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| 1 | Comparative analysis of clinicopathological correlations of cyclooxygenase-2 expression in resectable pancreatic cancer显示文摘AIM:To perform a comparative analysis of clinicopathological correlations of cyclooxygenase2 (COX2) expression in pancreatic cancer, examined by monoclonal and polyclonal antibodies.METHODS: The COX2 expression in 85 resection specimens of pancreatic ductal adenocarcinoma was immunohistochemically examined using both monoclonal and polyclonal antibodies. The final immunoscores were obtained by multiplying the percentage of positive cells with the numeric score reflecting the staining intensity.COX2 expression levels were classified into three categories (0, 1+, and 2+) and the clinicopathological correlations were statistically evaluated and analyzed.RESULTS: The positive tumor expression rates of COX2 were 80.5% using monoclonal antibody and 69.4% using polyclonal antibody. In the KaplanMeier analysis, no significant correlations were found between levels of COX2 expression and overall survival (OS), but trends to longer OS were found in COX2 negative cases using monoclonal antibody. Significantly longer disease free survival was revealed in COX2 negative cases using monoclonal antibody (P = 0.019). No correlations between COX2 expression levels and grade (G), tumor (T) status and nodal (N) status were demonstrated. Low histological grade showed a strong association with a longer OS (P < 0.001). Correlation of survival and T status revealed a shorter OS in T3 tumors, but the results reached only marginal statistical significance (P = 0.070). In the multivariate Cox proportional hazards regression model, histological grade, T and N status remained valuable predictors of a worse survival with borderline significance for T [hazards ratio (HR) = 4.18 for G (if G = 3, P < 0.001); HR = 1.64 for T (if T = 3, P = 0.065); HR = 2.53 for N (if N = 1, P = 0.006)]. Higher grade, T or N status was associated with a worse OS. CONCLUSION: The immunohistochemically assessed level of COX2 expression does not seem to represent a valuable independent prognostic factor and is not superior to the conventional prognostic factors. | Marketa Hermanova Petr Karasek Jiri Tomasek Jiri Lenz Jiri Jarkovsky Petr Dite | 2010 | World Journal of Gastroenterology2010，16，15： | 7 |
| 2 | Cementomimetics——constructing a cementum-like biomineralized microlayer via amelogenin-derived peptides显示文摘Cementum is the outer-,mineralized-tissue covering the tooth root and an essential part of the system of periodontal tissue that anchors the tooth to the bone. Periodontal disease results from the destructive behavior of the host elicited by an infectious biofilm adhering to the tooth root and left untreated,may lead to tooth loss. We describe a novel protocol for identifying peptide sequences from native proteins with the potential to repair damaged dental tissues by controlling hydroxyapatite biomineralization. Using amelogenin as a case study and a bioinformatics scoring matrix,we identified regions within amelogenin that are shared with a set of hydroxyapatite-binding peptides (HABPs) previously selected by phage display. One 22-amino acid long peptide regions referred to as amelogenin-derived peptide 5 (ADP5) was shown to facilitate cell-free formation of a cementum-like hydroxyapatite mineral layer on demineralized human root dentin that,in turn,supported attachment of periodontal ligament cells in vitro. Our findings have several implications in peptide-assisted mineral formation that mimic biomineralization. By further elaborating the mechanism for protein control over the biomineral formed,we afford new insights into the evolution of protein-mineral interactions. By exploiting small peptide domains of native proteins,our understanding of structure-function relationships of biomineralizing proteins can be extended and these peptides can be utilized to engineer mineral formation. Finally,the cementomimetic layer formed by ADP5 has the potential clinical application to repair diseased root surfaces so as to promote the regeneration of periodontal tissues and thereby reduce the morbidity associated with tooth loss. | Mustafa Gungormus Ersin E Oren Jeremy A Horst Hanson Fong Marketa Hnilova Martha J Somerman Malcolm L Snead Ram Samudrala Candan Tamerler Mehmet Sarikaya | 2012 | International Journal of Oral Science2012，4，2： | 5 |
