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327篇 您的检索式:作者名="MURTAZA"
    题名 作者 年代 出处 被引量
1Role of a probiotic (Saccharomyces boulardii) in management and prevention of diarrhoea显示文摘瞄准:估计酵母属 boulardii 的功效和安全(S。boulardii ) 在在减少腹泻的事件的频率在的尖锐水的腹泻和它的角色随后二个月。方法:从 2 瞬间的孩子到 12 岁,在 S 根据包括标准和随机的 ised 与尖锐腹泻被选择。boulardii 组(与 ORS,营养的支持和 S 一起对待。boulardii, 250 mg 出价) 并且在控制组(仅仅与 ORS 和营养的支持一起对待) 。直接疗法阶段是 5 d,每个孩子以后被跟随二个月。象药的安全一样的凳子的频率和一致性在每访问上被估计。二个组的比较以痢疾的事件的数字被做在随后二个月。结果:在每个组有五十个病人。象吝啬的年龄和凳子的平均频率那样的基线特征在 S 是可比较的。boulardii 和控制在试用在包括的时候组织。由 d 3 它分别地并且由 d 每 d 归结为 2.7 和 4.2 张凳子 6 它归结为 1.6 (S。boulardii 组) 并且 3.3 (控制组) 。腹泻的持续时间是在 S 的 3.6 d。而它是在控制组的 4.8 d, boulardii 组织(P = 0.001 ) 。在下列二个月内, S。有的 boulardii 组一显著地, 0.54 个事件的低频率作为与在控制的 1.08 个事件相比组织。这药很好被接受并且容忍。在治疗时期期间没有副作用的报告。结论:S。boulardii 显著地减少尖锐腹泻的频率和持续时间。凳子的一致性也改善。这药是容忍得好的。AG Billoo MA Memon SA Khaskheli G Murtaza Khalid Iqbal M Saeed Shekhani Ahson Q Siddiqi 2006World Journal of Gastroenterology2006,12,28:22
2Cloning and characterization of a potato StAN11 gene involved in anthocyanin biosynthesis regulation显示文摘Anthocyanins are a class of products of plant secondary metabolism and are responsible for tubers color in potato.The biosynthesis of anthocyanins is a complex Researchbiological process,in which multiple genes are involved including structural genes and regulatory genes.In this study,StAN11,a WD40-repeat gene,was cloned from potato cultivar Chieftain(Solanum tuberosum L.).StAN11(HQ599506)contained no intron and its open reading frame(ORF)was 1,029 bp long,encoding a putative protein of 342 amino acids.In order to verify its role in anthocyanin biosynthesis,StAN11 was inserted behind the CaMV-35S promoter of pCMBIA1304 and the recombination vector was introduced into the potato cultivar Désirée plants by Agrobacterium-mediated transformation.The color of transgenic tuber skin was significantly deepened,compared to the wild-type control,which was highly consistent with the accumulation of anthocyanin and expression of StAN11 in transgenic lines tuber skin.Further analysis on the expression of Flavonone-3-hydroxylase(F3H),Dihydroflavonol reductase(DFR),Anthocyanidin synthase(ANS),and Flavonoid 3-O-glucosyl transferase(3GT)in transgenic plants revealed that only DFR was upregulated.This result suggested that StAN11 regulated anthocyanin biosynthesis in potato by controlling DFR expression and accumulation of anthocyanin could be increased through overexpression of StAN11 in the tubers with the genetic background of anthocyanin biosynthesis.Wang Li Bing Wang Man Wang Min Chen Jing-Ming Yin Ghullam Murtaza Kaleri Rui-Jie Zhang Tie-Niu Zuo Xiong You Qing Yang 2014Journal of Integrative Plant Biology2014,56,4:13
3Effect of precut sphincterotomy on post-endoscopic retrograde cholangiopancreatography pancreatitis:A systematic review and meta-analysis显示文摘AIM:To conduct a systemic review and meta-analysis to investigate the role of early precut technique.Multiple randomized controlled trails(RCTs)have reported conflicting results of the early precut sphincterotomy.METHODS:MEDLINE/PubMed,EMBASE,Cochrane Central Register of Controlled Trials and Database of Systematic Reviews,and recent abstracts from major conference proceedings were searched(June 2013).Randomized and non-randomized studies comparing early precut technique with prolonged standard methods were