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| 1 | Systemic inflammation in colorectal cancer: Underlying factors,effects, and prognostic significance显示文摘Systemic inflammation is a marker of poor prognosis preoperatively present in around 20%-40%of colorectal cancer patients.The hallmarks of systemic inflammation include an increased production of proinflammatory cytokines and acute phase proteins that enter the circulation.While the low-level systemic inflammation is often clinically silent,its consequences are many and may ultimately lead to chronic cancer-associated wasting,cachexia.In this review,we discuss the pathogenesis of cancer-related systemic inflammation,explore the role of systemic inflammation in promoting cancer growth,escaping antitumor defense,and shifting metabolic pathways,and how these changes are related to less favorable outcome. | Anne E Tuomisto Markus J Makinen Juha P Vayrynen | 2019 | World Journal of Gastroenterology2019，25，31： | 27 |
| 2 | Advances in hepatitis C therapy: What is the current state-what come's next?显示文摘Chronic hepatitis C virus(HCV) infection affects 80-160 million people worldwide and is one of the leading causes of chronic liver disease.It is only a few years ago that standard treatment regimes were based on pegylated interferon alpha and ribavirin.However,treatment of HCV has undergone a revolutionary change in recent years.The admission of the nucleotide polymerase inhibitor Sofosbuvir enabled an interferon-free regimen with direct antiviral agents(DAA).Meanwhile seven DAAs are available and can be applied in several combinations for 8 to 24 wk depending on HCV genotype and patient characteristics such as cirrhosis and chronic renal failure.High rates of sustained virological response(SVR) rates can be achieved with these novel drugs.Even in difficult to treat populations such as patients with liver cirrhosis,HCV-human immunodeficiency virus co-infections,after liver transplantion,or with chronic kidney disease comparable high rates of SVR can be achieved.The anticipated 2nd generation DAAs are strikingly effective in patients so far classified as difficult to treat including decompensated liver cirrhosis or posttransplant patients.These 2nd generations DAAs will have higher resistance barriers,higher antiviral effects and a pan-genotypic spectrum.This review highlights the current state of the art of antiviral treatment in hepatitis Cand gives an outlook for upcoming therapies. | Steffen Zopf Andreas E Kremer Markus F Neurath Juergen Siebler | 2016 | World Journal of Hepatology2016，8，3： | 7 |
| 3 | Clinical and histopathological correlations of fecal calprotectin release in colorectal carcinoma显示文摘AIM:To determine calprotectin release before and after colorectal cancer operation and compare it to tumor and histopathological parameters.METHODS:The study was performed on patients with diagnosed colorectal cancer admitted for operation.Calprotectin was measured in a single stool sample before and three months after the operation using an enzymelinked immunosorbent assay(ELISA).Calprotectin levels greater than or equal to 50μg/g were considered positive.The compliance for collecting stool samples was assessed and the value of calprotectin was correlated to tumor and histopathological parameters of intra-and peri-tumoral inflammation.Surgical specimens were fixed in neutral buffered formalin and stained with hematoxylin and eosin.Staging was performed according to the Dukes classification system and the 7th edition tumor node metastasis classification system.Intra-and peri-tumoral inflammation was graded according to the Klintrup criteria.Immunohistochemical quantification was performed for MPO,CD45R0,TIA-1,CD3,CD4,CD8,CD57,and granzyme B.Statistical significance was measured using Wilcoxon signed rank test,Kruskal Wallis test and Spearman’s rank correlation coefficient as appropriate.RESULTS:Between March 2009 and May 2011,80 patients with colorectal cancer(46 men and 34 women,with mean age of 71±11.7 years old)were enrolled in the study.Twenty-six patients had rectal carcinoma,29 had left-side tumors,23 had right-side tumors,and2 had bilateral carcinoma.In total,71.2%of the patients had increased levels of calprotectin before the operation(median 205μg/g,range 50-2405μg/g)and experienced a significant decrease three months after the operation(46μg/g,range 10-384μg/g,P<0001).The compliance for collecting stool samples was 89.5%.Patients