|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 肾脏病变:对比扩散加权成像与对比增强MRI的病变特征显示文摘目的以MRI随访检查和组织病理学分析结果作为参照标准,比较扩散加权MRI与对比增强MRI对肾脏病变的诊断效能,并评价两者结合的诊断效能。方法机构审查委员会批准本项研究,不需病人知情同意,因其为符合HIPAA标准的回顾性研究。应用对比增强MRI和不同b值下屏气DWI评价64例病人(男46例,女18例,平均年龄60.7岁)的109个肾脏病灶。采用对比增强MRI判断标准评估肾脏病变特征,测量表观扩散系数(ADC)值。 | B. Taouli R.K. Thakur L. Mannelli J.S. Babb S. Kim E.M. Hecht 龙淼淼(译) 季倩(校) | 2009 | 国际医学放射学杂志2009，32，4： | 32 |
| 2 | Non-invasive diagnostic imaging of colorectal liver metastases显示文摘Colorectal cancer is one of the few malignant tumors in which synchronous or metachronous liver metastases [colorectal liver metastases(CRLMs)] may be treated with surgery. It has been demonstrated that resection of CRLMs improves the long-term prognosis. On the other hand, patients with un-resectable CRLMs may benefit from chemotherapy alone or in addition to liverdirected therapies. The choice of the most appropriate therapeutic management of CRLMs depends mostly on the diagnostic imaging. Nowadays, multiple non-invasive imaging modalities are available and those have a pivotal role in the workup of patients with CRLMs. Although extensive research has been performed with regards to the diagnostic performance of ultrasonography, computed tomography, positron emission tomography and magnetic resonance for the detection of CRLMs, the optimal imaging strategies for staging and follow up are still to be established. This largely due to the progressive technological and pharmacological advances which are constantly improving the accuracy of each imaging modality. This review describes the non-invasive imaging approaches of CRLMs reporting the technical features, the clinical indications, the advantages and the potential limitations of each modality, as well as including some information on the development of new imaging modalities, the role of new contrast media and the feasibility of using parametric image analysis as diagnostic marker of presence of CRLMs. | Pier Paolo Mainenti Federica Romano Laura Pizzuti Sabrina Segreto Giovanni Storto Lorenzo Mannelli Massimo Imbriaco Luigi Camera Simone Maurea | 2015 | World Journal of Radiology2015，7，7： | 13 |
| 3 | Serial diffusion-weighted MRI in patients with hepatocellular carcinoma: Prediction and assessment of response to transarterial chemoembolization. Preliminary experience显示文摘 | Lorenzo Mannelli Sooah Kim Cristina H. Hajdu James S. Babb Bachir Taouli | 2012 | European Journal of Radiology2012，，： | 3 |
| 4 | Impact of radiogenomics in esophageal cancer on clinical outcomes: A pilot study显示文摘BACKGROUND Esophageal cancer(ESCA)is the sixth most common malignancy in the world,and its incidence is rapidly increasing.Recently,several microRNAs(miRNAs)and messenger RNA(mRNA)targets were evaluated as potential biomarkers and regulators of epigenetic mechanisms involved in early diagnosis.In addition,computed tomography(CT)radiomic studies on ESCA improved the early stage identification and the prediction of response to treatment.Radiogenomics provides clinically useful prognostic predictions by linking molecular characteristics such as gene mutations and gene expression patterns of malignant tumors with medical images and could provide more opportunities in the management of patients with ESCA.AIM To explore the combination of CT radiomic features and molecular targets associated with clinical outcomes for characterization of ESCA patients.METHODS Of 15 patients with diagnosed ESCA were included in this study and their CT imaging and transcriptomic data were extracted from The Cancer Imaging Archive and gene expression data from The Cancer Genome Atlas,respectively.Cancer stage,history of significant alcohol consumption and body mass index(BMI)were considered as clinical outcomes.Radiomic analysis was performed on CT images acquired after injection of contrast medium.In total,1302 radiomics features were extracted from three-dimensional regions of interest by using PyRadiomics.Feature selection was performed using a correlation filter based on Spearman’s correlation(ρ)and Wilcoxon-rank sum test respect to clinical outcomes.Radiogenomic analysis involvedρanalysis between radiomic features associated with clinical outcomes and transcriptomic signatures consisting of eight N6-methyladenosine RNA