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| 1 | Severe acute pancreatitis: pathogenesis, diagnosis and surgical management显示文摘BACKGROUND: Severe acute pancreatitis is a subtype of acute pancreatitis, associated with multiple organ failure and systemic inflammatory response syndrome. In this qualitative review we looked at the principles of pathogenesis, classification and surgical management of severe acute pancreatitis. We also looked at the current shift in paradigm in the management of severe acute pancreatitis since the guideline developed by the British Society of Gastroenterology.DATA SOURCES: Studies published between 1st January 1991 and 31st December 2015 were identified with Pub Med, MEDLINE, EMBASE and Google Scholar online search engines using the following Medical Subject Headings: 'acute pancreatitis, necrosis, mortality, pathogenesis, incidence' and the terms 'open necrosectomy and minimally invasive necrosectomy'.The National Institute of Clinical Excellence(NICE) Guidelines were also included in our study. Inclusion criteria for our clinical review included established guidelines, randomized controlled trials and non-randomized controlled trials with a follow-up duration of more than 6 weeks.RESULTS: The incidence of severe acute pancreatitis within the UK is significantly rising and pathogenetic theories are still controversial. In developed countries, the most common cause is biliary calculi. The British Society of Gastroenterology,acknowledges the Revised Atlanta criteria for prediction of severity. A newer Determinant-based system has been developed.The principle of surgical management of acute necrotizing pancreatitis requires intensive care management, identifying infection and if indicated, debridement of any infected necrotic area. The current procedures opted for include standard surgical open necrosectomy, endoscopic necrosectomy and minimally invasive necrosectomy. The current paradigm is shifting towards a step-up approach.CONCLUSIONS: Severe acute pancreatitis is still a subject of grey areas in its surgical management even though new studies have been recorded since the origin of the latest UK guidelines for management of severe acute pancreatitis. | Mark Portelli Christopher David Jones | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，2： | 201 |
| 2 | Antibiotic prophylaxis in variceal hemorrhage:Timing,effectiveness and Clostridium difficile rates显示文摘AIM:To investigate if antibiotics administered within 8 h of endoscopy reduce mortality or increase the incidence of Clostridium difficile infection(CDI).METHODS:A 2-year retrospective analysis of all patients who presented with first variceal hemorrhage was undertaken.The primary outcome measure was 28-d mortality.Secondary outcome measures were 28-d rebleeding rates and 28-d incidence of CDI.All patients were admitted to a tertiary liver unit with a consultantled,24-h endoscopy service.Patients received standard care including terlipressin therapy.Data collection included:primary and secondary outcome measures,timing of first administration of intravenous antibiotics,eti-ology of liver disease,demographics,endoscopy details and complications.A prospective study was undertaken to determine the incidence of CDI in the study population and general medical inpatients admitted for antibiotic therapy of at least 5 d duration.Statistical analysis was undertaken using univariate,non-parametric tests and multivariate logistic regression analysis.RESULTS:There were 70 first presentations of variceal hemorrhage during the study period.Seventy percent of cases were male and 65.7% were due to chronic alcoholic liver disease.In total,64/70(91.4%) patients received antibiotics as prophylaxis during their admission.Specifically,53/70(75.7%) received antibiotics either before endoscopy or within 8 h of endoscopy [peri-endoscopy(8 h) group],whereas 17/70(24.3%) received antibiotics at > 8 h after endoscopy or not at all(non peri-endoscopy group).Overall mortality and rebleeding rates were 13/70(18.6%) and 14/70(20%),respectively.The periendoscopy(8 h) group was significantly less likely to die compared with the non peri-endoscopy group [13.2% vs 35.3%,P = 0.04,odds ratio(OR) = 0.28(0.078-0.997)] and showed a trend towards reduced rebleeding [17.0% vs 29.4%,P = 0.27,OR = 0.49(0.14-1.74)].On univariate analysis,the non peri-endoscopy group [P = 0.02,OR = 3.58(1.00-12.81)],higher model for end-stage liver disease(MELD) score(P = 0.02),presence