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| 1 | 大豆提取物抗戊四唑所致卵巢切除大鼠痉挛的作用(英文)显示文摘目的:研究大豆提取物抗戊四唑所致卵巢切除大鼠痉挛的作用。方法:雌性Wistar大鼠随机分为4组(n=15),分别为假手术组、卵巢切除组、低剂量大豆提取物组和高剂量大豆提取物组。假手术组大鼠行假手术,其余3组大鼠行卵巢切除术。每组大鼠再随机分为2个亚组,其中一个亚组(n=7)每日予低剂量戊四唑(40mg/kg)腹腔内注射,连续14d;另一亚组(n=8)予一次高剂量戊四唑(90mg/kg)腹腔内注射。在戊四唑注射前30min,低剂量大豆提取物(20mg/kg)及高剂量大豆提取物(60mg/kg)组分别腹腔内注射大豆提取物,假手术组及卵巢切除组注射生理盐水。上述步骤完成后,将大鼠置于树脂玻璃箱中观察60min。结果:重复低剂量注射戊四唑14d,卵巢切除组大鼠的痉挛评分在第3、5、8、10、11、12及13天低于假手术组(P<0.05或P<0.01),而低剂量大豆提取物组和高剂量大豆提取物组大鼠的痉挛评分高于卵巢切除组(P<0.05或P<0.01)。一次性高剂量注射戊四唑后,与假手术组相比,卵巢切除组大鼠阵发性强直性抽搐潜伏期延长,而最小阵发性痉挛潜伏期无明显变化;与卵巢切除组相比,低剂量及高剂量的大豆提取物显著缩短了大鼠阵发性强直性抽搐及最小阵发性痉挛的潜伏期(P<0.01)。结论:雌激素能够影响戊四唑所致大鼠痉挛的严重程度,而大豆中所含的植物雌激素也具有类似作用,这种作用还有待更多的研究予以证实。 | Ali Reza Ebrahimzadeh Bideskan Mahmoud Hosseini Toktam Mohammadpour Reza Karami Mehdi Khodamoradi Habibollah Nemati Karimooy Hassan Alavi | 2011 | 中西医结合学报2011，9，6： | 4 |
| 2 | 突厥蔷薇提取物抗戊四唑所致小鼠痉挛的作用(英文)显示文摘目的:研究突厥蔷薇(Rosa damascena)的水提物、乙醇提取物及三氯甲烷提取物对戊四唑所致小鼠惊厥的作用。方法:实验动物按如下方案分组:生理盐水对照组,地西泮组(3mg/kg),水提物组(100,500和1000mg/kg),乙醇提取物组(100,500和1000mg/kg),三氯甲烷提取物组(100,500和1000mg/kg)。所有药物均在注射戊四唑30min前皮下注射。记录并比较各组小鼠阵发性强直性抽搐潜伏期、最小阵发性痉挛潜伏期及死亡率。结果:与生理盐水对照组相比,三组水提物组小鼠的阵发性强直性抽搐潜伏期及最小阵发性痉挛潜伏期均有延长(P<0.05或P<0.01);一组乙醇提取物组(1000mg/kg)小鼠的最小阵发性痉挛潜伏期及两组乙醇提取物组(500和1000mg/kg)小鼠的阵发性强直性抽搐潜伏期均有延长(P<0.05,P<0.01);三组三氯甲烷提取物组小鼠的阵发性强直性抽搐潜伏期及最小阵发性痉挛潜伏期无明显变化。不同提取物各组的死亡率与对照组相比无明显差异。结论:本研究的结果证实了突厥蔷薇具有抗戊四唑所致小鼠惊厥的作用,其具体作用机制有待进一步研究。 | Mahmoud Hosseini Mahboobeh Ghasemzadeh Rahbardar Hamid Reza Sadeghnia Hassan Rakhshandeh | 2011 | 中西医结合学报2011，9，10： | 3 |
| 3 | Different effects of L-arginine on morphine tolerance in sham and ovariectomized female mice显示文摘Objective:The roles of gonadal hormones and nitric oxide(NO) on the analgesic effects of morphine,tolerance to morphine,and their interactions have been widely investigated.In the present study,the effect of L-arginine(an NO precursor) on morphine tolerance in sham and ovariectomized(OVX) female mice was investigated.Methods:Forty mice were divided into sham and OVX groups.On the first day,a hot plate test((55±0.2) °C;cut-off 30 s) was carried out as a base record 15 min before injection of morphine(10 mg/kg,subcutaneously(s.c.)) and was repeated every 15 min after injection.The sham group was then divided into two subgroups:sham-tolerance-L-arginine(Sham-Tol-LA) and sham-tolerance-saline(Sham-Tol-Sal) which received either L-arginine 50 mg/kg(intraperitoneally(i.p.)) or saline 10 ml/kg(i.p.),respectively,three times in a day for three consecutive days.Morphine tolerance was induced in animals by injecting 30 mg/kg morphine(s.c.) three times/day for three days.This treatment was also used for OVX subgroups.On the fifth day,the hot plate test was repeated.The analgesic effect of morphine was calculated as the maximal percent effect(MPE).The results were compared using repeated measure analysis of variance(ANOVA).Results:There was no significant difference in MPE between the OVX and sham groups.The MPEs in both the Sham-Tol-Sal and OVX-Tol-Sal groups were lower than those in both the sham and OVX groups(P<0.01).The MPE in the OVX-Tol-Sal group was greater than that in the Sham-Tol-Sal group(P<0.01).The MPE in the Sham-Tol-LA group was higher than that in the Sham-Tol-Sal group(P<0.01).However,there was no significant difference between the Sham-Tol-LA and sham groups or between the OVX-Tol-LA and OVX-Tol-Sal groups.Conclusions:The results of the present study showed that repeated administration of morphine causes tolerance to the analgesic effect of morphine.L-Arginine could prevent tolerance to morphine but its effect was different in the presence of ovarian hormones. | Reza KARAMI Mahmoud HOSSEINI Fatimeh KHODABANDEHLOO Leila KHATAMI Zahra TAIARANI | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，12： | 2 |
