|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 指南2.0:为成功制定指南而系统研发的全面清单显示文摘背景虽然当前已有一些评估卫生保健指南可靠性的工具,但仍缺乏针对制定指南实际步骤的指导。针对指南制定者们所需考虑的相关资源和工具,我们系统研发了一份全面的条目清单,但这并不意味着每篇指南都需遵守该清单的所有条目。方法我们检索了国际指南制定机构的指南制定手册、指南的指南(主要是来自国际和国家机构以及专业学会的方法学报告),以及提供系统指导的最新文章。经过反复评价这些资料,尽可能全面地罗列和提取条目,并制定与指南有关的重要主题。通过反复讨论,我们对条目进行评价以去重和补漏,同时邀请指南制定专家对所增加的条目进行修改并提出建议。结果我们制定了一份包含18个主题、146个条目的清单,并建立了帮助指南制定者应用这些条目的网站。这些主题和条目涵盖了指南从规划、完成、实施和评估的全过程。最终的清单版本也包括了培训所需的资料以及应用这些条目时用到的方法学参考文献的链接。解释本清单将提供给指南制定者用作参考。仔细考虑清单中的条目将有助于指南的制定、实施和评估,我们也将会通过大众反馈来修订并持续更新清单。 | Holger J. Schunemann Wojtek Wiercioch Itziar Etxeandia Maicon Falavigna Nancy Santesso Reem Mustafa Matthew Ventresca Romina Brignardello-petersen] Kaja-Triin Laisaar Sergio Kowalski Tejan Baldeh Yuan Zhang Uiia Raid Ignacio Neumann Susan L. Norris Judith Thornton Robin Harbour Shaun Treweek Gordon Guyatt Pablo Alonso-Coello Marge Reinap Jan Brozek Andrew Oxman Elie A. Akl | 2014 | 中国循证医学杂志2014，14，9： | 26 |
| 2 | Chemopreventive Effects of Black Tea Polyphenols in Mouse Skin Model of Carcinogenesis显示文摘In the present investigations, the antitumorigenic effect of black tea polyphenols (BTP) in twcrstage mouse skin model of carcinogenesis was studied. The animals were initiated with a single 'subcarcinogenic' topical dose (52 μg/200 μl acetone ) of 7, 12-dimethylbenzanthracene (DMBA). To evaluate the anti-tumour initiating activity, BTP was topically applied twice a week for three weeks prior to DMBA application, followed by topical treatment with 12-o-tetradecanoyl phorbol-13-acetate (TPA) (5 μg/200 μl acetone, 2x/wk. ) as promoter. For evaluation of antitumor promoting activity, BTP was applied prior to each treatment of TPA. BTP application showed marked inhibitory effect as antitumour initiator as well as antitumour promoter in mouse skin medel of two-stage carcinogenesis. Since initiation involves genetic pathway and tumour promotion involves epigenetic pathway, it seems that BTP exerts its antitumorigenic effect by altering both genetic and epigenetic | SEEMA JAVED N. K. MEHROTRA AND YOGESHWER SHUKLA(Laboratory of Environmental Chrcinogenesis, Industrial Toxicology Research Centre, M. G. Marg, P. O. Box 80,Lucknow - 226001, India) | 1998 | Biomedical and Environmental Sciences1998，11，4： | 15 |
| 3 | Neutral Red Retention by Earthworm Coelomocytes: A Biomarker of Cadmium Contamination in Soil显示文摘The earthworm Metaphire posthuma were used as a model to assess the toxic potential of cadmium incorporated into the soil by environmental or human activities. The retention period of neutral red in the lysosomes of the coelomocytes was used as a biomarker. The viability of harvested coelomocytes by a non_invasive extrusion protocol was 93% with no alteration by the dye during experimentation. The control cells retained dye for 119 and 121 min in normal soil and KCl, respectively, whereas a linear decline in the retention time in the treated earthworm coelomocytes was observed. This illustrated that the presence of cadmium caused damage to the lysosomes of the coelomocytes. | S. K. GUPTA Cell Biology Section, Industrial Toxicology Research Centre, M. G. Marg, P. B. No. 80, Lucknow 226 001, India | 2000 | Biomedical and Environmental Sciences2000，13，2： | 10 |
| 4 | 影响糖尿病患者心血管危险因素集簇现象的因素显示文摘目的 分析影响糖尿病患者多种心血管危险因素集簇现象的因素。方法 调查 6 54例糖尿病患者并发症情况和血糖、胰岛素、HbA1c、胆固醇、甘油三酯、LDL 胆固醇、HDL 胆固醇、体重指数、腰围、臀围以及腰臀围比值等因素 ,采用HOMA公式计算出胰岛素抵抗指数。按照并存心血管危险因素 (高血压、全身性肥胖、中心性肥胖、高胆固醇血症、低HDL 胆固醇血症 )数量 ,进行分析。结果 并有 3种以上的心血管危险因素明显地高于随机的单一因素并存的计算预测值 ,餐后胰岛素水平和胰岛素面积随危险因素的增加而增加。采用有性别差异的全身性肥胖和中心性肥胖的诊断标准 ,女性糖尿病患者有更多的心血管危险因素。如果采用男女性别相同的诊断标准 ,这种并存多种心血管危险因素的性别差异则消失。多数患者的这些危险因素未得到良好的控制。结论 糖尿病多种心血管危险因素集簇是常见的 。 | 许樟荣 Lynda Molyneaux 敬华 王玉珍 刘彦君 Marg RN McGill 黄列军 Dennis Yue | 2001 | 中华内分泌代谢杂志2001，17，5： | 8 |
