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| 1 | Placental-derived stem cells:Culture, differentiation and challenges显示文摘Stem cell therapy is a promising approach to clinical healing in several diseases. A great variety of tissues(bone marrow, adipose tissue, and placenta) arepotentially sources of stem cells. Placenta-derived stem cells(p-SCs) are in between embryonic and mesenchymal stem cells, sharing characteristics with both, such as non-carcinogenic status and property to differentiate in all embryonic germ layers. Moreover, their use is not ethically restricted as fetal membranes are considered medical waste after birth. In this context, the present review will be focused on the biological properties, culture and potential cell therapy uses of placental-derived stem cells. Immunophenotype characterization, mainly for surface marker expression, and basic principles of p-SC isolation and culture(mechanical separation or enzymatic digestion of the tissues, the most used culture media, cell plating conditions) will be presented. In addition, some preclinical studies that were performed in different medical areas will be cited, focusing on neurological, liver, pancreatic, heart, muscle, pulmonary, and bone diseases and also in tissue engineering field. Finally, some challenges for stem cell therapy applications will be highlighted. The understanding of the mechanisms involved in the p-SCs differentiation and the achievement of pure cell populations(after differentiation) are key points that must be clarified before bringing the preclinical studies, performed at the bench, to the medical practice. | Maira S Oliveira Joao B Barreto-Filho | 2015 | World Journal of Stem Cells2015，7，4： | 10 |
| 2 | Short-term effects of di-(2-ethylhexyl) phthalate on testes,liver, kidneys and pancreas in mice显示文摘瞄准:决定 di-(2-ethylhexyl ) 的生物化学的效果在生精的上皮的退化的过程的白天 10 上的睾丸,肝,肾和胰上的 phthalate (DEHP ) 。方法:包含 2% DEHP 的食谱被给男 Crlj : CD1 (ICR ) 老鼠 for10 天。DEHP 的剂量是 0.90 ± 0.52 mg/mouse/day。他们的睾丸,肝,肾 andpancreata 为察觉被检验单音 --(2-ethylhexyl ) phthalate (MEHP ) ,氮氧化物(NOx ) 生产了由每氮的氧化物的氧化(没有) 与自由激进分子,和类脂化合物一起每自由激进分子的链反应导致的氧化。结果:组织学的观察和浆液分析显示出严重 spermatogenic 骚乱, Leydig 房间机能障碍,肝机能障碍和脱水的存在。出人意料地,在睾丸的 MEHP 的集中在肝与那相比是极其低的。然而,在睾丸的 NOx 的集中象肝的集中一样高。而且,免费导致激进分子的类脂化合物组织化学地在睾丸然而并非在肝每氧化被检测。结论:结果显示阴囊的纸巾的高敏感引起到传播 MEHP 的 MEHP 而非特定的累积或举起进睾丸的那导致 DEHP 的 aspermatogenesisis。 | Yumi Miura Munekazu Naito Maira Ablake Hayato Terayama Shuang-Qin Yi Ning Qu Lin-Xian Cheng Shigeru Suna Fumihiko Jitsunari Masahiro Itoh | 2007 | Asian Journal of Andrology2007，9，2： | 6 |
| 3 | GO FAIR Brazil:A Challenge for Brazilian Data Science显示文摘The FAIR principles,an acronym for Findable,Accessible,Interoperable and Reusable,are recognised worldwide as key elements for good practice in all data management processes.To understand how the Brazilian scientific community is adhering to these principles,this article reports Brazilian adherence to the GO FAIR initiative through the creation of the GO FAIR Brazil Office and the manner in which they create their implementation networks.To contextualise this understanding,we provide a brief presentation of open data policies in Brazilian research and government,and finally,we describe a model that has been adopted for the GO FAIR Brazil implementation networks.The Brazilian Institute of Information in Science and Technology is responsible for the GO FAIR Brazil Office,which operates in all fields of knowledge and supports thematic implementation networks.Today,GO FAIR Brazil-Health is the first active implementation network in operation,which works in all health domains,serving as a model for other fields like agriculture,nuclear energy,and digital humanities,which are in the process of adherence negotiation.This report demonstrates the strong interest and effort from the Brazilian scientific communities in implementing the FAIR principles in their research data management practices. | Luana Sales Patricia Henning Viviane Veiga Maira Murrieta Costa Luis Fernando Sayao Luiz Olavo Bonino da Silva Santos Luis Ferreira Pires | 2020 | Data Intelligence2020，2，1： | 3 |