methylation regulators and five up-regulated miRNA.The significance level was set at P<0.05.RESULTS Of 25,five and 29 radiomic features survived after feature selection,considering stage,alcohol history and BMI as clinical outcomes,respectively.Radiogenomic analysis with stage as clinical outcome revealed that six of the eight mRNA regulators and two of the five up-regulated miRNA were significantly correlated with ten and three of the 25 selected radiomic features,respectively(-0.61<ρ<-0.60 and 0.53<ρ<0.69,P<0.05).Assuming alcohol history as clinical outcome,no correlation was found between the five selected radiomic features and mRNA regulators,while a significant correlation was found between one radiomic feature and three up-regulated miRNAs(ρ=-0.56,ρ=-0.64 andρ=0.61,P<0.05).Radiogenomic analysis with BMI as clinical outcome revealed that four mRNA regulators and one up-regulated miRNA were significantly correlated with 10 and two radiomic features,respectively(-0.67<ρ<-0.54 and 0.53<ρ<0.71,P<0.05).CONCLUSION Our study revealed interesting relationships between the expression of eight N6-methyladenosine RNA regulators,as well as five up-regulated miRNAs,and CT radiomic features associated with clinical outcomes of ESCA patients. | Valentina Brancato Nunzia Garbino Lorenzo Mannelli Marco Aiello Marco Salvatore Monica Franzese Carlo Cavaliere | 2021 | World Journal of Gastroenterology2021，27，36： | 3 |
| 5 | Pheochromoeytoma 显示文摘 | Lenders JW Eisenhofer G Mannelli M | 2005 | Lancet2005，366，： | 1 |
| 6 | Hepatocellular carinoma:as- sessment of response to transarterial chemoembolization with image subtraction 显示文摘 | Kim S Mannelli L HajduCH | 2010 | MagnReson Imaging2010，31，： | 1 |
| 7 | Oxaliplatin-in- dueed neuropathy:oxidative stress as pathological mechanism显示文摘 | Di Cesere Mannelli L Zanardelli M Failli P | 2012 | J Pain2012，13，3： | 1 |
| 8 | Clinically guided genetic screeningin a large cohort of Italian patients with pheochromocytomas and/or functional ornonfunctional paragangliomas显示文摘 | Mannelli M Castellano M Schiavi F | 2009 | J Clin Endocrinol Metab2009，94，5： | 1 |
| 9 | Hepatocellular carcino- ma: assessment of response to transarterial chemoembolization with image subtraction显示文摘 | Kim S Mannelli L Hajdu C H | 2010 | J Magn Reson Imaging2010，31，2： | 1 |
| 10 | Evaluation of nonenhancing tumor fraction assessed by dynamic contrast-enhanced MRI subtract on as a predictor of decrease in tumor volume in response to chemora- diotherapy in advanced cervical cancer 显示文摘 | Mannelli L Patterson A J Zahra M | 2010 | A JR Am J Roentqenol2010，195，2： | 1 |
| 11 | Phaeochromocytoma显示文摘 | Lenders JW Eisenhofer G Mannelli M | 2005 | Lancet2005，366，9486： | 1 |
| 12 | Phaeochromocytoma显示文摘 | LendersJW Eisenhofer G Mannelli M | 2005 | Lancet2005，366，9486： | 1 |
| 13 | Antidepres- sant-like effect of artemin in mice: A mechanism for acetyl-L: - carnitine activity on depression 显示文摘 | Di Cesare Mannelli L Vivoli E Salvicchi A | 2011 | Psychopharmacology2011，218，2： | 1 |
| 14 | Subclinical phaeochromo?cytoma显示文摘 | Mannelli M LendersJW Pacak K | 2012 | Best Pract Res Clin Endocrinol Metab2012，26，4： | 1 |
| 15 | Gi/o Proteins: Expression for Direct Activation Enquiry显示文摘 | DI CESARE MANNELLI L PACINI A TOSCANO A | 2006 | Protein Expr Pufif2006，47，1： | 1 |
| 16 | Biochemical diagnosis of pheochromocytoma: which test is best显示文摘 | Lenders JW pacak K walther MM Linehan WM Mannelli M Friberg P keiser HR Goldstein DS eisenhoferG | 2002 | JAMA2002，287，11： | 1 |
| 17 | MR elastography: Spleen stiffness measurements in healthy volunteers-preliminary experi- ence显示文摘 | Mannelli L Godfrey E Joubert I | 2010 | AJR Am J Roentgenol2010，195，2： | 1 |
| 18 | Oxaliplatininduced oxidative stress in nervous system-derived cellular models:could it correlate with in vivo neuropathy?显示文摘 | Di Cesare Mannelli L Zanardelli M Failli P | 2013 | Free Radical Biology and Medicine2013，61，： | 1 |
| 19 | Subtotal su- pracricoid laryngectomy; changing in indications, surgical tech- niques and use of new surgical devices显示文摘 | Mannelli G Meccariello G Deganello A | 2014 | Am J Otolaryngol2014，35，6： | 1 |
| 20 | Phaeochromocytoma显示文摘 | Lenders JW Eisenhofer G Mannelli M | 2005 | Lancet2005，366，9486： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员