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| 1 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 2 | The Sandfish's Skin:Morphology,Chemistry and Reconstruction显示文摘The sandfish is a lizard having the remarkable ability to move in desert sand in a swimming-like fashion. The most out-standing adaptations to this mode of life are the low friction behaviour and the extensive abrasion resistance of the sandfish skin against sand, outperforming even steel. We investigated the topography, the composition and the mechanical properties of sandfish scales. These consist of glycosylated keratins with high amount of sulphur but no hard inorganic material, such as silicates or lime. Remarkably, atomic force microscopy shows an almost complete absence of attractive forces between the scale surface and a silicon tip, suggesting that this is responsible for the unusual tribological properties. The unusual glycosylation of the keratins was found to be absolutely necessary for the described phenomenon. The scales were dissolved and reconstituted on a polymer surface resulting in properties similar to the original scale. Thus, we provide a pathway towards exploitation of the reconstituted scale material for future engineering applications. | Werner Baumgartner Friederike Saxe Agnes Weth David Hajas Darwin Sigumonrong Jens Emmerlich Martin Singheiser Wolfgang Bhme Jochen M. Schneider | 2007 | Journal of Bionic Engineering2007，4，1： | 10 |
| 3 | Noninvasive indocyanine green plasma disappearance rate predicts early complications,graft failure or death after liver transplantation显示文摘BACKGROUND:Early detection of graft malfunction or postoperative complications is essential to save patients and organs after orthotopic liver transplantation (OLT).Predictive tests for graft dysfunction are needed to enable earlier implementation of organ-saving interventions following transplantation.This study was undertaken to assess the value of indocyanine green plasma disappearance rates (ICG-PDRs) for predicting postoperative complications,graft dysfunction and patient survival following OLT.METHODS:Eighty-six patients undergoing OLT were included in this single-centre trial.ICG-PDR was assessed daily for the first 7 days following OLT.Endpoints were graft loss or death within 30 days and postoperative complications,graft loss,or death within 30 days.RESULTS:Postoperative complications of 31 patients included deaths (12 patients) or graft losses.ICG-PDR was significantly different in patients whose endpoints were graft loss or death beginning from day 3 and in those whose endpoints were graft loss,death,or postoperative complications beginning from day 4 after OLT.For day 7 measurements,receiver operating characteristic curve analysis revealed an ICG-PDR cut-off for predicting death or graft loss of 9.6% per min (a sensitivity of 75.0%,a specificity of 72.6%,positive predictive value 0.35 negative predictive value 0.94).For prediction of graft loss,death or postoperative complications,the ICG-PDR cut-off was 12.3%per min (a sensitivity of 68.9%,a specificity of 66.7%,positive predictive value 0.57,negative predictive value 0.77).CONCLUSIONS:ICG-PDR measurements on postoperative day 7 are predictive of early patient outcomes following OLT.The added value over that of routinely determined laboratory parameters is low. | Lutz Schneider Martin Spiegel Sebastian Latanowicz Markus A Weigand Jan Schmidt Jens Werner Wolfgang Stremmel Christoph Eisenbach | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 6 |
