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| 1 | Significant association between ABO blood group and pancreatic cancer显示文摘AIM:To evaluate whether the ABO blood group is related to pancreatic cancer risk in the general population of the United States.METHODS:Using the University of Pittsburgh's clinicalpancreatic cancer registry,the blood donor database from our local blood bank (Central Blood Bank),and the blood product recipient database from the regional transfusion service (Centralized Transfusion Service) in Pittsburgh,Pennsylvania,we identified 274 pancreatic cancer patients with previously determined serological ABO blood group information.The ABO blood group frequency was compared between these patients and 708842 individual,community-based blood donors who had made donations to Pittsburgh's Central Blood Bank between 1979 and 2009.RESULTS:The frequency of blood group A was statistically significantly higher amongst pancreatic cancer patients compared to its frequency amongst the regional blood donors [47.63% vs 39.10%,odds ratio (OR)=1.43,P=0.004].Conversely,the frequency of blood group O was significantly lower amongst pancreatic cancer patients relative to the community blood donors (32.12% vs 43.99%,OR=0.60,P=0.00007).There were limited blood group B (n=38) and AB (n=17) pancreatic cancer patients;the overall P trend value comparing patient to donor blood groups was 0.001.CONCLUSION:The ABO blood group is associated with pancreatic cancer risk.Future studies should examine the mechanism linking pancreatic cancer risk to ABO blood group. | Julia B Greer Mark H Yazer Jay S Raval M Michael Barmada Randall E Brand David C Whitcomb | 2010 | World Journal of Gastroenterology2010，16，44： | 10 |
| 2 | Survival after neoadjuvant chemotherapy or chemoradiotherapy for resectable oesophageal carcinoma: an updated meta-analysis显示文摘 | Katrin M Sjoquist Bryan H Burmeister B Mark Smithers John R Zalcberg R John Simes Andrew Barbour Val Gebski | 2011 | Lancet Oncology2011，，7： | 4 |
| 3 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 4 | Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy. | Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 5 | Metabolic engineering of astaxanthin production in tobacco flowers显示文摘 | VARDA M MARK H IRIS P | 2000 | Nat Biotechnol2000，18，： | 1 |
| 6 | On the 'downward control'of extratropical diabatic circulations by eddy-induced mean zonal forces显示文摘 | Haynes P H C J Marks M E McIntyre | 1991 | J Atmoa Sci1991，48，： | 1 |
| 7 | Perceived Risk and Chinese Consumers' Internet Banking Services Adoption 显示文摘 | Anita Lifen Zhao Stuart Hanmer - Lloyd Philippa Ward Mark M H Goode | 2008 | International Jour- nal of Bank Marketing2008，26，7： | 1 |
| 8 | Telangiectatic osteosarcoma:radiologic-pathologic comparison显示文摘 | Mark D M Suphanee wan Jaovisidha H Thomas T | 2003 | Radiology2003，229，： | 1 |
| 9 | Die Gitterstruktur, Gleitrichtungen und Gleitebenen des wei en Zinns显示文摘 | Mark H Polanyi M | 1923 | Z Phys1923，18，1： | 1 |
| 10 | Sea Level and Gas Hydrate Controlled Catastrophic Sediment Failures of Amazon Fan显示文摘 | Mark M Naja M Bilal H | 1998 | Geology1998，26，12： | 1 |
| 11 | Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-alpha-induced angiogenesis 显示文摘 | Pandey A Shao H Marks R M | 1995 | Science1995，268，5210： | 1 |
| 12 | J Colloid InterfSci 显示文摘 | Mattson J S Mark H B Malbin M D | 1969 | 31(1): 1161969，31，1： | 1 |
| 13 | Treatment of traumatic cervical arteriovenous fistulas with N-butyl-2- cyanoacrylate 显示文摘 | Jayaraman M V Do H M Marks M P | 2007 | Am J Neuroradiol2007，28，2： | 1 |
| 14 | Retinoid content,visual responses,and ocular morphology are compromised in the retinas of mice lacking the retinolcbinding protein receptor,STRA6显示文摘 | Ruiz A Mark M Jacobs H | 2012 | Invest Ophthalmol Vis Sci2012，53，： | 1 |
| 15 | On the 'downward control'of the extratropical diabatic circulations by eddy-induced mean zonal forces显示文摘 | Haynes P H M E Marks T G Shepherd | 1991 | J Atmos Sci1991，48，： | 1 |
| 16 | Magnesium and its alloys as orthopedic biomaterials: A review 显示文摘 | MARK P S ALEXIS M P JERAWALA H | 2006 | Biomaterials2006，27，9： | 1 |
| 17 | Anisotropic effects on the strain rate dependence of a wrought magnesium alloy 显示文摘 | MATTHEW T T MARK F H PHILLIP M G HAITHAM E K WILBURN R W | 2009 | Scripta Materialia2009，60，： | 1 |
| 18 | Human intestinal fatty acid binding protein: Report of an assay with studies in normal volunteers and intestinal ischemia显示文摘 | Joshua M Lieberman James Sacchettini Christine Marks William H Marks | 1997 | Surgery1997，，3： | 1 |
| 19 | Presenting scientific theories within risk assessments显示文摘 | Marks H M Coleman M E | 2005 | Human Ecol Risk Assessment2005，11，： | 1 |
| 20 | Prospective study of perceived stress in cardiac patients显示文摘 | Brummett B H Babyak M A Mark D B | 2004 | Ann Behav Med2004，27，1： | 1 |
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