 | Cytokine production and hospital mortality in patients with sepsis-induced stress hyperglycemia显示文摘 | LEONIDOU L MOUZAKI A MICHAI AKI M | 2007 | J Infect2007，55，4： | 1 |
| 13 | Fracture behavior of polypropylene/glass bead elastomer composites by using the essential work-of-fracture method 显示文摘 | MOUZAKIS D E STICKER F KARGER-KOCSIS J | 1998 | Journal of Materials Science1998，33，： | 1 |
| 14 | Fracture toughness assessment of poly( ethylene terephthalate)blends with glycidyl methacrylate modified polyolefin elastomer using essential work of fracture method显示文摘 | MOUZAKIS D E PAPKE N WU J S KARGER-KOCSIS J | 2001 | Journal of Applied Polymer Science2001，79，： | 1 |
| 15 | Cyclosporin A and FKS06 prevent the derepression of the IL-2 gene in mitogen-induced primary T lymphocytes 显示文摘 | Mouzaki A Dai Y Weil R | 1992 | Cytokine1992，4，： | 1 |
| 16 | Accelerated environmental ageing study of polyester/glass fiber reinforced composites (GFRPCs)显示文摘 | Dionysis E. Mouzakis Helen Zoga Costas Galiotis | 2007 | Composites Part B2007，，3： | 1 |
| 17 | Accelerated environmentalageing study of polyester/glass fiber reinforced com- posites (GFRPCs)显示文摘 | Mouzakis D E Zoga H | 2008 | Composites: B2008，39，： | 1 |
| 18 | Cytokine production and monocyle HLA-DR expression as predictors of outcome for patients with community-acquired severe infections显示文摘 | Lekkou A Karakantza M Mouzaki A | 2004 | Clin Diagn Lab Imumunol2004，11，1： | 1 |
| 19 | Cytokine production and monocyte HLADR expression as predictors of outcome for patients with communityacquired severe infections 显示文摘 | Lekkou A Karakantza M Mouzaki A | 2004 | Clin Diagn Lab Immunol2004，11，： | 1 |
| 20 | Assessing the carbon dioxide emission reduction potential of a natural gas container carrier显示文摘 | CALLEYA J MOUZAKIS P PAWLING R | 2011 | 2011，，： | 1 |
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