| 3 | High Hepatic SCD1 Activity Is Associated with Low Liver Fat Content in Healthy Subjects under a Lipogenic Diet显示文摘 | Günther Silbernagel Marketa Kovarova Alexander Cegan Jürgen Machann Fritz Schick Rainer Lehmann Hans-Ulrich H?ring Norbert Stefan Erwin Schleicher Andreas Fritsche Andreas Peter | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，12： | 3 |
| 4 | Effect of food preservatives on the inhibitory activity of acidocin CH5 and bacteriocin D 10显示文摘 | Marketa Giesova Jana Chumchalova Milada Plockova | 2004 | Eur Food Res Technol2004，218，： | 1 |
| 5 | Monitoring of malting process by characterization of glycation of barley protein Z显示文摘 | Bobálová J Petry-Podgórska I Marketa L | | 0，，04： | 1 |
| 6 | Steroids and insulin resistance in pregnancy显示文摘 | Daniela Vejrazkova Josef Vcelak Marketa Vankova Petra Lukasova Olga Bradnova Tereza Halkova Radmila Kancheva Bela Bendlova | 2012 | Journal of Steroid Biochemistry and Molecular Biology2012，，： | 1 |
| 7 | Phosphoinositide 3 - Kinase signaling - which way to target? 显示文摘 | MATTHIAS P W MARKETA Z MURIEL L | 2003 | Trends Pharmacol Sci2003，24，7： | 1 |
| 8 | Gas chromatographic determination of Salk(en)ylcysteine sulfoxides显示文摘 | Roman K Marketa S Jan V | 1999 | Journal of Chromatography A1999，862，1： | 1 |
| 9 | Possibilities of different animal milk detection in milk and dairy products-a review显示文摘 | MARKETA B SNASELOVA J | 2005 | Czech J Food Sci2005，23，： | 1 |
| 10 | Sensitive detection and separation of fluorescent derivatives using capillary electrophoresis with laser- induced fluorescence detection with 532nm Nd: YAG laser显示文摘 | Partik Vrabel Petr Taborsky Marketa Ryvolova | 2006 | J Lumin2006，118，2： | 1 |
| 11 | Determination of free amino acids in beers: a comparison of Czech and foreign brands显示文摘 | Ivana kabelova Marketa Dvorakova Hana Cizkova | 2008 | Journal of Food Composition and Analysis2008，，21： | 1 |
| 12 | Speciation analysis of elements in cereal flours by liquid chromatography-inductively coupled plasma mass spectrometly显示文摘 | Richard Koplik Marketa Borkova Barbara Bicanova | 2006 | Food Chemistry2006，99，： | 1 |
| 13 | Determination of free amino acids in cheeses from the Czech market显示文摘 | Ivana Kabelova Marketa Dvotakova Hana Cizkova | 2009 | Czech J Food Sci2009，27，3： | 1 |
| 14 | Organized Mesoporous TiO2 Films Exhibiting Greatly Enhanced Performance in Dye-Sensitized Solar Cells显示文摘 | Marketa Z Arnost Z Ladislav K | 2005 | NANOLETTERS2005，5，9： | 1 |
| 15 | Organized Mesoporous TiO2 Films Exhibiting Greatly Enhanced Performance in Dye-Sensitized Solar Cells 显示文摘 | Marketa Z Arnost Z | 2005 | NANO LETTERS2005，5，9： | 1 |
| 16 | Prognostic significance of anti-apoptosis proteins survivin and bcl-2 in non-small cell lung carcinomas 显示文摘 | LEOS KREN JAN BRAZDIL MARKETA HERMANOVA | 2004 | Appl Immunohistochem Mol Morphol2004，12，1： | 1 |
| 17 | Serine/threonine kinase 39 is a candidate gene for primary hypertension especially in women: results from two cohort studies in Swedes显示文摘 | Cristiano Fava Elisa Danese Martina Montagnana Marketa Sj?gren Peter Almgren Gunnar Engstr?m Peter Nilsson Bo Hedblad Gian C Guidi Pietro Minuz Olle Melander | 2011 | Journal of Hypertension2011，，3： | 1 |
| 18 | Stabilization/solidification of munition destruction waste by asphalt emulsion 显示文摘 | Marketa C Milan V Vratislav B | 2007 | J Hazard Mater2007，142，12： | 1 |
| 19 | Pseudocapaeitive lithium storagein TiOz (B) 显示文摘 | Marketa Z Martin K Ladislav K | 2005 | Chem Mater2005，17，： | 1 |
| 20 | Pseudocapaeitive lithium storagein TiO2 (B) 显示文摘 | Marketa Z Martin K Ladislav K | 2005 | Chem Mater2005，17，： | 1 |
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