| 5 | Antitumor Activity of Diallyl Sulfide in Two-StageMouse Skin Model of Carcinogenesis显示文摘It has been reported that diallyl sulfide (DAS), a sulfur-containing volatile compound in garlic (Allium sativum ), exerts anticarcinogenic activity in various rodent tumor models. In the present study, the antitumor property of DAS was tested in Swiss albino mice in the two steqe initiation-promotion mouse skin carcinogenesis. Skin cancers were initiated topically with a single subcarcinOgenic dose (52μg) of 7, 12-dimethyl benz (a) anthracene (DMBA). Promotion was performed by twice weekly applications of 12-O-tetradecanoyl phorbol-13-acetate (TPA) at a dose of 5μg/animal for 32 weeks. DAS was applied topically (250μg/animal) thrice weekly for 3 weeks for anti-initiating and 1 h prior to each promotion treatment for anti-promoting studies. The results showed that the treatment schedule of DAS can effectively delay the onset of tumorigenesis and reduce the cumulative number of tumors and the average number of tumors per mouse. In groups in which DAS applied prior to initiation or promotion, a significant population of the aniinals remained tumor-free till the termination of experiment. These findings suggest that DAS can effectively inhibit chemically induced mouse skincarcinogenesis. | ALKA SINGH AND YOGESHWER SHUKLA(Laboratory of Environmental Chrcinogenesis, Industrial ToxicologyResearch Centre, P. O. Box 80, M. G. Marg,Lucknow-226 001, India) | 1998 | Biomedical and Environmental Sciences1998，11，3： | 5 |
| 6 | The Soft X-ray Imager(SXI)on the SMILE Mission显示文摘The Soft X-ray Imager(SXI)is part of the scientific payload of the Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission.SMILE is a joint science mission between the European Space Agency(ESA)and the Chinese Academy of Sciences(CAS)and is due for launch in 2025.SXI is a compact X-ray telescope with a wide field-of-view(FOV)capable of encompassing large portions of Earth’s magnetosphere from the vantage point of the SMILE orbit.SXI is sensitive to the soft X-rays produced by the Solar Wind Charge eXchange(SWCX)process produced when heavy ions of solar wind origin interact with neutral particles in Earth’s exosphere.SWCX provides a mechanism for boundary detection within the magnetosphere,such as the position of Earth’s magnetopause,because the solar wind heavy ions have a very low density in regions of closed magnetic field lines.The sensitivity of the SXI is such that it can potentially track movements of the magnetopause on timescales of a few minutes and the orbit of SMILE will enable such movements to be tracked for segments lasting many hours.SXI is led by the University of Leicester in the United Kingdom(UK)with collaborating organisations on hardware,software and science support within the UK,Europe,China and the United States. | S.Sembay A.L.Alme D.Agnolon T.Arnold A.Beardmore A.Belén Balado Margeli C.Bicknell C.Bouldin G.Branduardi-Raymont T.Crawford J.P.Breuer T.Buggey G.Butcher R.Canchal J.A.Carter A.Cheney Y.Collado-Vega H.Connor T.Crawford N.Eaton C.Feldman C.Forsyth T.Frantzen G.Galgóczi J.Garcia G.Y.Genov C.Gordillo H-P.Gröbelbauer M.Guedel Y.Guo M.Hailey D.Hall R.Hampson J.Hasiba O.Hetherington A.Holland S-Y.Hsieh M.W.J.Hubbard H.Jeszenszky M.Jones T.Kennedy K.Koch-Mehrin S.Kögl S.Krucker K.D.Kuntz C.Lakin G.Laky O.Lylund A.Martindale J.Miguel Mas Hesse R.Nakamura K.Oksavik N.Østgaard H.Ottacher R.Ottensamer C.Pagani S.Parsons P.Patel J.Pearson G.Peikert F.S.Porter T.Pouliantis B.H.Qureshi W.Raab G.Randal A.M.Read N.M.M.Roque M.E.Rostad C.Runciman S.Sachdev A.Samsonov M.Soman D.Sibeck S.Smit J.Søndergaard R.Speight S.Stavland M.Steller TianRan Sun J.Thornhill W.Thomas K.Ullaland B.Walsh D.Walton C.Wang S.Yang | 2024 | Earth and Planetary Physics2024，8，1： | 4 |
