|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Schizonepeta tenuifolia inhibits collagen stimulated platelet function via suppressing MAPK and Akt signaling显示文摘The prevalence of cardiovascular diseases(CVDs)is increasing at a rapid pace in developed countries,and CVDs are the leading cause of morbidity and mortality.Natural products and ethnomedicine have been shown to reduce the risk of CVDs.Schizonepeta(S.)tenuifolia is a medicinal plant widely used in China,Korea,and Japan and is known to exhibit anti-inflammatory,antioxidant,and immunomodulatory activities.We hypothesized that given herbal plant exhibit pharmacological activities against CVDs,we specifically explored its effects on platelet function.Platelet aggregation was evaluated using standard light transmission aggregometry.Intracellular calcium mobilization was assessed using Fura-2/AM,and granule secretion(ATP release)was measured in a luminometer.Fibrinogen binding to integrin a_(Ⅱb)β_3,was assessed using flow cytometry.Phosphorylation of mitogen-activated protein kinase(MAPK)signaling molecules and activation of the protein kinase B(Akt)was assessed using Western blot assays.S.tenuifolia,extract potently and significantly inhibited platelet aggregation,calcium mobilization,granule secretion,and fibrinogen binding to integrin a_(Ⅱb)β_3.Moreover,all extracts significantly inhibited MAPK and Akt phosphorylation.S.tenuifolia extract inhibited platelet aggregation and granule secretion,and attenuated collagen mediated GPVI downstream signaling,indicating the potential therapeutic effects of these plant extracts on the cardiovascular system and platelet function.We suggest that S.tenuifolia extract may be a potent candidate to treat platelet-related CVDs and to be used as an antiplatelet and antithrombotic agent. | Bo-Ra Jeon Muhammad Irfan Minki Kim Seung Eun Lee Jeong Hoon Lee Man Hee Rhee | 2019 | The Journal of Biomedical Research2019，33，4： | 6 |
| 2 | Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses显示文摘 | Yanyan Yang Seung Cheol Kim Tao Yu Young-Su Yi Man Hee Rhee Gi-Ho Sung Byong Chul Yoo Jae Youl Cho Pham My-Chan Dang | 2014 | Mediators of Inflammation2014，，： | 1 |
| 3 | Fermented rice bran prevents atopic dermatitis in DNCB-treated NC/Nga mice显示文摘The fermentation of natural plants has a favorable effect on the functional and biological activities of living systems.These include anti-oxidative,anti-inflammatory,and anti-platelet aggregation activities.This is attributed to the chemical conversion of the parent plants to functional constituents,which show more potent biological activity.In our study,rice bran along with oriental medicinal plants(Angelicae gigantis,Cnidium officinale,Artemisia princeps,and Camellia sinensis) was fermented by Lactobacillus rhamnosus and Pichia deserticola(FRBE).We evaluated the effects of oral administration of FRBE on atopic dermatitis in l-chloro-2,4-dinitrobenzene(DNCB)-treated NC/Nga mice.FRBE significantly ameliorated the macroscopic and microscopic appearance of skin lesions in DNCB-induced atopic dermatitis and reduced levels of serum immunoglobulin E and the differential white blood cell count.In addition,it reduced skin thickness compared to that of atopic dermatitis-affected skin.FRBE treatment also reduced mast cell incorporation in skin lesions of atopic dermatitis.The total cell number in dorsal skin tissue and the axillary lymph node increased following DNCB application,and this was normalized by FRBE treatment.Moreover,it decreased the levels of CD8^+ helper T cells and Gr-1^+/CD11b^+ B cells in peripheral blood mononuclear cells and skin lesions in DNCB-induced atopic dermatitis.Using real-time polymerase chain reaction analysis,we demonstrated that FRBE significantly inhibited mRNA expression of cytokines(e.g.,interleukin-5 and interleukin-13) and cyclooxygenase-2 in AD skin lesions.These results suggest that FRBE could be a valuable herbal remedy for the treatment of atopic dermatitis. | Evelyn Saba Chun Hee Lee Da Hye Jeong Kija Lee Tae-Hwan Kim Seong-Soo Roh Seung-Hyung Kim Man Hee Rhee | 2016 | The Journal of Biomedical Research2016，30，4： | 1 |
| 4 | Antiplatelet Activity of Morus alba Leaves Extract, Mediated via Inhibiting Granule Secretion and Blocking the Phosphorylation of Extracellular-Signal-Regulated Kinase and Akt显示文摘 | Dong-Seon Kim Hyun Dong Ji Man Hee Rhee Yoon-Young Sung Won-Kyung Yang Seung Hyung Kim Ho-Kyoung Kim Joen-Rong Sheu | 2014 | Evidence-Based Complementary and Alternative Medicine2014，，： | 1 |
| 5 | Salicornia herbacea:botanical,chemical and pharmacological review of halophyte marsh plant显示文摘 | Man Hee Rhee Hwa-Jin Park Jae Youl Cho | | 0，，08： | 1 |
| 6 | Src/NF-κB-targeted inhibition of LPS-induced macrophage activation and dextran sodium sulphate-induced colitis by Archidendron clypearia methanol extract显示文摘 | Woo Seok Yang Jaehwi Lee Tae Woong Kim Ji Hye Kim Sukchan Lee Man Hee Rhee Sungyoul Hong Jae Youl Cho | 2012 | Journal of Ethnopharmacology2012，，1： | 1 |
| 7 | 8-(Tosylamino)quinoline inhibits macrophage-mediated inflammation by suppressing NF-KB signaling显示文摘 | Yongwoo JUNG Se Eun BYEON Dae Sung YOO Yong Gyu LEE Tao YU Yanyan YANG Ji Hye KIM Eunji KIM Deok JEONG Man Hee RHEE Eui Su CHOUNG Sungyoul HONG Jae Youl CliO | 2012 | Acta Pharmacologica Sinica2012，33，8： | 0 |
| 8 | Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling显示文摘Objective:To examine the antiplatelet and antithrombotic activity of Rumex acetosella extract.Methods:Standard light aggregometry was used for platelet aggregation,intracellular calcium mobilization assessed using Fura-2/AM,granule secretion(ATP release)by luminometer,and fibrinogen binding to integrin α_(Ⅱb)β_(3) detected using flow cytometry.Western blotting is carried out to determine the phosphorylation of mitogen-activated protein kinase(MAPK)and phosphoinositide 3-kinase(PI3K)/Akt signaling.Results:Rumex acetosella displayed the ability to inhibit platelet aggregation,calcium mobilization,granule secretion,and fibrinogen binding to integrin α_(Ⅱb)β_(3).Rumex acetosella has also down-regulated MAPK and PI3K/Akt phosphorylation(all P<0.01).Conclusion:Rumex acetosella extract exhibits antiplatelet activity via modulating GPVI signaling,and it may protect against the development of platelet-related cardiovascular diseases. | Bo-Ra Jeon Muhammad Irfan Seung Eun Lee Jeong Hoon Lee Man Hee Rhee | 2022 | Chinese Journal of Integrative Medicine2022，28，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员