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| 1 | Changes in the Prevalence of the Most Common Causes of Chronic Liver Diseases in the United States From 1988 to 2008显示文摘 | Zobair M. Younossi Maria Stepanova Mariam Afendy Yun Fang Youssef Younossi Hesham Mir Manirath Srishord | 2011 | Clinical Gastroenterology and Hepatology2011，，6： | 5 |
| 2 | Predictors of All-Cause Mortality and Liver-Related Mortality in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD)显示文摘 | Maria Stepanova Nila Rafiq Hala Makhlouf Ritambhara Agrawal Ishmeet Kaur Zahra Younoszai Arthur McCullough Zachary Goodman Zobair M. Younossi | 2013 | Digestive Diseases and Sciences2013，，10： | 4 |
| 3 | Independent Association Between Nonalcoholic Fatty Liver Disease and Cardiovascular Disease in the US Population显示文摘 | Maria Stepanova Zobair M. Younossi | 2012 | Clinical Gastroenterology and Hepatology2012，，6： | 3 |
| 4 | Changes in the Prevalence of the Most Common Causes of Chronic Liver Diseases in the United States From 1988 to 2008显示文摘 | Zobair M. Younossi Maria Stepanova Mariam Afendy Yun Fang Youssef Younossi Hesham Mir Manirath Srishord | 2011 | Clinical Gastroenterology and Hepatology2011，，6： | 2 |
| 5 | Anthropometric and Clinical Factors Associated with Mortality in Subjects with Nonalcoholic Fatty Liver Disease显示文摘 | Munkhzul Otgonsuren Maria Stepanova Lynn Gerber Zobair M. Younossi | 2013 | Digestive Diseases and Sciences2013，，4： | 1 |
| 6 | Effects of Sofosbuvir-based Treatment, With and Without Interferon, on Outcome and Productivity of Patients With Chronic Hepatitis C显示文摘 | Zobair M. Younossi Maria Stepanova Linda Henry Edward Gane Ira M. Jacobson Eric Lawitz David Nelson Lynn Gerber Fatema Nader Sharon Hunt | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 1 |
| 7 | Hepatic Gene Expression of Caucasian and African-American Patients with Obesity-Related Non-Alcoholic Fatty Liver Disease显示文摘 | Maria Stepanova Noreen Hossain Arian Afendy Kellie Perry Zachary D. Goodman Ancha Baranova Zobair Younossi | 2010 | Obesity Surgery2010，，5： | 1 |
| 8 | A Novel Diagnostic Biomarker Panel for Obesity-related Nonalcoholic Steatohepatitis (NASH)显示文摘 | Zobair M. Younossi Mohammed Jarrar Clare Nugent Manpreet Randhawa Mariam Afendy Maria Stepanova Nila Rafiq Zachary Goodman Vikas Chandhoke Ancha Baranova | 2008 | Obesity Surgery2008，，11： | 1 |
| 9 | Non-alcoholic steatohepatitis (NASH) in patients with polycystic ovarian syndrome (PCOS)显示文摘 | Noreen Hossain Maria Stepanova Arian Afendy Fatema Nader Youssef Younossi Nila Rafiq Zachary Goodman Zobair M. Younossi | 2011 | Scandinavian Journal of Gastroenterology2011，，4： | 1 |
| 10 | Independent Predictors of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease显示文摘 | Noreen Hossain Arian Afendy Maria Stepanova Fatema Nader Manirath Srishord Nila Rafiq Zachary Goodman Zobair Younossi | 2009 | Clinical Gastroenterology and Hepatology2009，，11： | 1 |
| 11 | Changes in the Prevalence of the Most Common Causes of Chronic Liver Diseases in the United States From 1988 to 2008显示文摘 | Zobair M. Younossi Maria Stepanova Mariam Afendy Yun Fang Youssef Younossi Hesham Mir Manirath Srishord | 2011 | Clinical Gastroenterology and Hepatology2011，，6： | 1 |
| 12 | Ledipasvir/sofosbuvir regimens for chronic hepatitis C infection: Insights from a work productivity economic model from the United States显示文摘 | Zobair M. Younossi Yushan Jiang Nathaniel J. Smith Maria Stepanova Rachel Beckerman | 2015 | Hepatology2015，，： | 1 |
| 13 | Establishment of Rhodiola quadrifida Hairy Roots and Callus Culture to Produce Bioactive Compounds显示文摘Rhodiola quadrifida is a rare mountain medicinal plant whose root extracts are used in traditional Chinese medicine as a hemostatic,antitussive,and tonic in the treatment of gynecological diseases.The aim of the study was to obtain R.quadrifida cultures at different degrees of differentiation in vitro and compare their growth characteristics and the content of salidroside and rosavin.Hairy roots were obtained by incubating cotyledons and hypocotyls in a suspension of Agrobacterium rhizogenes strain A4.The presence of the rolB and rolC genes was proven by polymerase chain reaction.The obtained roots were cultivated in Murashige-Skoog medium(MS).Calluses were obtained from the hairy roots in MS medium with the addition of hormones:3 mg/L 2,4 D and 0.5 mg/L BAP.The presence of the main secondary metabolites of R.quadrifida,salidroside and rosavin,in calluses and salidroside in hairy roots by HPLC/MS was confirmed.The content of salidroside in callus culture was significantly higher than in hairy roots,0.158 and 0.047%,respectively.The content of rosavin in callus culture was 0.07%.The content of rosavin and salidroside in callus culture was close to the level of these substances in the rhizomes of R.quadrifida plants growing in vivo,making this culture promising for its possible biotechnological use. | Anna Stepanova Maria Malunova Svetlana Salamaikina Renat Selimov Aleksandra Solov’eva | 2021 | Phyton-International Journal of Experimental Botany2021，90，2： | 0 |
