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| 1 | Microvessel angiogenesis: a possible cardioprotective mechanism of external counterpulsation for canine myocardial infarction显示文摘Background Enhanced external counterpulsation (EECP) has been demonstrated to be effective in the treatment of patients with coronary artery disease (CAD). It has been proposed that the beneficial effects of EECP observed in clinical studies may be due to the formation of new blood vessels (angiogenesis) and collateral development. However, there is a relative paucity of basic studies to support the proposed mechanisms. Methods Twelve Beagle dogs were anesthetized with 3% sodium pentobarbital, 1 mg/kg intraperitoneal injection and mechanically ventilated for the development of myocardial infarction. After coronary occlusion, all animals were randomly assigned to either EECP or control. EECP was given one hour per day, 5 days a week, for a total of 28 to 30 hours treatment over a 6-week course. Immunohistochemical studies of α-actin and von Willebrand factor (vWF) were used to detect newly developed microvessels. Systemic and local vascular endothelial growth factor (VEGF) were identified by enzyme linked immunosorbent assay (ELISA) and reverse-transcriptional polymerase chain reaction (RT-PCR) analysis. Results There was a significant increase in the density of microvessels per mm2 in the infarcted regions of EECP group compared to control group (vWF, 15.2±6.3 versus 4.9±2.1, P<0.05; α-actin, 11.8±5.3 versus 3.4±1.2, P<0.05), along with significant increase of positive vWF and α-actin stained area. Both immunohistochemical staining and RT-PCR analysis documented a significant increase in VEGF expression. These factors associated with angiogenesis corresponded to improved myocardial perfusion by 99mTc-sestamibi single-photon emission computed tomography. Conclusion Microvessel angiogenesis may be a mechanism of action for the improved myocardial perfusion after EECP therapy. | WUGui-fu DUZhi-min HUCheng-hen ZHENGZhen-sheng ZHANCheng-yang MAHong FANGDian-qiu JohnCKHui WilliamELawson | 2005 | Chinese Medical Journal2005，，14： | 12 |
| 2 | A test of Snowmelt Runoff Model(SRM)for the Gongnaisi River basin in the western Tianshan Mountains,China显示文摘The Snowmelt Runoff Model (SRM) is one of a very few models in the world today that requires remote sensing derived snow cover as model input. Owing to its simple data requirements and use of remote sensing to provide snow cover information, SRM is ideal for use in data sparse regions, particularly in remote and inaccessible high mountain watersheds. In order to verify the applicability of SRM in an environment of continental climate, a test of SRM is performed for the Gongnaisi River basin in the western Tianshan Mountains, the results show that two SRM average goodness-of-fit statistics for simulations, Nash-Sutcliff coefficient (R2) and volume difference (DV), are 0.87 and 0.90%, respectively. As compared with the application results over 80 basins in 25 different countries around the world, SRM performs well in the Gongnaisi River basin. The results also show that SRM can be a validated snowmelt runoff model capable of being applied in the western Tianshan Mountains. On the basis of snowmelt runoff simulation, together with a set of simplified hypothetical climate scenarios, SRM is also used to simulate the effects of climate change on snow cover and the consecutive snowmelt runoff. For a given hypothetical temperature increase of 4℃, the snow coverage and snowmelt season shift towards earlier dates, and the snowmelt runoff, as a result, is changed significantly at the same time. The simulation results show that the snow cover is sensitive to changes of climate, especially to the increase of temperature, the major effect of climate change will be a time shifting of snowmelt runoff to early spring months, resulting in a redistribution of seasonally runoff throughout the whole snowmelt season. | MAHong CHENGGuodong | 2003 | Chinese Science Bulletin2003，48，20： | 10 |
