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| 1 | Plecanatide-mediated activation of guanylate cyclase-C suppresses inflammation-induced colorectal carcinogenesis in Apc+/Min-FCCC mice显示文摘AIM To evaluate the effect of orally administered plecanatide on colorectal dysplasia in Apc^(+/Min-FCCC) mice with dextran sodium sulfate(DSS)-induced inflammation. METHODS Inflammation driven colorectal carcinogenesis was induced in Apc^(+/Min-FCCC) mice by administering DSS in their drinking water. Mice were fed a diet supplemented with plecanatide(0-20 ppm) and its effect on the multiplicity of histopathologically confirmed polypoid,flat and indeterminate dysplasia was evaluated. Plecanatide-mediated activation of guanylate cyclase-C(GC-C) signaling was assessed in colon tissues by measuring cyclic guanosine monophosphate(cG MP) by ELISA, protein kinase G-II and vasodilator stimulated phosphoprotein by immunoblotting. Ki-67, c-myc and cyclin D1 were used as markers of proliferation. Cellular levels and localization of b-catenin in colon tissues were assessed by immunoblotting and immunohistochemistry, respectively. Uroguanylin(UG) and GC-C transcript levels were measured by quantitative reverse transcription polymerase chain reaction(RT-PCR). A mouse cytokine array panel was used to detect cytokines in the supernatant of colon explant cultures. RESULTS Oral treatment of Apc^(+/Min-FCCC) mice with plecanatide produced a statistically significant reduction in the formation of inflammation-driven polypoid, flat and indeterminate dysplasias. This anti-carcinogenic activity of plecanatide was accompanied by activation of cG MP/GC-C signaling mediated inhibition of Wnt/b-catenin signaling and reduced proliferation. Plecanatide also decreased secretion of pro-inflammatory cytokines(IL-6, IL-1 TNF), chemokines(MIP-1, IP-10) and growth factors(GCSF and GMCSF) from colon explants derived from mice with acute DSS-induced inflammation. The effect of plecanatidemediated inhibition of inflammation/dysplasia on endogenous expression of UG and GC-C transcripts was measured in intestinal tissues. Although GC-C expression was not altered appreciably, a statistically significant increase in the level of UG transcripts was detected in the proximal small intestine and colon, potentially due to a reduction in intestinal inflammation and/or neoplasia. Taken together, these results suggest that reductions in endogenous UG, accompanied by dysregulation in GC-C signaling, may be an early event in inflammation-promoted colorectal neoplasia; an event that can potentially be ameliorated by prophylactic intervention with plecanatide.CONCLUSION This study provides the first evidence that orally administered plecanatide reduces the multiplicity of inflammation-driven colonic dysplasia in mice, demonstrating the utility for developing GC-C agonists as chemopreventive agents. | Wen-Chi L Chang Shet Masih Anusha Thadi Viren Patwa Apoorva Joshi Harry S Cooper Vaseem A Palejwala Margie L Clapper Kunwar Shailubhai | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 5 |
| 2 | Cobalt and sulfur co-doped nano-size TiO_2 for photodegradation of various dyes and phenol显示文摘Various compositions of cobalt and sulfur co-doped titania nano-photocatalyst are synthesized via sol–gel method. A number of techniques including X-ray diffraction(XRD), ultraviolet–visible(UV–Vis), Rutherford backscattering spectrometry(RBS), thermal gravimetric analysis(TGA)Raman, N2 sorption, electron microscopy are used to examine composition, crystalline phase, morphology, distribution of dopants, surface area and optical properties o synthesized materials. The synthesized materials consisted of quasispherical nanoparticles of anatase phase exhibiting a high surface area and homogeneous distribution o dopants. Cobalt and sulfur co-doped titania demonstrated remarkable structural and optical properties leading to an efficient photocatalytic activity for degradation of dyes and phenol under visible light irradiations. Moreover, the effect of dye concentration catalyst dose and p H on photodegradation behavior of environmental pollutants and recyclability of the catalyst is also examined to optimize the activity of nano-photocatalys and gain a better understanding of the process. | Asima Siddiqa Dilshad Masih Dalaver Anjum Muhammad Siddiq | 2015 | Journal of Environmental Sciences2015，27，11： | 3 |