| 4 | Does Parkinsonμs Disease and Type-2 Diabetes Mellitus Present Common Pathophysiological Mechanisms and Treatments?显示文摘 | Marcelo M.S. Lima Adriano D.S. Targa Ana C.D. Noseda Lais S. Rodrigues Ana Marcia Delattre Fabiola V. dos Santos Mariana H. Fortes Maira J. Maturana Anete C. Ferraz | 2014 | CNS & Neurological Disorders - Drug Targets2014，，3： | 2 |
| 5 | Cerebrospinal fluid shunting for hy- drocephalus in the adult:factors related to shunt revision显示文摘 | Puca A Anile C Maira G | 1991 | Neurosurgery1991，29，6： | 1 |
| 6 | Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene Activation 显示文摘 | Maira M Martens C Philips A | 1999 | Mol Cell Biol1999，19，11： | 1 |
| 7 | Craniopharyngiomas of the third ventricle:trans lamina termialis approach 显示文摘 | | 2000 | Neurosurgery2000，47，： | 1 |
| 8 | Tips for roving reference: how to best serve library users显示文摘 | Courtois Martin P Liriano Maira | 2000 | College-and-university-li- braries-Re ference-services2000，61，4： | 1 |
| 9 | Pure surgical treatments of109 aneurysms显示文摘 | Maira G Anile C Mangiola A et a1 | 2005 | J Neurosurg Sci2005，49，2： | 1 |
| 10 | Chordoma of the skull base: predictors of tumor recurrence显示文摘 | PALLINI R MAIRA G PIERCONTI F | 2003 | J Neuro surg2003，98，4： | 1 |
| 11 | Chordoma of the skull base:predictors of tumor recurrence显示文摘 | Pallini R Maira G Pierconti F | 2003 | J Neurosurg2003，98，： | 1 |
| 12 | Evidence for an Association of Human Papillomavirus and Breast Carcinomas显示文摘 | Andrea P.S. Damin Rachid Karam Claudio G. Zettler Maira Caleffi Claudio O.P. Alexandre | 2004 | Breast Cancer Research and Treatment2004，，2： | 1 |
| 13 | Gas phase photo-oxidation of toluene using nanometer-size TiO2 catalyst s显示文摘 | Maira A J Yeung K L Soria J | | 0，，： | 1 |
| 14 | Imidazo 显示文摘 | Stauffer F Maira SM Furet P | 2008 | Bioorg Med Cbem Lett2008，18，3： | 1 |
| 15 | From the bench to the bed side:Pl3K pathway inhibitors in clinical development 显示文摘 | Maira SM Finan P Garcia-Echeverria C | 2010 | Curt Top Microbiol Immunol2010，347，： | 1 |
| 16 | Surgical treatment of craniopharyngiomas:An evaluation of the transsphenoidal and pterional approaches显示文摘 | Maira G Anile C Ross GF | 1995 | Neurosurg -ery1995，36，： | 1 |
| 17 | EXTENSIVE CLINICAL EXPERIENCE: Primary Empty Sella显示文摘 | Laura De Marinis Stefania Bonadonna Antonio Bianchi Giulio Maira Andrea Giustina | 2005 | The Journal of Clinical Endocrinology & Metabolism2005，，9： | 1 |
| 18 | Identification and characterization of NVP-BEZ235,a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity 显示文摘 | Maira SM Stauffer F Brueggen J | 2008 | Mol Cancer Ther2008，7，7： | 1 |
| 19 | Net, a negative Rasswitchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-aeetylation 显示文摘 | Criqui-Filipe P Ducret C Maira SM | 1999 | EMBO J1999，18，12： | 1 |
| 20 | Nanosize Ti-W Mixed Oxides: Effect of doping level in the photocatalytic degradation of toluene using sunlighttype excitation显示文摘 | Fuerte A Hemandez-Alonso M D Maira A J | 2002 | Journal of Catalysis2002，212，1： | 1 |
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