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| 1 | Portal vein thrombosis in cirrhosis: Controversies and latest developments显示文摘Portal vein thrombosis(PVT) is encountered in livercirrhosis, particularly in advanced disease. It has been a feared complication of cirrhosis, attributed to significant worsening of liver disease, poorer clinical outcomes and potential inoperability at liver transplantation; also catastrophic events such as acute intestinal ischaemia. Optimal management of PVT has not yet been addressed in any consensus publication.We review current literature on PVT in cirrhosis; its prevalence, pathophysiology, diagnosis, impact on the natural history of cirrhosis and liver transplantation,and management. Studies were identified by a search strategy using MEDLINE and Google Scholar. The incidence of PVT increases with increasing severity of liver disease: less than 1% in well-compensated cirrhosis, 7.4%-16% in advanced cirrhosis. Prevalence in patients undergoing liver transplantation is 5%-16%.PVT frequently regresses instead of uniform thrombus progression. PVT is not associated with increased risk of mortality. Optimal management has not been addressed in any consensus publication. We propose areas for future research to address unresolved clinical questions. | Damian J Harding M Thamara PR Perera Frederick Chen Simon Olliff Dhiraj Tripathi | 2015 | World Journal of Gastroenterology2015，21，22： | 42 |
| 2 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 3 | Current status and recent advances of liver transplantation from donation after cardiac death显示文摘The last decade saw increased organ donation activity from donors after cardiac death (DCD). This contributed to a signif icant proportion of transplant activity. Despite certain drawbacks, liver transplantation from DCD donors continues to supplement the donor pool on the backdrop of a severe organ shortage. Understanding the pathophysiology has provided the basis for modulation of DCD organs that has been proven to be effective outside liver transplantation but remains experimental in liver transplantation models. Research continues on how best to further increase the utility of DCD grafts. Most of the work has been carried out exploring the use of organ preservation using machine assisted perfusion. Both ex-situ and in-situ organ perfusion systems are tested in the liver transplantation setting with promising results. Additional techniques involved pharmacological manipulation of the donor, graft and the recipient. Ethical barriers and end-of-life care pathways are obstacles to widespread clinical application of some of the recent advances to practice. It is likely that some of the DCD offers are in fact probably 'prematurely' of-fered without ideal donor management or even prior to brain death being established. The absolute benef its of DCD exist only if this form of donation supplements the existing deceased donor pool; hence, it is worthwhile revisiting organ donation process enabling us to identify counter remedial measures. | M Thamara PR Perera Simon R Bramhall | 2011 | World Journal of Gastrointestinal Surgery2011，3，11： | 16 |
| 4 | 化石燃料燃烧对儿童健康的多重威胁:空气污染和气候变化的影响显示文摘[背景]一直以来,评估和解决化石燃料对儿童健康风险的方法或者倾向于关注有毒气体排放,或者倾向于关注气候变化,这些方法分散而不完整。处于生长发育期的儿童,尤其是贫困儿童,现在承担着化石燃料燃烧所致环境污染和气候变化而引起的过重的疾病负担。[目的]针对化石燃料燃烧对儿童健康当前及预期的多重影响,本文对相关的翔实科学证据进行了综述,说明需要实施以儿童为中心的能源和气候综合政策,以期应对源于化石燃料污染所带来的全部生理和社会心理应激。[讨论]本文概述的数据显示,通过大幅减少对化石燃料的依赖,可以为儿童及其未来实现非常明显的健康和经济收益。这些收益不仅立竿见影,而且持续终生,甚至可能跨越几代人。[结论]除了进行强有力的科学和经济论证,采取紧急行动以减少化石燃料燃烧,这是保护我们最脆弱人群的当务之急和道义所在。 | 宋彦 金泰廙 Perera F P | 2017 | 环境与职业医学2017，34，8： | 13 |
