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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Medicinal plants from open-air markets in the State of Rio de Janeiro, Brazil as a potential source of new antimycobacterial agents显示文摘 | Fernanda Leit?o Suzana G. Leit?o Mara Zélia de Almeida Jéssica Cantos Tatiane Coelho Pedro Eduardo A. da Silva | 2013 | Journal of Ethnopharmacology2013，，： | 2 |
| 3 | Association of nonalcoholic fatty liver disease with insulin resistance显示文摘 | Giulio Marchesini Mara Brizi Antonio M Morselli-Labate Giampaolo Bianchi Elisabetta Bugianesi Arthur J McCullough Gabriele Forlani Nazario Melchionda | 1999 | The American Journal of Medicine1999，，5： | 2 |
| 4 | Political Con- nections and Corporate Bailouts 显示文摘 | Faceio Mara Ronald W Masulis John J | 2006 | Journal of Finance2006，61，： | 1 |
| 5 | S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial显示文摘 | Mato JM Cámara J Fernández de Paz J | 1999 | J Hepatol1999，30，6： | 1 |
| 6 | Phase-space tomography with a programmable Radon-Wigner display显示文摘 | Cámara A Alieva T Rodrigo J A | 2011 | Optics letters2011，36，13： | 1 |
| 7 | Struc- ture and cytotoxicity of new polyhydroxylated sterols from the Caribbean gorgonian Plexaurella grisea 显示文摘 | Ana Rueda Eva Zuh'a Mara J Orteg'a | 2001 | Steroids2001，66，： | 1 |
| 8 | Structure - based interpretation of the mutagenesis database for the nucleotide binding domains of P - glycoprotein 显示文摘 | Lawson J O' Mara ML Kerr ID | 2008 | BBA - Biomemberanes2008，1778，2： | 1 |
| 9 | Changes in volatile com- position of Madeira wines during their oxidative ageing显示文摘 | Ci MARA J S ALVES M A MARQUES J C | 2006 | Anal Chim Acta2006，563，1： | 1 |
| 10 | Intake of whole grains, re-fined grains,and cereal fiber measured with 7 -d diet records andassociations with risk factors for chronic disease 显示文摘 | Newby PK Maras J Bakun P | 2007 | Am J ClinNutr2007，86，6： | 1 |
| 11 | Frquency and fracture morphology of the postermedial fragment in bicondylar tibial plateau fracture patterns显示文摘 | Barei DP O′Mara J Taitsman LA | 2008 | J Orthop Trauma2008，22，3： | 1 |
| 12 | Near-fatal heat stroke during the1995heat wave in Chicago显示文摘 | Dematte JE O’Mara K Buescher J | 1998 | Annals of internal medicine1998，129，3： | 1 |
| 13 | Frequency and fracture morphology of the posteromedial fragment in bicondylar tibial plateau fracture patterns显示文摘 | Barei D P O’Mara T J Taitsman L A | 2008 | Jrthop Trauma2008，22，3： | 1 |
| 14 | Near-fatal heat stroke during the 1995 heat wave in Chicago显示文摘 | Dematte JE O'Mara K Buescher J | 1998 | Ann Intern Med1998，129，3： | 1 |
| 15 | Sorbitol-fermenting bifidobacteria as specific in- dicators of human faecal pollution显示文摘 | Mara D D Oragui J I | 1983 | Journal of Applied Bacteriology1983，55，2： | 1 |
| 16 | A comparison of parathyroid hormone‐related protein (1‐36) and parathyroid hormone (1‐34) on markers of bone turnover and bone density in postmenopausal women: The PrOP study显示文摘 | Mara J Horwitz Marilyn Augustine Leila Kahn Emily Martin Christine C Oakley Raquel M Carneiro Mary Beth Tedesco Angela Laslavic Susan M Sereika Alessandro Bisello Adolfo Garcia‐Oca?a Caren M Gundberg Jane A Cauley Andrew F Stewart | 2013 | J Bone Miner Res2013，，11： | 1 |
| 17 | Occurrence of Rhodococcus coprophilus and as- sociated aetinomycetes in feces, sewage, and freshwater显示文摘 | Mara D D Oragui J I | 1981 | Applied & Envirouraental Microbiology1981，42，6： | 1 |
| 18 | Empirical evaluation of spatial and non-spatial European-scale multimedia fate models:results and implications for chemical risk assessment显示文摘 | ARMITAGE J M COUSINS I T MARA H | 2007 | Journal of Environmental Monitoring2007，9，6： | 1 |
| 19 | Application of PLS and back-propagation neural networks for the estimation of soil properties显示文摘 | ZIAD R PHILIP K H MARA J J | 2005 | Chemometrics and Intelligent Laboratory Systems2005，75，1： | 1 |
| 20 | Composition and run-time adaptation of mismatching behavioral interfaces显示文摘 | Cámara J Salaün G Canal C | 2008 | J UCS2008，14，13： | 1 |
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