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| 1 | Colonic stenting versus emergency surgery for acute left-sided malignant colonic obstruction: a multicentre randomised trial显示文摘 | Jeanin E van Hooft Willem A Bemelman Bas Oldenburg Andreas W Marinelli Martijn F Lutke Holzik Marina J Grubben Mirjam A Sprangers Marcel G Dijkgraaf Paul Fockens | 2011 | Lancet Oncology2011，，4： | 3 |
| 2 | Laparoscopy in Combination with Fast Track Multimodal Management is the Best Perioperative Strategy in Patients Undergoing Colonic Surgery: A Randomized Clinical Trial (LAFA-study)显示文摘 | Malaika S. Vlug Jan Wind Markus W. Hollmann Dirk T. Ubbink Huib A. Cense Alexander F. Engel Michael F. Gerhards Bart A. van Wagensveld Edwin S. van der Zaag Anna A.W. van Geloven Mirjam A.G. Sprangers Miguel A. Cuesta Willem A. Bemelman | 2011 | Annals of Surgery2011，，6： | 3 |
| 3 | Quality of life after laparoscopic and open colorectal surgery: A systematic review显示文摘This study was a systematic review of the available evidence on quality of life in patients after laparoscopic or open colorectal surgery. A systematic review was performed of all randomized clinical trials (RCTs) that compared laparoscopic with open colorectal surgery. Study selection, quality assessment and data extraction were carried out independently by two reviewers. Primary endpoint was quality of life after laparoscopic and open colorectal surgery, as assessed by validated questionnaires. The search resulted in nine RCTs that included 2263 patients. Shortand long-term results of these RCTs were described in 13 articles. Postoperative follow-up ranged from 2 d to 6.7 years. Due to clinical heterogeneity, no meta-analysis could be conducted. Four RCTs did not show any difference in quality of life between laparoscopic or open colorectal surgery. The remaining five studies reported a better quality of life in favor of the laparoscopic group on a few quality of life scales at time points ranging from 1 wk to 2 years after surgery. In conclusion, based on presently available high-level evidence, this systematic review showed no clinically relevant differences in postoperative quality of life between laparoscopic and open colorectal surgery. | Sanne AL Bartels Malaika S Vlug Dirk T Ubbink Willem A Bemelman | 2010 | World Journal of Gastroenterology2010，16，40： | 3 |
| 4 | Hand-assisted or laparoscopic-assisted approach in colorectal surgery: a systematic review and meta-analysis显示文摘 | A. G. J. Aalbers S. S. A. Y. Biere M. I. Berge Henegouwen W. A. Bemelman | 2008 | Surgical Endoscopy2008，，8： | 2 |
| 5 | The potential benefits and disadvantages of laparoscopic surgery for ulcerative colitis: A review of current evidence显示文摘 | Christianne J. Buskens Saloomeh Sahami Pieter J. Tanis Willem A. Bemelman | 2013 | Best Practice & Research Clinical Gastroenterology2013，，： | 2 |
| 6 | Randomized Clinical Trial of Laparoscopic Versus Open Repair of the Perforated Peptic Ulcer: The LAMA Trial显示文摘 | Mari?tta J. O. E. Bertleff Jens A. Halm Willem A. Bemelman Arie C. Ham Erwin Harst Hok I. Oei J. F. Smulders E. W. Steyerberg Johan F. Lange | 2009 | World Journal of Surgery2009，，： | 2 |
| 7 | WONCA研究论文摘要汇编--结肠癌患者有症状复发和无症状复发的多中心队列研究显示文摘目的对结肠癌根治术后的患者进行随访,以及时发现复发症状和异时肿瘤。根据荷兰相关治疗指南,确定典型复发症状及诊断方法。方法回顾性分析在荷兰某两家医院进行连续性治疗结肠癌患者的临床资料,以2007年1月—2012年12月行结肠癌根治术的446例患者为研究对象,并对复发的74例患者进行进一步分析。结果 43例(58%)复发患者是在定期随访过程中发现,其中41例(95%)为无症状复发,肿瘤标志物检测、影像学检查及肠镜检查均显示有复发迹象。其余31例(42%)复发患者是在不定期间隔随访过程中发现,其中26例(84%)为有症状复发,典型临床症状为腹痛、排便异常及体质量减轻。无症状复发患者的存活率高于有症状复发患者。结论 42%的复发患者在不定期间隔随访过程中发现,主要依靠典型临床症状,初级保健医生应加强对复发率较高结肠癌患者的典型复发症状监测。 | duineveld l a vanasselt k m bemelman w a 本刊编辑部 | 2016 | 中国全科医学2016，19，22： | 2 |
| 8 | Early closure of a multicenter randomized clinical trial of endoscopic stenting versus surgery for stage IV left-sided colorectal cancer显示文摘 | J. van Hooft P. Fockens A. Marinelli R. Timmer A. van Berkel P. Bossuyt W. Bemelman | 2008 | Endoscopy2008，，03： | 2 |
| 9 | Faster Recovery of Gastrointestinal Transit After Laparoscopy and Fast-Track Care in Patients Undergoing Colonic Surgery显示文摘 | Sjoerd van Bree Malaika Vlug Willem Bemelman Markus Hollmann Dirk Ubbink Koos Zwinderman Wouter de Jonge Susanne Snoek Karen Bolhuis Esmerij van der Zanden Frans The Roel Bennink Guy Boeckxstaens | 2011 | Gastroenterology2011，，3： | 2 |
| 10 | Systematic review of endoscopic mucosal resection versus transanal endoscopic microsurgery for large rectal adenomas显示文摘 | R. Barendse F. van den Broek E. Dekker W. Bemelman E. de Graaf P. Fockens J. Reitsma | 2011 | Endoscopy2011，，11： | 2 |
