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| 1 | VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab显示文摘AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab. | Markus Moehler Christian Frings Annett Mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann | 2008 | World Journal of Gastroenterology2008，14，26： | 15 |
| 2 | The SGN VIGS Tool: User-Friendly Software to Design Virus-Induced Gene Silencing (VIGS) Constructs for Functional Genomics显示文摘 | Noe Femandez-Pozo Heman G. Rosli Gregory B. Martin Lukas A. Mueller | 2015 | Molecular Plant2015，8，3： | 12 |
| 3 | Stem cell treatment and cerebral palsy: Systemic review and meta-analysis显示文摘BACKGROUND Perinatal complications may result in life-long morbidities,among which cerebral palsy(CP)is the most severe motor disability.Once developed,CP is a nonprogressive disease with a prevalence of 1-2 per 1000 live births in developed countries.It demands an extensive and multidisciplinary care.Therefore,it is a challenge for our health system and a burden for patients and their families.Recently,stem cell therapy emerged as a promising treatment option and raised hope in patients and their families.AIM The aim is to evaluate the efficacy and safety of stem cell treatment in children with CP using a systematic review and meta-analysis METHODS We performed a systematic literature search on PubMed and EMBASE to find randomized controlled clinical trials(RCT)investigating the effect of stem cell transplantation in children with CP.After the review,we performed a randomeffects meta-analysis focusing on the change in gross motor function,which was quantified using the gross motor function measure.We calculated the pooled standardized mean differences of the 6-and/or 12-mo-outcome by the method of Cohen.We quantified the heterogeneity using the I-squared measure.RESULTS We identified a total of 8 RCT for a qualitative review.From the initially selected trials,5 met the criteria and were included in the meta-analysis.Patients’population ranged from 0.5 up to 35 years(n=282).We detected a significant improvement in the gross motor function with a pooled standard mean difference of 0.95(95%confidence interval:0.13-1.76)favoring the stem cell group and a high heterogeneity(I2=90.1%).Serious adverse events were rare and equally distributed among both intervention and control groups.CONCLUSION Stem cell therapy for CP compared with symptomatic standard care only,shows a significant positive effect on the gross motor function,although the magnitude of the improvement is limited.Short-term safety is present and further highquality RCTs are needed. | Simone Eggenberger Céline Boucard Andreina Schoeberlein Raphael Guzman Andreas Limacher Daniel Surbek Martin Mueller | 2019 | World Journal of Stem Cells2019，11，10： | 8 |
| 4 | Acute pancreatitis in aging animals:Loss of pancreatitis-associated protein protection?显示文摘AIM:To investigate the effect of age on severity of acute pancreatitis(AP) using biochemical markers,histology and expression of the protective pancreatitisassociated proteins(PAPs).METHODS:AP was induced via intraductal injection of 4% sodium taurocholate in young and old rats.Sera and pancreata were assayed at 24 h for the parameters listed above;we also employed a novel molecular technique to assess bacterial infiltration using polymerase chain reaction to measure bacterial genomic ribosomal RNA.RESULTS:At 24 h after induction of AP,the pancreata of older animals had less edema(mean ± SE histologic score of young vs old:3.11 ± 0.16 vs 2.50 ±-0.11,P < 0.05),decreased local inflammatory response(histologic score of stromal infiltrate:3.11 ± 0.27 vs 2.00 ± 0.17,P < 0.05) and increased bacterial infiltration(174% ± 52% increase from sham vs 377% ± 4%,P < 0.05).A decreased expression of PAP1 and PAP2 was demonstrated by Western blotting analysis and immunohistochemical staining.There were no differences in serum amylase and lipase activity,or tissue myeloperoxidase or monocyte chemotactic protein-1 levels.However,in the most-aged group,serum C-reactive protein levels were higher(young vs old:0.249 ± 0.04 mg/dL vs 2.45 ± 0.68 mg/dL,P < 0.05).CONCLUSION:In older animals,there is depressed PAP expression related to a blunted inflammatory response in AP which is associated with worsened bacterial infiltration and higher C-reactive protein level;this may explain the more aggressive clinical course. | Sophia Fu Albert Stanek Cathy M Mueller Nefertti A Brown Chongmin Huan Martin H Bluth Michael E Zenilman | 2012 | World Journal of Gastroenterology2012，18，26： | 5 |