| 5 | 低剂量利伐沙班或低剂量利伐沙班联合阿司匹林与缺血性脑卒中亚型显示文摘抗血小板治疗仍然是大多数非房颤相关性缺血性脑卒中亚型二级预防的主要手段。使用抗凝策略的患者的心血管结局(COMPASS)试验,评估了利伐沙班联合阿司匹林与利伐沙班单用或阿司匹林单用对脑卒中的二级预防的疗效。COMPASS研究是一项多中心双盲随机安慰剂对照研究,来自于33个国家的医院共纳入了27395例稳定的动脉粥样硬化性血管疾病患者。 | 樊蕴辉 Perera K | 2020 | 中国康复2020，35，1： | 13 |
| 6 | Recovery of Nitrogen and Phosphorous as Struvite From Swine Waste Biogas Digester Effluent显示文摘Objective To investigate the feasibility of nitrogen and phosphorus recovery from swine waste biogas digester effluent and the effects of pH and NH4+: Mg2+: PO43- molar ratio on its precipitation. Methods Precipitation experiments with swine waste biogas digester effluent were conducted at pH 7.5, 8.0, 8.5, and 9.0 together with NH4+: Mg2+: PO43- molar ratios 1: 0.2: 0.08, 1: 1: 1, and 1: 1.5: 1.5. Chemical and X-ray diffraction (XRD) analysis were done to determine the composition of the precipitate. Results The highest removal and recovery of NH4+ and PO43- were achieved at pH 9.0 in each experiment. The elevation of pH to 9.0 alone could decrease the initial PO43- concentration from 42 mg L-1 to 4.7 mg L-1 and 89.2% PO43- recovery was achieved. The pH-molar ratio combination 9.0-1: 1.5: 1.5 effected 76.5% NH4+ and 68.5% PO43- recovery. The molar ratio of 1: 1: 1 together with pH elevation to 9.0 was determined to be the optimum combination for both NH4+ and PO43- removal as it recovered over 70% and 97% of the initial NH4+ and PO43-, respectively. Conclusions Nitrogen and phosphorus can be recovered from biogas digester effluent as struvite. | P. W. ANTON PERERA | 2007 | Biomedical and Environmental Sciences2007，20，5： | 11 |
| 7 | Childhood constipation as an emerging public health problem显示文摘Functional constipation(FC) is a significant health problem in children and contrary to common belief, has serious ramifications on the lives of children and their families. It is defined by the Rome criteria which encourage the use of multiple clinical features for diagnosis. FC in children has a high prevalence(0.7%-29%) worldwide, both in developed and developing countries. Biopsychosocial risk factors such as psychological stress, poor dietary habits, obesity and child maltreatment are commonly identified predisposing factors for FC. FC poses a significant healthcare burden on the already overstretched health budgets of many countries in terms of out-patient care, in-patient care, expenditure for investigations and prescriptions. Complications are common and range from minor psychological disturbances, to lower health-related quality of life. FC in children also has a significant impact on families. Many paediatric clinical trials have poor methodological quality, and drugs proved to be useful in adults, are not effective in relieving symptoms in children. A significant proportion of inadequately treated children have similar symptoms as adults. These factors show that constipation is an increasing public health problem across the world with a significant medical, social and economic impact. This article highlights the potential public health impact of FC and the possibility of overcoming this problem by concentrating on modifiable risk factors rather than expending resources on high cost investigations and therapeutic modalities. | Shaman Rajindrajith Niranga Manjuri Devanarayana Bonaventure Jayasiri Crispus Perera Marc Alexander Benninga | 2016 | World Journal of Gastroenterology2016，22，30： | 10 |
