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| 1 | Highly dispersed iron species created on alkali-treated zeolite for ammonia SCR显示文摘Alkaline treatment using sodium hydroxide was introduced to obtain a hierarchical pore structure in H-ZSM-5 zeolite.Fe-exchanged zeolite catalysts were prepared by impregnation on the original and alkali-treated zeolites,and were evaluated for NOx reduction by NH3,NO oxidation,and NH3 oxidation reactions.The highly dispersed iron species as active sites can be obtained by controlling the pore structure and particle size of zeolite.Therefore,the Fe/ZSM-5 catalyst treated mildly by sodium hydroxide before iron exchange,which contains amounts of highly dispersed Fe species,obtains over80% NOx conversion at a wide temperature range of 250-500℃. | Jing Ma Duan Weng Xiaodong Wu Zhichun Si Zhenwei Wu | 2013 | Progress in Natural Science:Materials International2013，23，5： | 3 |
| 2 | 显示文摘 | Zhang Hongguo Ma Zhenwei Zhou Ji | 2000 | J Magn Magn Mater2000，213，1： | 1 |
| 3 | Microstructure and electrochemical hydrogen storage characteristics of La 0.67 Mg 0.33? x Ca x Ni 2.75 Co 0.25 ( x = 0–0.15) electrode alloys显示文摘 | Zhenwei Dong Yaoming Wu Liqun Ma Lidong Wang Xiaodong Shen Limin Wang | 2010 | International Journal of Hydrogen Energy2010，，4： | 1 |
| 4 | Mettl3 deficiency leads to the upregulation of Cav1.2 and increases arrhythmia susceptibility in mice显示文摘Methyltransferase-like 3(Mettl3)is a component of methyltransferase complex that mediates m6A modification of RNAs,and participates in multiple biological processes.However,the role of Mettl3 in cardiac electrophysiology remains unknown.This study aims to explore the ventricular arrhythmia susceptibility of Mettl3+/–mice and the underlying mechanisms.Mice were anesthetized with 2%avertin(0.1 mL/10 g body weight)for echocardiography and programmed electrical pacing.Whole-cell patch clamp technique was used to examine the electrophysiological property of cardiomyocytes.The expression of Cav1.2 was determined by qRT-PCR and western blot analysis.The m6A medication of mRNA was examined by MeRIP-Seq and MeRIP-qPCR.No differences are found in the morphology and function of the hearts between Mettl3+/–mice and wild-type(WT)controls.The QT and QTc intervals of Mettl3+/–mice are significantly longer.High-frequency electrical stimulation showed that heterozygous knockout of Mettl3 increases ventricular arrhythmia susceptibility.The whole-cell patch-clamp recordings showed that the APD is prolonged in Mettl3+/–ventricular myocytes and more EADs were observed.The density of ICa-L is substantially increased in ventricular myocytes of Mettl3+/–mice.The pore-forming subunit of L-type calcium channel Cav1.2 is upregulated in Mettl3+/–mice,while the mRNA of its coding gene CACNA1C does not change.MeRIP-Seq and MeRIP-qPCR showed that the m6A methylation of CACNA1C mRNA is decreased in cultured Mettl3-knockdown cardiomyocytes and Mettl3+/–hearts.Collectively,deficiency of Mettl3 increases ventricular arrhythmia susceptibility due to the upregulation of Cav1.2 by reducing m6A modification on CACNA1C mRNA in mice.This study highlights the role of m6A modification in the regulation of cardiac electrophysiology. | Ling Shi Xuexin Jin Zheng Li Rui Gong Yang Guo Jiudong Ma Yang Zhang Benzhi Cai Baofeng Yang Dongmei Gong Zhenwei Pan | 2022 | Acta Biochimica et Biophysica Sinica2022，54，2： | 1 |