| 3 | Genetic analysis and mapping of rice(Oryza sativa L.)male-sterile(OsMS-L)mutant显示文摘A rice male-sterile mutant OsMS-L of japonica cultivar 9522 background, was obtained in M4 population treated with Co γ-Ray. Genetic analysis indicated that the 60 male-sterile phenotype was controlled by a single recessive gene. Results of tissue section showed that at microspore stage, OsMS-L tapetum was retarded. Then tapetal cells ex- panded and microspores degenerated. No matured pollens were observed in OsMS-L anther locus. To map OsMS-L lo- cus, an F2 population was constructed from the cross be- tween the OsMS-L (japonica) and LongTeFu B(indica). Firstly, the OsMS-L locus was roughly mapped between two SSR markers, RM109 and RM7562 on chromosome 2. And then eleven polymorphic markers were developed for further fine fine-mapping. At last the OsMS-L locus was mapped between the two InDel markers, Lhs10 and Lhs6 with genetic distance of 0.4 cM, respectively. The region was delimited to 133 kb. All these results were useful for further cloning and functional analysis of OsMS-L. | LIUHaisheng CHUHuangwei LIHui WANGHonamei WEIJiali LINa DINGShuyan HUANGHai MAHong HUANGChaofeng LUODa YUANGzheng LIUJianhua ZHANGDabing | 2005 | Chinese Science Bulletin2005，50，2： | 6 |
| 4 | Effect of angiotensin converting enzyme inhibitor on the calcium transients and calcium handling proteins in ventricular myocytes from rats with heart failure显示文摘Background Chronic heart failure (CHF) is associated with calcium transients and calcium handling proteins. Angiotensin converting enzyme (ACE) inhibitor has been demonstrated to have beneficial effect on CHF. Yet studies addressed to the relationship between ACE inhibitor and calcium transients in CHF are rare. The aim of this study was to investigate the influence of ACE inhibitor (perindopril) on the contractility and calcium transients and calcium handling proteins in ventricular myocytes from rats with experimental heart failure.Methods Male Wistar rats were randomized to heart failure group treated with perindopril (CHF-T, 3 mg·kg -1 ·d -1 ), heart failure group without treatment (CHF-C) and sham-operated group (PS). Heart failure was induced by abdominal aortic constriction. All groups were further followed up for 12 weeks. Left ventricular myocytes were then isolated. Single cell shortening fraction and [Ca 2+ ]i were simultaneously measured by laser scanning confocal microscope under the field stimulation (1.0 Hz). Reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot were performed to evaluate the changes of mRNA and protein of Na +-Ca 2+ exchanger (NCX1), sarcoplasmic reticulum Ca 2+ -ATPase (SERCA2) and phospholamban (PLB).Results The fraction of cell shortening (FS%) and [Ca 2+ ] imax (nmol/L) were significantly reduced in group CHF-C compared with group PS (FS%: 7.51±1.15 vs 13.21±1.49;[Ca 2+ ] imax :330.85±50.05 vs 498.16±14.07; both P <0.01), and restored at least partially in CHF-T group. In CHF-C group, the left ventricular mRNA of NCX1 and PLB were significantly upregulated in comparing with PS group (R NCX1/β-Actin : 0.51±0.12 vs 0.19±0.06, P <0.01; R PLB/β-Actin : 0.26±0.12 vs 0.20±0.08, P <0.05), while SERCA2 mRNA was downregulated (0.48±0.10 vs 0.80±0.11, P <0.01). The mRNA levels of NCX1 and SERCA2 in CHF-T group were between the CHF-C and PS group, and the differences of the latter two groups were significant (all P <0.05). In CHF-C and CHF-T groups, the protein expression of NCX1 were 1.141±0.047 and 1.074±0.081 times of that in PS group respectively (both P <0.05), and SERCA2 protein levels were 0.803±0.100 and 0.893±0.084 times of that in PS group respectively (both P <0.05). The protein expression of NCX1 and SERCA2 in the CHF-C and CHF-T groups is significantly different (both P <0.05).ConclusionACE inhibitor could improve cardiac function of failing heart through directly enhancing the contractility of single cardiomyocyte, and these effects are probably mediated by its roles in preventing the deleterious changes of calcium transients and calcium handling proteins in CHF. | WANGLi-chun MAHong HEJian-gui LIAOXin-xue CHENWen-fang LENGXiu-yu MALi MAIWei-yi TAOJun ZENGWu-tao LIUJun DONGYu-gang TANGAn-li FENGChong | 2005 | Chinese Medical Journal2005，，9： | 2 |
| 5 | EFL EXTENSIVE READING AT COLLEGE LEVEL: MAJOR PROBLEMS AND POSSIBLE SOLUTIONS显示文摘This paper aims to identify problems in the teaching of tertiary extensive reading in China, and to recommend solutions to these problems. The author explores three major impediments to the teaching of extensive reading: a misconception about extensive reading, unsuitable reading material, and poor reading habits. Based on her years of teaching experience and extensive reading of literature works, she presents a new perspective and puts forward recommemtations ]'or removing these problems, including an adjustment to teaching goals, a change in reading material selection and an appropriate reading model. Meanwhile, the author recommends classroom-teaching practices that will benefit both teachers and students. | MengJianghong MaHong | 2004 | 中国英语教学:英文版2004，27，4： | 2 |