included.Pooled estimates of post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis(PEP),cannulation and adverse events were analyzed by using odds ratio(OR).Random and fixed effects models were used as appropriate.Publication bias was assessed by funnel plots.Heterogeneity among studies was assessed by calculating I2 measure of inconsistency.RESULTS:Seven randomized and seven non-randomized trials met inclusion criteria.Meta-analysis of RCTs showed a decrease trend for PEP with early precut sphincterotomy but was not statistically significant(OR=0.58;95%CI:0.32-1.05;P=0.07).No heterogeneity was noted among the studies with I2 of 0%.CONCLUSION:Early precut technique for common bile duct cannulation decreases the trend of post-ERCP pancreatitis.Abhishek Choudhary Jessica Winn Sameer Siddique Murtaza Arif Zainab Arif Ghassan M Hammoud Srinivas R Puli Jamal A Ibdah Matthew L Bechtold 2014World Journal of Gastroenterology2014,20,14:13
4Synthesis and Characterization of Nano-hydroxyapatite Powder Using Wet Chemical Precipitation Reaction显示文摘Hydroxyapatite(HA) nano-powder was synthesized via wet chemical technique in a used precipitation reaction,in which Ca(OH)_2 and H_3PO_4 were used as precursors.Deionised water was used as a diluting media for the reaction and ammonia was used to adjust the pH.The synthetic HA nano-powder has some medical applications such as a coating material in orthopaedic implants and in dental.HA powder has been studied at different temperatures from 100 to 800 ℃ to achieve the stoichiometric Ca/P ratio 1.667.The optimum temperature was found to be 600 ℃.Above this temperature,the HA powder decomposed to CaO.The crystallite size of HA powder was found to be in the range of 8.47—24.47 nm.The crystallographic properties were evaluated by X-ray diffraction,Fourier transform infrared spectroscopy,energy dispersive Xray spectroscopy and scanning electron microscopy.The results show that,high purity of nano-hydroxyapatite powders could be obtained at low temperatures,and the crystallinity,crystallite size and Ca/P ratio of the resulting nanoparticles were found to be dependent on the calcination temperature.When Ca/P ratio exceeded1.75,formation of CaO phase was observed.Syed Sibte Asghar Abidi Qasim Murtaza 2014Journal of Materials Science & Technology2014,30,4:8
5A study on p53 gene alterations in esophageal squamous cell carcinoma and their correlation to common dietary risk factors among population of the Kashmir valley显示文摘瞄准:为了系统地检验风险因素的关联的程度,例如年龄,与原因的体的 Tp53 分子损害消费了饮食的习惯和家庭倾向在北印度的 Kashmiri 人口之中提高食道的有鳞的房间癌(ESCC ) 的致癌作用严厉。方法:所有情况(n = 51 ) 并且控制(n = 150 ) 是克什米尔山谷的永久居民。基因改变在 Tp53 肿瘤的前 ons 5-8 被决定压制或在 45 个 ESCC 盒子之中的基因组织学地由 PCR-SSCP 分析证实了。为单个癌症盒子的数据(n = 45 ) 并且住院病人控制(n = 150 ) 与非癌症,疾病在癌症的家庭历史上包括了信息,与病人的年龄组一起的三十个占优势的普通饮食的风险因素。在到从这些参数的万物有灵论的数据的 p53 前 ons 的基因损害的关联被 Chi 平方测试与健康控制一起产生到所有 45 个组织学地证实的 ESCC 盒子。结果:(77.8%) 45 中的 35 个组织学地描绘了与 45 正常样品中的 1 个对比的有的类似的体细胞突变从一样的耐心的显示出的细菌线变化从邻近的区域获得了的肿瘤样品。 SSCP 分析表明了改变在 6 上在前被发现的那很普通的 p53 基因(77.7%),那没与个人和 clinicopathological 参数的年龄相关,但是与癌症的家庭历史显示出重要词语索引( P<0.05 )( CD = 58 ),在消费的一个未知地点,和饮食的习惯建议细菌线倾向局部地种芥属蔬菜“ Hakh ”( CD = 19.5 ),红 chillies ( CD = 20.2 ),热咸苏打茶( CD = 2.37 )并且本地烤的面包( CD = 1.1 )。结论:我们的学习建议那体的染色体变化特别在 6 Tp53 基因上的前,在人种上的食道的癌症病人之中,克什米尔山谷的同质的人口是仔细与到各种各样的普通饮食的风险因素,特别热的咸茶,肉,烤的面包和“ Hakh ”的继续的暴露有关,那富于 nitrosoamines 和家庭癌症历史。Imtiyaz Murtaza Dhuha Mushtaq Mushtaq A Margoob Amit Dutt Nisar Ahmad Wani Ishfaq Ahmad Mohan Lal Bhat 2006World Journal of Gastroenterology2006,12,25:8