| 5 | iASPP protects the heart from ischemia injury by inhibiting p53 expression and cardiomyocyte apoptosis显示文摘Currently, there remains a great need to elucidate the molecular mechanism of acute myocardial infarction in order to facilitate the development of novel therapy. Inhibitor of apoptosis-stimulating protein of p53 (iASPP) is a member of the ASPP family proteins and an evolutionarily preserved inhibitor of p53 that is involved in many cellular processes, including apoptosis of cancer cells. The purpose of this study was to investigate the possible role of iASPP in acute myocardial infarction. The protein level of iASPP was markedly reduced in the ischemic hearts in vivo and hydrogen peroxide-exposed cardiomyocytes in vitro. Overexpression of iASPP reduced the infarct size and cardiomyocyte apoptosis of mice subjected to 24 h of coronary artery ligation. Echocardiography showed that cardiac function was improved as indicated by the increase in ejection fraction and fractional shortening. In contrast, knockdown of iASPP exacerbated cardiac injury as manifested by impaired cardiac function, increased infarct size, and apoptosis rate. Mechanistically, overexpression of iASPP inhibited, while knockdown of iASPP increased the expressions of p53 and Bax, the key regulators of apoptosis. Taken together, our results suggested that iASPP is an important regulator of cardiomyocyte apoptosis, which represents a potential target in the therapy of myocardial infarction. | Timur Yagudin Yue Zhao Haiyu Gao Yang Zhang Ying Yang Xiaofang Zhang Wenbo Ma Tolessa Muleta Daba Vladimir Ishmetov Kai Kang Baofeng Yang Zhenwei Pan | 2021 | Acta Biochimica et Biophysica Sinica2021，53，1： | 1 |
| 6 | Correction: Characterization of a small-molecule inhibitor targeting NEMO/IKKβ to suppress colorectal lcancergrowth显示文摘In the process of collating the raw data,the authors noticed an inadvertent mistake occurred in Fig.3b that needs to be corrected after online publication of the article.In Fig.3b,as a result of an error in the graphics panel arrangement process,the band of NEMO was repeatedly inserted asβ-actin by mistake.The correct band is shown as below and in the updated Fig.3b.The correction did not affect any of our results or discussion as present in the original publication.We regret any inconvenience this has caused. | Zhenlong Yu Jian Gao Xiaolei Zhang Yulin Peng Wenlong Wei Jianrong Xu Zhenwei Li Chao Wang Meirong Zhou Xiangge Tian Lei Feng Xiaokui Huo Min Liu Mingliang Ye De-an Guo Xiaochi Ma | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 7 | Characterization of a small-molecule inhibitor targeting NEMO/IKKβto suppress colorectal cancer growth显示文摘NEMO/IKKβcomplex is a central regulator of NF-κB signaling pathway,its dissociation has been considered to be an attractive therapeutic target.Herein,using a combined strategy of molecular pharmacological phenotyping,proteomics and bioinformatics analysis,Shikonin(SHK)is identified as a potential inhibitor of the IKKβ/NEMO complex.It destabilizes IKKβ/NEMO complex with IC_(50) of 174 nM,thereby significantly impairing the proliferation of colorectal cancer cells by suppressing the NF-κB pathway in vitro and in vivo.In addition,we also elucidated the potential target sites of SHK in the NEMO/IKKβcomplex.Our study provides some new insights for the development of potent small-molecule PPI inhibitors. | Zhenlong Yu Jian Gao Xiaolei Zhang Yulin Peng Wenlong Wei Jianrong Xu Zhenwei Li Chao Wang Meirong Zhou Xiangge Tian Lei Feng Xiaokui Huo Min Liu Mingliang Ye De-an Guo Xiaochi Ma | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 0 |
