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| 1 | Aquaporins:Their role in cholestatic liver disease显示文摘This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and cholestasis.Canalicular bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8.The question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of cholestasis.Studies in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein downregulation.The combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water flow.Thus cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability. | Guillermo L Lehmann Maria C Larocca Leandro R Soria Raúl A Marinelli | 2008 | World Journal of Gastroenterology2008，14，46： | 8 |
| 2 | Colonic stenting versus emergency surgery for acute left-sided malignant colonic obstruction: a multicentre randomised trial显示文摘 | Jeanin E van Hooft Willem A Bemelman Bas Oldenburg Andreas W Marinelli Martijn F Lutke Holzik Marina J Grubben Mirjam A Sprangers Marcel G Dijkgraaf Paul Fockens | 2011 | Lancet Oncology2011，，4： | 3 |
| 3 | 神经生长因子增强小胶质细胞的神经保护作用显示文摘小胶质细胞是脑组织内的防御细胞,但在病理和生理条件下,调控小胶质细胞活化的因子并不十分清楚。本研究发现,神经生长因子(NGF)可以增强小胶质细胞的神经保护和抗炎功能。在体内和体外研究中都发现,小胶质细胞表达NGF受体。原代培养小胶质细胞,给予NGF处理,转录本分析结果显示,NGF对小胶质细胞的运动、吞噬和降解吞噬物的能力均产生影响。对功能的研究显示,NGF可增加小胶质细胞的膜运动能力和胞饮作用;在体研究显示,NGF可激活小胶质细胞释放向外整流电流,调节周围谷氨酸能神经元的神经传递。既往研究提示,小胶质细胞有清除脑内Aβ肽的功能,本研究观察了NGF对小胶质细胞吞噬能力的影响。结果显示,NGF可促进小胶质细胞通过Trk A途径清除Aβ,并加速其降解。此外,NGF还可减轻由Aβ导致的炎症激活。特异性激活小胶质细胞还可以减轻由Aβ导致的神经元树突损伤和长时程增强抑制。在对离体脑片的研究中,我们也发现NGF可以促进小胶质细胞吞噬Aβ。综上所述,本研究证实NGF可以促进小胶质细胞活化,活化的小胶质细胞通过抗炎作用减轻Aβ聚集,发挥神经保护作用。 | 唐颖馨 Rizzi C Tiberi A Giustizieri M Marrone MC Gobbo F Carucci NM Meli G Arisi I D'Onofrio M Marinelli S Capsoni S Cattaneo A | 2018 | 神经损伤与功能重建2018，13，2： | 2 |
| 4 | Binuclear Diorganotin ( IV ) Complexes with Bis ( O, O'-4-acyl-5-pyrazolonato ) bis (bidentate) Ligands 显示文摘 | Effendy Marchetti F Marinelli A | 2011 | Inorg Chem Acta2011，366，： | 1 |
| 5 | Clinical outcome of closed isolated subtalar dislocations显示文摘 | de Palma L Santucci A Marinelli M | 2008 | Arch Orthop Trauma Surg2008，128，6： | 1 |
| 6 | T2 relaxation times correlated with stage of lumbar intervertebral disk degeneration and patient age 显示文摘 | Marinelli N L Haughton V M Anderson P A | 2010 | AJNR Am J Neuroradiol2010，31，7： | 1 |
| 7 | A tumour score withmultidetectorspiral CT for venous infiltration in pancreatic cancer: influence on borderlineresectable 显示文摘 | Marinelli T Filippone A Tavano F | 2014 | Radiol Med2014，119，5： | 1 |
| 8 | T2 relaxation times of intervertebral disc tissue correlated with water con-tent and proteoglycan content 显示文摘 | Marinelli NL Haughton VM Muoz A | 2009 | Spine2009，34，5： | 1 |
| 9 | Binuclear Diorganotin (IV) Complexes with Bis (O, O'-4-acyl-5-pyrazolonato)bis (bidentate) Ligands 显示文摘 | Effendy Marchetti F Marinelli A | 2011 | Inorg Chem Acta2011，366，： | 1 |
| 10 | Profound hypoxemia precipitated by positive end - expiratory pressure: induction of an intracardiac shunt 显示文摘 | Ravenscraft S A Marinelli W A Johnson T | 1992 | Crit Care Med1992，20，3： | 1 |
| 11 | Distribution of electrically active detects in chemical vapor deposition diamond: model and measurement显示文摘 | Balducci A Marinelli M Milani E | 2005 | Appl Phys Lett2005，86，02： | 1 |
| 12 | Case report:orofacial characteristics of hallermann-streiff syndrome显示文摘 | Defraia E Marinelli A Alarashi M | 2003 | Eur J Paediatr Dent2003，4，3： | 1 |
| 13 | Systematic study of pre-irradiation effects in high efficieacy CVD diamond nuclear particle detectors显示文摘 | Marinelli M Milani E Paoletti A | 2002 | Nucl Instru and Meth in Phys Res A2002，476，： | 1 |
| 14 | T2 relaxation times of intervertebral disc tissue correlated with water con- tent and proteoglycan content显示文摘 | Marinelli NL Haughton VM Munoz A | 2009 | Spine2009，34，5： | 1 |
| 15 | Challenges and opportuni-ties in graphene commercialization 显示文摘 | ZURUTUZA A MARINELLI C | 2014 | Nature Nanotechn-ology2014，9，10： | 1 |
| 16 | A comparative study of isolated liver perfusion venous hepatic artery infusion with mitomycin C in rats显示文摘 | Marinelli A van de Velde C J Kuppen PJ | 1990 | Br J Cancer1990，62，6： | 1 |
| 17 | Water transpor ting properties of hepatoeyte basolateral and eanalicular plas ma membrane domains显示文摘 | Marinelli R A Tietz P S Caride A J etal | 2003 | JBiolChem2003，278，43： | 1 |
| 18 | PET/MRI of inflammation in myocardial infarction 显示文摘 | Lee W W Marinelli B van der Laan A M | 2012 | J Am Coll Car- diol2012，59，2： | 1 |
| 19 | Early closure of a multicenter randomized clinical trial of endoscopic stenting versus surgery for stage IV left-sided colorectal cancer显示文摘 | VAN HOOFT J E FOCKENS P MARINELLI A W | 2008 | Endoscopy2008，40，3： | 1 |
| 20 | Syntheis and antibacterial activity of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives显示文摘 | Zhu B Marinelli B A Abbanat D | 2007 | Bioorg Med Chem Lett2007，17，14： | 1 |
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