6Three-dimensional bio-printing: A new frontier in oncology research显示文摘Current research in oncology deploys methods that rely principally on two-dimensional(2D) mono-cell cultures and animal models.Although these methodologies have led to significant advancement in the development of novel experimental therapeutic agents with promising anticancer activity in the laboratory, clinicians still struggle to manage cancer in the clinical setting.The disappointing translational success is attributable mainly to poor representation and recreation of the cancer microenvironment present in human neoplasia.Threedimensional(3D) bio-printed models could help to simulate this micro-environment, with recent bio-printing of live human cells demonstrating that effective in vitro replication is achievable.This literature review outlines up-to-date advancements and developments in the use of 3D bio-printed models currently being used in oncology research.These innovative advancements in 3D bio-printing open up a new frontier for oncology research and could herald an era of progressive clinical cancer therapeutics.Nitin Charbe Paul A McCarron Murtaza M Tambuwala 2017World Journal of Clinical Oncology2017,8,1:6
7Predictors of response to antiviral therapy in patients with chronic hepatitis C from Pakistani population显示文摘背景丙肝病毒(HCV ) 在全世界组成一个主要公共健康问题,特别在开发象巴基斯坦一样的国家。在这研究,我们估计了在长期的丙肝病人的治疗在这研究由性,年龄,和病毒的 load.Methods 分类的干扰素(INF ) 的结果,有遗传型 3 的 750 个 HCV 积极病人被选择,从哪个 616 完成了全部治疗。他们的个人历史,支持处理的 HCV RNA 和浆液丙氨酸 transaminase (中高音) 是 quantified.Patients 与 INF- 2b 的联合治疗被对待 300 万个单位(三次一个星期) 正 ribavirin (1000-1200mg 每天) 为 24 个星期。在 24 个星期以后,他们的 HCV RNA 和浆液中高音水平是从 616 个病人,的 quantified.Results (63.5%) 391 对治疗学的政体(加 ribavirin 的 INF- 2b ) 作出回应。在应答者之中, 27.1% 是男人, 36.4% 是女人。最好的治疗反应在有 Iow 的病人被观察病毒的负担 8 ?????牴湡睳汥 吗??Hafsa Aziz Muhammad Amin Athar Shahnaz Murtaza Javaid Irfan Yasir Waheed Iram Bilal Abida Raza 2011Chinese Medical Journal2011,,9:6
8Laboratory scale studies on removal of chromium from industrial wastes显示文摘Chromium being one of the major toxic pollutants is discharged from electroplating and chrome tanning processes and is also found in the effluents of dyes, paint pigments, manufacturing units etc. Chromium exists in aqueous systems in both trivalent (Cr 3+) and hexavalent (Cr 6+) forms. The hexavalent form is carcinogenic and toxic to aquatic life, whereas Cr 3+ is however comparatively less toxic. This study was undertaken to investigate the total chromium removal from industrial effluents by chemical means in order to achieve the Pakistan NEQS level of 1 mg/L by the methods of reduction and precipitation. The study was conducted in four phases. In phase Ⅰ, the optimum pH and cost effective reducing agent among the four popular commercial chemicals was selected. As a result, pH of 2 was found to be most suitable and sodium meta bisulfate was found to be the most cost effective reducing agent respectively. Phase Ⅱ showed that lower dose of sodium meta bisulfate was sufficient to obtain 100 % efficiency in reducing Cr 6+ to Cr 3+, and it was noted that reaction time had no significance in the whole process. A design curve for reduction process was established which can act as a tool