| 4 | Synthesis and Characterization of Sol-Gel Derived MgO/CNTs Nanocomposite显示文摘 | Ali Asghar Hosseini Farshad Taleshi Mahmoud Tajbakhsh Maryam Farhang | 2010 | Journal of Chemistry and Chemical Engineering2010，4，7： | 2 |
| 5 | Novel cationic-modified salep as an efficient flocculating agent for settling of cement slurries 显示文摘 | Ali Pourjavadi Seyed Mahmoud Fakoorpoor Seyed Hassan Hosseini | 2013 | Carbohydrate Polymers2013，93，： | 1 |
| 6 | Evaluation of stress intensity factor and fatigue growth of surface cracks in tension plates显示文摘 | Hosseini A Mahmoud M A | 1985 | Engng Fracture Mech1985，22，： | 1 |
| 7 | Assessment of stress intensity factor and aspect ratio variability of surface cracks in bending plates显示文摘 | Mahmoud M A Hosseini A | 1986 | Engng Fracture Mech1986，24，： | 1 |
| 8 | Cloning, Expression, Purification and Refolding of Caprine Prochymosin显示文摘 | MohammadHadi Eskandari Arsalan Hosseini Sepideh Alasvand Zarasvand Mahmoud Aminlari | 2012 | Food Biotechnology2012，，2： | 1 |
| 9 | Evaluation of stress intensity factor and fatigue growth of surface cracks in tension plates 显示文摘 | Hosseini A Mahmoud M A | 1985 | Engng Fracture Mech1985，22，： | 1 |
| 10 | Assessment of stress intensity factor and aspect ratio variability of surface cracks in bending plates 显示文摘 | Mahmoud M A Hosseini A | 1986 | Engng Fracture Mech1986，24，： | 1 |
| 11 | Serum C-reactive protein in asthma and its ability in predicting asthma control,a case-control study显示文摘 | Mahmoud Monadi Alireza Firouzjahi Amin Hosseini | 2016 | Caspian J Intern Med2016，7，1： | 1 |
| 12 | The impact of vitamin and/or mineral supplementation on lipid profiles in type 2 diabetes显示文摘 | Maryam Sadat Farvid Fereydoun Siassi Mahmoud Jalali Mostafa Hosseini Navid Saadat | 2003 | Diabetes Research and Clinical Practice2003，，1： | 1 |
| 13 | A Potential Association between Helicobacter pylori CagA EPIYA and Multimerization Motifs with Cytokeratin 18 Cleavage Rate during Early Apoptosis显示文摘 | Samaneh Saberi Masoumeh Douraghi Kayhan Azadmanesh Mohammad Ali Shokrgozar Hojjat Zeraati Mahmoud Eshagh Hosseini Mohammad Ali Mohagheghi Mahbubeh Parsaeian Marjan Mohammadi | 2012 | Helicobacter2012，，5： | 1 |
| 14 | Evaluation of stress intensity factor and fatigue growth of surface cracks in tension plates显示文摘 | Hosseini A Mahmoud M A | 1985 | Engng Fracture Mech1985，22，： | 1 |
| 15 | Assessment of stress intensity factor and aspect ratio variability of surface cracks in bending plates显示文摘 | Mahmoud M A Hosseini A | 1986 | Engng Fracture Mech1986，24，： | 1 |
| 16 | The effect of carbon nanotubes on the corrosion and tribological behavior of electroless Ni–P–CNT composite coating显示文摘 | Mostafa Alishahi Seyed Mahmoud Monirvaghefi Ahmad Saatchi Seyed Mehdi Hosseini | 2011 | Applied Surface Science2011，，7： | 1 |
| 17 | Evaluation of stress intensity factor and fatigue growth of surface cracks in tension plates显示文摘 | Hosseini A Mahmoud M A | 1985 | Engineering Fracture Mechanics1985，22，： | 1 |
| 18 | Assessment of stress intensity factor and aspect ratio variability of surface cracks in bending plates显示文摘 | Mahmoud M A Hosseini A | 1986 | Engineering Fracture Mechanics1986，24，： | 1 |
| 19 | Dynamic analysis of two-dimensional func tionally graded thick hollow cylinder with finite length under impact loading显示文摘 | Masoud Asgari Mehdi Akhlaghi Seyed Mahmoud Hosseini | 2009 | Acta Mechanica2009，208，34： | 1 |
| 20 | A New Helicobacter pylori Vacuolating Cytotoxin Determinant, the Intermediate Region, Is Associated With Gastric Cancer显示文摘 | Joanne L. Rhead Darren P. Letley Marjan Mohammadi Nawfal Hussein Mohammad A. Mohagheghi Mahmoud Eshagh Hosseini John C. Atherton | 2007 | Gastroenterology2007，，3： | 1 |
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