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| 1 | Comparative study of microRNA profiling in keloid fibroblast and annotation of differential expressed microRNAs显示文摘蟹状肿是由于皮损害的异常愈合成长的像肿瘤的皮疤,没有有效 treatment.The 分子的机制位于 \O 下面蟹状肿致病仍然大部分未知。在这研究,我们比较了表示在导出蟹状肿的成纤维细胞和正常成纤维细胞之间介绍的 microRNA (miRNA )( 包括胎儿、成年的真皮的成纤维细胞) 由 miRNA microarray 分析。我们发现在导出蟹状肿的成纤维细胞的 miRNA 侧面与在 normalfibroblasts 的那些是不同的。九 miRNAs 是表示其六在蟹状肿成纤维细胞(KF ) 是显著地起来调整的差别,包括 miR-152, miR-23b-3p, miR-31-5p, miR-320c, miR-30a-5p,和 hsv1-miR-H7,并且其三是调整 significantlydown 的包括 miR-4328, miR-145-5p,和 miR-143-3p。差别的功能的注解表示了他们在为疤创伤愈合重要的几条发信号的小径被充实的 miRNA targetsrevealed。在结论,我们 demonstratethat miRNA 表示侧面在 KF 被改变与相比可以为探索蟹状肿的致病在胎儿、成年的真皮的成纤维细胞,和 expressionprofile 提供有用线索。miRNAs 可能部分由影响相关的几条发信号的小径使创伤愈合留下疤痕贡献 etiologyof 蟹状肿。 | Chao Li Yuehong Bai Hua Liu Xuemei Zuo Haichang Yao Yiming Xu Manlin Cao | 2013 | Acta Biochimica et Biophysica Sinica2013，45，8： | 15 |
| 2 | Preparation of an amphoteric flocculant having both high polymer content and low viscosity and its polymerization kinetics显示文摘It is not easy for liquid cationic flocculant diallyldimethyl-ammonium chloride(DM) homopolymer to simultaneously exhibit both low viscosity and high polymer content, which limited its application in offshore oilfield.In this paper, sodium allylsulfonate(XS) and sodium formate were used in the aqueous solution polymerization of DM.An amphoteric flocculant(PDMXS) with the properties of high polymer content(about 55 wt%) and low viscosity(efflux time measured by an Apply 4 viscometer was less than 100 s) was prepared.The optimum reaction conditions were identified as follows: the mass ratio of XS/DM was 10 wt%, the concentration of sodium formate was 2000 mg·L^(-1), reaction temperature was 55 ℃, the concentration of KPS was 0.5 wt% and the reaction time was 4 h.The polymerization kinetics was discussed.The results showed that R_p∝ [M]^(1.97)[I]^(0.68)[CTA]^(0.71) and the apparent activation energy was 72.55 kJ·mol^(-1). | Shenwen Fang Manlin Wang Zipei Xu Lei Zhai Xiujun Wang Yan Xiong | 2019 | Chinese Journal of Chemical Engineering2019，27，1： | 3 |
| 3 | Hydrogen-rich saline attenuates neuronal ischemia reperfusion injury by protecting mitochondrial function in rats显示文摘 | Yaomei Cui Hao Zhang Muhuo Ji Min Jia Huixian Chen Jianjun Yang Manlin Duan | 2014 | Journal of Surgical Research2014，，： | 2 |
| 4 | A novel combination belief rule base model for mechanical equipment fault diagnosis显示文摘Due to the excellent performance in complex systems modeling under small samples and uncertainty,Belief Rule Base(BRB)expert system has been widely applied in fault diagnosis.However,the fault diagnosis process for complex mechanical equipment normally needs multiple attributes,which can lead to the rule number explosion problem in BRB,and limit the efficiency and accuracy.To solve this problem,a novel Combination Belief Rule Base(C-BRB)model based on Directed Acyclic Graph(DAG)structure is proposed in this paper.By dispersing numerous attributes into the parallel structure composed of different sub-BRBs,C-BRB can effectively reduce the amount of calculation with acceptable result.At the same time,a path selection strategy considering the accuracy of child nodes is designed in C-BRB to obtain the most suitable submodels.Finally,a fusion method based on Evidential Reasoning(ER)rule is used to combine the belief rules of C-BRB and generate the final results.To illustrate the effectiveness and reliability of the proposed method,a case study of fault diagnosis of rolling bearing is conducted,and the result is compared with other methods. | Manlin CHEN Zhijie ZHOU Bangcheng ZHANG Guanyu HU You CAO | 2022 | Chinese Journal of Aeronautics2022，35，5： | 2 |