| 8 | 未固结流砂地层采油过程中出砂情况模拟实验显示文摘为了研究未固结流砂储集层在采油过程中的出砂情况和影响出砂的主要因素,进行了不同条件下的出砂过程模拟实验。使用水洗白砂、黏土(高岭土)和蒸馏水制成未固结流砂地层模型,利用新开发的出砂模拟装置进行了模拟实验,并分析了作用于地层的拖曳力和地层胶结特征对出砂的影响。研究表明,随着拖曳力的增加,出砂速度和产油速度都加快;随着胶结物含量的增加,出砂量和产油量明显降低,甚至在胶结物含量较高的情况下出砂量几乎为零。地层压力大的油藏在开采期间由于产生了较大的拖曳力更可能出砂,而拖曳力和有效地层应力共同影响油藏的总体产油量。可以根据地层黏土含量估计出砂情况,从而通过采取适当的防砂措施尽可能减少出砂量。某些情况下油藏比气藏更容易出砂。 | PERERA M S A RANJITH P G RATHNAWEERA T D DE SILVA G P D LIU T | 2017 | 石油勘探与开发2017，44，5： | 8 |
| 9 | Struvite Recovery from Swine Waste Biogas Digester Effluent through a Stainless Steel Device under Constant pH Conditions显示文摘To investigate the struvite precipitation under constant and non-constant pH conditions and to test a stainless steel device under different operating regimes to maximize the recovery of struvite.Methods The molar ratio of NH4+:Mg2+:PO43-was adjusted to 1:1.2:1.2 and pH was elevated to 9.0.The absorbance measurement was used to trace the process of struvite crystallization.Wastewater and precipitate analysis was done by standard analytical methods.Results The pH constant experiment reported a significantly higher struvite precipitation(24.6±0.86 g) than the non-constant pH experiment(19.8±1.86 g).The SAR ranged from 5.6 to 8.2 g m-2 h-1 to 3.6-4.8 g m-2 h-1 in pH constant and non-constant experiments,respectively.The highest struvite deposit on the device was found in regime 3 followed by in regimes 2 and 4.The highest PO43-(97.2%) and NH4+(71%) removal was reported in the R1 regime.None of the influent Cu2+ or Zn2+ was precipitated on the device.Conclusion A higher struvite yield is evident in pH constant experiments.Moreover,the stainless steel device facilitates the isolation of heavy metal free pure(around 96%) struvite from swine waste biogas digester effluent contaminated with cu2+ and Zn2+ and the highest yield is attainable with the device operating at 50 rpm with agitation by a magnetic stirrer. | P.W.ANTON PERERA | 2009 | Biomedical and Environmental Sciences2009，22，3： | 6 |
| 10 | 益肾蠲痹丸对类风湿性关节炎的药效学研究(英文)显示文摘目的:使用弗氏完全佐剂制作大鼠关节炎模型,评价益肾蠲痹丸对类风湿性关节炎的药效。方法:使用弗氏完全佐剂造模后,测量益肾蠲痹丸对对侧足爪肿胀和脏器指数的影响;ELISA法检测其对血清肿瘤坏死因子α(TNF-α),白介素1β(IL-1β),白介素-6(IL-6)的影响;分光光度法测量总一氧化氮合酶(tNOS)和诱导型一氧化氮合酶(iNOS)活性;并用Western blot法检测益肾蠲痹丸对凋亡蛋白Bcl-2表达的影响。结果:益肾蠲痹丸可有效抑制大鼠佐剂性关节炎所引起的足跖肿胀,且对胸腺脾脏指数无明显影响。益肾蠲痹丸可有效抑制血清中TNF-α,IL-1β,IL-6含量;抑制血清中iNOS活性;下调Bcl-2在滑膜组织中的表达。结论:益肾蠲痹丸的抗类风湿关节炎的作用与其调节主要炎症因子,下调炎症部位Bcl-2蛋白表达有关。 | PERERA Pathirage-Kamal 彭程 吕雪 李运曼 方伟蓉 韩才峰 | 2010 | 中国天然药物2010，8，1： | 5 |
| 11 | 益肾蠲痹丸对大鼠胶原性关节炎继发病变治疗作用的实验研究显示文摘目的:评价益肾蠲痹丸对大鼠胶原性关节炎(collegen induced arthritis,CIA)继发病变的治疗作用,并探讨其可能的作用机制。方法:于大鼠左后足底皮内注射胶原乳剂制备CIA模型,造模两周后灌胃给药14天,每4天测量1次右后足跖容积。处死后取右后足作病理切片。Western blot法测定踝关节滑膜组织中NF-κBp65亚基和环氧化酶-2蛋白表达。结果:益肾蠲痹丸可抑制CIA大鼠的足趾肿胀,与模型相比有显著或极显著差异;显著降低NF-κBp65亚基和COX-2的水平。结论:益肾蠲痹丸对CIA大鼠具有较强的抗炎作用,机制可能与抑制NF-κBp65亚基和COX-2的表达有关。 | 彭程 李运曼 Pathirage Kamal Perera 韩才峰 滕奇 | 2010 | 中国中医药科技2010，17，5： | 5 |
