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| 1 | Tenecteplase Reperfusion therapy in Acute ischaemic Cerebrovascular Events-Ⅱ (TRACE Ⅱ): rationale and design显示文摘Background and purpose Tenecteplase(TNK)is a promising agent for treatment of acute ischaemic stroke(AIS).We hypothesised that recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)is non-inferior to rt-PA in achieving excellent functional outcome at 90 days,when administered within 4.5 hours of ischaemic stroke onset.Methods and design Tenecteplase Reperfusion therapy in Acute ischemic Cerebrovascular Events(TRACE)is a phase Ⅲ,multicentre,prospective,randomised,open-label,blinded-end point non-inferiority study.Patients eligible for intravenous thrombolysis therapy are randomised to rhTNK-tPA 0.25 mg/kg(single bolus)to a maximum of 25 mg or rt-PA 0.9 mg/kg(10%bolus+90%infusion/1 hour)to a maximum of 90 mg.Medications considered necessary for the patient’s health may be given at the discretion of the investigator during 90-day follow-up.Study outcomes The primary study outcome is excellent functional outcome defined as modified Rankin Scale(mRS)0–1 at 90 days.Secondary efficacy outcomes include favourable functional outcome defined as mRS≤2 at 90 days,ordinal distribution of mRS and major neurological improvement on the National Institutes of Health Stroke Scale.Safety outcomes are symptomatic intracranial haemorrhage within 36 hours and death from any cause.Discussion There is no completed registration study of TNK in AIS worldwide.TRACE Ⅱ strives to provide evidence for a new drug application for rhTNK-tPA in AIS within 4.5 hours through a well-designed and rigorously executed randomised trial in China. | Shuya Li Bruce C V Campbell Lee H Schwamm Marc Fisher Mark Parsons Hao Li Yuesong Pan Yongjun Wang | 2022 | Stroke & Vascular Neurology2022，7，1： | 2 |
| 2 | 查看详情显示文摘 | Iojoiu C Abadie Marc J.M Harabagiu V Pinteala M.and Simionescu Bogdan C | | 0，，： | 1 |
| 3 | Cardiac function during intraperitoneal CO2 insuttlation for aortic surgery: s transesophageal echocardiographic study显示文摘 | Pascal A Antoine V Marc C | 2006 | Anesth Analg2006，102，5： | 1 |
| 4 | Analysis of Groundwater' Resource Decline in an Intermountain Aquifer System in Central Iran显示文摘 | Marc V C Mahdi R Kristine M | | Geologica Belgica0，15，3： | 1 |
| 5 | Effectcs of a porous pavement with reservoir structure on the quality of runoff water and soil 显示文摘 | Legre M Colandini V Marc Le C | 1996 | The Science of the Total Environment1996，189，190： | 1 |
| 6 | Structural Snapshots of Human HDAC8 ProvideInsights into the Class I His- tone Deacetylases显示文摘 | John RS Robert JS Bradley AK Clifford M Joseph DH Andy JJ Christine L Andrew A Joseph JB Ellen C Jie T Bi CS Erik V Robert W Ellen ML Douglas RD Gyorgy S Marc N Mark WK Ronald VS Duncan EM and Leslie WT | 2004 | Structure2004，12，： | 1 |
| 7 | Functional study of the human thyroid perexidase gene promoter显示文摘 | Marc A Gilbert V Daniel C | 1992 | Eur J Biochem1992，203，3： | 1 |
| 8 | Skin contact irritation conditions the development and severity of allergic contact dermatitis 显示文摘 | MARLENE B CYNL C MARC V | 2007 | J Invest Dermatol2007，127，6： | 1 |
| 9 | Enhancement of oxidative stress tolerance in transgenic tobacco plants overproducing Fe-superoxide dismutase in chloroplasts显示文摘 | WIM V C KATELIJNE C MARC V M DIRK I LUIT S | 1996 | Plant Physiology1996，112，： | 1 |
| 10 | Effects of a porous pavement with reservoir structure on the quality of runoff water and soil 显示文摘 | LEGRET M COLANDINI V ke MARC C | 1996 | The Science of the Total Environment1996，28，： | 1 |
| 11 | Ultra-wideband,short-pulse ground-penetrating radar:Simulation and Measurement显示文摘 | Stanislav V Lawrence C Marc A R | 1997 | IEEE Transactions on Geoscience and Remote Sensing1997，35，3： | 1 |
