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| 1 | Device-associated infection rates, mortality, length of stay and bacterial resistance in intensive care units in Ecuador: International Nosocomial Infection Control Consortium's findings显示文摘AIM To report the results of the International Nosocomial Infection Control Consortium(INICC) study conducted in Quito, Ecuador.METHODS A device-associated healthcare-acquired infection(DAHAI) prospective surveillance study conducted from October 2013 to January 2015 in 2 adult intensive care units(ICUs) from 2 hospitals using the United States Centers for Disease Control/National Healthcare Safety Network(CDC/NHSN) definitions and INICC methods. RESULTS We followed 776 ICU patients for 4818 bed-days. The central line-associated bloodstream infection(CLABSI) rate was 6.5 per 1000 central line(CL)-days, the ventilator-associated pneumonia(VAP) rate was 44.3 per 1000 mechanical ventilator(MV)-days, and the catheterassociated urinary tract infection(CAUTI) rate was 5.7 per 1000 urinary catheter(UC)-days. CLABSI and CAUTI rates in our ICUs were similar to INICC rates [4.9(CLABSI) and 5.3(CAUTI)] and higher than NHSN rates [0.8(CLABSI) and 1.3(CAUTI)]- although device use ratios for CL and UC were higher than INICC and CDC/NSHN's ratios. By contrast, despite the VAP rate was higher than INICC(16.5) and NHSN's rates(1.1), MV DUR was lower in our ICUs. Resistance of A. baumannii to imipenem and meropenem was 75.0%, and of Pseudomonas aeruginosa to ciprofloxacin and piperacillin-tazobactam was higher than 72.7%, all them higher than CDC/NHSN rates. Excess length of stay was 7.4 d for patients with CLABSI, 4.8 for patients with VAP and 9.2 for patients CAUTI. Excess crude mortality in ICUs was 30.9% for CLABSI, 14.5% for VAP and 17.6% for CAUTI. CONCLUSION DA-HAI rates in our ICUs from Ecuador are higher than United States CDC/NSHN rates and similar to INICC international rates. | Estuardo Salgado Yepez Maria M Bovera Victor D Rosenthal Hugo A González Flores Leonardo Pazmino Francisco Valencia Nelly Alquinga Vanessa Ramirez Edgar Jara Miguel Lascano Veronica Delgado Cristian Cevallos Gasdali Santacruz Cristian Pelaéz Celso Zaruma Diego Barahona Pinto | 2017 | World Journal of Biological Chemistry2017，8，1： | 23 |
| 2 | Brazilian biosafety law and the new breeding technologies显示文摘Globally,the area of land cultivated with genetically modified(GM)crops has increased a thousand-fold over the last two decades.Although this technology has become important for food production,the regulatory frameworks that underpin these outcomes are based on a list of requirements for a risk assessment that differ from country to country.In recent years,policymakers have had the opportunity to learn from the controversies over transgenics to create effective regulatory milestones for emerging technologies,allowing them to reach their potential for a more sustainable agriculture,ensuring food security.In Brazil,Law No.11.105 of 24 March 2005 established a framework with four main organizations responsible for risk assessment and management.However,most of new breeding technologies did not exist at that time and were not considered in this law.In2016,Normative Resolution No.16 of the National Biosafety Technical Commission(CTNBio)was established to address this gap based on the evaluation of the products obtained through these techniques(termed Innovative Precision Improvement Techniques in the resolution),in a case-by-case consultation system.Briefly,if the product is designated to be a GM,the developer will have to go through the biosafety requirements and will be approved only after CTNBio risk assessment.If the product is designated not to be GM(for the purposes of the legislation),then it can be registered using the