| 12 | A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion显示文摘heterodimeric 的激活(α /β) 由 cytosolic 蛋白质 talin 的 integrin transmembrane 受体为调整多样的 cell-adhesion-dependent 过程是关键的包括血凝结,改变的组织,和癌症转移。这进程被 talin (talin-FERM ) 的 N 终端 FERM (four-point-one-protein/ezrin/radixin/moesin ) 领域的重合的绑定触发到内部膜表面和 integrin β细胞质的尾巴,但是这些有约束力的事件怎么空间与时间地被调整,仍然保持阴暗。这里,我们报导休眠 talin 的水晶结构,揭示怎么一个 C 终端 talin 杆片断(talin-RS ) 自我面具经由一个大接口的 talin-FERM 上的一个关键 integrin 有约束力的地点。出人意料地,结构也在静电地妨碍 talin-FERM 绑定到膜的 talin-RS 上揭示不同否定地控告的表面。为 talin 的如此的双禁止的拓扑学与生物化学、功能的数据一致,但是与一个以前的模型显著地不同。我们与 phosphotidylinositol-4,5-bisphosphate (PIP2 ) 在丰富之上显示出那 - 已知的 talin 使活跃之物,膜强烈在 talin-FERM 上吸引断然控告的表面并且同时在 talin-RS 上排斥否定地控告的表面。如此的静电的 “ pull-push”过程支持 talin-FERM 的双抑制的消除,它不同于经典 “位的 clash”为常规导致 PIP2 的 FERM 领域激活当模特儿。这些数据因此解开膜依赖者 FERM 领域规定的一种新类型并且说明它怎么调停 talin 开/关换到调整 integrin transmembrane 发信号和房间粘附。 | Xianqiang Song Jun Yang Jamila Hirbawi Sheng Ye H Dhanuja Perera Esen Goksoy Pallavi Dwivedi Edward F Plow Rongguang Zhang Jun Qin | 2012 | Cell Research2012，22，11： | 5 |
| 13 | Sign changing solutions of Kirchhoff type problems via invariant sets of descent flow显示文摘 | Zhitao Zhang Kanishka Perera | 2005 | Journal of Mathematical Analysis and Applications2005，，2： | 3 |
| 14 | Dengue fever may mislead the surgeons when it presents as an acute abdomen显示文摘Objective: To review the management experience of a consecutive series of patients presenting as acute surgical abdomen whom were ultimately diagnosed to have DF(Dengue fever)/ DHF(Dengue heamorrhagic fever),Methods: Clinical data of all cases of apparent acute abdomen(AA) which were later confirmed as having DF/DHF reviewed by two surgical units from December 2012 to December 2013 were analyzed,Initially confirmed patients with DF/DHF who developed abdominal symptoms were not considered,Results: Out of the seventeen cases(7 males,age range 10-71 years) presented with fever and AA; appendicitis,cholecystitis,pancreatitis and non-specific peritonitis were suspected initially in 8,5,1 and 3 cases,respectively,Neutropenia or thrombocytopenia signifying DF/DHF occurred only in 11 patients at first evaluation thus six remained as surgical candidates beyond 24 h,One patient underwent appendicectomy with a prolonged hospital stay,DF was confirmed by serology in all patients,latest by fourth day of admission,One required blood product transfusion,4 needed critical care treatment and there was 1 death,Conclusions: DF/DHF misleads the clinicians when it presents as AA,Initial heamatological and ultrasonographic findings may be equivocal creating a diagnostic and management dilemma,Vigilant clinical suspicion and early dengue serological assessment is advisable in equivocal cases of AAs with fever in dengue endemic areas,to confirm/exclude the infection in order to avoid unnecessary surgical morbidity in the presence of DF. | Bingumal Jayasundara Lalith Perera Ajith de Silva | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，1： | 3 |
| 15 | Low-Cost UV-IR Dual Band Detector Using Nonporous ZnO Film Sensitized by PbS Quantum Dots显示文摘一个便宜光导的双乐队的察觉者用 PbS 量点(QD ) 敏化的一部 nanoporous ZnO 电影被准备。在房间温度,设备与 4.0 的 370 nm 山峰 responsivity 在 200400 nm 的波长范围显示出紫外回答吗? | 邵佳锋 A. G. U. Perera P. V. V. Jayaweera 贺德衍 | 2010 | Chinese Physics Letters2010，27，2： | 3 |
| 16 | Virology, epidemiology, pathogenesis, and control of enterovirus 71显示文摘 | Tom Solomon Penny Lewthwaite David Perera Mary Jane Cardosa Peter McMinn Mong How Ooi | 2010 | The Lancet Infectious Diseases2010，，11： | 2 |
