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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death显示文摘 | Alexander Seiler Manuela Schneider Heidi F?rster Stephan Roth Eva K. Wirth Carsten Culmsee Nikolaus Plesnila Elisabeth Kremmer Olof R?dmark Wolfgang Wurst Georg W. Bornkamm Ulrich Schweizer Marcus Conrad | 2008 | Cell Metabolism2008，，3： | 2 |
| 3 | Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23–01): a phase 3 randomised controlled trial显示文摘 | Viviana Galimberti Bernard F Cole Stefano Zurrida Giuseppe Viale Alberto Luini Paolo Veronesi Paola Baratella Camelia Chifu Manuela Sargenti Mattia Intra Oreste Gentilini Mauro G Mastropasqua Giovanni Mazzarol Samuele Massarut Jean-Rémi Garbay Janez Zgajn | 2013 | Lancet Oncology2013，，4： | 2 |
| 4 | Contribution of different vegetable types to exogenous nitrate and nitrite exposure显示文摘 | Manuela Correia ngela Barroso M Fátima Barroso | 2010 | Food Chemistry2010，120，4： | 1 |
| 5 | Enhanced motor cor- tex facilitation in patients with vascular cognitive impair- ment no dementia显示文摘 | Rita B Raffaele F Manuela P | 2011 | Neurosci Lett2011，503，3： | 1 |
| 6 | MicroRNAgene expression deregulation in human breast cancer显示文摘 | Marilena VI Manuela F Chang-Gong L | 2005 | Cancer Res2005，65，16： | 1 |
| 7 | Proteolysis in dry fermented sausages:The effect of selected exogenous proteases显示文摘 | Olga D Manuela F Gonzalo D | 1997 | Meat Science1997，46，1： | 1 |
| 8 | Synthesis and characterization of novel diazenes bearing pyrrole, thiophene and thiazole heterocycles as efficient photochromic and nonlinear optical (NLO) materials显示文摘 | M. Manuela M. Raposo A. Maurício C. Fonseca M. Cidália R. Castro M. Belsley M. Fátima S. Cardoso Luís M. Carvalho Paulo J. Coelho | 2011 | Dyes and Pigments2011，，1： | 1 |
| 9 | Mechanisms mediating the enhanced transcription of the P2X3 receptor gene by calcitonin gene related pertide in reigeminal sensory neurons 显示文摘 | Manuela SI Rashid G Elsa F | 2008 | Journal of Biological Chemistry2008，283，18： | 1 |
| 10 | Evidence that N-acetylcysteine inhibits TNF-α-induced cerebrovascularen-dothelin-1 up regulation via inhibition of mitogen-andstress-activated protein kinase显示文摘 | MATTHIAS D MANUELA F MIRANDA K | 2006 | Free Radic BiolMed2006，41，： | 1 |
| 11 | Sensitivity of Chlamydia suis to cathelicidin peptides显示文摘 | MANUELA D ANTONIETTA D F RENATO G | 2007 | Vet Mi-crobiol2007，123，11： | 1 |
| 12 | Number of Actives Sites in TAME Synthesis: Mechanism and Kinetic Modeling显示文摘 | Manuela V F Jose M L | 2004 | Ind Eng Chem Res (S0098- 6445)2004，43，5： | 1 |
| 13 | Cognitive recovery after delayed carbon mono-xide encephalopathy显示文摘 | Leonardo C Manuela B Paola F | 2005 | Clin Neurol Neurosurg2005，107，4： | 1 |
| 14 | Lipophilic phenolic antioxidants: Correlation between antioxidant profile, partition coefficients and redox properties显示文摘 | Fernanda M.F. Roleira Christophe Siquet Elizabeta Orrù E. Manuela Garrido Jorge Garrido Nuno Milhazes Gianni Podda Fátima Paiva-Martins Salette Reis Rui A. Carvalho Elisiário J. Tavares da Silva Fernanda Borges | 2010 | Bioorganic & Medicinal Chemistry2010，，16： | 1 |
| 15 | MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multi- ficality显示文摘 | Laura G Francesca F Manuela F | 2009 | Clin Cancer Res2009，15，16： | 1 |
| 16 | Intact glucosinolates modulate hepatic cytochrome P450 and phase Ⅱ conjugation activities and may contribute directly to the chemopreventive activity of cruciferous vegetables显示文摘 | Ahmad F Abdull Razis Manuela Bagatta | | 0，，11： | 1 |
| 17 | Angiotensin Type 2 Receptor Stimulation Ameliorates Left Ventricular Fibrosis and Dysfunction via Regulation of Tissue Inhibitor of Matrix Metalloproteinase 1/Matrix Metalloproteinase 9 Axis and Transforming Growth Factor β1 in the Rat Heart显示文摘 | Dilyara Lauer Svetlana Slavic Manuela Sommerfeld Christa Th?ne-Reineke Yuliya Sharkovska Anders Hallberg Bjorn Dahl?f Ulrich Kintscher Thomas Unger Ulrike Muscha Steckelings Elena Kaschina | 2014 | Hypertension2014，，3： | 1 |
| 18 | Peritonneal elimination of homocysteine moieties in continuous ambulatory peritoneal dialysis patients显示文摘 | Andreas V Manuela F Menelaos P | 1999 | Kidney Int1999，55，5： | 1 |
| 19 | Biomechanical analysis of cages for posterior lumbar interbody fusion显示文摘 | Alfonso F Fabio G Manuela TR | 2007 | Med Eng Phys2007，29，1： | 1 |
| 20 | Enhanced motor cor- tex facilitation in patients with vascular cognitive impair- ment no dementia 显示文摘 | Rita B Raffaele F Manuela P | 2011 | Neurosci Lett2011，503，3： | 1 |
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