for treatment of industrial effluents. Phase Ⅲ studies indicated the best pH was 8.5 for precipitation of Cr 3+ to chromium hydroxide by using lime. An efficiency of 100 % was achievable and a settling time of 30 minutes produced clear effluent. Finally in Phase Ⅳ actual waste samples from chrome tanning and electroplating industries, when precipitated at pH of 12 gave 100 % efficiency at a settling time of 30 minutes and confirmed that chemical means of reduction and precipitation is a feasible and viable solution for treating chromium wastes from industries.M.A.Baig Mohsin Mir Shazad Murtaza Zafar I. Bhatti 2003Journal of Environmental Sciences2003,15,3:6
9Disposal and Use of Sewage on Agricultural Lands in Pakistan: A Review显示文摘Raw sewage is widely used on agricultural soils in urban areas of developing countries to meet water shortages. Although it is a good source of plant nutrients, such sewage also increases the heavy metal load to soils, which may impact the food chain. Management options for sewage contaminated soils includes addition of nontoxic compounds such as lime, calcium sulfate and organic matter, which form insoluble metal complexes, thus reducing metal phytoavailability to plants. In this paper we review the variation in irrigation quality of sewage at different sites and its impact on the quality of soils and vegetables. Although quality of sewage was highly variable at source, yet the effluent from food industries was relatively safe for irrigation. In comparison effluent samples collected from textile, dyeing, calendaring, steel industry, hospitals and clinical laboratories, foundries and tanneries were hazardous with respect to soluble salts, sodium adsorption ratio and heavy metals like zinc, copper, iron, manganese, nickel, cobalt and cadmium. The sewage quality in main drains was better than that at the industry outlet, but was still not safe for irrigation. In general, higher accumulation of metals in fruits and vegetable roots was recorded compared to that in plant leaves. Edible parts of vegetables (fruits and/or leaves) accumulated metals more than the permissible limits despite the soils contained ammonium bicarbonate diethylenetriaminepentaacetic acid extractable metals within a safe range. In either case further scientific investigations are needed to ensure safe management strategies. Cadmium appeared to be the most threatening metal especially in leafy vegetables. It is advisable to avoid leafy vegetables cultivation in sewage irrigated areas everywhere to restrict its entry into food chain.G. MURTAZA A. GHAFOOR M. QADIR G. OWENS M. A. AZIZ M. H. ZIA SAIFULLAH 2010Pedosphere2010,20,1:6
10金果榄种子特性及不同沙藏方式促进发芽的研究显示文摘为了解金果榄(Tinospora sagittata Gagnep)种子的生理特性和萌发、生长特性,分别用鲜果实和鲜种子进行沙藏处理后,对野生金果榄果实、种子和胚形态结构进行了观察;用含5 mg/L赤霉素的MS培养基培养、沙藏2个月和4个月对金果榄种子进行无菌发芽试验。结果表明,室温(日夜温差>10℃)湿润沙藏可打破金果榄种子休眠,促进种子萌发,保持种子活力;赤霉素处理能快速打破种子休眠,15 d后发芽率达到80%以上;金果榄种子经风干后2个月、4个月的发芽率分别为20%和10%,表明金果榄种子不适合干燥贮藏。因此,金果榄的休眠类型主要是由于萌发抑制物存在而导致的生理休眠。薛襟祺 Mohammad Murtaza Alami 王学奎 刘三波 龚达林 王雪松 2019湖北农业科学2019,58,22:5