existing procedures.Currently,152 GM products are commercially approved in Brazil.In 2018,CTNBio assessed the first consultation on commercial release of plants generated using the new breeding technologies and has subsequently approved six products.It is expected that many institutions would be able to participate in Brazilian and world markets,developing and introducing new biotechnological solutions and products through a more sustainable approach and without facing public disapproval,a common issue for GM crops. | Alexandre Lima NEPOMUCENO Renata FUGANTI-PAGLIARINI Maria Sueli Soares FELIPE Hugo Bruno Correa MOLINARI Edivaldo Domingues VELINI Eduardo Romano de Campos PINTO Maria Lucia Zaidan DAGLI Galdino ANDRADE FILHO Patricia Machado Bueno FERNANDES | 2020 | Frontiers of Agricultural Science and Engineering2020，7，2： | 5 |
| 3 | High prevalence of vitamin A deficiency in Crohn's disease patients according to serum retinol levels and the relative dose-response test显示文摘AIM:To assess the vitamin A status of patients with Crohn's disease(CD) by evaluating serum retinol levels and the relative dose response(RDR) test(liver retinol stores).METHODS:Vitamin A nutritional status was measured by serum retinol obtained by high performance liquid chromatography and the RDR test for evaluation of the hepatic stores.Body composition was performed by densitometry by dual-energy X-ray absorptiometry.Vitamin A dietary intake was assessed from a semiquantitative food frequency questionnaire.RESULTS:This study included 38 CD patients and 33 controls.Low serum retinol concentrations were detected in 29% of CD patients vs 15% in controls(P < 0.005).The RDR test was positive in 37% of CD patients vs 12% in controls,which indicated inadequate hepatic vitamin A stores(P < 0.005).Individuals with hypovitaminosis A had lower BMI and body fat compared with those without this deficiency.There was no association between vitamin A deficiency and its dietary intake,ileal location,presence of disease activity and prior bowel resections.CONCLUSION:Patients with CD have higher prevalence of vitamin A deficiency,as assessed by two independent methods. | Márcia Soares-Mota Tianny A Silva Luanda M Gomes Marco AS Pinto Laura MC Mendon?a Maria Lúcia F Farias Tiago Nunes Andrea Ramalho Cyrla Zaltman | 2015 | World Journal of Gastroenterology2015，21，5： | 4 |
| 4 | 青少年和年轻成人先天性心脏病的心理社会远期转归显示文摘目的先天性心脏病(CHD)是一种在全球范围内高发的慢性疾病,通常在出生时或出生前确诊。由于诊断以及早期药物和手术治疗的条件较好,患者的生存率达到90%,并且生存时间不断延长,面临着生活中的各种挑战。该研究探讨了不同人口统计学、临床和心理社会变量对CHD青少年和年轻成人患者的生活质量(QOL)感知、心理社会适应和精神障碍患病率的影响,评估CHD青少年和年轻成人患者的生活质量、心理社会适应和精神障碍发病率,确定哪些变量(人口统计学、临床和心理社会变量)对缓解压力、促进恢复起到积极作用,哪些变量起到不良作用。方法该研究入组了150名CHD患者(男87例,女63例),年龄12~26岁(平均年龄:17.45±3.373岁)。对参与者进行了关于社会支持、家庭教育方式、自我形象、人口统计信息和生理限制等方面的访谈。他们对标准化精神病学访谈(SADS-L)中的问题进行了回答,并填写了自我报告问卷,以进行生活质量(WHOQOL-BREF)和心理社会适应(YSR/ASR)的评估。结果所有参与者精神障碍的终身患病率为18.7%(女性25.4%,男性13.8%)。57.1%的参与者有过留级(平均1.53±0.804年)。与整体葡萄牙人相比,CHD患者的生活质量感知在社会关系、环境、身体和总体方面较好。而女性、学习成绩差、较少的社会支持、复杂性CHD、紫绀型CHD、中重度残留病灶、接受过手术和有生理限制患者生活质量感知较差。除了紫绀,所有这些变量也会引起较差的心理社会适应。结论女性CHD患者及学习成绩差且获得社会支持少的CHD患者的心理社会适应和生活质量较差。 | Maria Emlha Gulmaraes Arelas Catarina I. Pinto Patricia F. Vieira Flavio Teixeira Rosalia. Coelho Isabela Freitas Samantha Matos Marta Castro Sofia Sarmento Victor Viana Jorge Quintas Jose C. Areias | 2013 | 中国当代儿科杂志2013，15，10： | 3 |