of hepatorenal syndrome [P < 0.01,OR = 11.25(2.24-56.42)] and suffering a clinical episode of sepsis [P = 0.03,OR = 4.03(1.11-14.58)] were significant predictors of death at 28 d.On multivariate logistic regression analysis,lower MELD score [P = 0.01,OR = 1.16(1.04-1.28)] and periendoscopy(8 h) group [P = 0.01,OR = 0.15(0.03-0.68)] were independent predictors of survival at 28 d.The CDI incidence(5.7%) was comparable to that in the general medical population(5%).CONCLUSION:Antibiotics administered up to 8 h following endoscopy were associated with improved survival at 28 d.CDI incidence was comparable to that in other patient groups. | Matthew RL Brown Graeme Jones Kathryn L Nash Mark Wright Indra Neil Guha | 2010 | World Journal of Gastroenterology2010，16，42： | 13 |
| 3 | Apoptosis block as a barrier to effective therapy in non small cell lung cancer显示文摘Lung cancer, is the most common cause of cancer death in men and second only to breast cancer in women. Currently, the first line therapy of choice is platinumbased combination chemotherapy. A therapeutic plateau has been reached with the prognosis for patients with advanced non-small cell lung cancer(NSCLC) remaining poor. New biomarkers of prognosis as well as new therapies focusing on molecular targets are emerging helping to identify patients who are likely to benefit from therapy. Despite this, drug resistance remains the major cause for treatment failure. In this article we review the role of apoptosis in mediating drug resistance in NSCLC. Better understanding of this fundamental biological process may provide a rationale for overcoming the current therapeutic plateau. | Ian Paul J Mark Jones | 2014 | World Journal of Clinical Oncology2014，5，4： | 7 |
| 4 | The numbers of fungi: is the descriptive curve flattening?显示文摘The recent realistic estimate of fungal numbers which used various algorithms was between 2.2 and 3.8 million.There are nearly 100,000 accepted species of Fungi and fungus-like taxa,which is between 2.6 and 4.5%of the estimated species.Several forums such as Botanica Marina series,Fungal Diversity notes,Fungal Biodiversity Profiles,Fungal Systematics and Evolution-New and Interesting Fungi,Mycosphere notes and Fungal Planet have enhanced the introduction of new taxa and nearly 2000 species have been introduced in these publications in the last decade.The need to define a fungal species more accurately has been recognized,but there is much research needed before this can be better clarified.We address the evidence that is needed to estimate the numbers of fungi and address the various advances that have been made towards its understanding.Some genera are barely known,whereas some plant pathogens comprise numerous species complexes and numbers are steadily increasing.In this paper,we examine ten genera as case studies to establish trends in fungal description and introduce new species in each genus.The genera are the ascomycetes Colletotrichum and Pestalotiopsis(with many species or complexes),Atrocalyx,Dothiora,Lignosphaeria,Okeanomyces,Rhamphoriopsis,Thozetella,Thyrostroma(rela-tively poorly studied genera)and the basidiomycete genus Lepiota.We provide examples where knowledge is incomplete or lacking and suggest areas needing further research.These include(1)the need to establish what is a species,(2)the need to establish how host-specific fungi are,not in highly disturbed urban areas,but in pristine or relatively undisturbed forests,and(3)the need to establish if species in different continents,islands,countries or regions are different,or if the same fungi occur worldwide?Finally,we conclude whether we are anywhere near to flattening the curve in new species description. | Kevin D.Hyde Rajesh Jeewon Yi-Jyun Chen Chitrabhanu S.Bhunjun Mark S.Calabon Hong-Bo Jiang Chuan-Gen Lin Chada Norphanphoun Phongeun Sysouphanthong Dhandevi Pem Saowaluck Tibpromma Qian Zhang Mingkwan Doilom Ruvishika S.Jayawardena Jian-Kui Liu Sajeewa S.N.Maharachchikumbura Chayanard Phukhamsakda Rungtiwa Phookamsak Abdullah M.Al-Sadi Naritsada Thongklang Yong Wang Yusufjon Gafforov E.B.Gareth Jones Saisamorn Lumyong | 2020 | Fungal Diversity2020，，4： | 3 |
| 5 | A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis显示文摘 | Stephen Stewart Martin Prince Margaret Bassendine Mark Hudson Oliver James David Jones Chris Record Christopher P. Day | 2007 | Journal of Hepatology2007，，2： | 3 |