11Supramolecular Nanohelix Fabricated by Pillararene-Based Host–Guest System for Chirality Amplification, Transfer, and Circularly Polarized Luminescence in Water显示文摘Amplified chirality and Förster resonance energy transfer(FRET)-assisted chirality transfer frommolecular to nanoscale level have been shown to play a vital role in co-assembled nanohelix for potential energy transfer in biological systems.Herein,we have constructed a chiral host–guest complex donor system for chiral amplification via induced chirality of pillar[5]arene host and loaded it with an achiral dye acceptor to demonstrate how chirality-assisted excitation energy transfer occurred in the supramolecular nanohelix system in an aqueous medium.Krishnasamy Velmurugan Adil Murtaza Azhar Saeed Jianing Li Kaiya Wang Minzan Zuo Qian Liu Xiao-Yu Hu 2022CCS Chemistry2022,4,10:3
12Information fusion in aquaculture:a state-of the art review显示文摘Efficient fish feeding is currently one of biggest challenges in aquaculture to enhance the production of fish quality and quantity. In this review, an information fusion approach was used to integrate multisensor and computer vision techniques to make fish feeding more efficient and accurate. Information fusion is a well-known technology that has been used in different fields of artificial intelligence, robotics, image processing,computer vision, sensors and wireless sensor networks.Information fusion in aquaculture is a growing field of research that is used to enhance the performance of an'industrialized' ecosystem. This review study surveys different fish feeding systems using multi-sensor data fusion, computer vision technology, and different food intake models. In addition, different fish behavior monitoring techniques are discussed, and the parameters of water, p H, dissolved oxygen, turbidity, temperature etc.,necessary for the fish feeding process, are examined.Moreover, the different waste management and fish disease diagnosis techniques using different technologies,expert systems and modeling are also reviewed.Shahbaz Gul HASSAN Murtaza HASAN Daoliang LI 2016Frontiers of Agricultural Science and Engineering2016,3,3:3
13Optical spin-symmetry breaking for high-efficiency directional helicity-multiplexed metaholograms显示文摘Helicity-multiplexed metasurfaces based on symmetric spin–orbit interactions (SOIs) have practical limits because they cannot provide central-symmetric holographic imaging. Asymmetric SOIs can effectively address such limitations, with several exciting applications in various fields ranging from asymmetric data inscription in communications to dual side displays in smart mobile devices. Low-loss dielectric materials provide an excellent platform for realizing such exotic phenomena efficiently. In this paper, we demonstrate an asymmetric SOI-dependent transmission-type metasurface in the visible domain using hydrogenated amorphous silicon (a-Si:H) nanoresonators. The proposed design approach is equipped with an additional degree of freedom in designing bi-directional helicity-multiplexed metasurfaces by breaking the conventional limit imposed by the symmetric SOI in half employment of metasurfaces for one circular handedness. Two on-axis, distinct wavefronts are produced with high transmission efficiencies, demonstrating the concept of asymmetric wavefront generation in two antiparallel directions. Additionally, the CMOS compatibility of a-Si:H makes it a cost-effective alternative to gallium nitride (GaN) and titanium dioxide (TiO2) for visible light. The cost-effective fabrication and simplicity of the proposed design technique provide an excellent candidate for high-efficiency, multifunctional, and chip-integrated demonstration of various phenomena.Muhammad Ashar Naveed Muhammad Afnan Ansari Inki Kim Trevon Badloe Joohoon Kim Dong Kyo Oh Kashif Riaz Tauseef Tauqeer Usman Younis Murtaza Saleem Muhammad Sabieh Anwar Muhammad Zubair Muhammad Qasim Mehmood Junsuk Rho 2021Microsystems & Nanoengineering2021,7,2:3