with T3 and T4 tumors had significantly higher values than those with T1 and T2 cancers(P=0.022).For all other tumor parameters(N,M,G,L,V,Pn)and location,no significant difference in calprotectin concentration was found.Furthermore,the calprotectin levels and histological grading of both peri-and intra-tumoral inflammation was not correlated.Additional testing with specific markers for lymphocytes and neutrophils also revealed no statistically significant correlation.CONCLUSION:Fecal calprotectin decreases significantly after colorectal cancer operation.Its value depends exclusively on the individual T-stage,but not on other tumor or histopathological parameters. | Frank Serge Lehmann Francesca Trapani Ida Fueglistaler Luigi Maria Terracciano Markus von Flüe Gieri Cathomas Andreas Zettl Pascal Benkert Daniel Oertli Christoph Beglinger | 2014 | World Journal of Gastroenterology2014，20，17： | 6 |
| 4 | EV和HEV的爪形离合器变速器显示文摘电动汽车是在减少对化石燃料依赖和环境污染的同时,确保人类移动灵活性和实现汽车产业可持续发展的有效路径。在中国,通过”九五”、“十五”和”十一五”期间国家科技计划的持续支持和能源基金组织等国际社会的帮助,电动汽车技术的开发及产业化工作得以不断深入,并得到国际社会的广泛认可。 | Markus Schnablerhofer f&e | 2012 | 汽车零部件2012，，10： | 4 |
| 5 | The Dynamic Self-Concept: A Social Psychological Perspective显示文摘 | H Markus E Wurf | 1987 | Annual Review of Psychology1987，，： | 2 |
| 6 | Incorporating a statistically based shape model into a system for computor-assisted anterior cruciate ligament surgery显示文摘 | Markus F St(e)phane L R(e)mi J | 1999 | Medical Image Analysis1999，3，3： | 1 |
| 7 | Acute and chronic presentation of intestinal nonrotation in adults显示文摘 | Markus Flüe M.D. Urs Herzog M.D. Christoph Ackermann M.D. Peter Tondelli M.D. Felix Harder M.D | 1994 | Diseases of the Colon & Rectum1994，，2： | 1 |
| 8 | A Common C→T Polymorphism at nt 46 in the Promoter Region of Coagulation Factor XlI is Associated With Decreased Factor XII Activity显示文摘 | Georg E Markus E Christine M | 2001 | Thrombosis Research2001，101，： | 1 |
| 9 | The impact of relocation up onmortality rates of institutionalized aged persons显示文摘 | Markus E Blenkner M Bloom M | 1971 | J Gerontol1971，26，4： | 1 |
| 10 | Joint effects of C - reactive protein and glycated hemoglobin in predicting future cardiovascu - lar events of patients with advanced atherosclerosis 显示文摘 | Martin S Markus E Jasmin A | 2003 | Circulation2003，108，19： | 1 |
| 11 | Template-controlled synthesis of wire-like cadmium sulfide nanoparticle assemblies within core-shell cylindrical polymer brushes显示文摘 | Mingfu Zhang Markus Drechsler Axel H E Müller | 2004 | Chemistry of Materials2004，16，3： | 1 |
| 12 | The Dynamic Self-concept: A Social Psychological Perspective 显示文摘 | Markus H Wurf E | 1987 | Annual Review of Psychology1987，，3： | 1 |
| 13 | Intrathecal treatment with anti - Nogo - A antibody improves functional reco- very in adult rats after stroke显示文摘 | TSAI Y MARKUS T M ANDREWS E M | 2007 | Exp Brain Res2007，182，2： | 1 |
| 14 | The dynamic self-concept:A social psychological perspective显示文摘 | Markus H Wurf E | 1987 | Annual Review of Psychology1987，38，： | 1 |
| 15 | Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle–mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response显示文摘 | Ivan Grskovic Anna Kutsch Christian Frie Gergely Groma Jacek Stermann Ursula Schl?tzer‐Schrehardt Anja Niehoff Stephen E Moss Sabrina Rosenbaum Ernst P?schl Markus Chmielewski Gunter Rappl Hinrich Abken John F Bateman Kathryn SE Cheah Mats Paulsson Bent B | 2012 | J Bone Miner Res2012，，11： | 1 |
| 16 | Modelling the long-term performance of zero-valent iron using a spatio-temporal approach for iron aging显示文摘 | Irina K Peter B Markus E | 2007 | Contaminant Hydrology2007，90，12： | 1 |
| 17 | IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin A-induced liver injury in mice显示文摘 | Annette E Markus B Thomas P | 2007 | Hepatology2007，45，2： | 1 |
| 18 | A learning reactive scheduler using CBR/L显示文摘 | Szelke E Markus G | 1997 | Computers in Industry1997，33，： | 1 |
| 19 | Relevance of the chronobiological and non- chronobiological actions of melatonin for enhancing therapeutic ef- ficacy in neurodegenerative disorders 显示文摘 | Cecon E Markus R P | 2011 | Recent Pat Endocr Metab Immune Drug Discov2011，5，2： | 1 |
| 20 | Joint effects of C - reactive protein and glycated hemoglobin in predicting future cardio vascular events of patients with advanced athero sclerosis 显示文摘 | Martin S Markus E Jasmin A et ai | 2003 | Circulation2003，108，19： | 1 |
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