| 6 | Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease:a systematic review显示文摘 | Mahong J Petrich A | 2002 | BMC Infec Dis2002，2，1： | 1 |
| 7 | A magnetic record of heavy metal pollution in the Yangtze River subaqueous del- ta 显示文摘 | DongchenYin ZhangweiGuo Mahong Lei | 2014 | Science of the Total Environment2014，，： | 1 |
| 8 | Sel-fassembled nanopar-ticle drug delivery systems from galactosylated polysaccharide-doxorubicin conjugate loaded doxorubicin显示文摘 | Cao Yu Gu Ying MaHong | 2010 | InternationalJournal of Biological Macromolecules2010，46，2： | 1 |
| 9 | Optoelectronic Detecting System for Inner Walls of Pipes显示文摘This paper is concerned with a high characteristic image processing and recognition system that is used for inspecting real-time blemishes, streaks and cracks on the inner walls of high accuracy pipes. As a regular detector, the BP neural network is used for extracting features of the image inspected and classifying these images, it takes fully advantage of the function of artificial neural network, such as the information distributed memory, large scale self-adapting parallel processing, high fault-tolerant ability and so forth. Besides, an improved BP algorithm is used in the system for training the network, and making the learning procedure of the net converges to the minimum of overall situation at high rate. | BAIBaoxing MAHong | 1998 | Semiconductor Photonics and Technology1998，4，2： | 1 |
| 10 | Effects of high bone turnover on the biomechanical properties of the L3 vertebra in an ovine model of early stage osteo- porosis显示文摘 | Kennedy OD Brennan O Mahong NJ | 2008 | Spine(Phila Pa 1976)2008，33，23： | 1 |
| 11 | Stress distribution in the single-unit osseointegrated deltal implant: finite element analyses of axial and off axial loading 显示文摘 | O' Mahong A Boweles Q Woolsey G | 2000 | Implant Dent2000，9，3： | 1 |
| 12 | Proteomic analysis of a model unicellular green alga,Chlamydomonas reinhardtii,during short-term exposure to irradiance stress reveals significant down regulation of several heat-shock proteins显示文摘 | Mahong B Roytrakul S Phaonaklop N | | 0，，03： | 1 |
| 13 | Angiostatin generation by human pancreatic cancer显示文摘 | Seidel A Albo D | 1998 | J Surg Res1998，77，1： | 1 |
| 14 | NanostructuredvaGnadiumdioxidethinfilmswithlowphasetransitiontemGperature 显示文摘 | ChenSihai MaHong DaiJun etal | 2007 | Applied Physics Letters2007，90，10： | 1 |
| 15 | Functional evaluation : the Barthel Index显示文摘 | Mahong H Bathel DW | 1965 | Md State Med J1965，14，： | 1 |
| 16 | Proteomic analysis of a model unicellular green alga,Chlamydomonas reinhardtii,during short-term exposure to irradiance stress reveals significant down regulation of several heatshock proteins显示文摘 | MAHONG B ROYTRAKUL S | | 0，，03： | 1 |
| 17 | Recurrence of fetal macrosomia in non - diabetic pregnancies 显示文摘 | Walsh CA Mahong RT Foley ME | 2007 | J Obstet Gynecol2007，27，4： | 1 |
| 18 | Proteomic analysis of salinitystressed Chlamydomonas reinhardtii revealed differential suppression and induction of a large number of important housekeeping proteins显示文摘 | YOKTHONGWATTANA C MAHONG B | | 0，，03： | 1 |
| 19 | Effect of Adjuvants on Activity and Persistence of Soil-applied Herbicide Anwei显示文摘The paper researched effect of adjuvants on activity and persistence of soil-applied herbicide Anwei.There were five adjuvants (fertility, Q7, oil, anionic and nonionic surfactants) in the experiment. We explored the influence of adjuvants on activity and persistence of Anwei by field trial. The results indicated that Q7, oil, anionic surfactant can increased activity of Anwei, and can lengthened its persistence for about five days. | MAHong LIHong-yuan TAOBo | 2005 | Journal of Northeast Agricultural University(English Edition)2005，12，1： | 0 |
| 20 | Effect of Heavy Ion Head Irradiation on Immune System Function in Rat显示文摘Heavy ion radiation is a great threat to astronaut’s health.While as the most promising cancer radiotherapy,the effect of heavy ion brain radiation on immune system function in the relevant research is rare.So the brain injury model that rats were subjected to 15 Gy of head irradiation was built.By detecting lymphocyte percentage,thymus,spleen,body weight and different developmental stages | YU Ying-qi WANG Xiao SUI Li KONG Fu-quan LEI Run-hong MAHong DENG Yu-lin LI Qiang | 2013 | Annual Report of China Institute of Atomic Energy2013，，1： | 0 |
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