| 5 | Construction and immunogenicity of recombinant adenovirus expressing ORF2 of PCV2 and porcine IFN gamma显示文摘 | Liu Genmei Luo Manlin Chen Ruiai Huang Hongliang Pei Dangshuai | 2011 | Vaccine2011，，47： | 2 |
| 6 | Up-regulation of carcinoembryonic antigen-related cell adhesion molecule 1 in gastrointestinal cancer and its clinical relevance显示文摘 | Muqing Zhou Zhiming Jin Yiwen Liu Yiqing He Yan Du Cuixia Yang Yingzhi Wang Jiajie Hu Lian Cui Feng Gao Manlin Cao | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 2 |
| 7 | Construction and immu-nogenicity of recombinant adenovirus expressing ORF2 ofPCV2 and porcine IFN gamma显示文摘 | Genmei L Manlin L Ruiai C | 2011 | Vaccine2011，29，： | 1 |
| 8 | Mitochondrial F1Fo-ATP synthase translocates to cell surface in hepatocytes and has high activity in tumor-like acidic and hypoxic environment显示文摘F1Fo-ATP synthase 原来是思维只在线粒体的内部膜定位。然而,最近的研究在房间膜的外面上证明宫外的 F1Fo-ATP synthase 的存在。宫外的 ATP synthase 为肿瘤目标治疗作为一个标记被建议。不过,宫外的 ATP synthase 的蛋白质运输机制仍然是不清楚的。关于肿瘤,因为它的普遍表示,宫外的 ATP synthase 的特性被询问。在当前的学习,我们构造了绿色荧光灯 protein-ATP5B 熔化蛋白质并且介绍了它进 HepG2 房间学习 ATP synthase 的本地化。ATP5B 的表示与不同恶意在六根房间线被分析。这些房间是有教养的在正常、像肿瘤酸并且 hypoxic 条件。结果建议 ATP synthase 的宫外的表示是从线粒体的 translocation 的后果。表示和宫外的 ATP synthase 的催化活动作为在不太恶意的房间的表面上在恶意的房间的表面上是类似的。有趣地,宫外的 ATP synthase 的表示不是起来调整的在像肿瘤酸并且 hypoxic 微型环境。然而,宫外的 ATP synthase 的催化活动在像肿瘤的微型环境是起来调整的。因此,为肿瘤目标治疗的宫外的 ATP synthase 的特性依靠被观察在的催化活动的高水平酸并且在肿瘤纸巾的 hypoxic 微型环境。 | Zhan Ma Manlin Cao Yiwen Liu Yiqing He Yingzhi Wang Cuixia Yang Wenjuan Wang Yan Du Muqing Zhou Feng Gao | 2010 | Acta Biochimica et Biophysica Sinica2010，42，8： | 1 |
| 9 | Effects of Hydroxyethyl Starch 130/0.4 on Pulmonary Capillary Leakage and Cytokines Production and NF-κB Activation in CLP-Induced Sepsis in Rats显示文摘 | Xiaomei Feng Wei Yan Xiaoming Liu Manlin Duan Xinhua Zhang Jianguo Xu | 2006 | Journal of Surgical Research2006，，1： | 1 |
| 10 | Influence of Wind Deviation Angle on n-Hexane Evaporation Loss of Internal Floating-Roof Tanks显示文摘With the increasing attention to environmental protection,it is still necessary to strictly control the oil evaporation loss from the IFRT(internal floating-roof tank)to the atmosphere.Upon using n-hexane as a representative of light oil,the effects of the WDAs(wind deviation angles)on airflow distribution,the wind speed,the n-hexane vapor concentration,and the evaporation loss rate in the IFRT were investigated,and the mass transfer of the vapor-air was analyzed.The results are shown as follows:when the WDA is 0°,the vapor concentration in the gas space above the floating deck is the lowest;when the WDA is 22.5°,the oil evaporation loss rate is the largest;when the WDA is 45°,the vapor concentration is the highest,but the evaporation loss rate is the smallest.It is recommended to arrange the vent to the wind direction with an angle of 45°to reduce the evaporation loss and protect the atmospheric environment. | Huang Weiqiu Xu Manlin Li Fei Ji Hong Fang Jie | 2020 | China Petroleum Processing & Petrochemical Technology2020，22，2： | 1 |
