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| 1 | Clinical significance of cytomegalovirus infection in patients with inflammatory bowel disease显示文摘Cytomegalovirus(CMV) infection is common in humans.The virus then enters a 'latency phase' and can reactivate to different stimuli such as immunosuppression.The clinical significance of CMV infection in inflammatory bowel disease is different in Crohn's disease(CD) and ulcerative colitis(UC).CMV does not interfere in the clinical course of CD.However,CMV reactivation is frequent in severe or steroid-resistant UC.It is not known whether the virus exacerbates the disease or simply appears as a bystander of a severe disease.Different methods are used to diagnose CMV colitis.Diagnosis is classically based on histopathological identification of viral-infected cells or CMV antigens in biopsied tissues using haematoxylin-eosin or immunohistochemistry,other tests on blood or tissue samples are currently being investigated.Polymerase chain reaction performed in colonic mucosa has a high sensitivity and a positive result could be associated with a worse prognosis disease;further studies are needed to determine the most appropriate strategy with positive CMV-DNA in colonic mucosa.Specific endoscopic features have not been described in active UC and CMV infection.CMV colitis is usually treated with ganciclovir for several weeks,there are different opinions about whether or not to stop immunosuppressive therapy.Other antiviral drugs may be used.Multicenter controlled studies would needed to determine which subgroup of UC patients would benefit from early antiviral treatment. | Elena Garrido Elisa Carrera Rebeca Manzano Antonio Lopez-Sanroman | 2013 | World Journal of Gastroenterology2013，19，1： | 7 |
| 2 | First-line single-agent cetuximab in elderly patients with metastatic colorectal cancer. A phase II clinical and molecular study of the Spanish group for digestive tumor therapy (TTD)显示文摘 | J. Sastre E. Aranda C. Grávalos B. Massutí M. Varella-Garcia F. Rivera G. Soler A. Carrato J.L. Manzano E. Díaz-Rubio M. Hidalgo | 2009 | Critical Reviews in Oncology and Hematology2009，，1： | 2 |
| 3 | Sorafenib for non-selected patient population with advanced hepatocellular carcinoma: efficacy and safety data according to liver function显示文摘 | Jon Zugazagoitia Aránzazu Manzano Javier Sastre Jose María Ladero Javier Puente Eduardo Díaz-Rubio | 2013 | Clinical and Translational Oncology2013，，2： | 2 |
| 4 | Efficacy of the vaccination in inflammatory bowel disease显示文摘Inflammatory bowel disease (IBD) is associated with conditions that may predispose to infections, such as the lack of an appropriate innate immune response to infectious agents, malnutrition, surgery, and immunosuppressive and biological drugs. Some of these infections may be preventable by vaccination. Therefore, for this particular patient population, the benefits of implementing a well-established immunization protocol in daily clinical practice are potentially even greater than for the general population. In recent years international consensus guidelines have been published, but in spite of theses recommendations, studies have shown that a significant number of patients with IBD remain inadequately immunized. Another important issue regarding immunization in this population is that vaccine efficacy among patients receiving immunosuppressive therapies has been variable. In a healthy population, a humoral immune response to hepatitis B vaccination (HBV) is expected in > 90%, whereas a much lower rate is achieved in the IBD patients. Immunosuppressive, anti-tumor necrosis factor therapy and disease activity have been implicated in the impaired efficacy of the vaccination. The serological response to HBV should be confirmed and patients with an inadequate response should receive a second full series of vaccine. Modified dosing regimens, including doubling the standard antigen dose, might increase the effectiveness. Response to influenza, pneumococcal and tetanus immunization is still not clear, as there are studies that show a normal response to the vaccination while others demonstrate a lack of efficacy. We pose a series of questions on the efficacy of the different vaccinations recommended for IBD patients and attempt to answer them using scientific evidence. | Elisa Carrera Rebeca Manzano Elena Garrido | 2013 | World Journal of Gastroenterology2013，19，9： | 2 |
| 5 | Markers for bacterial infection in children with fever without source显示文摘 | Manzano S Bailey B Gervaix A | 2011 | Arch Dis Child2011，96，5： | 1 |
| 6 | An evolutionary multiobjective framework for structural damage localization and quantification显示文摘 | Perera R Ruiz A Manzano C | | 0，，10： | 1 |
| 7 | Effects of CaMK Ⅱ-mediated phosphorylation of ryanodine receptor type 2 on is-let calcium handling,insulin secretion,and glucose tolerance显示文摘 | Dixit SS Wang T Manzano EJ | | 0，，3： | 1 |
| 8 | Differential effects of triiodothyronine and the thyroid hormone receptor beta-specific agonist GC-1 onthyroid hormonetarget genesinthe brain显示文摘 | Manzano J Morte B Scanlan TS | 2003 | Endocrinology2003，144，12： | 1 |
| 9 | Flavor Mixing, Gauge Invariance and Wave Function Renormalization显示文摘 | Espriu D Manzano J Talavera P | 2002 | Physical Review D2002，66，07： | 1 |
| 10 | Value of the ankle-brachial index in cardiovascular risk stratification of patients without known atherotrom-hotic disease显示文摘 | MANZANO L MOSTAZA J M SUAREZ C | 2007 | Med Clin (Barc)2007，128，： | 1 |
| 11 | Ho- mografts and xenografts tbr right ventricular outflow tract re- construction: long-term results 显示文摘 | Christenson JT Sierra J Colina Manzano NE | 2010 | Ann Thorac Surg2010，90，： | 1 |
| 12 | Noradrenaline transporter and its turnover rate are decreased in blood lymphocytes of patients with major depression显示文摘 | Mata S Urbina M Manzano E | 2005 | J Neuroimmunol2005，170，12： | 1 |
| 13 | Com- parison o{ two repositioning schedules {or the prevention of pressure ulcers in patients on mechanical ventilation with al- ternating pressure air mattresses 显示文摘 | Manzano F Colmenero M P~rez-P6rez A M | 2014 | Intensive Care Med2014，40，11： | 1 |
| 14 | Testing intravitreal toxicity of bevacizumab (Avastin)显示文摘 | Manzano RP Peyman GA Khan P Kivilcim M | 2006 | Retina2006，26，3： | 1 |
| 15 | Different proinflammatory cytokine serum pattern in neonate patients undergoing open heart surgery 显示文摘 | Alcaraz AJ Manzano L Sancho L | 2005 | J Clin Immunol2005，25，3： | 1 |
| 16 | The influence of thermochemical sulphate reduction on hydrocarbon tomposition in Nisku reservoirs,Brazeau river area,Alberta,Canada显示文摘 | MANZANO B K FOWLER M G MACHEL H G | 1997 | Organic Geochemistry1997，27，78： | 1 |
| 17 | Association of hyperhomocysteinemia with liver steatosis in patients with chronic hep- atitis C 显示文摘 | Fernandez-Miranda C Manzano ML Fernandez I | 2011 | Med Clin (Bare)2011，136，2： | 1 |
| 18 | A nested PCR method to detect Listeria momocytogenes in artificially contaminated blood specimens显示文摘 | Cocolin L Manzano M Cantomi C | 1997 | Res Microbiol1997，148，： | 1 |
| 19 | Processes of desertification by goats overgrazing in the Tamaulipan thornscrub (matorral) in north eastern Mexico显示文摘 | Manzano M G Navar J | 2000 | Journal of Arid Environments2000，44，： | 1 |
| 20 | An application of PCR- DGGE analysis to profile the yeast populations in raw milk 显示文摘 | Cocolin L Aggio D Manzano M | 2002 | International Dairy Journal2002，12，5： | 1 |
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