| 7 | Evaluation of Cytogenetic Effects of Isoproturon on the Root Meristem Cells of Allium sativum显示文摘Objective\ To validate the use of Allium sativum as a reliable test model for genotoxicity, isoproturon, a substituted phenylalkylurea herbicide, was evaluated on the root meristem cells by this plant system. Method\ Test concentrations were selected by determining EC50 and root tips were exposed to various concentrations for 6 or 24 hr. EC50 concentration was calculated to be 70.8 ppm for the root growth. In addition to root growth retardation exposure to isoproturon induced morpholoogical changes like discolouration and stiffness of roots. Results\ Exposure to various experimental concentrations of isoproturon (35-280 ppm), including EC50, significantly and dose-dependently inhibited the mitotic index and induced chromosome breaks/mitotic aberrations at 6 or 24 hr. Conclusion\ The frequency of aberrations was found to be decreased in a dose dependant manner at 24 or 48 hr post exposure, however in comparison of control cells the frequency of aberrations was considerably high which indicates genotoxicity potentials of isoproturon. Further, present study also suggests that Allium sativum is a sensitive, efficient, and reliable test system for measuring the genotoxicity potential of environmental chemicals. | L. K. S. CHAUHAN, P. N. SAXENA, AND S. K. GUPTA1Cell Biology Section, Industrial Toxicology Research Centre, P. B. No. 80, M. G. Marg, Lucknow- 226001, India\ \ | 2001 | Biomedical and Environmental Sciences2001，14，3： | 3 |
| 8 | 科技改善妊娠糖尿病不良结局显示文摘整个孕期良好的血糖控制是母婴健康的关键,而合理的应用科技是达到这一成功的基石。我们可以通过血糖仪,糖化血红蛋白(HbA_1c),持续血糖监测,辅理善瞬感扫描检测仪来监测血糖;运用胰岛素泵,闭环胰岛素输注系统来降糖治疗。产后48小时我们通过Pea Pod仪器测定新生儿身体成份来判断孕期血糖控制情况。 | Marg McGill 邢玉微 许樟荣 | 2017 | 临床荟萃2017，32，8： | 2 |
| 9 | 中美冠心病监护病房护理工作的调查与比较显示文摘 | 刘绍辉 张琼 Jae Patton Marge Funk | 2001 | 护士进修杂志2001，16，3： | 2 |
| 10 | Clinical value of plasma soluble urokinase-type plasminogen activator receptor levels in term neonates with infection or sepsis: a prospective study显示文摘 | Siahanidou T Margeli A Tsirogianni C | 2014 | Mediators Inflamm2014，2014，37： | 1 |
| 11 | Maintenance treatment with pegylated liposomal doxorubicin versus observation following induction chemotherapy for metastatic breast cancer:GEICAM 2001-01 study 显示文摘 | ALBA E RUIZ-BORREGO M MARGELI M | 2010 | Breast Cancer Res Treat2010，122，： | 1 |
| 12 | A new noninvasive method for the estimation ofpeak dPdt 显示文摘 | Rhodes J UdeIson JE Marg GR | 2010 | Circulation2010，88，6： | 1 |
| 13 | Visual acu-ity development in human infants: Evoked potential measurements 显示文摘 | Marg E Freeman DN Peltzman P | 1976 | Invest Ophthalmol Vis Sci1976，15，2： | 1 |
| 14 | Transition from Educational System to Labour Market in the European Union: A Comparison between New and Old Members显示文摘 | Saar Ellu Marge Unt and Irena Kogan | 2008 | International Journal of Comparative Sociology2008，49，1： | 1 |
| 15 | The PRECEDE-PRCEED model: application to planning a child pedestrian injury prevention pro- gram 显示文摘 | Peter H Steve J Marg H | 1997 | Injury Prevention1997，3，： | 1 |
| 16 | Detection of serum deoxyribonucleic acid methylation markers: a novel diagnostic tool for thyroid cancer显示文摘 | Shuiying I-I Marge E Ralph PT | 2006 | Clin Endocrinol Metab2006，91，1： | 1 |
| 17 | Effects of activator and high-pull headgear combination therapy:skeletal,dentoalveolar,and soft tissue profile changes 显示文摘 | | 2007 | Eur J Orthod2007，29，2： | 1 |
| 18 | Effects of Preoperative Education on Patient Outcomes After Joint Replacement Surgery显示文摘 | Marge Kearney Mary Kay Jennrich Sheri Lyons | 2011 | Orthopaedic Nursing2011，30，6： | 1 |
| 19 | DNA binding controls inactivation and nuclear accumulaton of the transcription factor STATI显示文摘 | Meyer T Marg A Lemke P | 2003 | Gene Dev2003，17，16： | 1 |
| 20 | Radiation Heat Transfer in Cellular Foam Insulation 显示文摘 | Glicksman L R Marge A L Moreno J D | 1992 | HTD Developments in Radiative Heat Transfer ASME1992，203，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员