| 11 | Measurement of the intestinal permeability in chronic kidney disease显示文摘AIM: To evaluate methods measuring the intestinal permeability in chronic kidney disease(CKD) and clarify whether there is an increased intestinal permeability in CKD.METHODS: We reviewed the literature in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis(PRISMA) protocol and performed a systematic literature search through MEDline and EMBASE. All controlled trials and cohort studies using non-invasive methods to assess intestinal permeability in CKD patients were included. Excluded were: Conference abstracts and studies including patients younger than 18 years or animals. From the included studies we summarized the used methods and their advantages and disadvantages. For the comparison of their results we divided the included studies in two categories based on their included patient population, either assessing the intestinal permeability in mild to moderate CKD patients or in end stage renal disease(ESRD) patients. Results were graphically displayed in two plots, one comparing the intestinal permeability in mild to moderate CKD patients to healthy controls and one comparing the intestinal permeability in ESRD patients to healthy controls. RESULTS: From the 480 identified reports, 15 met our inclusion criteria. Methods that were used to assess the intestinal permeability varied from markers measured in plasma to methods based on calculating the urinary excretion of an orally administered test substance. None of the applied methods has been validated in CKD patients and the influence of decreased renal function on the different methods remains unclear to a certain extent. Methods that seem the least likely to be influenced by decreased renal function are the quantitative PCR(qPCR) for bacterial DNA in blood and D-lactate. Considering the results published by the included studies; the studies including patients with mild to moderate CKD conducted conflicting results. Some studies did report an increase in intestinal permeability whilst other did not find a significant increased permeability. However, despite the variety in used methods among the different studies, all studies measuring the intestinal permeability in ESRD point out a significant increased intestinal permeability. Results should nevertheless be interpreted with caution due to the possible influence of a decreased glomerular filtration rate on test results.CONCLUSION: The intestinal permeability in CKD:(1) could be measured by qPCR for bacterial DNA in blood and D-lactate; and(2) seems to be increased in ESRD. | Matty L Terpstra Ramandeep Singh Suzanne E Geerlings Frederike J Bemelman | 2016 | World Journal of Nephrology2016，5，4： | 2 |
| 12 | European evidence-based Consensus on the management of ulcerative colitis: Current management显示文摘 | S.P.L. Travis E.F. Stange M. Lémann T. ?resland W.A. Bemelman Y. Chowers J.F. Colombel G. D'Haens S. Ghosh P. Marteau W. Kruis N.J.McC. Mortensen F. Penninckx M. Gassull | 2008 | Journal of Crohn’s and Colitis2008，，1： | 2 |
| 13 | Modern surgical strategies for perianal Crohn's disease显示文摘One of the most challenging phenotypes of Crohn’s disease is perianal fistulizing disease(PFCD).It occurs in up to 50%of the patients who also have symptoms in other parts of the gastrointestinal tract,and in 5%of the cases it occurs as the first manifestation.It is associated with severe symptoms,such as pain,fecal incontinence,and a significant reduction in quality of life.The presence of perianal disease in conjunction with Crohn’s disease portends a significantly worse disease course.These patients require close monitoring to identify those at risk of worsening disease,suboptimal biological drug levels,and signs of developing neoplasm.The last 2 decades have seen significant advancements in the management of PFCD.More recently,newer biologics,cell-based therapies,and novel surgical techniques have been introduced in the hope of improved outcomes.However,in refractory cases,many patients face the decision of having a stoma made and/or a proctectomy performed.In this review,we describe modern surgical management and the most recent advances in the management of complex PFCD,which will likely impact clinical practice. | Gilmara Pandolfo Zabot Ornella Cassol Rogerio Saad-Hossne Willem Bemelman | 2020 | World Journal of Gastroenterology2020，26，42： | 2 |
| 14 | Diagnostic laparoscopy and laparoscopic ultrasound for staging of patients with malignant proximal bile duct obstruction显示文摘 | Esther H. B. M. Tilleman M.D. Steve M. M. Castro Olivier R. C. Busch M.D. Willem A. Bemelman M.D. Thomas M. Gulik M.D. Huug Obertop M.D. Dirk J. Gouma M.D | 2002 | Journal of Gastrointestinal Surgery2002，，3： | 2 |
| 15 | Randomized clinical trial of laparoscopic versus open repair of the perforated peptic ulcer: the LAMA trial显示文摘 | Bettleff M J Halm JA Bemelman WA | 2009 | World J Surg2009，33，7： | 1 |
| 16 | Increased plasma concentrations of soluble tumor necrosis factor receptors in sepsis syndrome:correlation with plasma creatinine values显示文摘 | Froon AH Bemelmans MH Greve JW | 1994 | Crit Care Med1994，22，： | 1 |
| 17 | Morbidity if temporary loop ileostomies显示文摘 | Bakx R Busch OR Bemelman WA Veldink GJ | 2004 | Dig Surg2004，21，： | 1 |
| 18 | Isolation meth-ods for the volatile components of grapefruit juice, distil-lation and solvent extraction methods 显示文摘 | Nunea A J Bemelmans J M H Maarse H | 1984 | Chroma-tographia1984，18，3： | 1 |
| 19 | Laparo- scopic ileocolic resection versus infliximab treatment of distal ileitis in Crohn's disease: a randomized muhicenter trial 显示文摘 | Eshuis EJ Bemelman WA van Bodegraven AA | 2008 | BMC Surg2008，8，1： | 1 |
| 20 | Cytokines tumor necro- sis factor and interleukin - 6 in experimental biliary obstruction in mice 显示文摘 | I Bemelmans MH Gouma D J Greve JW | 1992 | Hepatology1992，15，6： | 1 |
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