14Pancreatic stents for prophylaxis against post-ERCP pancreatitis: a meta-analysis and systematic review显示文摘Abhishek Choudhary Matthew L. Bechtold Murtaza Arif Nicholas M. Szary Srinivas R. Puli Mohamed O. Othman Wilson P. Pais Mainor R. Antillon Praveen K. Roy 2011Gastrointestinal Endoscopy2011,,2:3
15Influence of Tb on easy magnetization direction and magnetostriction of ferromagnetic Laves phase GdFe_2 compounds显示文摘The crystal structure,magnetization,and spontaneous magnetostriction of ferromagnetic Laves phase Gd Fe2 compound have been investigated.High resolution synchrotron x-ray diffraction(XRD) analysis shows that Gd Fe2 has a lower cubic symmetry with easy magnetization direction(EMD) along [100] below Curie temperature TC.The replacement of Gd with a small amount of Tb changes the EMD to [111].The Curie temperature decreases while the field dependence of the saturation magnetization(Ms) measured in temperature range 5–300 K varies with increasing Tb concentration.Coercivity Hc increases with increasing Tb concentration and decays exponentially as temperature increases.The anisotropy in Gd Fe2 is so weak that some of the rare-earth substitution plays an important role in determining the easy direction of magnetization in GdFe_2.The calculated magnetostrictive constant λ100 shows a small value of 37×10^(-6).This value agrees well with experimental data 30×10^(-6).Under a relatively small magnetic field,GdFe_2 exhibits a V-shaped positive magnetostriction curve.When the field is further increased,the crystal exhibits a negative magnetostriction curve.This phenomenon has been discussed in term of magnetic domain switching.Furthermore,magnetostriction increases with increasing Tb concentration.Our work leads to a simple and unified mesoscopic explanation for magnetostriction in ferromagnets.It may also provide insight for developing novel functional materials.Adil Murtaza 杨森 周超 宋晓平 2016Chinese Physics B2016,25,9:2
16Bleeding risk with clopidogrel and percutaneous endoscopic gastrostomy显示文摘AIM To compare bleeding within 48 h in patients undergoing percutaneous endoscopic gastrostomy(PEG) with or without clopidogrel.METHODS After institutional review board approval, a retrospective study involving a single center was conducted on adult patients having PEG(1/08-1/14). Patients were divided into two groups: Clopidogrel group consisting of those patients taking clopidogrel within 5 d of PEG and the non-clopidogrel group including those patients not taking clopidogrel within 5 d of the PEG.RESULTS Three hundred and nineteen PEG patients were found. One hundred and sixty-eight males and 151 females with mean body mass index 28.47 ± 9.75 kg/m2 and mean age 65.03 ± 16.11 years were identified. Thirtythree patients were on clopidogrel prior to PEG with 286 patients not on clopidogrel. No patients in either group developed hematochezia, melena, or hematemesiswithin 48 h of percutaneous endoscopic gastrostomy(PEG). No statistical differences