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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | A practical approachfor fish freshness determinations using a portable electronic nose显示文摘 | Manuela 0 Gabriela V Gustavo P ef al | 2001 | Sensors and Actuators B: Chemical2001，80，： | 1 |
| 3 | A practical approach for fish freshness determinations using a portable electronic nose显示文摘 | Manuela O Gabriela V Gustavo P R | 2001 | Sensors and Actuators B2001，80，2： | 1 |
| 4 | Loureiro Number of Actives Sites in TAME Synthesis: Mechanism and Kinetic Modeling显示文摘 | Manuela V Ferreira Jose M | 2004 | Ind Eng Chem Res2004，，43： | 1 |
| 5 | Apractical approach for fish freshness determinations using a portable electronic nose显示文摘 | MANUELA O GABRIELA V GUSTAVO P | 2001 | Sensors and Actuators B2001，80，： | 1 |
| 6 | A pratical electronic nose显示文摘 | Manuela O Gabriela V Gustavo P | 2001 | Sensors and Actuators B2001，80，： | 1 |
| 7 | Low dielectric constant porous BN/SiCO made by pyrolysis of filled gels显示文摘 | Manuela V Steffen W Stefano M | 2007 | Journal of the European Ceramic Society2007，27，： | 1 |
| 8 | A practical approach for fish freshness determinations using a portable electronic nose显示文摘 | Manuela O C Gabriela V Gustavo P | 2001 | Sensors and Actuators B2001，80，： | 1 |
| 9 | Number of Actives Sites in TAME Synthesis: Mechanism and Kinetic Modeling显示文摘 | Manuela V F Jose M L | 2004 | Ind Eng Chem Res (S0098- 6445)2004，43，5： | 1 |
| 10 | Analysis of Possible Mech- anisms Accounting for Raf-1 Kinase Inhibitor Protein Downregula- tion in Hepatoceilular Carcinoma显示文摘 | Paola P Manuela L Nicoletta V | 2012 | OMICS A Journal of Integra- tive Biology2012，16，11： | 1 |
| 11 | Number of active sites in TAME synthesis: Mechanism and kinetic modeling 显示文摘 | Manuela V Ferreira Jose M Loureiro | 2004 | Ind Eng Chem Res2004，43，12： | 1 |
| 12 | Peritonneal elimination of homocysteine moieties in continuous ambulatory peritoneal dialysis patients显示文摘 | Andreas V Manuela F Menelaos P | 1999 | Kidney Int1999，55，5： | 1 |
| 13 | Synthesis and multi-target biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents 显示文摘 | Elisabet V Irene S Manuela B | 2014 | J Med Chem2014，57，6： | 1 |
| 14 | Tourette syndrome and chronic tics in a sample of children and adolescents显示文摘 | SACCOMAMI L FABIANA V MANUELA B | 2005 | Brain & Development2005，27，5： | 1 |
| 15 | Risk stratification for S plenic M arginal Z one L ymphoma based on haemoglobin concentration, platelet count, high lactate dehydrogenase level and extrahilar lymphadenopathy: development and validation on 593 cases显示文摘 | Carlos Montalbán Víctor Abraira Luca Arcaini Eva Domingo‐Domenech Pablo Guisado‐Vasco Emilio Iannito Manuela Mollejo Estella Matutes Andrés Ferreri Antonio Salar Sara Rattotti Andrea Carpaneto Ricardo Pérez Fernández José L. Bello Miguel Hernández Dolores | 2012 | Br J Haematol2012，，2： | 1 |
| 16 | Taenia solium oncosphere antigens induce immunity in pig against experimental cysticerco- sis 显示文摘 | Manuela V Robert H G Armando G | 2002 | Vet Parasitol2002，108，： | 1 |
| 17 | A practical approach for fish freshness determinations using a portable electronic nose显示文摘 | Manuela O Gabriela V Gustavo P | 2001 | Sensors and Actuators B:chemical2001，80，： | 1 |
| 18 | New Tn916-related elements causing erm (B)-mediated erythromycin resistance in tetracycline-susceptible pneumococci显示文摘 | Ileana C Emily T Manuela V etal | 2007 | J Antimicrob Chemother2007，60，1： | 1 |
| 19 | MicroRNA gene expression deregulation in human breast cancer 显示文摘 | Marilena V Iorio Manuela F | 2005 | Cancer Res2005，65，16： | 1 |
| 20 | Optimization of nonlinear constrained particle swarm 显示文摘 | ANTONIO ISMAEL de F V EDITE MANUELA da G P | 2006 | UKIO Technologinis ir Ekonominis Vystmas2006，12，1： | 1 |
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