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| 1 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 2 | Review:infrared spec-troscopy-enabling an evidence-based diagnostic surveillance approach to agricultural and environmental management in developing countries显示文摘 | Keith D S Markus G W | 2007 | Journal of Near Infrared Spectroscopy2007，15，1： | 1 |
| 3 | Frequency stabi- lization of a Q-switched Nd : YAG laser oscillator with sta- bility better 300 kHz following an rf-sideband scheme显示文摘 | MARTIN O THOMAS W MARKUS G | 2009 | Optics Communications2009，282，16： | 1 |
| 4 | Ageing of polypropylene:processes and consequences显示文摘 | Joachim F Markus G Christian P Johannes W | 1999 | Polym Test1999，18，4： | 1 |
| 5 | Structure-property relations in molded, nucleated isotaetic polypropylene显示文摘 | Housmans J W Markus G Gerrit W M P | 2009 | Polymer2009，50，： | 1 |
| 6 | Reappraisal of the timing of the breakup of Gondwana based on sedimentological and seismic evidence from the Morondava Basin,Madagascar显示文摘 | Markus G Clark D N Mette W | 2004 | Journal of African Earth Sciences2004，38，4： | 1 |
| 7 | Slug,a highly conserved zinc finger transcriptional repressor,protects hematopoietic pro-genitor cells from radiation-induced apoptosis in vivo显示文摘 | Inoue A Markus G Wu W | 2002 | Cancer Cell2002，24，： | 1 |
| 8 | Concrete prestressed with textile fabric显示文摘 | Hans W R Markus K Christian U G | 2003 | Journal of Advanced Concrete Technology2003，1，3： | 1 |
| 9 | Ageing of polypropylene: processes and consequences显示文摘 | Joachim F Markus G Christian P Johannes W | 1999 | Polym Test1999，18，4： | 1 |
| 10 | Can the time window for administration of thrombolytics in stroke be increased显示文摘 | DONNAN G A HOWELLS D W MARKUS R | 2003 | CNS Drugs2003，17，14： | 1 |
| 11 | Hypoxia promotes osteogenesis but suppresses adipogenesis of human mesenchymal stromal cells in a hypoxia-inducible factor-1 dependent manner显示文摘 | Markus W Timo G Ferenz L | 2012 | PLo S One2012，7，46： | 1 |
| 12 | Cuffed tracheal tubes in children-things have changed显示文摘 | MARKUS W ANDREAS C G | 2006 | Pediatric Anesthesia2006，16，： | 1 |
| 13 | On-site Transformer Partial Discharge Diagnosis 显示文摘 | DETLE W G MARKUS S | 2012 | IEEE CONFERENCE PUBLICATIONS2012，12，： | 1 |
| 14 | NIR-light triggered delivery of macromolecules into the cytosol显示文摘 | Susana C R Markus O Pilar R G Carolin G Pavlov A M Sukhorukov G B Parak W J | 2012 | Journal of Controlled Release2012，159，1： | 1 |
| 15 | 查看详情显示文摘 | Hong C Yi W Jonathan N Zhang X W Steve W Markus H Michael H W L John P G Jones P D | | 0，，04： | 1 |
| 16 | CS Freiburg:Coordinating robots for successful soccer playing 显示文摘 | Thilo W Jens-Steffen G Markus D | 2002 | IEEE Trans on Robotics and Auto2002，18，： | 1 |
| 17 | Conformational analysis of the hydrophobie peptideαs1-casein(136-196)显示文摘 | Michael H A Harold M F J Markus W G | 1999 | Biochimica et Biophysica Acta1999，1431，2： | 1 |
| 18 | TIPSS for variceal hemorrhage after living related liver transplantation:A dangerous indication显示文摘门全身的 stent 分流(TIPSS ) 是的 transjugular 肝内的介绍在门静脉高血压的处理的主要突破,演变到大程度,。有由于门静脉高血压在食管为 variceal 出血要求 TIPSS 的进步接枝纤维变性 / 肝硬化的一个 21 岁的男病人对在生活以后的二年联系了的常规措施无答复肝移植(LDLT ) 。随后,然而, variceal 出血被控制肝功能戏剧性地减少了与连续多机关失败。CT 扫描在肝揭示了实质的坏死。病人经历了成功的“高迫切”的尸体肝移植并且在 20 在一个马厩调节的手术后的 d 上被解除。 | Peter Schemmer Boris Radeleff Christa Flechtenmacher Arianeb Mehrabi Gtz M Richter Markus W Büchler Jan Schmidt | 2006 | World Journal of Gastroenterology2006，12，3： | 0 |
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