| 4 | CT diagnosis of recurrence after pancreatic cancer:Is there a pattern?显示文摘AIM:To investigate predilection sites of recurrence of pancreatic cancer by computed tomography(CT)in follow-up after surgery. METHODS:Seventy seven patients with recurrence after pancreatic cancer surgery were retrospectively identified.The operative technique,R-status,T-stage and development of tumor markers were evaluated. Two radiologists analyzed CT scans with consensus readings.Location of local recurrence,lymph node recurrence and organ metastases were noted.Surgery and progression of findings on follow-up CT were con-sidered as reference standard. RESULTS:The mean follow-up interval was 3.9± 1.8 mo,with a mean relapse-free interval of 12.9± 10.4 mo.The predominant site of recurrence was local (65%),followed by lymph node(17%),liver metastasis (11%)and peritoneal carcinosis(7%).Local recurrence emerged at the superior mesenteric artery(n=28),the hepatic artery(n=8),in an area defined by the surrounding vessels:celiac trunk,portal vein,inferior vena cava(n=22),and in a space limited by the mesenteric artery,portal vein and inferior vena cava(n=17). Lymph node recurrence occurred in the mesenteric root and left lateral to the aorta.Recurrence was confirmed by surgery(n=22)and follow-up CT(n=55).Tumor markers[carbohydrate antigen 19-9(CA19-9),carcinoembryonic antigen(CEA)]increased in accordance with signs of recurrence in most cases(86%CA19-9;79.2% CEA). CONCLUSION:Specific changes of local and lymph node recurrence can be found in the course of the cardinal peripancreatic vessels.The superior mesenteric artery is the leading structure for recurrence. | Tobias Heye Nicola Zausig Miriam Klauss Reinhard Singer Jens Werner Gtz Martin Richter Hans-Ulrich Kauczor Lars Grenacher | 2011 | World Journal of Gastroenterology2011，17，9： | 6 |
| 5 | 陶瓷球头和金属球头配伍聚乙烯臼杯的20年长期对比磨损研究显示文摘背景关节承载面是假体磨损过程中的重要假体相关因素。目前已知聚乙烯磨损是全髋关节置换术后髋臼和股骨假体组件无菌性松动的主要原因。方法本项前瞻性研究中,共随机挑选了80例同时期患者共93个髋关节接受了非骨水泥髋关节置换术,使用钛涂层的RM臼杯和CLS股骨柄。80例髋关节使用陶瓷球头,13例使用钴铬钼合金球头,所有股骨头直径均为32 mm。所有患者平均年龄为52岁,研究平均随访时间为19.3年。所有患者均获得随访。结果随访时使用EBRA系统对髋臼假体组件的磨损、倾斜和前倾角进行影像学评估。其中55例髋关节进行了磨损率的确认。翻修病例的平均磨损率为0.191 mm年/,而未翻修病例的平均磨损率为0.105 mm年/(P=0.041)。钴铬钼合金组平均磨损率为0.190 mm年/,陶瓷组平均磨损率为0.107 mm年/(P=0.025)。钴铬钼合金组的翻修率(13例中6例)明显高于陶瓷组(80例中11例)。股骨球头磨损率与其材料(P=0.025)、股骨柄周围骨溶解(P=0.003)、臼杯骨溶解(P=0.011)、臼杯翻修(P=0.041)以及臼杯倾斜(P=0.012)呈正性相关。结论本长期研究表明,在20年的时间里,陶瓷股骨头与钴铬钼合金股骨头相比造成的线性磨损更少,从而显著减少骨溶解的发生以及任一假体部件的翻修。 | Martin Ihle Sabine Mai Werner E. Siebert 张卓(译) 陈文(校) | 2010 | 中华关节外科杂志(电子版)2010，4，3： | 4 |
| 6 | The peroxisome proliferator-activated receptor-α (PPAR-α) agonist, AVE8134, attenuates the progression of heart failure and increases survival in rats显示文摘 | Wolfgang LINZ Paulus WOHLFART Manuel BAADE Kristin BREITSCHOPF EugenFALK Hans-Ludwig SCHAFER Martin GERL Werner KRAMER Hartmut RUTTEN | 2009 | Acta Pharmacologica Sinica2009，30，7： | 3 |
| 7 | High-pitch spiral acquisition: A new scan mode for coronary CT angiography显示文摘 | Stephan Achenbach Mohamed Marwan Tiziano Schepis Tobias Pflederer Herbert Bruder Thomas Allmendinger Martin Petersilka Katharina Anders Michael Lell Axel Kuettner Dieter Ropers Werner G. Daniel Thomas Flohr | 2009 | Journal of Cardiovascular Computed Tomography2009，，2： | 2 |
