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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | A new class of bivariate copulas显示文摘 | Jos~ Antonio R L Manuel lJ F | 2004 | Statistics & Probability Letters2004，66，： | 1 |
| 3 | A two-popula- tion bioelectrochemical model of a microbial fuel cell 显示文摘 | PINTO R P SR1NIVASAN B MANUEL M F | 2010 | Biore- source Technology2010，101，： | 1 |
| 4 | Catalytic oxidation of NO to NO2 on N-doped activated car- bons显示文摘 | Juliana P S Sousa Manuel F R Pereira Jos6 L Figueiredo | 2011 | Catal Today2011，176，： | 1 |
| 5 | Immediate application of positive-end expiratory pressure is more effective than delayed positive-end expiratory pressure to reduce extravascular lung water 显示文摘 | Manuel R Enrique F Benjamin H | 1999 | Cri Care Med1999，27，2： | 1 |
| 6 | Fractionation oflignocelluloses, solubilization of corn stalk hemicelluloses byautohydrolysis in aqueous medium显示文摘 | MANUEL R JUAN F T JOAQUfN Q | 1998 | Biomass Bioenergy1998，15，6： | 1 |
| 7 | A new class of bivariate copulas显示文摘 | Jose Antonio R L Manuel U F | 2004 | Statistics & Probability Letters2004，66，： | 1 |
| 8 | The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome显示文摘 | Manuel L R Jose L S M | 2005 | Endocrine Reviews2005，26，2： | 1 |
| 9 | The ef-fective pollination period in‘Clemenules’mandarin,‘Owari’Satsuma mandarin and‘Valencia’sweet orange显示文摘 | CARLOS M AMPARO M F CARMINA R MANUEL A | 2007 | Plant Sci-ence2007，2，： | 1 |
| 10 | Efficacy of glimepiride/metformin combination versus glibenclamide/metformin in patients with uncontrolled type 2 diabetes mellitus 显示文摘 | MANUEL G O JES US F G R RAFAEL V O | 2009 | Journal of Diabetes and Its Complications2009，23，6： | 1 |
| 11 | Bragg system for temperature monitoring in dist-ribution transformer 显示文摘 | Alessandra F P Manuel L B Paul C R | 2010 | Electric Power SystemsResearch(S0378-7796)2010，80，1： | 1 |
| 12 | Efficient sub-pixel image registration algorithms显示文摘 | Manuel S G Samuel T T James F R | 2008 | Optics Letters2008，33，2： | 1 |
| 13 | Bragg system for temperature monitoring in distribution transformers 显示文摘 | ALESSANDRA F P MANUEL L B PAUL C R | 2010 | Elec- tric Power Systems Research2010，80，1： | 1 |
| 14 | Adsorption of dyes on activated carbons:influence of surface chemical groups显示文摘 | Manuel F R P Soares S F Orfao J J M | 2003 | Carbon2003，41，4： | 1 |
| 15 | A Two-population Bio-electroehemical Model of a Microbial Fuel Cell 显示文摘 | PINTO R P SRINIVASAN B MANUEL M F | 2010 | Bioresource Technology2010，101，14： | 1 |
| 16 | Imaging techniques for assessing hepatic fat content in nonalcoholic fatty liver disease 显示文摘 | Ernesto R V Rafael F Manuel M L | 2008 | Annals of Hepatology2008，7，3： | 1 |
| 17 | Prospective analysis of risk factors for hepatocelluar cacinoma in patients with liver cirrhosis 显示文摘 | Rosarlo F Manuel R Carmen A N | 2003 | Hepatology2003，37，： | 1 |
| 18 | 查看详情显示文摘 | Manuel G R Fiona F John E O Andrew I M Wemer J B Johannes G V Marcinhet P | | 0，，： | 1 |
| 19 | Evolution of austenite static recrystaUization and grain size dtu-ing hot rolling of a V-microalloyed steel 显示文摘 | Manuel G Lucia R Bemardo J F | 2009 | Materials Science and Engineering2009，501，12： | 1 |
| 20 | The Chlamydomonas genome reveals the evolution of key animal and plant functions 显示文摘 | Merchant S S Prochnik S E Vallon O Harris E H Karpowicz S J Witman G B Terry A Salamov A Fritz-Laylin L K Marechal- Drouard L Marshall W F Qu L H Nelson D R Sanderfoot A A Spalding M H Kapitonov V V Ren Q Ferris P Lindquist E Shapiro H Lucas S M Grimwood J Schmutz J Cardol P Cerutti H Chanfreau G Chen C L Cognat V Croft M T Dent R Dutcher S Fernandez E Fukuzawa H Gonzalez-Ballester D Gonzalez-Halphen D Hallmann A Hanikenne M Hippler M Inwood W Jabbari K Kalanon M Kuras R Lefebvre P A Lemaire S D Lobanov A V Lohr M Manuell A Meier I Mets L Mittag M Mittelmeier T Moroney J V Moseley J Napoli C Nedelcu A M Niyogi K Novoselov S V Paulsen I T Pazour G Purton S Ral J P Riano-Pachon D M Riekhof W Rymarquis L Schroda M Stern D Umen J Willows R Wilson N Zimmer S LAllmer J Balk J Bisova K Chen C J Elias M Gendler K Hauser C Lamb M R Ledford H Long J C Minagawa J Page M D Pan J Pootakham W Roje S Rose A Stahlberg E Terauchi A M Yang P Ball S Bowler C Dieckmann C L GIadyshev V N Green P Jorgensen R Mayfield S Mueller-Roeber B Rajamani S Sayre R T Brokstein P Dubchak I Goodstein D Hornick L Huang Y W Jhaveri J Luo Y Martinez D Ngau W C Otillar B Poliakov A Porter A Szajkowski L Werner G Zhou K Grigoriev I V Rokhsar D S Grossman A R | 2007 | Science2007，318，5848： | 1 |
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