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| 1 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 2 | 1989-1994年中国脊髓灰质炎病毒的分子流行病学显示文摘1989~1994年中国发生的脊髓灰质炎流行,疫情开始集中于华东、中南地区,后期趋于南部沿海一带。对近百份来自18个省、市、自治区脊灰病毒流行期间标本的分子生物学特征分析,发现流行主要由脊灰病毒Ⅰ型野毒株引起,未发现Ⅱ型野毒株,但1993年在新疆分离到1株Ⅲ型野毒株。Ⅰ型野毒株中共存在4个基因型病毒,其中CHNP1-R91型病毒为这几年流行中新产生的重组病毒,在VP1/2A区含有一段疫苗株序列,另一段野毒株序列很可能来自CHNP1-JX89型病毒。这两个基因型病毒分布在全国大部份地区。病毒核酸的亲缘关系研究还证明,92~94年流行在南方沿海一带的脊髓灰质炎,主要由91年产生的重组病毒引起。此研究揭示了各地区、各基因型病毒与疫情之间的流行病学关系及传播模式。 | 郑渡平 张礼璧 侯晓辉 朱宏 Mac Otten David R Kilpatnck Mark Pallansch Olen M Kew | 1995 | 病毒学报1995，11，4： | 4 |
| 3 | Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis显示文摘 | Katrin M Sjoquist Bryan H Burmeister B Mark Smithers John R Zalcberg R John Simes Andrew Barbour Val Gebski | 2011 | Lancet Oncology2011，，7： | 4 |
| 4 | Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers显示文摘Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ morphogenesis.Its impact on beef cattle muscle growth remains undefined.Method: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of age.At 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells.The resulting steers were harvested at 14 months of age.Results: Vitamin A administration increased cattle growth at 2 months.At 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and MYOG.Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro.More myotubes and a higher degree of myogenesis was observed in vitamin A groups.Consistently,vitamin A increased Latissimus dorsi(LD) muscle fiber size at harvest.In addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers.Furthermore,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal muscle.Conclusion: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers. | Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu Martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 5 | 伦理学与SARS:多伦多的教训显示文摘SARS的流行说明传染病在世界范围内流行是件多么容易的事,为了更好地应对下一次流行病,我们不仅要解决医学方面的问题,也同样需要解决伦理学方面的问题。 | Peter A Singer Solomon R Benatar Mark Bernstein Abdallah S Daar Bernard M Dickens Susan K MacRae Ross E G Upshur Linda Wright Randi Zlotnik Shaul 肖月 | 2004 | 英国医学杂志中文版2004，7，4： | 3 |
| 6 | Quantification of human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) mRNA in testicular tissue of infertile patients显示文摘Aim: To evaluate the quantitative detection of human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) mRNA as diagnostic parameters in the workup of testicular tissue specimens from patients presenting with non-obstructive azoospemia. Methods: hTR and hTERT mRNA expression were quantified in 38 cryopreserved testicular tissue specimens by fluorescence real-time reverse transcription- polymerase chain reaction (RT-PCR)in a LightCycler(r). This was paralleled by conventional histological workup in all tissue specimens and additional semithin sectioning preparation in cases with maturation arrest ( n = 12) and Sertoli-cell-only syndrome ( n = 12). Results: The average normalized hTERT expression (NhTERT) Was 131.9 ± 48.0 copies (mean ± SD) in tissue specimens with full spermatogenesis, NhTERT = 51.2 ± 17.2 copies in those with maturation arrest and NhTERT = 2.7 ± 2.4 copies in those with Sertoli-cell-only syndrome (SCOS). The discriminant analysis showed that detection of NhTERT (NhTR) had a predictive value of 86.8 % (55.3 % ) for correct classification in one of the three histological subgroups.Conclusion: Our results demonstrate that quantitative detection of hTERT mRNA expression in testicular tissue enables a molecular-diagnostic classification of gametogenesis. Quantitative detection of hTERT in testicular biopsies is thus well suited for supplementing the histopathological evaluation. | Mark Schrader Markus Müller Rüdiger Heicappell Bernd Straub Kurt Miller | 2001 | Asian Journal of Andrology2001，3，4： | 3 |
| 7 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 8 | Inflammation and Alzheimer’s disease显示文摘 | Haruhiko Akiyama Steven Barger Scott Barnum Bonnie Bradt Joachim Bauer Greg M Cole Neil R Cooper Piet Eikelenboom Mark Emmerling Berndt L Fiebich Caleb E Finch Sally Frautschy W.S.T Griffin Harald Hampel Michael Hull Gary Landreth Lih–Fen Lue Robert Mrak | 2000 | Neurobiology of Aging2000，，3： | 2 |
| 9 | Tolllike receptor2 m ediates lipopolysaccharides induced cellular signaling显示文摘 | Yan R B Mark M R Gray A | 1998 | Nature1998，395，： | 2 |
| 10 | Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury显示文摘 | Caudrillier Axelle Kessenbrock Kai Gilliss Brian M Nguyen John X Marques Marisa B Monestier Marc Toy Pearl Werb Zena Looney Mark R | 2012 | EN2012，，7： | 2 |
| 11 | Electric load forecasting using an artificial neural network 显示文摘 | Park D C El-Sharkawi M A Marks R J | 1991 | IEEE Transactions on Power Systems1991，6，2： | 2 |
| 12 | Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis 显示文摘 | Pandey A Shao H Marks R M | 1995 | Science1995，268，5210： | 1 |
| 13 | Control of nutrient losses to water from agriculture in Europe 显示文摘 | Archer J R Marks M J | 1997 | Proceedings of Fertilizer Society1997，405，： | 1 |
| 14 | Toll-like receptor 2 mediates lipoplysaccharide-induced celluar signalling 显示文摘 | Yang R B Mark M R Gray A | 1998 | Nature1998，395，6699： | 1 |
| 15 | Electric load forecasting using an artificial neural network 显示文摘 | EI-Sharkawi M A Marks R J II Atlas L E | 1991 | IEEE Transactions on Power System1991，6，2： | 1 |
| 16 | DNA damage, poly (ADP-ribosyl) ation and apoptotic cell death as a potential common pathway of cytotoxic drug action显示文摘 | Marks D I Fox R M | 1991 | Biochemical pharmacology1991，42，10： | 1 |
| 17 | Poly- morphous low - grade adenocarcinoma and adenoid cystic carcino- ma: a review and comparison of immunohistochemical markers 显示文摘 | Mark R Darling Johann W Schneider Vincent M Phillips | 2002 | Oral Oncol2002，7，38： | 1 |
| 18 | The Impact of Group-based Credit Programs on Poor Households in Bangladesh: Does the Gender of the Participants Matter?显示文摘 | Pitt Mark M Shahidur R Khandker | 1988 | Journal of Political Economy1988，106，5： | 1 |
| 19 | Anisotropic effects on the strain rate dependence of a wrought magnesium alloy 显示文摘 | MATTHEW T T MARK F H PHILLIP M G HAITHAM E K WILBURN R W | 2009 | Scripta Materialia2009，60，： | 1 |
| 20 | Trends in non-melanocytic skin cancer treated in Australia:the second national survey显示文摘 | Marks R Staples M Giles G | 1993 | Int J Cancer1993，53，： | 1 |
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