| 8 | Osteoprotegerin Is a Risk Factor for Progressive Atherosclerosis and Cardiovascular Disease显示文摘 | Stefan Kiechl Georg Schett Gregor Wenning Kurt Redlich Martin Oberhollenzer Agnes Mayr Peter Santer Josef Smolen Werner Poewe Johann Willeit | 2004 | Circulation: Journal of the American Heart Association2004，，18： | 2 |
| 9 | 灵芝中肿瘤细胞凋亡诱导剂的研究显示文摘灵芝水提物(LZ)对8种肿瘤细胞增殖的抑制作用具有剂量依赖关系。通过透析和离子交换凝胶过滤层析方法从LZ中分离出活性组分LZ-DN-2-2和LZ-DW-2-a-3。LZ、LZ-DN-2-2和LZ-DW-2-a-3可剂量依赖地诱导SW620细胞凋亡,使细胞增殖周期停滞于G0期。 | 张劲松 唐庆九 ZIMMERMAN-KORDMANN Martin REUTTER Werner 樊华 | 2006 | 食用菌学报2006，13，2： | 2 |
| 10 | A Wheel Passing a Crossing Nose Dynamic Analysis under High Axle Loads Using Finite Element Modeling显示文摘 | MARTIN Pletz WERNER Daves HENIZ Ossberger | 2012 | Proceedings of the Institution of Mechanical Engineers PartF:Journal of Rail and Rapid Transit2012，226，10： | 1 |
| 11 | Caspase 3 inactivates biologically active full length interleukin-33 as a classical cytokine but does not prohibit nuclear translocation显示文摘 | Shafaqat Ali Dang Quan Nguyen Werner Falk Michael Uwe Martin | 2009 | Biochemical and Biophysical Research Communications2009，，3： | 1 |
| 12 | Green peduncles may indicate postharvest freshness of sweet cherries显示文摘 | Manfred Linke Werner B. Herppich Martin Geyer | 2010 | Postharvest Biology and Technology2010，，2： | 1 |
| 13 | Particle dispersion in aswirling confined jet flow 显示文摘 | Sommerfeld Martin Krebs Werner | 1990 | Particle&Particle Systems Characterization1990，7，1234： | 1 |
| 14 | ERCP or EUS for tissue diagnosis of biliary strictures? a prospective comparative study显示文摘 | Thomas R?sch Kim Hofrichter Eckart Frimberger Alexander Meining Peter Born Norbert Weigert Hans-Dieter Allescher Meinhard Classen Marius Barbur Ulrich Schenck Martin Werner | 2004 | Gastrointestinal Endoscopy2004，，3： | 1 |
| 15 | A Wheel Passing a Crossing Nose: Dynamic Analysis under High Axle Loads Using Finite Element Modeling 显示文摘 | Martin Pletz Werner Daves Heinz Ossberger | 2012 | Proc IMechE Part F: J Raft and Rapid Transit2012，，10： | 1 |
| 16 | A novel approach for reliable microarray analysis of microdissected tumor cells from formalin-fixed and paraffin-embedded colorectal cancer resection specimens显示文摘 | Silke Lassmann Clemens Kreutz Anja Schoepflin Ulrich Hopt Jens Timmer Martin Werner | 2009 | Journal of Molecular Medicine2009，，2： | 1 |
| 17 | Endothelial-Regenerating Cells: An Expanding Universe显示文摘 | Martin Steinmetz Georg Nickenig Nikos Werner | 2010 | Hypertension2010，，3： | 1 |
| 18 | Surgical Management of Pulmonary Metastases from Colorectal Cancer in 153 Patients显示文摘 | Süleyman Yedibela Peter Klein Karsta Feuchter Martin Hoffmann Thomas Meyer Thomas Papadopoulos Jonas G?hl Werner Hohenberger | 2006 | Annals of Surgical Oncology2006，，11： | 1 |
| 19 | Web composition :An object oriented support system for the web engineering life cycle显示文摘 | Hans Werner Gellerson Robert Wicke Martin Gaedke | 1997 | Computer Networks and ISDN System1997，1，4： | 1 |
| 20 | Antigen retrieval, signal amplification and intensification in immunohistochemistry显示文摘 | Martin Werner Reinhard Wasielewski Paul Komminoth | 1996 | Histochemistry and Cell Biology1996，，4： | 1 |
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