| 8 | Two-dimensional atomically thin Pt layers on MXenes: The role of electronic effects during catalytic dehydrogenation of ethane and propane显示文摘Atomically thin Pt nanolayers were synthesized on the surface of Mo2TiC2 MXenes and used for the catalytic dehydrogenation of ethane and propane into ethylene and propylene,two important chemicals for the petrochemical industry.As compared with Pt nanoparticles,the atomically thin Pt nanolayer catalyst showed superior coke-resistance(no deactivation for 24 h),high activity(turnover frequencies(TOFs)of 0.4–1.2 s^(-1)),and selectivity(>95%)toward ethylene and propylene.The unique Pt nanolayer has a similar geometric surface to Pt nanoparticles,enabling the investigations of the electronic effect on the catalytic performance,where the geometric effect is negligible.It is found that the electronic effect plays a critical role in dehydrogenative product selectivity and catalyst stability.The metal–support interaction is found dependent on the substrate and metal components,providing wide opportunities to explore high-performance MXene-supported metallic catalysts. | Zhe Li Tobias K.Misicko Fan Yang Xiaopeng Liu Zhenwei Wu Xiaoyang Gao Tao Ma Jeffrey T.Miller Daniela S.Mainardi Collin D.Wick Zhenhua Zeng Yang Xiao Yue Wu | 2024 | Nano Research2024，17，3： | 0 |
| 9 | The effect of Pickering emulsion adjuvants on the immune efficacy of the COVID-19 polypeptide vaccine显示文摘Pickering emulsions were prepared by phacoemulsification in an ice water bath with squalene as the oil phase and an aluminum adjuvant as the particle stabilizer.The effects of formulation and process conditions on the size and distribution of the Pickering emulsions were investigated.Pickering emulsions prepared under the optimal prescription and process conditions were mixed with a peptide antigen to obtain a peptide vaccine.The optimal prescription and process condition of the Pickering emulsion is as follows:squalene as the oil phase,ultra-pure water as the water phase with 5 mg/mL aluminum adjuvant,and an ultrasonication time of 4 min at 200 W power.BALB/c mice were immunized with the peptide vaccine,and the ability of the Pickering emulsion as an immunological adjuvant to improve the efficacy of the peptide vaccine was evaluated.Under optimal conditions,a Pickering emulsion with a small particle size(430.8 nm),uniform distribution(polydispersion index of 16.9%),and zeta potential of 31.5 mV,was obtained.Immunological results showed that the serum specific antibody level in the vaccinated group reached 1×104 after three immunizations.The proportion of CD4+T cells and CD4/CD8 cells was significantly higher(P<0.05)in the vaccinated groups than the blank control group.Further,cytokine(TNF-��)secretion decreased in the aluminum adjuvant and Pickering emulsion groups but increased in the Freund’s adjuvant group.All three vaccinated groups of mice exhibited low but detectable levels of IFN-��secretion. | Zhuanqing Huang Qi Sun Haoyuan Shi Sen Yang Yuanyuan Li Yue Ma Fei Yang Zhenwei Shi Yalong Yang Ying Zhang Hui Gong Fenghua Xu | 2023 | ChemPhysMater2023，2，3： | 0 |
| 10 | Corrigendum to:iASPP protects the heart from ischemia injury by inhibiting p53 expression and cardiomyocyte apoptosis显示文摘Acta Biochimica et Biophysica Sinica,30 October 2020,http://gffzzd3cc09b8251d45dfsfbc9fncu9pp96b0u.ffgz.tsg.suse.edu.cn/10.1093/abbs/gmaal04 Following the publication of this article,the authors notified the journal they had neither labeled the bottom images in Fig.5.as Fig.5G,nor included information about these images in the figure caption.In addition,the authors had provided the journal with the wrong representative images of the NC and SI groups.The corrected figure and caption appear below,and the authors apologize for these errors. | Timur Yagudin Yue Zhao Haiyu Gao Yang Zhang Ying Yang Xiaofang Zhang Wenbo Ma Tolessa Muleta Daba Vladimir Ishmetov Kai Kang Baofeng Yang Zhenwei Pan | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 0 |
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