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| 1 | Carcinogenic Helicobacter pylori in gastric pre-cancer and cancer lesions: Association with tobacco-chewing显示文摘AIM:To investigate the low gastric cancer incidence rate relative to the highly prevalent Helicobacter pylori(H.pylori)infection;data relevant to H.pylori infection during gastric carcinogenesis in Indian patients is currently lacking.METHODS:The present study examines the prevalence of H.pylori infection in DNA derived from 156endoscopic gastric biopsies of different disease groups that represent gastric pre-cancer[intestinal metaplasia(n=15),dysplasia(n=15)],cancer[diffuse adenocarcinoma(n=44),intestinal adenocarcinoma(n=21)],and symptomatic but histopathologically-normal controls(n=61).This was done by generic ureC polymerase chain reaction(PCR)and cagA-specific PCR that could specifically identify the carcinogenic H.pylori strain.RESULTS:Our analysis showed the presence of H.pylori infection in 61%of symptomatic histopathologically-normal individuals,however only 34%of control tissues were harboring the cagA+H.pylori strain.A similar proportion of H.pylori infection(52%)and cagA(26%)positivity was observed in the tumor tissue of the gastric cancer group.In comparison,H.pylori infection(90%)and cagA positivity(73%)were the highest in gastric pre-cancer lesions.In relation to tobacco and alcohol abuse,H.pylori infection showed an association with tobacco chewing,whereas we did not observe any association between tobacco smoking or alcohol abuse with prevalence of H.pylori infection in the tissue of any of the patient groups studied.CONCLUSION:High incidence of H.pylori infection and carcinogenic cagA positive strain in pre-cancer lesions during gastric carcinogenesis may be | Arvind Pandey Satyendra Chandra Tripathi Sutapa Mahata Kanchan Vishnoi Shirish Shukla Sri Prakash Misra Vatsala Misra Suresh Hedau Ravi Mehrotra Manisha DwivediZ Alok C Bharti | 2014 | World Journal of Gastroenterology2014，20，22： | 4 |
| 2 | Berberine and Curcumin Target Survivin and STAT3 in Gastric Cancer Cells and Synergize Actions of Standard Chemotherapeutic 5-Fluorouracil显示文摘 | Arvind Pandey Kanchan Vishnoi Sutapa Mahata Satyendra Chandra Tripathi Sri Prakash Misra Vatsala Misra Ravi Mehrotra Manisha Dwivedi Alok C. Bharti | 2015 | Nutrition and Cancer2015，，8： | 2 |
| 3 | Johnson Multiplex PCR for Detection of Genes for Staphylococcus aureus Enterotoxins, Exfoliative Toxins, Toxic Shock Syndrome Toxin 1, and Methicillin Resistance显示文摘 | Manisha Mehrotra Gehua Wang Wendy M | 2000 | Journal of Clinical Microbiology2000，38，3： | 1 |
| 4 | Multiplex PCR for Detection of Genes for Staphylococcus aureus Enterotoxins, Exfoliative Toxins, Toxic Shock Syndrome Toxin 1, and Methicillin Resistance显示文摘 | Manisha Mehrotra Gehua Wang Wend Y M Johnson | 2000 | Journal of Clinical Microbiology2000，38，3： | 1 |
| 5 | Multiplex PCR for detection of genes for Staphylococcus aureus enterotox- ins,exfoliative toxins, toxic shock syndrome toxin 1, and methicil- lin resistance 显示文摘 | Manisha Mehrotra Gehua Wang Wendy M Johnson | 2000 | Journal of Clinical Microbiology2000，38，3： | 1 |
| 6 | Multiplex PCR for Detection of Genes for staphylococcus aureus enterotoxins,exfoliative toxins toxic shock syndyme toxin, and Methicillin Resistance显示文摘 | Manisha Mehrotra Wang Ge-hua and Wendym Ohnson | 2000 | Clin Microbiol2000，38，3： | 1 |
| 7 | Multiplex PCR for Detection of Genes for Staphylococcus aureus Enterotoxins, Exfoliative Toxins,Toxic Shock Syndrome Toxin 1,and Methicillin Resistance显示文摘 | Manisha Mehrotra Gehua Wang Wendy M ohnson | 2000 | Journal of clinical microbiology2000，38，3： | 1 |
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