| 5 | Histomorphologic Tumor Regression and Lymph Node Metastases Determine Prognosis Following Neoadjuvant Radiochemotherapy for Esophageal Cancer: Implications for Response Classification显示文摘 | Paul M. Schneider Stephan E. Baldus Ralf Metzger Martin Kocher Rudolf Bongartz Elfriede Bollschweiler Hartmut Schaefer Juergen Thiele Hans P. Dienes Rolf P. Mueller Arnulf H. Hoelscher | 2005 | Annals of Surgery2005，，5： | 2 |
| 6 | Smash,sense,pils,gcrappa:how to choose the optimal method显示文摘 | Felix Breuer Matthias Mueller | 2004 | Top Magn Reson Imaging2004，15，4： | 1 |
| 7 | Current opinions and recommendations on multimodal intraoperative monitoring during spine surgeries显示文摘 | Martin Sutter Vedran Deletis Jiri Dvorak Andreas Eggspuehler Dieter Grob David MacDonald Alfred Mueller Francesco Sala Tetsuya Tamaki | 2007 | European Spine Journal2007，，2： | 1 |
| 8 | Endothelial-Vasoprotective Effects of High-Density Lipoprotein Are Impaired in Patients With Type 2 Diabetes Mellitus but Are Improved After Extended-Release Niacin Therapy显示文摘 | Sajoscha A. Sorrentino Christian Besler Lucia Rohrer Martin Meyer Kathrin Heinrich Ferdinand H. Bahlmann Maja Mueller Tibor Horváth Carola Doerries Mariko Heinemann Stella Flemmer Andrea Markowski Costantina Manes Matthias J. Bahr Hermann Haller Arnold vo | 2010 | Circulation2010，，1： | 1 |
| 9 | Transpupillary thermotherapy (TTT) in circumscribed choroidal hemangioma显示文摘 | Anne V. Fuchs Arthur J. Mueller Martin Grueterich Michael W. Ulbig | 2002 | Graefe’s Archive for Clinical and Experimental Ophthalmology2002，，1： | 1 |
| 10 | Lung wedge resection improves outcome in stage I primary spontaneous pneumothorax显示文摘 | Martin Czerny Andreas Salat Tatjana Fleck Wolfgang Hofmann Daniel Zimpfer Franz Eckersberger Walter Klepetko Ernst Wolner Michael-Rolf Mueller | 2004 | The Annals of Thoracic Surgery2004，，5： | 1 |
| 11 | A Randomized Phase II Study of Pemetrexed in Combination With Cisplatin or Carboplatin as First-line Therapy for Patients With Locally Advanced or Metastatic Non–Small-Cell Lung Cancer显示文摘 | Wolfgang H.W. Schuette Andreas Groeschel Martin Sebastian Stefan Andreas Thomas Mueller Folker Schneller Sylvia Guetz Corinna Eschbach Sabine Bohnet Monika I. Leschinger Martin Reck | 2013 | Clinical Lung Cancer2013，，： | 1 |
| 12 | One Hundred Thirty-Two Consecutive Pediatric Liver Transplants Without Hospital Mortality: Lessons Learned and Outlook for the Future显示文摘 | Dieter C. Broering Jong-Sun Kim Teresa Mueller Lutz Fischer Rainer Ganschow Turan Bicak Lars Mueller Christian Hillert Christian Wilms Bernd Hinrichs Knut Helmke Werner Pothmann Martin Burdelski Xavier Rogiers | 2004 | Annals of Surgery2004，，6： | 1 |
| 13 | Dam safety, emergency action plans and water alarm systems显示文摘 | Martin Wieland and Rudolf Mueller | 2009 | International Water Power & Dam Construction2009，1，： | 1 |
| 14 | Development of a technology for automation and miniaturization of protein crystallization显示文摘 | Uwe Mueller Lajos Nyarsik Martin Horn | 2001 | Journal of Biotechnology2001，85，1： | 1 |
| 15 | Nitric oxide is induced by wounding and influences jasmonic acid signaling in Arabidopsis thaliana显示文摘 | Xi Huang Kurt Stettmaier Christa Michel Peter Hutzler Martin J. Mueller J?rg Durner | 2004 | Planta2004，，6： | 1 |
| 16 | Barrett's esophagus: histopathologic definitions and diagnostic criteria 显示文摘 | James Mueller Martin Wcrner Manfred Stohe | 2004 | World J Surg2004，28，2： | 1 |
| 17 | Misfire Detection by Evaluating Crankshaft Speed A Means to Comply with OBD Ⅱ显示文摘 | Martin Klenk Winfried Moser Werner Mueller | 1993 | SAE paper 9303991993，，： | 1 |
| 18 | Endothelial-Vasoprotective Effects of High-Density Lipoprotein Are Impaired in Patients With Type 2 Diabetes Mellitus but Are Improved After Extended-Release Niacin Therapy显示文摘 | Sajoscha A. Sorrentino Christian Besler Lucia Rohrer Martin Meyer Kathrin Heinrich Ferdinand H. Bahlmann Maja Mueller Tibor Horváth Carola Doerries Mariko Heinemann Stella Flemmer Andrea Markowski Costantina Manes Matthias J. Bahr Hermann Haller Arnold vo | 2010 | Circulation2010，，1： | 1 |
| 19 | Terminal Differentiation of Human Breast Cancer through PPARγ显示文摘 | Elisabetta Mueller Pasha Sarraf Peter Tontonoz Ronald M. Evans Katherine J. Martin Ming Zhang Christopher Fletcher Samuel Singer Bruce M. Spiegelman | 1998 | Molecular Cell1998，，3： | 1 |
| 20 | Nitric oxide is induced by wounding and influences jasmonic acid signaling in Arabidopsis thaliana显示文摘 | Xi Huang Kurt Stettmaier Christa Michel Peter Hutzler Martin J. Mueller J?rg Durner | 2004 | Planta2004，，6： | 1 |
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