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9篇 您的检索式:作者名="Maolei"
    题名 作者 年代 出处 被引量
1Co-seismic displacements of 2011 Japan Mw9.0 earthquake recorded by far-field GPS stations显示文摘Co-seismic displacements of the 2011 Mw9.0 Japan earthquake recorded by GPS stations in China and surrounding areas showed a movement toward the epicenter. The horizontal displacements were up to 1-3 cm in northeastern China, 3-8 mm in the North China, and 2 cm in the Korean peninsula. The vertical movements in China were small uplifts.Yang Shaomin Nie Zhaosheng Jia Zhige Chen Huijie Peng Maolei 2011Geodesy and Geodynamics2011,2,3:7
2GeneticDiversityAnalysisofTibetanBrassicacampestrisI[J]显示文摘WANGJinxiong(王晋雄) LIUJia(刘佳) MAOLei(毛磊) etal 西藏农业科技0,,:1
3Video stabilization and target tracking for airship monitoring system显示文摘ZHANG Maolei CHEN Tao YUAN Hongyong 2010Progress in Safety Science and Technology Series2010,3,8:1
4A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers显示文摘Mutations of the RAS oncogene are found in around 30%of all human cancers yet direct targeting of RAS is still considered clinically impractical except for the KRAS^(G12C)mutant.Here we report that RAS-ON(RASON),a novel protein encoded by the long intergenic non-protein coding RNA 00673(LINC00673),is a positive regulator of oncogenic RAS signaling.RASON is aberrantly overexpressed in pancreatic ductal adenocarcinoma(PDAC)patients,and it promotes proliferation of human PDAC cell lines in vitro and tumor growth in vivo.CRISPR/Cas9-mediated knockout of Rason in mouse embryonic fibroblasts inhibits KRAS-mediated tumor transformation.Genetic deletion of Rason abolishes oncogenic KRAS-driven pancreatic and lung cancer tumorigenesis in LSL Kras^(G12D);Trp53R172H/+mice.Mechanistically,RASON directly binds to KRAS^(G12D)/V and inhibits both intrinsic and GTPase activating protein(GAP)-mediated GTP hydrolysis,thus sustaining KRAS^(G12D/V)in the GTP-bound hyperactive state.Therapeutically,deprivation of RASON sensitizes KRAS mutant pancreatic cancer cells and patient-derived organoids to EGFR inhibitors.Our findings identify RASON as a critical regulator of oncogenic KRAS signaling and a promising therapeutic target for KRAS mutant cancers.Rongjie Cheng Fanying Li Maolei Zhang Xin Xia Jianzhuang Wu Xinya Gao Huangkai Zhou Zhi Zhang Nunu Huang Xuesong Yang Yaliang Zhang Shunli Shen Tiebang Kang Zexian Liu Feizhe Xiao Hongwei Yao Jianbo Xu Chao Yan Nu Zhang 2023Cell Research2023,33,1:1
5Vaccination with the repeat β-hCG C-terminal peptide carried by heat shock protein-65 (HSP65) for inducing antitumor effects显示文摘Jie Yang Yankai Zhang Huaqian Wang Zhenqiu Gao Zeyu Wang Bin Liu Xiuhua Zhang Mingzhu Du Xiao Huang Maolei Xu Jie Wu Taiming Li Jingjing Liu Rongyue Cao 2012Tumor Biology2012,,:1
6LTE system optimization on application of MTC显示文摘Maolei Daiqian Zhangyincheng 2012Telecommunication Network Technology2012,,8:1
7Loss of the TNFα function inhibits Wnt/β-catenin signaling, exacerbates obesity development in adolescent spontaneous obese mice显示文摘Maolei Gong Chuanguo Liu Liang Zhang Hongbin Zhang Jie Pan 2014Molecular and Cellular Biochemistry (-)2014,,1:1
8Video Target Tracking Based on Scale Adaptation and Tracking Box Rotations显示文摘Ma Wei Chen Jianguo Zhang Maolei 2012Journal of Tsinghua University2012,52,1:1
9Nu- merical simulation study on CO2 flooding in ultra-low permeability reservoirs显示文摘Cui Maolei Ding Yunhong Yang Zhengming 2011Procedia Environmental Sci- ences2011,,14:1
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