were observed between the two groups with 48 h for hemoglobin decrease of > 2 g/dL(2 vs 5 patients; P = 0.16), blood transfusions(2 vs 7 patients; P = 0.24), and repeat endoscopy for possible gastrointestinal bleeding(no patients in either group). CONCLUSION Based on the results, no significant post-procedure bleeding was observed in patients undergoing PEG with recent use of clopidogrel.Umair Sohail Chela Harleen Amin O Mahdi Murtaza Arif Douglas L Nguyen Matthew L Bechtold 2016World Journal of Gastrointestinal Endoscopy2016,8,16:2
17最新无模型深度强化学习研究:从零开始训练机器人“玩乐高”显示文摘伯克利最新提出无模型深度强化学习方法——soft Q-learning(SQL)算法,该算法可以对模拟和现实世界的任务执行组合性,同时在该算法基础上提出了一种使用具有表达性的神经网络策略学习机器人操作技能的学习框架。Tuomas Haarnoja Vitchyr Pong Aurick Zhou Murtaza Dalal Pieter Abbeel Sergey Levine 2018机器人产业2018,,3:2
18Biocompatibility of iron carbide and detection of metals ions signaling proteomic analysis via HPLC/ESl-Orbitrap显示文摘最近,磁性的 nanoparticles (NP ) 广泛地在食物工业和生物医学的处理被使用了。然而,在为临床的申请的磁性的 NP 的考虑前,表达式 proteomics 上的 biocompatibility 机制充分还没被阐明了。因此,这研究被承担识别在人的颈的癌症表明蛋白质的金属离子的潜在的 biomarkers 房间线(HeLa ) 房间。这里,我们报导在里面在蛋白质许多 HeLa 房间的房间周期反应和重要变化的 vitro 调查当暴露了到自我定制的吸水的 Fe 2 C NP。比较 proteomic 途径基于 18 标记的 O 与离子陷井团分析器(HPLC/ESI-Orbitrap ) 结合了高效液体 chromatography/electrospray 电离被使用,并且 394 蛋白质被识别。基于表明反应的特定的金属离子有 46 显著地区分的蛋白质。在他们之中, 60S ribosomal 蛋白质 L37a, serine/arginine-rich 拼接因素 7, calmodulin,和 calumenin 是 downregulated,而 transketolase 是 overexpressed。Fe 2调整 C 的蛋白质被 STRING 算法成功地创造显示出在蛋白质之间的强壮的相互作用。这个工作愿望不仅帮助理解表明能潜在地被用来为疾病的诊断开发治疗学的协议而且为定制 biocompatible 给方向的蛋白质的金属离子的分子的机制磁性的 NP。Murtaza Hasan Wenlong Yang Yanmin Ju Xin Chu Yun Wang Yulin Deng Nasir Mahmood Yanglong Hou 2017Nano Research2017,10,6:2
19One-pot Synthesis,Crystal Structures and Antimicrobial Activities of Two New 1,4-Disubstituted 1,2,3-Triazole-4-Carboxylates显示文摘Two new 1,4-disubstituted 1,2,3-triazoles-4-carboxylates were synthesized via click reaction. Compound 1a was synthesized by the interaction of 6-nitro-tetrazolo[1.5-a]-pyridine with ethyl propynoate at room temperature in the presence of Cu(OAc)2 as a catalyst and THF as solvent. Compound 1b was also synthesized by the same manner except that tert-butyl propionate, instead of ethyl propynoate, was used. The compounds were characterized by IR, 1H-NMR, 13C-NMR and single-crystal X-ray diffraction analysis. Compound 1a(C10H9N5O4) crystallizes in the triclinic system, space group P1 with a = 5.0894(9), b = 8.9834(13), c = 13.089(2) ?, α= 83.041(7), β= 80.256(7), γ=87.296(8)°, V = 585.24(16)?3, Z = 2, Mr = 263.22, crystal size(mm) = 0.37 × 0.20 ×0.18,(I > 2σ(I)) = 8557, 2493, 1229, Rint = 0.057. Compound 1b(C12H13N5O4) crystallizes in the monoclinic system, space group P21/c with a = 6.8854(5), b = 21.783(2), c = 9.3986(8) ?,β = 93.239(4)°, V = 1407.4(2)?3, Z = 4, Mr = 291.27, crystal size(mm) = 0.38 × 0.22 × 0.20,(I > 2σ(I)) = 11842, 3172, 1866, Rint = 0.047. Antimicrobial assay results showed that the title compounds display excellent activities to different bacterial and fungal strains.MUHAMMAD Naeem Ahmed KHAWAJA Ansar Yasin MUHAMMAD Nawaz Tahir IFZAN Arshad MURTAZA Madni 2015Chinese Journal of Structural Chemistry2015,34,1:2
20The burden of strokeand transient ischemic attack in Pakistan : a community-based prevalence study显示文摘Kamal AK Itrat A Murtaza M 2009BMC Neurol2009,9,:1
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