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| 1 | Effect of a bacterial inoculum and additive on dry matter in situ degradability of sugarcane silage显示文摘The objective of this study was to evaluate the effect of adding a bacterial inoculum and a handmade additive to sugarcane silage(SCS) on the in situ digestibility of dry matter(DM). The treatments were: T1) sugarcane silage(SCS) and T2) sugarcane silage with 1% inoculum and 1% additive(SCS+). The bacterial inoculum consisted of 10.0% molasses, 1.0% yogurt, 5.0% chicken manure, 0.5% urea, and 83.0% water, and the additive was formulated with 1.0% urea, 0.1% ammonium sulfate, and 0.25% phosphorus. In situ dry matter digestibility(DMD) was determined using the nylon bag technique with four cows equipped with ruminal fistulas. Cows were fed with ensiled sugarcane supplemented with 1 kg of commercial concentrate. 5 g of ground sample for each sugarcane treatment were weighted in nylon bags and incubated for 4, 8, 12, 24, 48, and 72 h in a completely randomized design with six replicates. The DMD(%) was higher(P<0.05) for SCS+ for all incubation times when compared with SCS. There were no differences in ruminal p H between the treatments for all the incubation times. The data suggested that the sugarcane silage with bacterial inoculum and additive could be an alternative for providing forage for ruminants during the season of low growth and quality grass. | José A Reyes-Gutiérrez Oziel D Montaez-Valdez Ramón Rodríguez-Macias Mario Ruíz-López Eduardo Salcedo-Pérez Cándido E Guerra-Medina | 2015 | Journal of Integrative Agriculture2015，14，3： | 3 |
| 2 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 3 | 22-gauge core vs 22-gauge aspiration needle for endoscopic ultrasound-guided sampling of abdominal masses显示文摘AIM To compare the aspiration needle(AN) and core biopsy needle(PC) in endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) of abdominal masses.METHODS Consecutive patients referred for EUS-FNA were included in this prospective single-center trial. Each patient underwent a puncture of the lesion with both standard 22-gauge(G) AN(Echo Tip Ultra; Cook Medical, Bloomington, Indiana, United States) and the novel 22 G PC(Echo Tip Pro Core; Cook Medical, Bloomington, Indiana, United States) in a randomized fashion; histology was attempted in the PC group only. The main study endpoint was the overall diagnostic accuracy, including the contribution of histology to the final diagnosis. Secondary outcome measures included material adequacy, number of needle passes, and complications.RESULTS Fifty six consecutive patients(29 men; mean age 68 years) with pancreatic lesions(n = 38), lymphadenopathy(n = 13), submucosal tumors(n = 4), or others lesions(n = 1) underwent EUS-FNA using both of the needles in a randomized order. AN and PC reached similar overall results for diagnostic accuracy(AN: 88.9 vs PC: 96.1, P = 0.25), specimen adequacy(AN: 96.4% vs PC: 91.1%, P = 0.38), mean number of passes(AN: 1.5 vs PC: 1.7, P = 0.14), mean cellularity score(AN: 1.7 vs PC: 1.1, P = 0.058), and complications(none). A diagnosis on the basis of histology was achieved in the PC group in 36(64.3%) patients, and in 2 of those as the sole modality. In patients with available histology the mean cellularity score was higher for AN(AN: 1.7 vs PC: 1.0, P = 0.034); no other differences were of statistical significance.CONCLUSION Both needles achieved high overall diagnostic yields and similar performance characteristics for cytological diagnosis; histological analysis was only possible in 2/3 of cases with the new needle. | William Sterlacci Athanasios D Sioulas Lothar Veits Pervin G?nüllü Guido Schachschal Stefan Groth Mario Anders Christos K Kontos Theodoros Topalidis Andrea Hinsch Michael Vieth Thomas R?sch Ulrike W Denzer | 2016 | World Journal of Gastroenterology2016，22，39： | 2 |
| 4 | Modifi cation of sleep architecture in an animal model of experimental cirrhosis显示文摘AIM: To analyze the polygraphic sleep patterns during cirrhosis progression in a rat model by repeated CCl4 administration. METHODS: Male Wistar rats received three weekly injections of CCl4 for 11 wk, and were analyzed before and during the induction of cirrhosis. Rats were implanted with electrodes to record their sleep patterns. Polygraph recordings were made weekly over 11 wk for 8 h, during the light period. After a basal recording, rats received three weekly injections of CCl4. Histological conf irmation of cirrhosis was performed after 11 wk.RESULTS: The results showed a progressive decrease in total wake time that reached statistical signif icance from the second week of treatment. In addition, there was an increase in total time of slow wave sleep (SWS) and rapid eye movement sleep (REM sleep) in most of the 11 wk. SWS showed no signif icant variations.During the final weeks, a significant increase in REM sleep frequency was also observed. Histological analyses of the livers showed unequivocal signs of cirrhosis. CONCLUSION: These data suggest that hepatic failure produced by CCl4 administration is capable of modifying the sleep pattern even after only a few doses. | Anabel Jiménez-Anguiano Vanessa Díaz-Medina Blanca Eugenia Farfán-Labonne Gloria Giono-Chiang David Kersenobich Mario García-Lorenzana Maria Concepción Gutiérrez-Ruiz Javier Velázquez-Moctezuma | 2009 | World Journal of Gastroenterology2009，15，41： | 2 |