| 11 | Isotoosendanin exerts inhibition on triple-negative breast cancer through abrogating TGF-β-induced epithelial—mesenchymal transition via directly targeting TGFβR1显示文摘As the most aggressive breast cancer,triple-negative breast cancer(TNBC) is still incurable and very prone to metastasis.The transform growth factor β(TGF-β)-induced epithelial—mesenchymal transition(EMT) is crucially involved in the growth and metastasis of TNBC.This study reported that a natural compound isotoosendanin(ITSN) reduced TNBC metastasis by inhibiting TGF-β-induced EMT and the formation of invadopodia.ITSN can directly interact with TGF-β receptor type-1(TGFβR1) and abrogated the kinase activity of TGFβR1,thereby blocking the TGF-β-initiated downstream signaling pathway.Moreover,the ITSN-provided inhibition on metastasis obviously disappeared in TGFβR1-overexpressed TNBC cells in vitro as well as in mice bearing TNBC cells overexpressed TGFβR1.Furthermore,Lys232 and Asp351 residues in the kinase domain of TGFβR1 were found to be crucial for the interaction of ITSN with TGFβR1.Additionally,ITSN also improved the inhibitory efficacy of programmed cell death 1 ligand 1(PD-L1) antibody for TNBC in vivo via inhibiting the TGF-β-mediated EMT in the tumor microenvironment.Our findings not only highlight the key role of TGFβR1 in TNBC metastasis,but also provide a leading compound targeting TGFβR1 for the treatment of TNBC metastasis.Moreover,this study also points out a potential strategy for TNBC treatment by using the combined application of anti-PD-L1 with a TGFβR1 inhibitor. | Jingnan Zhang Ze Zhang Zhenlin Huang Manlin Li Fan Yang Zeqi Wu Qian Guo Xiyu Mei Bin Lu Changhong Wang Zhengtao Wang Lili Ji | 2023 | Acta Pharmaceutica Sinica B2023，13，7： | 1 |
| 12 | Construction and immunegenicity of recombinant adenovirus expressing ORF2 of PCV2 and porcine IFN gamma显示文摘 | Genmei L Manlin L Ruiai C | 2011 | Vaccine2011，29，47： | 1 |
| 13 | Growth of self-assembled monolayer on tetrahedral amorphous carbon film coated magnetic head显示文摘 | Zhang Huayu Tan Manlin Zhu Zhenye | 2008 | Surface and Coatings Technology2008，202，15： | 1 |
| 14 | 显示文摘 | Tan Manlin Zhu Jiaqi Han Jiecai | 2008 | Mater Res Bull2008，43，2： | 1 |
| 15 | Ceramide-induced apoptosis: role of catalase and hepatocyte growth factor显示文摘 | Ram Kannan ManLin Jin Maria-Andreea Gamulescu DavidR. Hinton | 2004 | Free Radical Biology and Medicine2004，，2： | 1 |
| 16 | Construction and immuno- genicity of recombinant adenovirus expressing ORF2 of PCV2 and porcine IFN gamma 显示文摘 | Genmei L Manlin L Ruiai C | 2011 | Vaccine2011，29，47： | 1 |
| 17 | Raman characterization of boron doped tetrahedral amorphous carbon films显示文摘 | Manlin Tan Jiaqi Zhu Jiecai Han Wei Gao Aiping Liu Xiao Han | 2007 | Materials Research Bulletin2007，，2： | 1 |
| 18 | A Reliable Routing Algorithm with Network Coding in Internet of Vehicles显示文摘The intelligent vehicle network uses advanced information technology to establish an efficient integrated vehicle transport system,which has received great attention in industry and academia. Internet of Vehicles(IoV)in an urban environment is operated in a wireless environment with high bit error rate and interference. In addition,the wireless link between vehicles is likely to be lost. All of this makes it an important challenge to provide reliable mobile routing in an urban traffic environment. In this paper,a reliable routing algorithm with network coding(RR_NC)is proposed