| 3 | Energy consumption, real income and temporal causality: results from a multi-country study based on cointegration and error-correction modelling techniques显示文摘 | Abul M.M. Masih Rumi Masih | 1996 | Energy Economics1996，，3： | 2 |
| 4 | 药品生产质量管理规范(GMP)的演变显示文摘GMP代表良好生产实践规范。在药品生产过程中,GMP是一系列用以确保连续生产出符合预定质量参数药品的活动。此外,GMP是质量保证的一部分,以确保药品始终如一地符合法规要求的质量标准进行生产和控制,并保护患者。因此,作为制药行业的从业人员,知道并了解药品生产质量管理规范(GMPs)的发展历程是一项重要的工作。 | Masih Sabet | 2013 | 流程工业2013，，22： | 2 |
| 5 | Polycyclic aromatic hydrocarbons (PAHs) concentrations and related carcinogenic potencies in soil at a semi-add region of India 显示文摘 | Masih A Taneja A | 2006 | Chemosphere2006，65，3： | 1 |
| 6 | Lycopene content ofhydroponic and non-hydroponic tomatoes during postharvest storage 显示文摘 | Ajlouni S Kremer S Masih L | 2001 | Food Australia2001，5，53： | 1 |
| 7 | Energy Consumption, Real Income and Temporal Causality: Results from a Multi-Country Study Based on Cointegrafion and Error-Correction Modeling Techniques显示文摘 | A M M Masih R Masih | 1996 | Energy Economics1996，18，3： | 1 |
| 8 | Energy consumption and real income temporal causality, results for a multi-country study based on cointegration and error-correction tech- niques显示文摘 | MASIH A MASIH R | 1996 | Energy Economies1996，18，3： | 1 |
| 9 | Energy consumption,real income and temporal causality:results from a multi-country study based on cointegration and error-correction modelling techniques显示文摘 | Masih R | 1996 | Energy Economics1996，，18： | 1 |
| 10 | Concentrations, sources, and exposure profiles of polycyclic aromatic hydrocarbons (PAHs) in particu- late matter (PMlo) in the north central part of India显示文摘 | MASIH A SAINI R SINGHVI R | 2010 | Environmental monitoring and assessment2010，163，： | 1 |
| 11 | A Multivariate Cointegrated Modeling Approach in Testing Temporal Causality Between Energy Consumption,Real Income and Prices with an Application to Two Asian LDCs显示文摘 | MASIH R | 1998 | Applied Economics1998，3，10： | 1 |
| 12 | Effects of sweetpotato flour on quality of cookies 显示文摘 | Saeed S Ahmad M M Kausar H Parveen S Masih S Salam A | 2012 | Journal of Agricultural Research2012，50，4： | 1 |
| 13 | Hydrothermal synthesis of pure ZSM-22 under mild conditions显示文摘 | Masih D Kobayashi T Baba T | 2007 | ( 31 ) : 3303-33052007，，31： | 1 |
| 14 | Energy Consumption, Real Income and Temporal Causality: Results from a Multi-country Study Based on Cointegration and Error- correction Modeling Techniques 显示文摘 | Masih A M M Masih R | 1996 | Energy Economics1996，，18： | 1 |
| 15 | Soft tissue Langerhans ' cell histiocytosis in an adult:a case presentation with flow cytometric analysis and literature review显示文摘 | aI-Abbadi M Masih A Braylan RC | | 0，，： | 1 |
| 16 | Energy consumption,real income and temporal causality:results from a multi-country study based on co-integration and error-correction modeling techniques显示文摘 | Masih A M Masih R | 1996 | Energy Economics1996，18，3： | 1 |
| 17 | Excretory-secretory products (ESP) from Fasciola hepatica induce tolerogenic properties in myeloid dendritic cells显示文摘 | Cristian Falcón Franco Carranza Fernando F. Martínez Carolina P. Knubel Diana T. Masih Claudia C. Motrán Laura Cervi | 2010 | Veterinary Immunology and Immunopathology2010，，1： | 1 |
| 18 | A Multivariate Cointegrated Modeling Ap-proach in Testing Temporal Causality between Energy Consumption,Real In-come and Prices with an Application to Two Asian LDCs显示文摘 | Abul M M Masih Rumi Masih | 1998 | Applied Eco-nomics1998，30，10： | 1 |
| 19 | Imaging of pigmented villonodular显示文摘 | Masih S Antebi A | | 0，，： | 1 |
| 20 | Mismatch repair proteins are recruited to replicating DNA through interaction with proliferating cell nuclear antigen (PCNA) 显示文摘 | Masih PJ Kunnev D Melendy T | 2008 | Nucleic Acids Res2008，36，1： | 1 |
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