| 6 | Randomized trial of mediastinal lymph node sampling versus complete lymphadenectomy during pulmonary resection in the patient with N0 or N1 (less than hilar) non–small cell carcinoma: Results of the American College of Surgery Oncology Group Z0030 Trial显示文摘 | Gail E. Darling Mark S. Allen Paul A. Decker Karla Ballman Richard A. Malthaner Richard I. Inculet David R. Jones Robert J. McKenna Rodney J. Landreneau Valerie W. Rusch Joe B. Putnam | 2011 | The Journal of Thoracic and Cardiovascular Surgery2011，，3： | 3 |
| 7 | 小P值并不能保证可靠结果:以帕金森病的静息态脑功能成像元分析为例显示文摘Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain disorders.For precise localization of abnormal brain activity,a voxel-level comparison is needed.Because of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1]. | 贾熙泽 赵娜 董昊铭 孙家伟 Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa 陈博宇 陈俊 Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito 范国光 Federica Di Nardo 冯怡萱 Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay B.Horak 胡晓 胡晓飞 黄飚 黄沛钰 贾泽娟 Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani 李静 李晴 刘爱萍 刘波 刘虎 刘卫国 Renaud Lopes 娄毓婷 罗巍 Tara Madhyastha 毛妮妮 Grainne McAlonan Martin J.McKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica 商慧芳 James M.Shine Priyank Shukla Tomas Slavicek 宋潇鹏 Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt 王健 王珏 Z.Jane Wang 魏鲁庆 邬霞 徐晓俊 闫磊 杨靓 杨万群 姚乃琳 张得龙 张久权 张敏鸣 张艳玲 周彩红 严超赣 左西年 Mark Hallett 吴涛 臧玉峰 | 2021 | Science Bulletin2021，66，21： | 3 |
| 8 | Consensus Panel Recommendation for Incorporating Lipoprotein-Associated Phospholipase A 2 Testing into Cardiovascular Disease Risk Assessment Guidelines显示文摘 | Michael H. Davidson Marshall A. Corson Mark J. Alberts Jeffrey L. Anderson Philip B. Gorelick Peter H. Jones Amir Lerman Joseph P. McConnell Howard S. Weintraub | 2008 | The American Journal of Cardiology2008，，12： | 3 |
| 9 | Effect of particle degradation on electrostatic sensor measurements and flow characteristics in dilute pneumatic conveying显示文摘 | Wei Chen Jianyong Zhang Timothy Donohua Kenneth Williams Ruixue Cheng Mark Jones Bin Zhou | 2017 | Particuology2017，15，4： | 2 |
| 10 | Video-assisted thoracic surgery versus open lobectomy for lung cancer: A secondary analysis of data from the American College of Surgeons Oncology Group Z0030 randomized clinical trial显示文摘 | Walter J. Scott Mark S. Allen Gail Darling Bryan Meyers Paul A. Decker Joe B. Putnam Robert W. Mckenna Rodney J. Landrenau David R. Jones Richard I. Inculet Richard A. Malthaner | 2010 | The Journal of Thoracic and Cardiovascular Surgery2010，，4： | 2 |
| 11 | Auxin Binding Protein 1 Reinforces Resistance to Sugarcane Mosaic Virus in Maize显示文摘 | Pengfei Leng Qing Ji Torben Asp Ursula K. Frei Christina R. Ingvardsen Yongzhong Xing Bruno Studer Margaret Redinbaugh Mark Jones Priyanka Gajjar Sisi Liu Fei Li Guangtang Pan Mingliang Xu Thomas Lǖbberstedt | 2017 | Molecular Plant2017，10，10： | 2 |
| 12 | Axon regeneration through scars and into sites of chronic spinal cord injury显示文摘 | Paul Lu Leonard L. Jones Mark H. Tuszynski | 2006 | Experimental Neurology2006，，1： | 2 |
| 13 | Statin therapy is associated with fewer deaths in patients with bacteraemia显示文摘 | Peter Kruger Kenneth Fitzsimmons David Cook Mark Jones Graeme Nimmo | 2006 | Intensive Care Medicine2006，，1： | 2 |
| 14 | Conflict Reduction in Map Generalization Using Iterative Improvement显示文摘 | J. Mark Ware Christopher B. Jones | 1998 | GeoInformatica1998，，4： | 1 |
| 15 | Community service in the transition: Shifts and continuities in participation from high school to college 显示文摘 | MARKS H JONES S | 2004 | The Journal of Higher Education2004，75，： | 1 |
| 16 | Investiga- ting the processes necessary for satisfactory freeze-drying of waterlogged archaeological wood显示文摘 | Samuel P Nigel K H Slater Mark Jones | 2009 | J Archaeol Sci2009，36，4： | 1 |
| 17 | The tomato Cf-2 disease resistance locus comprises two functional genes encoding leucine- rich repeat proteins 显示文摘 | Mark S D Jones D A Keddie J S etal | 1996 | Cell1996，84，： | 1 |
| 18 | Logistics planning under uncertainty for disposition of radioactive wastes 显示文摘 | List George F Wood Bryan Turnquist Mark A Nozick Linda K Jones Dean A Lawton Craig R | 2006 | Computers and Operations Research2006，33，3： | 1 |
| 19 | Option pricing:a simplified approach显示文摘 | Ross Stephen A Stein Mark R | 1979 | Journal of Financial Eonomics1979，7，5： | 1 |
| 20 | Cisatracurium in dogs with and without porto-systemic shunts显示文摘 | Adams WA Mark Senior J Jones RS | 2006 | Anaesth Analg2006，33，1： | 1 |
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