| 17 | Generative design of stable semiconductor materials using deep learning and density functional theory显示文摘Semiconductor device technology has greatly developed in complexity since discovering the bipolar transistor.In this work,we developed a computational pipeline to discover stable semiconductors by combining generative adversarial networks(GAN),classifiers,and high-throughput first-principles calculations.We used CubicGAN,a GAN-based algorithm for generating cubic materials and developed a classifier to screen the semiconductors and studied their stability using first principles.We found 12 stable AA′MH_(6)semiconductors in the F-43m space group including BaNaRhH_(6),BaSrZnH_(6),BaCsAlH_(6),SrTlIrH_(6),KNaNiH_(6),NaYRuH_(6),CsKSiH_(6),CaScMnH_(6),YZnMnH_(6),NaZrMnH_(6),AgZrMnH_(6),and ScZnMnH_(6).Previous research reported that five AA′IrH_(6)semiconductors with the same space group were synthesized.Our research shows that AA′MnH_(6)and NaYRuH_(6)semiconductors have considerably different properties compared to the rest of the AA′MH_(6)semiconductors.Based on the accurate hybrid functional calculations,AA′MH_(6)semiconductors are found to be wide-bandgap semiconductors.Moreover,BaSrZnH_(6)and KNaNiH_(6)are direct-bandgap semiconductors,whereas others exhibit indirect bandgaps. | Edirisuriya M.Dilanga Siriwardane Yong Zhao Indika Perera Jianjun Hu | 2022 | npj Computational Materials2022，，1： | 2 |
| 18 | A systematic review on the safety and efficacy of yttrium-90 radioembolization for unresectable, chemorefractory colorectal cancer liver metastases显示文摘 | Akshat Saxena Lourens Bester Leonard Shan Marlon Perera Peter Gibbs Baerbel Meteling David L. Morris | 2014 | Journal of Cancer Research and Clinical Oncology2014，，4： | 2 |
| 19 | Negligible risk of inducing resistance in Mycobacterium tuberculosis with single-dose rifampicin as post-exposure prophylaxis for leprosy显示文摘Post-exposure prophylaxis(PEP)for leprosy is administered as one single dose of rifampicin(SDR)to the contacts of newly diagnosed leprosy patients.SDR reduces the risk of developing leprosy among contacts by around 60%in the first 2–3 years after receiving SDR.In countries where SDR is currently being implemented under routine programme conditions in defined areas,questions were raised by health authorities and professional bodies about the possible risk of inducing rifampicin resistance among the M.tuberculosis strains circulating in these areas.This issue has not been addressed in scientific literature to date.To produce an authoritative consensus statement about the risk that SDR would induce rifampicin-resistant tuberculosis,a meeting was convened with tuberculosis(TB)and leprosy experts.The experts carefully reviewed and discussed the available evidence regarding the mechanisms and risk factors for the development of(multi)drug-resistance in M.tuberculosis with a view to the special situation of the use of SDR as PEP for leprosy.They concluded that SDR given to contacts of leprosy patients,in the absence of symptoms of active TB,poses a negligible risk of generating resistance in M.tuberculosis in individuals and at the population level.Thus,the benefits of SDR prophylaxis in reducing the risk of developing leprosy in contacts of new leprosy patients far outweigh the risks of generating drug resistance in M.tuberculosis. | Liesbeth Mieras Richard Anthony Wim van Brakel Martin W.Bratschi Jacques van den Broek Emmanuelle Cambau Arielle Cavaliero Christa Kasang Geethal Perera Lee Reichman Jan Hendrik Richardus Paul Saunderson Peter Steinmann Wing Wai Yew | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 20 | Several distinct genes encode nearly identical 16 kDa proteolipids of the vacuolar H+-ATPase from Arabidopsis thaliana显示文摘 | Imara Y. Perera Xuhang Li Heven Sze | 1995 | Plant Molecular Biology1995，，2： | 2 |
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