维普期刊资源整合服务平台（V6.5）

维普中文期刊产品整合服务

4篇 您的检索式：作者名="Martin Styner"

选中清除导出查看参考文献查看引证文献引用追踪共1页首页上一页第1页下一页末页 /1 跳转

		题名	作者	年代	出处	被引量
	1	Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development显示文摘Brain size and cognitive skills are the most dramatically changed traits in humans during evolution and yet the genetic mechanisms underlying these human-specific changes remain elusive.Here,we successfully generated 11 transgenic rhesus monkeys(8 first-generation and 3 second-generation)carrying human copies of MCPH1,an important gene for brain development and brain evolution.Brain-image and tissue-section analyses indicated an altered pattern of neural-cell differentiation,resulting in a delayed neuronal maturation and neural-fiber myelination of the transgenic monkeys,similar to the known evolutionary change of developmental delay(neoteny)in humans.Further brain-transcriptome and tissue-section analyses of major developmental stages showed a marked human-like expression delay of neuron differentiation and synaptic-signaling genes,providing a molecular explanation for the observed brain-developmental delay of the transgenic monkeys.More importantly,the transgenic monkeys exhibited better short-term memory and shorter reaction time compared with the wild-type controls in the delayed-matching-to-sample task.The presented data represent the first attempt to experimentally interrogate the genetic basis of human brain origin using a transgenic monkey model and it values the use of non-human primates in understanding unique human traits.	Lei Shi Xin Luo Jin Jiang Yongchang chen Cirong Liu Ting Hu Min Li Qiang Lin Yanjiao Li Jun Huang Hong Wang Yuyu Niu Yundi Shi Martin Styner Jianhong Wang Yi Lu Xuejin Sun Hualin Yu Weizhi Ji Bing Su	2019	National Science Review2019，6，3：	12
	2	Diffusion imaging quality control via entropy of principal direction distribution显示文摘	Mahshid Farzinfar Ipek Oguz Rachel G. Smith Audrey R. Verde Cheryl Dietrich Aditya Gupta Maria L. Escolar Joseph Piven Sonia Pujol Clement Vachet Sylvain Gouttard Guido Gerig Stephen Dager Robert C. McKinstry Sarah Paterson Alan C. Evans Martin A. Styner	2013	Neuroimage2013，，：	1
	3	Prenatal isolated mild ventriculomegaly is associated with persistent ventricle enlargement at ages 1 and 2显示文摘	Amanda E. Lyall Sandra Woolson Honor M. Wolfe Barbara Davis Goldman J. Steven Reznick Robert M. Hamer Weili Lin Martin Styner Guido Gerig John H. Gilmore	2012	Early Human Development2012，，8：	1
	4	Prenatal isolated mild ventriculomegaly is associated with persistent ventricle enlargement at ages 1 and 2显示文摘	Amanda E. Lyall Sandra Woolson Honor M. Wolfe Barbara Davis Goldman J. Steven Reznick Robert M. Hamer Weili Lin Martin Styner Guido Gerig John H. Gilmore	2012	Early Human Development2012，，8：	1

返回顶部每页显示：

共1页首页上一页第1页下一页末页 /1 跳转

goolge学术搜索-维普

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费