| 12 | Bistatic terra SARX/F-SAR spaceborne-airborne SAR experiment:Description,data processing,and results显示文摘 | MARC R C STEFAN V B | 2010 | IEEE Transactions on Geoscience and Remote Sensing2010，48，2： | 1 |
| 13 | Therapeutic anticoagulation for splanchnic vein thrombosis in acute pancreatitis: A national survey and case-vignette study显示文摘BACKGROUND Splanchnic vein thrombosis(SVT)is a major complication of moderate and severe acute pancreatitis.There is no consensus on whether therapeutic anticoagulation should be started in patients with acute pancreatitis and SVT.AIM To gain insight into current opinions and clinical decision making of pancreatologists regarding SVT in acute pancreatitis.METHODS A total of 139 pancreatologists of the Dutch Pancreatitis Study Group and Dutch Pancreatic Cancer Group were approached to complete an online survey and case vignette survey.The threshold to assume group agreement was set at 75%.RESULTS The response rate was 67%(n=93).Seventy-one pancreatologists(77%)regularly prescribed therapeutic anticoagulation in case of SVT,and 12 pancreatologists(13%)for narrowing of splanchnic vein lumen.The most common reason to treat SVT was to avoid complications(87%).Acute thrombosis was the most important factor to prescribe therapeutic anticoagulation(90%).Portal vein thrombosis was chosen as the most preferred location to initiate therapeutic anticoagulation(76%)and splenic vein thrombosis as the least preferred location(86%).The preferred initial agent was low molecular weight heparin(LMWH;87%).In the case vignettes,therapeutic anticoagulation was prescribed for acute portal vein thrombosis,with or without suspected infected necrosis(82%and 90%),and thrombus progression(88%).Agreement was lacking regarding the selection and duration of long-term anticoagulation,the indication for thrombophilia testing and upper endoscopy,and about whether risk of bleeding is a major barrier for therapeutic anticoagulation.CONCLUSION In this national survey,the pancreatologists seemed to agree on the use of therapeutic anticoagulation,using LMWH in the acute phase,for acute portal thrombosis and in the case of thrombus progression,irrespective of the presence of infected necrosis. | Noor J Sissingh Jesse V Groen Hester C Timmerhuis Marc G Besselink Bas Boekestijn Thomas L Bollen Bert A Bonsing Frederikus A Klok Hjalmar C van Santvoort Robert C Verdonk Casper H J van Eijck Jeanin E van Hooft Jan Sven D Mieog | 2023 | World Journal of Gastroenterology2023，29，21： | 1 |
| 14 | No link between avascular necrosis of the femoral head and antiphospholipid antibodies显示文摘 | Dromer C Marc V Laroche M | 1997 | Rev Rhum Engl Ed1997，64，： | 1 |
| 15 | Plant Sensitivity to Low Intensity 105 GHz Electromagnetic Radiation显示文摘 | Marc T Verdus M C Norris V | 2004 | Bioelectromagnetics2004，25，： | 1 |
| 16 | Interactome: gateway into systems biology 显示文摘 | Michael E C Niels K Marc V | 2005 | Hum Mol Genet2005，14，2： | 1 |
| 17 | Magnetic reso- nance imaging and axial inw~lvement in spondylarthropathies: delineation of the spinal entheses 显示文摘 | Marc V Dromer C Le Guennec P | 1997 | Rev Rhum Engl Ed1997，64，79： | 1 |
| 18 | Design for testability in hardware-software systems显示文摘 | Harald P E V Marc F W Ronald C V | 1996 | IEEE Design and Test of Computers1996，13，3： | 1 |
| 19 | Genome sequence of the palaeopolyp|oid soybean 显示文摘 | Jeremy S Steven B C Jessica S Ma J X Therese M William N David L H Qijian S Jay J T Cheng J L Xu D Uffe H Gregory D M Yeisoo Y Tetsuya S Taishi U Madan K B Devinder S Babu V Erika L Myron P David G Shu S Q David G Kerrie B Montona F Brian A Du J C Tian Z Zhu L Navdeep G Trupti J Marc L Anand S Zhang X C Kazuo S Henry T N Rod A Perry C James S Jane G Dan R Gary S Randy C S Scott A J | 2010 | Nature2010，463，： | 1 |
| 20 | High speed acquisition of multiparameter data using a Macintosh IIcx 显示文摘 | BERNO A JOHN S V MARC C | 1991 | Nucl Instrum Methods1991，5657，2： | 1 |
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