| 14 | Tumor irradiation may facilitate the detection of tumor-specific mutations in plasma显示文摘BACKGROUND The mutation-based analysis of circulating tumor DNA(ctDNA)is a promising diagnostic tool for clinical oncology.However,it has low success rate because many cancer patients do not have detectable ctDNA in the bloodstream.AIM To evaluate whether preoperative tumor irradiation results in a transient increase of plasma ctDNA concentration due to the induction of apoptosis in radiationexposed cells.METHODS This study focused on patients with locally advanced rectal cancer,because preoperative tumor irradiation is a part of their standard treatment plan.Nine subjects,whose tumors contained KRAS,NRAS or BRAF mutations,donated serial blood samples 1 h prior to the first fraction of irradiation(at baseline),immediately after the first fraction(time 0),and 1,3,6,12,24,36,48,72 and 96 h after the first fraction.The amount of mutated gene copies was measured by droplet digital PCR.RESULTS Five out of nine patients were mutation-negative by ctDNA test at baseline;two of these subjects demonstrated an emergence of the mutated DNA copies in the bloodstream within the follow-up period.There were 4 patients,who had detectable ctDNA in the plasma at the start of the experiment;three of them showed an evident treatment-induced increase of the content of mutated RAS/RAF alleles.CONCLUSION Local tumor irradiation may facilitate the detection of tumor-specific DNA in the bloodstream.These data justify further assessment of the clinical feasibility of irradiation-assisted liquid biopsy. | Ekaterina Kuligina Fedor Moiseyenko Sergey Belukhin Ekaterina Stepanova Maria Zakharova Vera Chernobrivtseva Ikram Aliev Tatiana Sharabura Vladimir Moiseyenko Svetlana Aleksakhina Tatiana Laidus Aleksandr Martianov Maksim Kholmatov Aldon Whitehead Grigoriy Yanus Evgeny Imyanitov | 2021 | World Journal of Clinical Oncology2021，12，12： | 0 |
| 15 | Significance of native PLGA nanoparticles in the treatment of Alzheimer’s disease pathology显示文摘Alzheimer’s disease (AD) is believed to be triggered by increased levels/aggregation of β-amyloid (Aβ) peptides. At present, there is no effective disease-modifying treatment for AD. Here, we evaluated the therapeutic potential of FDA-approved native poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles on Aβ aggregation and in cellular/ animal models of AD. Our results showed that native PLGA can not only suppress the spontaneous aggregation but can also trigger disassembly of preformed Aβ aggregates. Spectroscopic studies, molecular dynamics simu-lations and biochemical analyses revealed that PLGA, by interacting with the hydrophobic domain of Aβ1-42, prevents a conformational shift towards the β-sheet structure, thus precluding the formation and/or triggering disassembly of Aβ aggregates. PLGA-treated Aβ samples can enhance neuronal viability by reducing phosphor-ylation of tau protein and its associated signaling mechanisms. Administration of PLGA can interact with Aβ aggregates and attenuate memory deficits as well as Aβ levels/deposits in the 5xFAD mouse model of AD. PLGA can also protect iPSC-derived neurons from AD patients against Aβ toxicity by decreasing tau phosphorylation. These findings provide unambiguous evidence that native PLGA, by targeting different facets of the Aβ axis, can have beneficial effects in mouse neurons/animal models as well as on iPSC-derived AD neurons - thus signifying its unique therapeutic potential in the treatment of AD pathology. | Bibin Anand Qi Wu Maryam Nakhaei-Nejad Govindarajan Karthivashan Lyudmyla Dorosh Sara Amidian Abhishek Dahal Xiuju Li Maria Stepanova Holger Wille Fabrizio Giuliani Satyabrata Kar | 2022 | Bioactive Materials2022，7，11： | 0 |
| 16 | A Palladium Based Alloy for Prosthetic Dentistry: Structure and Properties显示文摘Using the results of physical and chemical researches and mechanical tests of the Pd-Au-Cu-Sn system alloys, a new palladium-based alloy has been chosen and studied in detail. It has a higher plasticity and a lower hardness than the Palladent alloy, widely used in prosthetic dentistry: its hardness is lower than 300 MPa, and its specific elongation is 10%~14 %. At the same time, such important practical characteristics of the alloys as the strength of adhesion to ceramics and thermal expansion coefficient are almost similar. | STEPANOVA Galina PARUNOV Vitaly VASEKIN Vasily KAREVA Maria SINAGEJKINA Julia | 2012 | 贵金属2012，33，A01： | 0 |
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