| 5 | Natural course of functional dyspepsia after Helicobacter pylori eradication:a seven-year survey显示文摘 | Di Mario F Stefani N BòN D | 2005 | Dig Dis Sci2005，50，12： | 1 |
| 6 | Wavelet-Based image estimation : An empirical bayes approach using jeffreys'noninformative prior 显示文摘 | MARIO A T ROBERT D N | 2001 | IEEE Trans Image Processing2001，10，9： | 1 |
| 7 | Gradient pro- jection for sparse reconstruction: Application to com- pressed sensing and other inverse problems显示文摘 | Mario A T F Robert D N Stephen J W | 2007 | IEEE Journal of Selected Topics in Signal Processing2007，1，4： | 1 |
| 8 | Gene expression during cold acclimation in strawberry显示文摘 | CHRISTIAN N D FRANCOIS O MARIO H | 1997 | Plant Cell Physiology1997，38，7： | 1 |
| 9 | Incidence and predictors of coronary stent thrombosis: Evidence from an international collaborative meta-analysis including 30 studies, 221,066 patients, and 4276 thromboses显示文摘 | Fabrizio D’Ascenzo Mario Bollati Fabrizio Clementi Davide Castagno Bo Lagerqvist Jose M. de la Torre Hernandez Juri?n M. ten Berg Bruce R. Brodie Philip Urban Lisette Okkels Jensen Gabriel Sardi Ron Waksman John M. Lasala Stefanie Schulz Gregg W. Stone Fl | 2013 | International Journal of Cardiology2013，，： | 1 |
| 10 | Statin Therapy and Outcome After Ischemic Stroke: Systematic Review and Meta-Analysis of Observational Studies and Randomized Trials显示文摘 | Danielle Ní Chróinín Kjell Asplund Signild ?sberg Elizabeth Callaly Elisa Cuadrado-Godia Exuperio Díez-Tejedor Mario Di Napoli Stefan T. Engelter Karen L. Furie Sotirios Giannopoulos Antonio M. Gotto Niamh Hannon Fredrik Jonsson Moira K. Kapral Joan Martí | 2013 | Stroke2013，，2： | 1 |
| 11 | Grazing intensity and ecosystem processes in a northern mixed-grass prairie,USA显示文摘 | Mario E B Bob D P Paul E N | 1998 | Ecological Applications1998，8，： | 1 |
| 12 | Impact of living with bipolar patients: Making sense of caregivers' burden显示文摘The aim of the present review was to examine objective and subjective burdens in primary caregivers(usually family members) of patients with bipolar disorder(BD) and to list which symptoms of the patients are considered more burdensome by the caregivers. In order to provide a critical review about caregiver's burden in patients with bipolar disorder, we performed a detailed Pub Med, Bio Med Central, ISI Web of Science, Psyc INFO, Elsevier Science Direct and Cochrane Library search to identify all papers and book chapters in English published during the period between 1963 and November 2011. The highest levels of distress were caused by the patient's behavior and the patient's role dysfunction(work, education and social relationships). Furthermore, the caregiving role compromises other social roles occupied by the caregiver, becoming part of the heavy social cost of bipolar affective disorder. There is a need to better understand caregivers' views and personal perceptions of the stresses and demands arising from caring for someone with BD in order to develop practical appropriate interventions and to improve the training of caregivers. | Maurizio Pompili Désirée Harnic Xenia Gonda Alberto Forte Giovanni Dominici Marco Innamorati Konstantinos N Fountoulakis Gianluca Serafini Leo Sher Luigi Janiri Zoltan Rihmer Mario Amore Paolo Girardi | 2014 | World Journal of Psychiatry2014，4，1： | 1 |
| 13 | Ubiquitin-Proteasome system and proteasome inhibition:New strategies in stroke therapy显示文摘 | Cezary W Mario D N | 2004 | Stroke2004，35，： | 1 |
| 14 | Gene expression during cold acclimation in strawberry显示文摘 | Christian N D Francois O Mario H | 1997 | Plant Cell Physiology1997，38，7： | 1 |
| 15 | Drug administration via the laryngeal mask airway显示文摘 | Trevisanuto D Doglioni N Mario F | 2006 | Resuscitation2006，71，2： | 1 |
| 16 | Grazing Intensity and Ecosystem Processes in a Northern Mixed-Grass Prairie, USA显示文摘 | MARIO E B BOB D P PAUL E N | 1998 | Ecological Applications1998，8，2： | 1 |
| 17 | Increased production of soluble TLR2 by lamina propria mononuclear cells from ulcerative colitis patients显示文摘 | Enzo Candia David Díaz-Jiménez Patricia Langjahr Lucía E. Nú?ez Marjorie de la Fuente Nancy Farfán Francisco López-Kostner Mario Abedrapo Manuel Alvarez-Lobos George Pinedo Caroll J. Beltrán Carlos González María-Julieta González Rodrigo Quera Marcela A. | 2011 | Immunobiology2011，，6： | 1 |
| 18 | Grazing intensity and ecosystem processes in a northern mixed-grass prairie, USA显示文摘 | Mario E B Bob D P Paul E N | 1998 | Ecological Applications1998，8，： | 1 |
| 19 | Laparoscopic Repair of Renal Artery Aneurysm: A Description of the Technique and Results in 2 Cases显示文摘 | Octavio A. Castillo Gonzalo J. Vitagliano Rafael Sanchez-Salas Hernán Chamorro Mario Fava Manuel A. Díaz | 2008 | Surgical Laparoscopy Endoscopy & Percutaneous Techniques2008，，4： | 1 |
| 20 | Predicting Mortality in Spontaneous Intracerebral Hemorrhage can Modification to Original Score Improve the Prediction? 显示文摘 | Daniel A G Gustavo P Mario D N | 2006 | Stroke2006，37，： | 1 |
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