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| 1 | Improvement in dysphagia and quality of life with self-expanding metallic stents in malignant esophageal strictures 显示文摘 | MAROJU NK ANBALAGAN P KATE V | 2006 | Indian J Gastroenterol2006，25，2： | 1 |
| 2 | Is Helicobacter pylori eradication indicated in cirrhotic patients with peptic ulcer disease?显示文摘 | Villalan R Maroju NK Kate V | 2006 | Trop Gastroenterol2006，27，4： | 1 |
| 3 | Enterocutaneous fistulae :etiol- ogy,treatment,and outcome--a study from South India显示文摘 | Kumar P Maroju NK Kate V | 2011 | Saudi J Gastroenterol2011，17，6： | 1 |
| 4 | Improvement in dysphagia and quality of life with self-ecpandinmetallic stents inmalignant esophageal strictures显示文摘 | Maroju NK Anbalagan P Kat EV | 2006 | Indian J Gastroenterol2006，25，2： | 1 |
| 5 | Delay in surgery for acute appendicitis显示文摘 | MAROJU NK SMILE SR SISTLA SC | 2004 | ANZ J2004，74，： | 1 |
| 6 | Helicobacter py- Iori eradication indicated in cirrhotic patients with peptic ulcer disease? 显示文摘 | VILLALAN R MAROJU NK KATE V | 2006 | Gastroenterol2006，27，4： | 1 |
| 7 | Sterno- cleidomastoid muscle myocutaneous flap for corrosive phaxynge- sophageal strictures 显示文摘 | Ananthakrishman A Parthasarathy G Maroju NK | 2007 | Worl J Surg2007，31，： | 1 |
| 8 | Trop Postoperative intussusception in the adult:a case report显示文摘 | Maroju N K Srinivasan K Kadambari D | 2004 | Gastroenterol2004，25，1： | 1 |
| 9 | Stemocleidomastoid muscle myocutaneous flap for corrosive pharyngoesophageal strictures 显示文摘 | Ananthakrishnan N Parthasarathy G Maroju NK | 2007 | World J Surg2007，31，： | 1 |
| 10 | Delay in surgery for acute appendicitis显示文摘 | Maroju N K Robinson Smile S Sistla S C | 2004 | ANZ J Surg2004，74，9： | 1 |
| 11 | Stern- ocleidomastoid muscle myocutaneous flap for corrosive pharyn- gesophageal strictures显示文摘 | Ananthakrishman A Parthasarathy G Maroju NK | 2007 | Worl J Surg2007，31，： | 1 |
| 12 | Serum pepsinogen Ⅰ and Ⅱ levels in various gastric disorders with special reference to their use as a screening test for carcinoma stomach显示文摘 | Parthasarathy G Maroju NK Kate V | 2007 | Trop Gas-troentero2007，28，4： | 1 |
| 13 | Delay in surgery for acute appendicitis 显示文摘 | Maroju NK Robinson Smile S Sistla SC | 2004 | ANZ J Surg2004，74，9： | 1 |
| 14 | Is Helicobacter pylori eradication indicated in cirrhotic patients with peptic ulcer disease显示文摘 | Villalan R Maroju NK Kate V | 2006 | Trop Gastroenterol2006，27，4： | 1 |
| 15 | Sternocleidomastoid Muscle Myocutaneous Flap for Corrosive Pharyngoesophageal Strictures显示文摘 | N. Ananthakrishnan G. Parthasarathy Nanda Kishore Maroju Vikram Kate | 2007 | World Journal of Surgery2007，，8： | 1 |
| 16 | Clinical Outcomes of the Marginal Ulcer Bleeding after Gastrectomy: As Compared to the Peptic Ulcer Bleeding with Nonoperated Stomach显示文摘 | Woo Chul Chung Eun Jung Jeon Kang-Moon Lee Chang Nyol Paik You Suk Oh Yang Woon Lee Sang Bae Kim Kyong-Hwa Jun Hyung Min Chin N. K. Maroju | 2012 | Gastroenterology Research and Practice2012，，： | 1 |
| 17 | Postoperative intussusception in the adult:a case report显示文摘 | Maroju NK Srinivasan K Kadambari D | 2004 | Trop Gastroentero12004，25，1： | 1 |
| 18 | Enterocutaneous fistulae: etiology, treatment, and outcome- a study from South India显示文摘 | Kumar P Maroju NK Kate V | 2011 | Saudi J Gas- troenterol2011，17，6： | 1 |
| 19 | Serum pepsinogen Ⅰ and Ⅱ levels in various gastric disorders with special reference to their use as a screening test for carcinoma stomach 显示文摘 | Parthasarathy G Maroju NK Kate V | 2007 | Trop Gastroenterol2007，28，4： | 1 |
| 20 | Site-Specific Conjugation of Cell Wall Polyrhamnose to Protein SpyAD Envisioning a Safe Universal Group A Streptococcal Vaccine显示文摘Development of an effective vaccine against the leading human bacterial pathogen group A Streptococcus(GAS)is a public health priority.The species defining group A cell wall carbohydrate(GAC,Lancefield antigen)can be engineered to remove its immunodominant N-acetylglucosamine(GlcNAc)side chain,implicated in provoking autoimmune cross-reactivity in rheumatic heart disease,leaving its polyrhamnose core(GACPR).Here we generate a novel protein conjugate of the GACPR and test the utility of this conjugate antigen in active immunization.Instead of conjugation to a standard carrier protein,we selected SpyAD,a highly conserved GAS surface protein containing both B-cell and T-cell epitopes relevant to the bacterium that itself shows promise as a vaccine antigen.SpyAD was synthesized using the XpressTM cell-free protein expression system,incorporating a non-natural amino acid to which GACpr was conjugated by site-specific click chemistry to yield high molecular mass SpyAD-GACPR conjugates and avoid disruption of important T-cell and B-cell immunological epitopes.The conjugated SpyAD-GACPR elicited antibodies that bound the surface of multiple GAS strains of diverse M types and promoted opsonophagocytic killing by human neutrophils.Active immunization of mice with a multivalent vaccine consisting of SpyAD-GACPR,together with candidate vaccine antigens streptolysin O and C5a peptidase,protected against GAS challenge in a systemic infection model and localized skin infection model,without evidence of cross reactivity to human heart or brain tissue epitopes.This general approach may allow GAC to be safely and effectively included in future GAS subunit vaccine formulations with the goal of broad protection without autoreactivity. | Nina J.Gao Satoshi Uchiyama Lucy Pill Samira Dahesh Joshua Olson Leslie Bautista Shilpa Maroju Aym Berges Janet ZLiu Raymond HZurich Nina Mvan Sorge Jeff Fairman Neeraj Kapoor Victor Nizet | 2021 | Infectious Microbes & Diseases2021，3，2： | 0 |
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