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| 1 | Stem cell treatment and cerebral palsy: Systemic review and meta-analysis显示文摘BACKGROUND Perinatal complications may result in life-long morbidities,among which cerebral palsy(CP)is the most severe motor disability.Once developed,CP is a nonprogressive disease with a prevalence of 1-2 per 1000 live births in developed countries.It demands an extensive and multidisciplinary care.Therefore,it is a challenge for our health system and a burden for patients and their families.Recently,stem cell therapy emerged as a promising treatment option and raised hope in patients and their families.AIM The aim is to evaluate the efficacy and safety of stem cell treatment in children with CP using a systematic review and meta-analysis METHODS We performed a systematic literature search on PubMed and EMBASE to find randomized controlled clinical trials(RCT)investigating the effect of stem cell transplantation in children with CP.After the review,we performed a randomeffects meta-analysis focusing on the change in gross motor function,which was quantified using the gross motor function measure.We calculated the pooled standardized mean differences of the 6-and/or 12-mo-outcome by the method of Cohen.We quantified the heterogeneity using the I-squared measure.RESULTS We identified a total of 8 RCT for a qualitative review.From the initially selected trials,5 met the criteria and were included in the meta-analysis.Patients’population ranged from 0.5 up to 35 years(n=282).We detected a significant improvement in the gross motor function with a pooled standard mean difference of 0.95(95%confidence interval:0.13-1.76)favoring the stem cell group and a high heterogeneity(I2=90.1%).Serious adverse events were rare and equally distributed among both intervention and control groups.CONCLUSION Stem cell therapy for CP compared with symptomatic standard care only,shows a significant positive effect on the gross motor function,although the magnitude of the improvement is limited.Short-term safety is present and further highquality RCTs are needed. | Simone Eggenberger Céline Boucard Andreina Schoeberlein Raphael Guzman Andreas Limacher Daniel Surbek Martin Mueller | 2019 | World Journal of Stem Cells2019，11，10： | 8 |
| 2 | Endovascular Treatment of Posterior Circulation Aneurysms by Using Guglielmi Detachable Coils: A 10-year Single-center Experience with Special Regard to Technical Development 显示文摘 | Pasquale Mordasini Gerhard Schroth Raphael Guzman | 2005 | AJNR2005，26，8： | 1 |
| 3 | Cell Transplantation Therapy for Stroke显示文摘 | Tonya Bliss Raphael Guzman Marcel Daadi Gary K. Steinberg | | 2007 (2, P)0，，： | 1 |
| 4 | Thrombophilic Genetic Factors PAI-1, MTHFRC677T, V Leiden 506Q, and Prothrombin 20210A in Noncirrhotic Portal Vein Thrombosis and Budd-Chiari Syndrome in a Caucasian Population显示文摘 | Mario D’Amico Pietro Sammarco Linda Pasta Raphael Guzman | 2013 | International Journal of Vascular Medicine2013，，： | 1 |
| 5 | Preoperative transarterial embolization of vertebral metastases显示文摘 | Raphael Guzman Susan Dubach-Schwizer Paul Heini Karl-Olof Lovblad Daniel Kalbermatten Gerhard Schroth Luca Remonda | 2005 | European Spine Journal2005，，： | 1 |
| 6 | Preoperative transarterial embolization of vertebral metastases显示文摘 | Raphael Guzman Susan Dubach-Schwizer Paul Heini Karl-Olof Lovblad Daniel Kalbermatten Gerhard Schroth Luca Remonda | 2005 | European Spine Journal2005，，3： | 1 |
| 7 | Lignocellulosic Micro and Nanofibrillated Cellulose Produced by Steam Explosion for Wood Adhesive Formulations显示文摘The reinforcing impact of Lignocellulosic micro and nanofibrillated cellulose(L-MNFCs)obtained from Eucalyp-tus Globulus bark in Urea-Formaldehyde UF adhesive was tested.L-MNFCs were prepared by an environmentally friendly,low-cost process using a combination process involving steam explosion followed by refining and ultra-fine grinding.Obtained L-MNFCs showed a web-like morphology with some aggregates and lignin nanodroplets.They present a mixture of residual fibers and fine elements with a width varying between 5 nm to 20μm,respec-tively.The effects of the addition of low amounts of L-MNFCs(1%wt.)on the properties of three different adhe-sives(Urea-Formaldehyde UF,Phenol-Formaldehyde PF,and Tannin-Hexamine TH)were studied by the evolution of the pH,the viscosity,and the mechanical properties.Results showed that the viscosity of PF and UF adhesives increased with the addition of L-MNFCs,unlike TH.Meanwhile,the addition led to better mechan-ical behavior for the three adhesives.Particleboards were then prepared using modified UF with L-MNFCs and tested.Results showed that an amount of 1%wt.of L-MNFCs was sufficient to increase the internal bonding by≈67%,the modulus of elasticity by≈43%,and the modulus of rupture by≈29%. | Saad Nader Felipe Guzman Raphael Becar Cesar Segovia Cecilia Fuentealba Miguel Peirera Evelyne Mauret Nicolas Brosse | 2022 | Journal of Renewable Materials2022，10，2： | 0 |
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