to solve the above problems. A routing node sequence is discovered in IoV from source to destination by multi-metric ant colony optimization algorithm(MACO),and then clusters are formed around every node in the sequence. By adding linear encoding into the transmission of data between vehicle's clusters,the RR_NC provides much more reliable transmission and can recover the original message in the event of disorder and loss of message. Simulations are taken under different scenarios,and the results prove that this novel algorithm can deliver the information more reliably between vehicles in real-time with lower data loss and communication overhead. | Zhen Wang Jianqing Li Manlin Fang Yang Li Botao Feng | 2017 | China Communications2017，14，5： | 1 |
| 19 | Effect of Substrate Bias on Microstructure and Properties of Tetrahedral Amorphous Carbon Films显示文摘The microstructure and properties of tetrahedral amorphous carbon (ta-C) films deposited by the filtered cathodic vacuum arc technology has been investigated by visible Raman spectroscopy, AFM and Nano-indentor. The Raman spectra have been fitted with a single skewed Lorentzian lineshape described by BWF function defining coupling coefficient, which characterizes the degree of asymmetry and is correlated with the sp3 content. When the substrate bias is -80 V, the sp3 content is the most and simultaneously the coupling coefficient is the least, following with the minimum root mean square surface roughness (Rq=0.23 nm) and the highest hardness (51.49 GPa), Young′s modulus (512.39 GPa), and critical scratching load (11.72 mN). As the substrate bias is increased or decreased, the sp3 content and other properties lower correspondingly. | Jiaqi ZHU Jiecai HAN Songhe MENG Qiang LI Manlin TAN | 2003 | Journal of Materials Science & Technology2003，19，z1： | 0 |
| 20 | Thrombospondin-1 Expression in RPE and Choroidal Neovascular Membranes显示文摘Purpose: To investigate the expression of thrombospondin 1 (TSP-1) in retinal pigment epithelium (RPE) and choroidal neovascular membranes (CNVMs) from patients with age-related macular degeneration (AMD). Methods: Tissue sections from normal human fetal and adult eyes and surgically removed CNVMs were immunostained for TSP-1 localization. Polymerase chain reaction and Western blotting were used to analyze TSP-1 mRNA and protein from human RPE cells, respectively. TSP-1 in the supernatant of cultured RPE cells and eye explants were measured using enzyme-linked immunosorbent assay. MTT assay was used to evaluate the RPE survival after TSP-1 treatment. Results: The strongest immunostaining for TSP-1 was observed in the RPE monolayer around drusen in early AMD. The intensity of TSP-1 staining in normal eye sections was much weaker than that of early AMD and CNVM. TSP-1 mRNA was positive in cultured fetal and adult RPE cells. There was increasing secretion of TSP-1 into the supernatant of cultured RPE and eye explants. The specific band of TSP-1 was identified by Western blot. No significant inhibition of RPE survival was found with the exposure to TSP-1. Conclusions: TSP-1 expression in drusen and CNVM was upregulated and associated with RPE monolayer. TSP-1 may be a natural negative regulator for choroidal neovascularization. | Shikun He Francesca Incardona Manlin Ji Stephen J. Ryan David R. Hinton | 2006 | 眼科学报2006，22，4： | 0 |
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