| 5 | Characterization of goat whey proteins and their bioactivity and toxicity assay显示文摘Goat whey is an industry-discarded dairy by-product that has interesting nutritional value and a nutrient composition with important functional potential,where proteins have a high biological value and play an important role in the organism’s physiology.Therefore,the aim of this study was to identify,quantify,concentrate and investigate the capacity of goat whey proteins to perform different biological activities and to evaluate their acute toxicity.Concentrated proteins were quantified and identified by Bradford,Kjehdal and SDS-PAGE methods.Antibacterial activity was performed against Listeria monocytogenes,Salmonella spp.,Staphylococcus aureus,Pseudomonas aeruginosa and Escherichia coli microorganisms and showed MIC ranging from 15 to 120μg mL-1,with the highest inhibition for L.monocytogenes growth.Antiproliferative activity was performed against human malignant melanoma cells and their proliferation inhibition was up to 66.8%within 72 h of exposure.The highest antioxidant capacity was obtained at concentration 2 mg that showed 29.69%of inhibition of DPPH radical oxidation.The acute toxicity test was performed using Artemia franciscana larvae in which whey proteins were able to preserve larval survival throughout exposure.Thus,we can conclude that goat’s whey has proteins that can play a positive effect on health,with antimicrobial activity and without toxicity.The present study highlights the great potential of goat’s whey to be developed as a safe biopreservative or as a functional ingredient in the food industry. | Maria Isabel Ferreira Campos Paula Perazzo de Souza Barbosa Laura Junqueira Camargo Luciano Da Silva Pinto Bianca Mataribu Catarina Serr˜ao Luis Fernando Marques-Santos Jos´e Hon´orio Lopes Julia Mariano Caju de Oliveira Carlos Alberto de Almeida Gadelha Tatiane Santi-Gadelha | 2022 | Food Bioscience2022，46，2： | 2 |
| 6 | Intravoxel incoherent motion MR imaging for prostate cancer: An evaluation of perfusion fraction and diffusion coefficient derived from different b ‐value combinations显示文摘 | Yuxi Pang Baris Turkbey Marcelino Bernardo Jochen Kruecker Samuel Kadoury Maria J. Merino Bradford J. Wood Peter A. Pinto Peter L. Choyke | 2012 | Magn Reson Med2012，，： | 2 |
| 7 | The use of lidocaine as an anti-inflammatory substance: A systematic review显示文摘 | Hugo Cesar Pinto Marques Caracas José Vinícius Bolognesi Maciel Patrícia Machado Rodrigues e Silva Martins Margareth Maria Gomes de Souza Lucianne Cople Maia | 2008 | Journal of Dentistry2008，，2： | 1 |
| 8 | 壳聚糖基皮革抗菌涂层的研究(续)显示文摘自抗菌类涂料在鞋材中应用以来,引起了制造商和消费者的极大兴趣。研究利用壳聚糖固有的抗菌活性和成膜性制备皮革抗菌材料。考虑到皮革鞣制的特殊性,采用不同的涂饰技术,如转鼓浸渍、辊涂和喷涂。结果表明,采用转鼓浸渍的方法效果最佳。进一步研究了转鼓浸渍涂饰方法中壳聚糖的用量、增溶酸剂的类型和浸渍时间,对抗菌剂抗菌能力的影响。由于壳聚糖价格昂贵(成本原因)以及对最终试验结果(采用SEM考察了抗菌能力和成膜效果)的分析,得出最佳方案:壳聚糖用量为1%(w/v),溶剂为甲酸,转鼓浸渍时间为2h。 | Isabel P. Fernandes Joana S. Amaral Vera Pinto Maria José Ferreira Maria Filomena Barreiro 陈小珂 | 2014 | 中国皮革2014，43，5： | 1 |
| 9 | Under expression of the Na+ -dependent neutral amino acid transporter ASCT2 in the spontaneously hypertensive rat kidney显示文摘 | Maria Joan Pinho Vanda Pinto Maria Paula Serrao | 2007 | American Journal of Physiology Regulatory Integrative and Comparative Physiology2007，293，： | 1 |
| 10 | Age and years in practice as factors associated with needlestick and sharps injuries among health care workers in a Portuguese hospital显示文摘 | Artur Martins Ana C. Coelho Manuela Vieira Manuela Matos Maria L. Pinto | 2012 | Accident Analysis and Prevention2012，，： | 1 |
| 11 | How does fish metamorphosis affect aromatic amino acid metabolism?显示文摘 | Wilson Pinto Luis Figueira Maria Teresa Dinis ct al | 2009 | Amino Acids2009，36，： | 1 |
| 12 | Lipoxygenase inhibition by flavonoids: semiempirical study of the structure–activity relation显示文摘 | Modesto Redrejo-Rodriguez Adrian Tejeda-Cano Maria del Carmen Pinto Pedro Mac??as | 2003 | Journal of Molecular Structure: THEOCHEM2003，，1： | 1 |
| 13 | Thirty years of information literacy ( 1977 - 2007) :A terminologi - cal, conceptual and statistical analysis 显示文摘 | Maria Pinto Jos6 Antonio Cord6n Raquel G6mez Diaz | 2010 | Journal of Li- brarian - ship and Information Science2010，，1： | 1 |
| 14 | Operational optimization of the utility system of an oil refinery显示文摘 | Micheletto Sandra R Carvalho Maria C A Pinto Jose M | | 0，，： | 1 |
| 15 | Succinate Dehydrogenase Kidney Cancer: An Aggressive Example of the Warburg Effect in Cancer显示文摘 | Christopher J. Ricketts Brian Shuch Cathy D. Vocke Adam R. Metwalli Gennady Bratslavsky Lindsay Middelton Youfeng Yang Ming-Hui Wei Stephen E. Pautler James Peterson Catherine A. Stolle Berton Zbar Maria J. Merino Laura S. Schmidt Peter A. Pinto Ramaprasa | 2012 | The Journal of Urology2012，，： | 1 |
| 16 | Microstructural and hardness investigation of an aluminum-copper alloy processed by laser surface melting 显示文摘 | Maria Aparecida Pinto Noe Cheung Maria Clara Filippini Ierardi | 2003 | Materials Characterization2003，50，： | 1 |
| 17 | Co-nanoencapsulated meloxicam and curcumin improves cognitive impairment induced by amyloid-beta through modulation of cyclooxygenase-2 in mice显示文摘Alzheimer’s disease is a progressive brain disorder and complex mechanisms are involved in the physiopathology of Alzheimer’s disease.However,there is data suggesting that inflammation plays a role in its development and progression.Indeed,some non-steroidal antiinflammatory drugs,such as meloxicam,which act by inhibiting cyclooxygenase-2 have been used as neuroprotective agents in different neurodegenerative disease models.The purpose of this study was to investigate the effects of co-nanoencapsulated curcumin and meloxicam in lipid core nanocapsules(LCN)on cognitive impairment induced by amyloid-beta peptide injection in mice.LCN were prepared by the nanoprecipitation method.Male Swiss mice received a single intracerebroventricular injection of amyloid-beta peptide aggregates(fragment 25–35,3 nmol/3μL)or vehicle and were subsequently treated with curcumin-loaded LCN(10 mg/kg)or meloxicam-loaded LCN(5 mg/kg)or meloxicam+curcumin-co-loaded LCN(5 and 10 mg/kg,respectively).Treatments were given on alternate days for 12 days(i.e.,six doses,once every 48 hours,by intragastric gavage).Our data showed that amyloid-beta peptide infusion caused long-term memory deficits in the inhibitory avoidance and object recognition tests in mice.In the inhibitory avoidance test,both meloxicam and curcumin formulations(oil or co-loaded LCN)improved amyloid-beta-induced memory impairment in mice.However,only meloxicam and curcumin-co-loaded LCN attenuated non-aversive memory impairment in the object recognition test.Moreover,the beneficial effects of meloxicam and curcuminco-loaded LCN could be explained by the anti-inflammatory properties of these drugs through cortical cyclooxygenase-2 downregulation.Our study suggests that the neuroprotective potential of meloxicam and curcumin co-nanoencapsulation is associated with cortical cyclooxygenase-2 modulation.This study was approved by the Committee on Care and Use of Experimental Animal Resources,the Federal University of Pampa,Brazil(approval No.02-2015)on April 16,2015. | Maria Eduarda Ziani Gutierrez Anne Suély Pinto Savall Edina da Luz Abreu Kelly Ayumi Nakama Renata Bem Dos Santos Marina Costa Monteiro Guedes Daiana SilvaÁvila Cristiane Luchese Sandra Elisa Haas Caroline Brandão Quines Simone Pinton | 2021 | Neural Regeneration Research2021，16，4： | 1 |
| 18 | Antimitotic agents increase the production of doubled-haploid embryos from cork oak anther culture显示文摘 | Beatriz Pintos Jose A Manzanera Maria A Bueno | 2007 | Journal of Plant Physiology2007，164，： | 1 |
| 19 | Photochemical treatment of solutions of azo dyes containing TiO2显示文摘 | Ana M F Oliveira-campos Elisa M M S Pinto | 1999 | Chemosphere1999，39，5： | 1 |
| 20 | Composition of hydrolysates from meat显示文摘 | Maria ElisabethM Pinto E Silva Rosa N Mazzilli Fabiana Cusin | 1999 | Journal of Food Composition and Analysis1999，，12： | 1 |
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